X500 Resveratrol for PCOS: Clinical Dosage Protocol with Morning-Noon-Night Timing (2026)
Peer-Reviewed Clinical Results
Morning + Noon + Night Protocol
Significant hormonal and metabolic improvements in 3 months
Study acknowledged RevGenetics for providing resveratrol
X500 Resveratrol is the exact micronized trans-resveratrol used in the peer-reviewed PCOS clinical study published in the Journal of Clinical Endocrinology & Metabolism. The study explicitly acknowledged RevGenetics for providing the resveratrol.
Protocol: X500 Dosage for PCOS Support
Based on the peer-reviewed clinical study (PMID: 27754722) that acknowledged RevGenetics for providing X500 Resveratrol, here is the complete PCOS protocol:
The PCOS Resveratrol Protocol: Morning-Noon-Night
Establishes first wave of anti-inflammatory support
Maintains constant levels during peak metabolic hours
Overnight support when hormonal regulation peaks
Total Daily Dose
The exact dosage used in the peer-reviewed PCOS clinical study
Why Split into Morning, Noon, and Night?
Constant Anti-Inflammatory Pressure: Splitting the 1,500mg daily dose into three doses maintains consistent resveratrol levels throughout the 24-hour cycle. A single large dose creates a spike followed by decline. The Morning-Noon-Night protocol provides sustained anti-inflammatory pressure on ovarian tissue, supporting continuous hormonal modulation rather than intermittent bursts.
Clinical Duration Requirement
The clinical study demonstrated significant hormonal modulation after 3 months of consistent daily supplementation. Plan for a minimum 90-day commitment to the protocol.
Study Reference:
Banaszewska B, et al. "Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial." J Clin Endocrinol Metab. 2016;101(11):4322-4328. PMID: 27754722
"We thank RevGenetics for providing resveratrol for this study."
PCOS Clinical Study Results Using X500 Resveratrol
Double-Blind, Placebo-Controlled Trial Results
The peer-reviewed clinical study (ClinicalTrials.gov: NCT01720459) tested X500 Resveratrol at 1,500mg daily in women with PCOS. After 3 months of the protocol, participants showed:
Total Testosterone
DHEAS
Fasting Insulin
Insulin Sensitivity
Study Details: Randomized, double-blind, placebo-controlled trial | 30 women with PCOS | 3-month treatment period | Published in Journal of Clinical Endocrinology & Metabolism
Why These Results Matter for PCOS
PCOS (Polycystic Ovary Syndrome) affects an estimated 5-6 million women in the United States. The condition is characterized by:
- Elevated testosterone and other androgens
- Insulin resistance and metabolic dysfunction
- Irregular menstrual cycles
- Fertility challenges
The X500 clinical study showed resveratrol significantly reduced both ovarian androgens (testosterone) and adrenal androgens (DHEAS), while improving insulin sensitivity. According to the study authors:
"The findings suggest resveratrol can improve the body's ability to use insulin and potentially lower the risk of developing diabetes. The supplement may be able to help reduce the risk of metabolic problems common in women with PCOS."
Additional Research Using X500
X500 Resveratrol has also been used in research by leading institutions including:
- Albert Einstein College of Medicine, Bronx, NY
- Harvard Medical School, Boston, MA
- Stanford University, Palo Alto, CA
- National Institute on Aging, Baltimore, MD
- National University of Ireland Galway
Multi-Institution Study:
Research published in Cell Metabolism (2017) also used X500 Resveratrol. PMID: 28329397
These peer-reviewed studies demonstrate the quality and reliability of X500's micronized trans-resveratrol formulation.
Why Micronized Resveratrol Absorbs Better Than Standard Resveratrol
The Bioavailability Challenge
Standard resveratrol has notoriously poor bioavailability. Research shows oral bioavailability of standard resveratrol is less than 1% due to:
- Poor water solubility
- Large particle sizes limiting absorption
- Rapid metabolism in intestine and liver
- First-pass hepatic metabolism
Micronization solves the particle size problem by reducing resveratrol to ultra-fine particles, increasing surface area for absorption in the digestive tract.
Micronized Resveratrol Research:
A study on micronized resveratrol (SRT501) showed plasma levels 3.6-fold higher than equivalent doses of non-micronized resveratrol. PMID: 21680702
X500's Micronization Advantage
X500 uses advanced micronization technology to achieve:
- Ultra-fine particle sizes for better dissolution
- Increased surface area for absorption
- Higher plasma concentrations of active resveratrol
- More resveratrol reaching target tissues
The clinical PCOS study results demonstrate that X500's micronized formulation delivers therapeutic levels of resveratrol, as evidenced by the significant improvements in hormonal and metabolic markers.
Clean Formulation: X500 contains only pure micronized trans-resveratrol sourced from Polygonum cuspidatum and HPMC vegetarian capsules. No fillers, rice, or artificial chemicals.
X500 vs. Standard Resveratrol Supplements
| Feature | X500 Micronized Resveratrol | Standard Resveratrol | Generic Supplements |
|---|---|---|---|
| Particle Size | Micronized ultra-fine | Standard large particles | Varies, usually large |
| Absorption | 3.6x higher plasma levels (micronized) | Less than 1% bioavailability | Poor absorption |
| PCOS Clinical Research | Study: PMID 27754722 | Limited research | No clinical backing |
| RevGenetics Acknowledged | Yes, in published study | No | No |
| Form | Pure trans-resveratrol | Often mixed isomers | Unknown purity |
| Fillers | None | Varies | Often contains fillers |
| Manufacturing | GMP-certified since 2007 | Varies by brand | Often overseas |
| Best Use | PCOS support, hormonal balance, metabolic health |
General wellness | Unknown |
Research-Backed Health Benefits of Resveratrol
X500 Resveratrol supports multiple health pathways through superior micronized absorption, ensuring therapeutic levels reach target tissues.
