NAD, Resveratrol, Sirtuins and evidence of Rejuvenation
It is hard to imagine that back in 1997, when it was first discovered that resveratrol reduced the initiation and progression of cancer in rodents, this natural compound would have such profound influence in the field of aging as well (Science, 1997, v.275 p.218).
Initially different groups of researchers proposed that resveratrol was increasing the fitness in a broad group of animals and extending lifespan. However, this later point has been contested. There is an overwhelming amount of evidence that resveratrol improves your health and reduces the incidence of many diseases (e.g., cancer and cardiovascular diseases) but it remains to be determined if it can extend life. Nevertheless, determining the mechanism of how resveratrol functions, has remained an active area of research. 
NAD, Resveratrol and Sirtuins
About 10 years ago, a group led by scientists discovered that resveratrol’s mechanism of action involves a family of proteins called sirtuins. Since then a large amount of research on sirtuins have demonstrated that these proteins can dramatically improved the health and fitness of rodents. But the details continue to elude scientist, however, another Harvard group recently made a major discovery on the mechanism of sirtuin action. The research group reported in December, that sirtuin 1 activation could rejuvenate mice muscle tissue, (equivalent of a 70 year old human rejuvenated to the appearance of a 20 year old) in as little as one week period by repairing the mitochondria function (Cell, 2013, v.155 p.1624).
NAD, Resveratrol, Sirtuins And The Mitochondria
Mitochondria dysfunction has long been known to be involved with aging. However, the mechanism and the severity of this dysfunction in aging have been debated. In the current research, the group first demonstrated that in aging, the mitochondria changed by expressing lower amounts of key proteins that prevent its normal function. They then demonstrated that these changes could be regulated by sirtuin 1. And finally, they tested these observations by increasing the function of the mitochondria by stimulating sirtuin1 activity. In the experiment they stimulated the sirtuin activity by injecting the mice with NMN (a precursor of NAD+, an activator of sirtuins).
NAD, Resveratrol, Sirtuins And Todays Sirtuin Activators
Now before we all go running off and injecting ourselves with NMN, we should note that they injected the equivalent (for a human weighting 185 lbs.) a 1.5 oz of NMN twice a day everyday for a week. Not exactly something that we can do.
But the importance of this experiment is the fact they worked. The new challenge will now be to find more efficient methods of activating sirtuins in order to get these remarkable rejuvenation changes. Until that day, resveratrol remains the best natural activator of sirtuins.
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