New TA-65 Study In 2013:
TA-65 & Telomeres, the structures at the ends of chromosomes, have been linked to many important biological functions. As our cells divide, our telomeres shorten and when they reach a critical length the cell becomes unstable and generally loses it’s ability to grow and is considered at this point old. That, unfortunately, is the best case scenario.
In other scenarios, the short telomeres can also cause DNA instabilities that can lead to various age-related diseases such as cancer and cardiovascular diseases. To offset the telomere shortening, cells activate the enzyme telomerase, which can elongate the telomere DNA and delay the onset of aging and diseases that are caused by the telomere shortening. In spite of this, cells cannot constantly keep the telomerase enzyme active at all times and thus aging and the many age-related diseases eventually occur.
Understandably, scientists have actively researched the telomere and telomerase biology in the hopes of offsetting these negative outcomes. In recent years scientist have succeeded in finding natural and genetic methods to alter these biological processes and have begun testing in human volunteers.
Experimental set up for the new TA-65 study
In a new TA-65 study led by Calvin Harley, a group of individuals took part in a commercial age-management product that is primarily composed of TA-65, a natural plant extract that has been demonstrated to activate telomerase and improve the function of human cells. The results of the study were very encouraging, but the study requires some explanation.
The subjects selected were individuals motivated in maintaining good health. Each subject was followed for 2.5 years, and the biological parameters (cholesterol, blood pressure, etc.) tested during treatment were compared to the baseline levels at the start of the new TA-65 study for each individual and not between individuals. In other words, the individuals maintained their own varied healthy lifestyles, and changes that did occur might then be attributed to this new TA-65 study product that they were consuming. As mentioned, the results were very encouraging.
Results of the New TA-65 Study
UPDATE 2018: The full 2013 study is now available as of this writing for free at Research Gate (Read the 2013 TA-65 study on Research Gate) and shown below. We suggest skipping to the “Discussion and Conclusions” section at the end of this impressive study: A Natural Product Telomerase Activator as Part of a Health Maintenance Program: Metabolic and Cardiovascular Response