Super Fisetin 500mg: Patent-Pending 25-50x Enhanced Absorption Technology
🔬 Patent Pending
Super Fisetin delivers 500mg of 98% pure fisetin with patent-pending RGBooster1™ absorption technology, designed to achieve 25-50x better absorption than standard fisetin supplements.
In the landmark 2018 Mayo Clinic study, fisetin was identified as the most potent senolytic of 10 flavonoids tested, extending both healthspan and lifespan in mice. However, standard fisetin has notoriously poor bioavailability. Super Fisetin solves this challenge with enhanced delivery.
Serving: 500mg 98% pure fisetin + RGBooster1™
🍓 The Strawberry Math: Why Enhanced Absorption Matters
Strawberries are the richest dietary source of fisetin at 160 μg per gram. But to get a meaningful dose, you'd need to eat an impractical amount:
500mg raw fisetin
500mg enhanced fisetin
But here's the real math: With 25-50x enhanced absorption, one Super Fisetin serving delivers the equivalent absorbed fisetin of:
That's 37-55 cups of strawberries EVERY DAY for comparable absorption
💰 Cost Comparison: Strawberries vs. Super Fisetin
| Source | Amount Needed | Daily Cost | Monthly Cost (5-day protocol) |
Practical? |
|---|---|---|---|---|
|
Fresh Strawberries Raw fisetin only |
6.9 lbs/day | ~$34.50 | $172.50 | ❌ Impractical |
|
Fresh Strawberries Matching 25x absorption |
172 lbs/day | ~$860 | $4,300 | ❌ Impossible |
|
Fresh Strawberries Matching 50x absorption |
345 lbs/day | ~$1,725 | $8,625 | ❌ Impossible |
|
Super Fisetin 500mg + RGBooster1™ |
2 capsules/day | ~$7.40 | $37.03 | ✓ Practical |
Calculation basis: Strawberries at $5/lb average (organic). Super Fisetin $222.20 for 60 capsules (6-month supply at 5 days/month = 10 capsules/month).
The 5-Day Cycling Protocol: Hit-and-Run Senolytic Strategy
Super Fisetin uses a unique 5-day cycling protocol based on the "hit-and-run" mechanism observed in senolytic research. You take Super Fisetin for 5 consecutive days per month, then take the rest of the month off.
Step-by-Step Protocol for Super Fisetin
- Choose Your 5-Day Window: Select 5 consecutive days each month for your senolytic protocol. Many users choose the first 5 days of each month for easy tracking.
- Take 2 Capsules Daily: Take 2 capsules (500mg total fisetin) each day during your 5-day window. Take with food to reduce any stomach sensitivity.
- Maintain Medication Spacing: Take Super Fisetin 3-4 hours before or after any medications. The enhanced delivery system may affect medication absorption.
- Rest for Remaining Days: After 5 days, stop taking Super Fisetin for the rest of the month. This hit-and-run approach allows your body to clear senescent cell debris.
- Repeat Monthly: Repeat the 5-day protocol each month. One bottle of 60 capsules provides a 6-month supply (10 capsules per month).
Why 5 Days?
Research shows senolytics don't need continuous dosing. Once senescent cells are cleared, they stay cleared. The body needs time to process and remove the cellular debris.
6-Month Supply
One bottle of 60 capsules lasts approximately 6 months when following the 5-day protocol (10 capsules per month).
Aligned with Research
The Mayo Clinic study showed "acute or intermittent treatment" was effective. The AFFIRM-LITE trial uses a similar approach: 2 consecutive days per month.
Cost Effective
At $222.20 for 6 months, Super Fisetin costs just $37.03/month, less than many daily supplements.
⚠️ Important Safety Information: Super Fisetin is designed for healthy adults only. The enhanced delivery system may affect medication absorption. Take Super Fisetin 3-4 hours before or after any medications. Always consult your healthcare provider before use.
The Fisetin Bioavailability Challenge: Why Standard Supplements Underperform
The Core Problem: Fisetin has extremely poor bioavailability. Research shows it has a half-life of only 2.7 minutes after IV administration, and less than 10% of orally consumed fisetin reaches the bloodstream. This is why clinical trials use mega-doses of 1,400-2,000mg, as they're trying to overcome terrible absorption with brute force.