Hormonal Balance Support
Clinical research showed significant reductions in testosterone and DHEAS levels, supporting healthy hormonal balance in women with PCOS.
Metabolic Health
The PCOS study demonstrated 31.8% reduction in fasting insulin and 66.3% improvement in insulin sensitivity after 3 months of the protocol.
Cardiovascular Wellness
Resveratrol supports cardiovascular health through improved vascular function and circulation.
Sirtuin Activation
Activates SIRT1 longevity pathways more effectively due to superior absorption, supporting healthy aging processes.
Antioxidant Protection
Enhanced absorption delivers more resveratrol to cells for free radical protection and oxidative stress support.
Anti-Inflammatory Support
Superior bioavailability ensures therapeutic levels for support of the body's natural inflammatory response.
How to Use X500 Resveratrol
Research-Based Dosing Options
- General health support: 1-2 capsules daily (500-1000mg)
- PCOS/hormonal support: 3 capsules daily (1,500mg) split Morning, Noon, Night as used in clinical study
- Metabolic health focus: 3 capsules daily based on research protocol
- Cardiovascular support: 2-4 capsules daily
Complementary Supplements
X500 pairs well with other longevity-supporting supplements:
- M98 Resveratrol Complete - For maximum trans-resveratrol potency
- Advanced NMN 1000 - NAD+ precursor for cellular energy
- MetaCurcumin 277x - Anti-inflammatory support
Important Safety Information: Consult your healthcare provider before starting resveratrol supplementation, especially if taking anticoagulants or antiplatelet medications. Resveratrol may enhance the effects of blood-thinning medications. Women with hormonal conditions should discuss appropriate dosing with their healthcare provider.
Quality Standards
- Pure micronized trans-resveratrol
- Sourced from Polygonum cuspidatum
- HPMC vegetarian capsules
- No fillers, rice, or artificial chemicals
- Third-party tested for purity and potency
- GMP-certified manufacturing since 2007
- 30-day money-back guarantee
Frequently Asked Questions About X500 Resveratrol for PCOS
How much resveratrol should I take for PCOS?
Based on the peer-reviewed clinical study (PMID: 27754722) that used RevGenetics X500, take 1,500mg daily (3 capsules). Split the dose into Morning, Noon, and Night to maintain constant anti-inflammatory pressure on ovarian tissue. This protocol showed 23.1% testosterone reduction, 22.2% DHEAS decrease, and 66.3% insulin sensitivity improvement after 3 months.
What is the best time to take resveratrol for PCOS?
Split your 1,500mg daily dose (3 capsules) into Morning, Noon, and Night. Take 1 capsule (500mg) with breakfast, 1 with lunch, and 1 with dinner. This timing maintains consistent resveratrol levels throughout the day, providing sustained anti-inflammatory support for ovarian tissue rather than a single spike followed by decline.
How long does resveratrol take to work for PCOS?
The clinical study protocol was 3 months (90 days) of consistent daily supplementation at 1,500mg. Significant hormonal and metabolic improvements were documented after this 3-month period. For hormonal modulation in PCOS, plan for a minimum 3-month commitment to the Morning-Noon-Night protocol.
Is X500 the same resveratrol used in the PCOS clinical study?
Yes. The published study (J Clin Endocrinol Metab, 2016) explicitly states: "We thank RevGenetics for providing resveratrol for this study." X500 is the exact same micronized trans-resveratrol formulation used in this peer-reviewed clinical research.
Why split the resveratrol dose into three times daily?
Splitting 1,500mg into Morning, Noon, and Night doses maintains constant anti-inflammatory pressure on ovarian tissue throughout the 24-hour cycle. A single large dose creates a spike followed by decline, while split dosing keeps resveratrol levels more consistent for sustained hormonal support.
What PCOS results did the clinical study show?
The 3-month clinical trial using X500 Resveratrol showed: 23.1% reduction in total testosterone, 22.2% decrease in DHEAS (adrenal androgen), 31.8% reduction in fasting insulin, and 66.3% increase in insulin sensitivity. These results were statistically significant compared to placebo.
Scientific References
- Banaszewska B, Wrotynska-Barczynska J, Spaczynski RZ, Pawelczyk L, Duleba AJ. (2016). "Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial." J Clin Endocrinol Metab. 101(11):4322-4328. PMID: 27754722
- Howells LM, Berry DP, Elliott PJ, et al. (2011). "Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases." Cancer Prev Res. 4(9):1419-25. PMID: 21680702
- Walle T. (2011). "Bioavailability of resveratrol." Ann N Y Acad Sci. 1215:9-15. PMID: 21261636
- Smoliga JM, Blanchard O. (2014). "Enhancing the delivery of resveratrol in humans: if low bioavailability is the problem, what is the solution?" Molecules. 19(11):17154-72. PMID: 25347459
- Fadlalmola HA, et al. (2023). "Efficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials." Pan Afr Med J. 44:134. PMC10276340
Note: All references are peer-reviewed studies available on PubMed. The PCOS clinical study explicitly acknowledged RevGenetics for providing the resveratrol used in the research.