Longevity Supplements: 7 Pathways to Healthy Aging

Science-backed supplements targeting NAD+ restoration, sirtuin activation, senolytic clearance, autophagy, telomere support, and inflammation control. Made in USA with third-party testing.

USA
Made in USA
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Certified
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HPLC
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2007
Since

Understanding Longevity Supplement Pathways

Longevity supplements (Wikidata Q188) are compounds that target the fundamental mechanisms of biological aging at the cellular level. Rather than addressing symptoms, these supplements work on the root causes of age-related decline: reduced cellular energy, accumulation of senescent cells, decreased autophagy, telomere shortening, chronic inflammation, and impaired stress resistance pathways.

Modern aging research has identified seven primary pathways that influence how we age. RevGenetics offers specialized products for each pathway, allowing you to build a comprehensive longevity stack based on your individual goals. Understanding these pathways helps you select the right supplements for your needs.

NAD+ Restoration addresses the decline in nicotinamide adenine dinucleotide that occurs with age. NAD+ is essential for cellular energy production, DNA repair, and sirtuin function. NMN supplements directly restore NAD+ levels. Sirtuin Activation uses compounds like resveratrol to activate the "longevity genes" that regulate stress resistance and cellular repair. Senolytic Clearance employs compounds like fisetin and quercetin to selectively eliminate senescent "zombie cells" that accumulate with age and drive inflammation.

Autophagy Induction supports the cellular cleanup process that removes damaged proteins and organelles. Spermidine is the primary autophagy-inducing supplement. Telomere Support uses TA-65 to activate telomerase, the enzyme that maintains the protective caps on chromosomes. Inflammation Control with MetaCurcumin (277x absorption) addresses the chronic low-grade inflammation that accelerates aging. AMPK Activation with EGCG supports metabolic health and cellular energy sensing.

The RevGenetics Quality Standard

RevGenetics was the first supplement company to provide public Certificates of Analysis (COAs) for every batch. Since 2007, we have maintained the highest quality standards in the industry.

Made in USA manufacturing
cGMP certified facilities
Third-party tested
Public COAs for every batch
HPLC verified potency
Stability tested (24+ months)
Anthony Loera, Founder and CEO of RevGenetics

Anthony Loera, Founder & CEO

19+ years formulating longevity supplements | Pioneer in COA transparency

Last Updated: January 7, 2026

Select Your Longevity Pathway

Click any pathway to explore products targeting that mechanism

⚡

NAD+ Restoration

Cellular energy, DNA repair, sirtuin substrate

→ NMN Supplements
🧬

Sirtuin Activation

Longevity genes, stress resistance

→ Resveratrol
🎯

Senolytic Clearance

Remove zombie cells, reduce inflammation

→ Fisetin & Quercetin
♻️

Autophagy Induction

Cellular cleanup, renewal

→ Spermidine
🔬

Telomere Support

Chromosome protection, cellular age

→ TA-65
🔥

Inflammation Control

277x absorption, inflammaging

→ MetaCurcumin
🍃

AMPK Activation

Metabolic health, energy sensing

→ EGCG

Longevity Supplement Comparison Matrix

All 7 pathways at a glance

Pathway Product Primary Mechanism Dosing Best For
NAD+ Restoration NMN Supplements NAD+ precursor Daily Foundation of any stack
Sirtuin Activation Resveratrol SIRT1 activation Daily Synergy with NMN
Senolytic Clearance Fisetin / Quercetin Senescent cell apoptosis Periodic (pulse) Reduce zombie cells
Autophagy Induction Spermidine Cellular recycling Daily Cellular cleanup
Telomere Support TA-65 Telomerase activation Daily Chromosome protection
Inflammation Control MetaCurcumin 277x NF-kB inhibition Daily Inflammaging
AMPK Activation EGCG Metabolic sensor Daily Metabolic health

Shop by Category

FOUNDATION

NMN Supplements

Powder (147 servings), NADShield Capsules (NNMT protection), High-Dose 1000mg. 30-minute absorption, 99% purity.

Shop NMN →
SIRTUIN

Resveratrol Supplements

X500 for PCOS (1,500mg protocol), Nitro500 for heart (dual-pathway), M98 for 98% absorption (Polydatin).

Shop Resveratrol →
SENOLYTIC

Fisetin & Quercetin

Super Fisetin for targeted senolytic clearance. Quercetin for broader senolytic and anti-inflammatory support. Pulse dosing protocols.

Shop Senolytics →
AUTOPHAGY

Spermidine Supplements

Autophagy-inducing polyamine for cellular renewal. Supports cardiovascular and cognitive health through enhanced cellular cleanup.

Shop Spermidine →
TELOMERE

TA-65 Telomerase Activator

100 Units (maintenance) vs 250 Units (clinical dose). 530bp telomere increase in Salvador study. GRAS certified.

Shop TA-65 →
INFLAMMATION

Curcumin Supplements

MetaCurcumin 277x absorption via liquid micelle technology. No black pepper needed. Gentle on stomach.

Shop Curcumin →
AMPK

EGCG Green Tea Extract

800mg high-potency formula. Autophagy and AMPK activation. Caffeine-free option for sensitive users.

Shop EGCG →

Frequently Asked Questions

What are the main categories of longevity supplements?

Longevity supplements target 7 primary aging pathways: NAD+ restoration (NMN), sirtuin activation (Resveratrol), senolytic clearance (Fisetin/Quercetin), autophagy induction (Spermidine), telomere support (TA-65), inflammation control (Curcumin), and AMPK activation (EGCG).

Which longevity supplement should I start with?

Most researchers recommend starting with NAD+ support (NMN) as the foundation because NAD+ decline affects virtually all cellular processes. After establishing NAD+ support, add Resveratrol which works synergistically. Then consider Senolytics for periodic clearance.

Can I combine multiple longevity supplements?

Yes. A comprehensive stack might include: NMN daily for NAD+, Resveratrol daily for sirtuins (synergy with NMN), Spermidine daily for autophagy, Curcumin for inflammation, and Senolytics periodically (not daily) for senescent cell clearance.

What quality standards should I look for?

Look for: Made in USA manufacturing, cGMP certified facilities, third-party testing with public COAs, HPLC verified potency, and stability testing. RevGenetics was the first supplement company to provide public COAs for every batch.

How long until I see results?

Timeline varies: NAD+ restoration (NMN) often shows energy improvements within 2-4 weeks. Sirtuin benefits accumulate over months. Telomere support (TA-65) shows measurable changes at 3-6 months. Autophagy benefits are cumulative over months to years.

Are longevity supplements safe for long-term use?

Most longevity supplements have good safety profiles. NMN has GRAS status since 2018. TA-65 has GRAS certification with year-long clinical trials. Resveratrol, Quercetin, Fisetin, and Spermidine are naturally occurring compounds with extensive safety data.

Important Health Information

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Quality Assurance:

  • Made in USA manufacturing
  • cGMP certified facilities
  • Third-party tested for purity
  • Public COAs for every batch
  • HPLC verified potency
  • Ships to 50+ countries