Fisetin Bioavailability: Formulation Comparison
| Formulation Type | Bioavailability Enhancement | Research Source | Notes |
|---|---|---|---|
| Standard Fisetin Powder | 1x (baseline) | Multiple studies | Poor water solubility, rapid metabolism |
| Standard Fisetin Capsules | <10% absorption | PMC3689181 | Why AFFIRM-LITE uses 1,400-2,000mg |
| Nanoemulsion Fisetin | 24x improvement | Ragelle et al. | Intraperitoneal administration |
| Hydrogel Formulation | 27x improvement | PMC9574875 | Human clinical study |
| Super Fisetin + RGBooster1™ | 25-50x target | Patent pending | Proprietary absorption technology |
📊 Human Clinical Evidence
A 2022 randomized double-blind crossover study in healthy adults showed that hydrogel-encapsulated fisetin achieved 23.9-fold higher peak concentration and 26.9-fold greater bioavailability (AUC) compared to standard fisetin. The enhanced formulation maintained detectable plasma levels for 8 hours versus only 2 hours for standard fisetin.
Source: J Nutr Sci. 2022. PMC9574875
The Science: Fisetin as the Most Potent Natural Senolytic
The Landmark Mayo Clinic Study (2018)
In a groundbreaking study, researchers at Mayo Clinic and Scripps Research Institute screened 10 flavonoid compounds for senolytic activity. The results were clear: fisetin was the most potent senolytic of all compounds tested.
Key findings from the study:
- Fisetin selectively killed senescent cells while sparing healthy cells
- Acute or intermittent treatment reduced senescence markers in multiple tissues
- Late-life intervention extended both median and maximum lifespan in mice
- The effect was consistent with a "hit-and-run" mechanism, meaning you don't need continuous dosing
What Are Senescent Cells?
Senescent cells are "zombie cells" that have stopped dividing but don't die. Instead, they accumulate with age and release inflammatory signals (called SASP, or Senescence-Associated Secretory Phenotype) that damage surrounding healthy cells. This process contributes to aging and age-related diseases.
Senolytics like fisetin work by selectively triggering apoptosis (programmed cell death) in these zombie cells, allowing the body to clear them and reduce the inflammatory burden.
📄 Key Study: Mayo Clinic 2018
"Of the 10 flavonoids tested, fisetin was the most potent senolytic. Chronic administration of fisetin to wild-type mice late in life improved tissue homeostasis, suppressed age-related pathology, and extended median and maximum lifespan."
Source: Yousefzadeh MJ et al. EBioMedicine. 2018;36:18-28. PMID: 30279143
📄 Ongoing Clinical Trial: AFFIRM-LITE
The AFFIRM-LITE study (NCT03675724) is testing high-dose fisetin (1,400-2,000mg) in older adults for 2 consecutive days per month. Results are expected by October 2026. The high doses are used because standard fisetin has poor bioavailability.
Source: ClinicalTrials.gov NCT03675724
Super Fisetin patent documentation (redacted)
Fisetin Supplement Comparison: How Super Fisetin Stacks Up in 2026
The fisetin supplement market offers many options, but most fail to address the fundamental bioavailability problem. Here's how Super Fisetin compares:
| Product Type | Dose | Absorption Enhancement |
Monthly Cost (5-day protocol) |
Key Limitation |
|---|---|---|---|---|
| Standard Fisetin 100mg | 100mg | None | $15-25 | Very poor absorption |
| Standard Fisetin 500mg | 500mg | None | $30-50 | Very poor absorption |
| Liposomal Fisetin | 100-200mg | Moderate | $40-60 | Limited enhancement data |
|
AFFIRM-LITE Protocol (Research dosing) |
1,400-2,000mg | None | $100-200+ | Brute-force approach |
| Super Fisetin + RGBooster1™ | 500mg | 25-50x | $37.03 | Patent-pending technology |
Key Insight: Clinical trials use mega-doses of standard fisetin (1,400-2,000mg) because they're trying to overcome poor absorption through sheer quantity. Super Fisetin takes a different approach: enhanced delivery technology that makes a 500mg dose work harder.
