RevGenetics Ultimate 6-Compound Longevity Protocol
Ultimate 6-Compound Longevity Protocol: Five Pathways, One Monthly Supply
The Ultimate 6-Compound Longevity Protocol combines six RevGenetics formulas into one monthly supply on a staggered daily schedule, covering NAD+, sirtuin, inflammation response, senescence, and AMPK pathways.*
6 products, 1 protocol 4.8 / 5 across 155 reviews Staggered dosing plan Save $172.75
$371.75 bought separately
$199
Monthly Supply | $6.63/day | 46% off
Formulas reviewed by: Dr. Hector Valenzuela, Ph.D., Chief Science Officer
What You Save By Taking The Protocol
$172.75 Saved Every Month
Purchased individually at regular price, these six products total $371.75. As the protocol they are $199, which works out to $6.63 per day for the full six-compound stack.
What that includes: Advanced NMN 1000, X500 Resveratrol, MetaCurcumin 277x, Super Z Quercetin with Zinc, DiBerberine 300x, and Super Fisetin 500.
How The Individual Products Are Rated
Transparency note: This protocol is newly listed, so it does not have reviews of its own yet. The ratings below belong to the six individual products inside it, left by customers who bought them separately.
| Product | Rating | Reviews |
|---|---|---|
| MetaCurcumin 277x | 4.9 / 5 | 46 |
| X500 Resveratrol | 4.9 / 5 | 44 |
| Advanced NMN 1000 | 4.8 / 5 | 48 |
| Super Z Quercetin + Zinc | 5.0 / 5 | 6 |
| Super Fisetin 500 | 4.5 / 5 | 10 |
| DiBerberine 300x | 5.0 / 5 | 1 |
| All six combined | 4.8 / 5 weighted average | 155 reviews |
Ratings come from verified customer reviews on each product's own page and are accurate as of August 2026. DiBerberine 300x is the newest formula in the lineup and has a single review so far, so read that score with the sample size in mind.
The Daily Protocol (Step-by-Step)
How To Take All Six Compounds
- Morning, with a healthy fat: Take X500 Resveratrol alongside olive oil, avocado, or another fat source to support absorption.
- Morning, same time: Take Advanced NMN 1000 for NAD+ precursor support.*
- Morning, same time: Take MetaCurcumin 277x and Super Z to complete the morning core.
- Before your largest meal: Take DiBerberine 300x 15 to 30 minutes before a carbohydrate-heavy meal, kept separate from curcumin.
- Per label: Follow the Super Fisetin 500 label for senolytic dosing. It is a six-month supply, so it is not taken daily like the others.
Why the stagger: Berberine and curcumin have shown minor antagonistic effects when taken together in research models. Separating DiBerberine from the morning core keeps the AMPK and sirtuin sides of the protocol from competing in the same digestive window.
Morning Core vs Mealtime: The Two-Window Approach
Window 1: Morning Core (4 compounds)
Products: Advanced NMN 1000, X500 Resveratrol, MetaCurcumin 277x, Super Z
Pathways: NAD+ production, sirtuin signaling, healthy inflammation response, senescent-cell support*
Note: Take X500 with a healthy fat.
Window 2: Mealtime (1 compound)
Product: DiBerberine 300x
Pathway: AMPK activation and metabolic support*
Timing: 15 to 30 minutes before your largest carbohydrate-containing meal, away from curcumin.
Separate Track: Senolytic
Product: Super Fisetin 500
Pathway: Senescent-cell support*
Timing: Per label. This is a six-month supply, not a daily capsule like the rest.
