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Discussing Strokes And Resveratrol

Discussing Strokes And Resveratrol

anthony-loera anthony-loera
2 minute read

Resveratrol on Strokes: The blood-brain barrier is tissue that is separating normal circulating blood from the central nervous system (i.e., the brain). This barrier is essential for maintaining the normal environment and function of the brain. Cerebrovascular endothelial cells (CEC) are the main tissue that makes up the blood-brain barrier by creating tight junctions between themselves and not allowing for dissolved components in the blood from affecting the brain. However, this system is not perfect. Studies have shown that oxidized LDL (commonly referred as the “bad cholesterol”) can damage the CEC to the point of causing cell death, which would then leave the barrier vulnerable to all types of compounds. In a current study, a group of researchers decided to evaluate the protective effects of resveratrol on CEC treated with oxidized LDL (Journal of Nutrition, 2010, vol 140, no. 12:2187-2192). What the authors observed was that resveratrol was able to completely normalized the injuries to CEC that altered the permeability of the blood brain barrier. Furthermore they also noticed that disruption to the tight junction proteins was prevented and other organs, i.e. the mitochondria, within the CEC were also left undamaged when treated with resveratrol. These results are very promising considering that keeping damages to the blood-brain barrier can result in prevention or treatment of brain-related diseases such as strokes.

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