What's In Super Fisetin?
Core Ingredients
- Fisetin (500mg, 98% purity): High-purity fisetin extracted from natural sources, the most potent senolytic of 10 flavonoids tested in Mayo Clinic research
- RGBooster1™ (Patent Pending): Proprietary absorption-supporting blend designed to achieve 25-50x better bioavailability than standard fisetin
Quality Standards
- 98% pure fisetin (pharmaceutical grade)
- Third-party tested for purity and potency
- Manufactured in FDA-registered facilities
- 60 vegetarian capsules per bottle
- No artificial fillers
- Patent-pending delivery technology
Complementary Supplements
Super Fisetin can be combined with other longevity-supporting supplements:
- Advanced NMN 1000 - NAD+ precursor for cellular energy
- M98 Resveratrol Complete - Sirtuin-activating polyphenol
- EGCG 800 - Green tea catechin for metabolic support
- Advanced NAD with NADShield - NAD+ with NNMT protection
Note: Space out supplements by 30+ minutes for optimal absorption.
Frequently Asked Questions About Super Fisetin
How much fisetin would I need from strawberries to match Super Fisetin?
To get 500mg of raw fisetin, you'd need to eat 6.9 lbs of strawberries. But with Super Fisetin's 25-50x enhanced absorption, the equivalent absorbed fisetin would require 172-345 lbs of strawberries daily, clearly impossible and costing $860-$1,725 versus one $37/month serving of Super Fisetin.
Why does the AFFIRM-LITE study use such high fisetin doses?
The AFFIRM-LITE trial uses 1,400-2,000mg of standard fisetin because regular fisetin has extremely poor bioavailability, with less than 10% reaching the bloodstream. They're using a brute-force approach to overcome absorption limitations. Super Fisetin addresses this differently with enhanced delivery technology.
What makes fisetin the "most potent senolytic"?
In the 2018 Mayo Clinic study (PMID: 30279143), researchers screened 10 flavonoid compounds including quercetin, curcumin, EGCG, and resveratrol. Fisetin outperformed all others at selectively killing senescent cells while sparing healthy cells. It also extended lifespan when given late in life.
What is the 5-day cycling protocol?
Take Super Fisetin for 5 consecutive days per month, then stop for the rest of the month. This "hit-and-run" approach aligns with senolytic research showing that intermittent treatment effectively clears senescent cells. One bottle provides a 6-month supply.
Will I feel tired after taking Super Fisetin?
Research suggests clearing senescent cells does not cause lasting tiredness. Animal studies show improved energy and physical function after senolytic treatment. Senescent cells release inflammatory signals (SASP), so reducing them may actually improve energy levels over time.
Is Super Fisetin safe to take with medications?
Super Fisetin is designed for healthy adults only. The enhanced delivery system may affect medication absorption. Always take Super Fisetin 3-4 hours before or after any medications, and consult your healthcare provider before use.
Scientific References
- Yousefzadeh MJ, et al. (2018). "Fisetin is a senotherapeutic that extends health and lifespan." EBioMedicine, 36:18-28. PMID: 30279143
- Sundarrajan S, et al. (2022). "Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin." J Nutr Sci, 11:e74. PMC9574875
- Khan N, et al. (2013). "Fisetin: A dietary antioxidant for health promotion." Antioxid Redox Signal, 19(2):151-62. PMC3689181
- Grynkiewicz G, Demchuk OM. (2019). "New Perspectives for Fisetin." Front Chem, 7:697. PMID: 31696111
- Kubina R, et al. (2023). "Fisetin: In Search of Better Bioavailability, From Macro to Nano Modifications: A Review." Int J Mol Sci, 24(18):14159. PMC10532335
- ClinicalTrials.gov. "AFFIRM-LITE: Alleviation of Frailty and Inflammation in Older Adults." NCT03675724
Note: All references are peer-reviewed studies available on PubMed or registered clinical trials.