TA-65 Telomerase Activator: Clinical Evidence for Telomere Support

The most studied telomerase activator available. Double-blind trials show 530bp telomere increase. GRAS certified. Choose 100 Units for maintenance or 250 Units for clinical-level support.

530bp
Telomere Increase
12+
Published Studies
GRAS
Safety Certified
500+
Study Participants

Understanding TA-65 Telomerase Activator

TA-65 is a purified compound derived from Astragalus membranaceus root that activates telomerase, the enzyme responsible for maintaining and lengthening telomeres. Telomeres (Wikidata Q170050) are protective caps at the ends of chromosomes that shorten with each cell division and with age. When telomeres become critically short, cells enter senescence or die. TA-65 activates telomerase to lengthen these protective structures, particularly targeting the critically short telomeres that trigger cellular aging.

RevGenetics offers TA-65 in two potencies: 100 Units for daily maintenance and 250 Units for clinical-level support. The 250 Unit dosage matches the protocol used in the landmark Salvador 2016 study published in Rejuvenation Research, which demonstrated 530 base pairs of telomere lengthening over 12 months in a double-blind, placebo-controlled trial of 117 subjects aged 53-87. The placebo group lost 290 base pairs during the same period (p=0.005).

A second major clinical trial (Singaravelu 2021) with 500 subjects demonstrated that TA-65 significantly reduces immunosenescent CD8+CD28- T cells, the dysfunctional immune cells that accumulate with age and impair immune response. This 9-month double-blind study showed a decrease of 28 cells per microliter in the TA-65 group versus an increase of 4.38 cells per microliter in placebo.

What Do TA-65 "Units" Mean?

TA-65 Units are a proprietary measurement of telomerase activation potency, not milligrams of raw material. One Unit represents a standardized amount of purified Cycloastragenol (the active compound) that produces a specific level of telomerase activation in cell-based assays. This unit system ensures consistent potency across batches. The 250 Unit dosage was specifically selected for clinical trials based on cell culture optimization and was the dose that produced the 530bp telomere lengthening result.

Why TA-65 Differs from Generic Astragalus

Generic astragalus supplements contain whole root powder or crude extracts with trace amounts of Cycloastragenol. TA-65 uses a proprietary extraction and purification process that concentrates the telomerase-activating compound by orders of magnitude. Only TA-65 has GRAS (Generally Recognized as Safe) certification and double-blind placebo-controlled human trials. Generic astragalus products have no clinical evidence for telomere effects and are not standardized for Cycloastragenol content.

Anthony Loera, Founder and CEO of RevGenetics

Anthony Loera, Founder & CEO

19+ years in longevity supplements | Authorized TA-65 distributor since 2010

Last Updated: January 7, 2026

TA-65 Potency Comparison

100 Units (Maintenance) vs 250 Units (Clinical Dose)

Feature TA-65 100 Units TA-65 250 Units
Potency per Capsule 100 Units 250 Units
Capsules per Bottle 30 capsules 90 capsules
Supply Duration 1 month 3 months
Price $100.00 $600.00
Cost per Month $100/month $200/month
Clinical Study Match Immunosenescence study Telomere lengthening study (Salvador 2016)
Demonstrated Effect T cell support 530bp telomere increase
GRAS Certified Yes Yes
Best For Daily maintenance, budget-conscious users Clinical-level support, measured shorter telomeres

TA-65 vs Generic Astragalus

Why purified Cycloastragenol matters

Feature TA-65 (Purified) Generic Astragalus
Active Compound Concentrated Cycloastragenol Trace Cycloastragenol (if any)
Standardization Yes (Units system) No
Double-Blind Trials Yes (2 major trials) No
GRAS Certified Yes No
Proven Telomere Effect 530bp increase (p=0.005) No clinical evidence
Price Range $100-200/month $10-30/month
Value Proposition Proven efficacy, safety certification Low cost, unproven effects

Shop TA-65 Telomerase Activator

MAINTENANCE TA-65 100 Units telomerase activator

TA-65 100 Units

$100.00
  • 100 Units per capsule
  • 30 capsules (1-month supply)
  • Daily maintenance dosage
  • GRAS certified safe
  • Purified Cycloastragenol
View TA-65 100U
CLINICAL DOSE TA-65 250 Units clinical strength telomerase activator

TA-65 250 Units

$600.00
  • 250 Units per capsule
  • 90 capsules (3-month supply)
  • Salvador study dosage
  • 530bp telomere increase shown
  • GRAS certified safe
View TA-65 250U

Peer-Reviewed Clinical Evidence

Telomere Lengthening in Humans

Salvador L, et al. Rejuvenation Research, 2016 | PMID: 26950204

Double-blind, placebo-controlled. 117 subjects aged 53-87. 12 months.

530bp telomere increase vs 290bp loss in placebo (p=0.005)

Immunosenescence Reduction

Singaravelu G, et al. OBM Geriatrics, 2021

Double-blind, placebo-controlled. 500 subjects. 9 months. UCLA analysis.

28 cells/μl decrease in senescent T cells vs 4.38 increase in placebo

Healthspan Extension (Preclinical)

Bernardes de Jesus B, Blasco MA, et al. Aging Cell, 2011

Spanish National Cancer Centre (CNIO). Dr. Maria Blasco.

Increased healthspan without increasing cancer incidence

T Cell Function Enhancement

Fauce SR, Jamieson BD, et al. Journal of Immunology, 2008

UCLA study on antiviral function of CD8+ T lymphocytes.

1.5-2.5x increase in telomerase activity in T cells

Frequently Asked Questions

What do TA-65 Units mean?

TA-65 Units are a proprietary measurement of telomerase activation potency, not milligrams. One Unit represents a standardized amount of purified Cycloastragenol that produces a specific level of telomerase activation in cell assays. The 250 Unit dosage was used in the clinical trial showing 530bp telomere lengthening.

Why is TA-65 different from generic astragalus?

TA-65 contains purified Cycloastragenol extracted through a proprietary process that concentrates the telomerase-activating compound. Generic astragalus has trace amounts. Only TA-65 has GRAS certification and double-blind clinical trials proving telomere effects.

Should I take 100 Units or 250 Units?

100 Units is for daily maintenance at $100/month. 250 Units matches the clinical study dose showing 530bp telomere increase, recommended for clinical-level support at $200/month. Consider 250 Units if you have tested with shorter telomeres.

What clinical evidence supports TA-65?

TA-65 has 12+ peer-reviewed publications including two double-blind trials. Salvador 2016 showed 530bp telomere increase (p=0.005). Singaravelu 2021 showed immunosenescent T cell reduction. Dr. Blasco's 2011 study showed healthspan extension without increased cancer.

Is TA-65 safe for long-term use?

TA-65 has GRAS (Generally Recognized as Safe) certification. Year-long clinical studies showed no product-related toxicity. Dr. Blasco's research confirmed no increased cancer incidence. Safety margins are orders of magnitude above supplement doses.

How long until I see results?

Clinical studies show measurable telomere changes within 3-6 months, with optimal results at 12 months. The Salvador study demonstrated significant lengthening by month 9. Individual responses vary based on baseline telomere length, age, and lifestyle.

Important Health Information

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Quality Assurance:

  • GRAS certified for medical foods
  • 12+ peer-reviewed publications
  • Double-blind placebo-controlled trials
  • Third-party tested for purity
  • GMP certified manufacturing
  • Ships to 50+ countries