| Product | Bought Separately | In The Protocol |
|---|---|---|
| Advanced NMN 1000 | $40.00 | Included |
| X500 Resveratrol | $44.95 | Included |
| MetaCurcumin 277x | $54.95 | Included |
| Super Z Quercetin + Zinc | $33.95 | Included |
| DiBerberine 300x | $47.95 | Included |
| Super Fisetin 500 | $149.95 | Included |
| Total | $371.75 | $199.00, save $172.75 |
The Six Compounds and What Each One Does
Advanced NMN 1000
High-purity nicotinamide mononucleotide, a direct NAD+ precursor. NAD+ levels decline with age, and NMN is the precursor most closely studied for supporting them.*
X500 Micronized Trans-Resveratrol
500mg pure trans-resveratrol per capsule, micronized for absorption. Resveratrol is the classic sirtuin-pathway compound in longevity research.*
MetaCurcumin 277x
Liquid micelle curcumin with tetrahydrocurcuminoids. Standard curcumin barely absorbs, which is the problem this delivery system is built to solve.*
Super Z Quercetin with Zinc
Micelle-delivered quercetin paired with a zinc ionophore formula, for senescent-cell and immune support.*
DiBerberine 300x
Enteric-coated dihydroberberine, a more bioavailable berberine metabolite, for AMPK activation and metabolic support.*
Super Fisetin 500
A six-month senolytic supply at a meaningful dose. Fisetin is the flavonoid most associated with senescent-cell research.*
Who This Protocol Is For
A Good Fit If You
- Already take two or three longevity compounds and want the full stack without managing separate reorders
- Want pathway coverage rather than a random assortment of bottles
- Care about absorption technology, not just milligrams on a label
- Want a written dosing schedule instead of guessing at timing
Quality Assurance
- Third-party tested every batch, ISO 17025 labs
- Public Certificate of Analysis
- GMP-certified manufacturing, made in the USA
- Formulas reviewed by Dr. Hector Valenzuela, Ph.D.
Storage and Handling
Store in a cool, dry place. No refrigeration required for any compound in the protocol.
Before You Start
Consult a qualified healthcare provider before use, especially if you are pregnant, nursing, taking medication, managing blood sugar, taking anticoagulant or antiplatelet medication, or preparing for surgery.
If you are new to these compounds: introduce them gradually rather than all at once, so you can tell how you respond to each one.
Frequently Asked Questions
What is included in the Ultimate 6-Compound Longevity Protocol?
Six products: Advanced NMN 1000, X500 Micronized Trans-Resveratrol, MetaCurcumin 277x, Super Z Nano Quercetin with Zinc, DiBerberine 300x, and Super Fisetin 500.
Does the protocol have customer reviews?
The protocol is newly listed and does not have its own reviews yet. The six products inside it hold a combined 155 verified reviews averaging 4.8 out of 5, broken down by product in the ratings table above.
How is this different from the 4-Compound Protocol?
The 4-Compound Protocol covers resveratrol, curcumin, quercetin, and dihydroberberine. The 6-Compound version adds Advanced NMN 1000 for NAD+ support and Super Fisetin 500 for senescent-cell support, which are the two most requested additions.
How much does it save compared with buying separately?
At regular prices the six products total $371.75. The protocol is $199, a saving of $172.75, or about $6.63 per day for the complete stack.
Why is DiBerberine taken separately from the morning stack?
Berberine and curcumin have shown minor antagonistic effects when taken together in research models. Taking DiBerberine before your largest meal keeps it in a separate digestive window from MetaCurcumin, and also lines it up with the carbohydrate load it is intended to support.*
Do I take all six every day?
Five are daily. Super Fisetin 500 is a six-month senolytic supply and is taken per its label rather than as a daily capsule, which is why one box lasts far longer than the others.
Can I still buy the compounds individually?
Yes. Every compound in the protocol is sold on its own. The protocol exists for people who want the full stack in one order at a lower combined price.
Scientific References
- Wherry S, et al. (2025). "Combinations of histone deacetylase inhibitors extend chronological lifespan in S. cerevisiae." Yeast model research on resveratrol, curcumin, quercetin, and berberine combinations.
- Yousefzadeh MJ, et al. (2018). "Fisetin is a senotherapeutic that extends health and lifespan." EBioMedicine. PMID: 30279143
- McReynolds MR, Chellappa K, Baur JA. (2020). "Age-related NAD+ decline." Exp Gerontol. PMID: 32097708
- Camacho-Pereira J, et al. (2016). "CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction." Cell Metab. PMID: 27304511
- Yoshino J, Baur JA, Imai SI. (2018). "NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR." Cell Metab. PMID: 29249689
Research context: Several of the combination findings above come from S. cerevisiae, a yeast model used in cellular aging studies. Yeast results are useful for mapping pathways and are not human lifespan results.
