Advanced NMN 1000: Nicotinamide Mononulceotide
- Boosts daily energy levels
- Supports healthy aging and longevity
- Enhances cellular health and vitality
- Promotes optimal mitochondrial function
Advanced NMN 1000: Evidence-Based NAD+ Support
Pharmaceutical-grade nicotinamide mononucleotide backed by 15+ peer-reviewed studies
What Our Customers Are Saying
Advanced NMN 1000 vs. Competition
| Feature | Advanced NMN 1000 | NR Supplements | Elysium Type Formulas | Standard NMN |
|---|---|---|---|---|
| Active Compound | NMN (Direct NAD+ precursor) | NR (Requires conversion) | NR + Pterostilbene | NMN (Unprotected) |
| Dose per Serving | 1000mg | 300mg | 250mg NR | 250-500mg |
| Absorption Time | 30 minutes | 2-4 hours | 2-6 hours | 6-8 hours |
| Acid Protection | pH-sensitive coating | No | No | Usually no |
| Stability | 24+ months | 18 months | 12 months | 6-12 months |
| Price per 1000mg | $1.50 | $8.33 | $11.96 | $3-6 |
| Third-Party Testing | Every batch | Periodic | Periodic | Varies |
| Research Calculator | Included | No | No | No |
The Science Behind Advanced NMN 1000
Advanced NMN 1000 delivers 1000 mg of pharmaceutical-grade nicotinamide mononucleotide per serving. This dosage aligns with clinical research protocols that have demonstrated measurable increases in NAD+ biomarkers.
NAD+ (nicotinamide adenine dinucleotide) serves as a critical coenzyme in over 500 enzymatic reactions. Research indicates NAD+ levels decline approximately 50% between ages 40 and 60, correlating with decreased mitochondrial function and cellular energy production.
NAD+ Biosynthesis Pathway
Simplified pathway based on Mills et al., Cell Metabolism (2016)
Clinical Evidence Supporting NMN Supplementation
Key Human Clinical Trials (2021-2024)
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Lin Yi et al. (2023) - GeroScience
80 healthy adults, 300-900 mg/day for 60 days. Result: Significant increase in blood NAD+ levels. Optimal dosing identified at 600 mg. -
Yoshino et al. (2021) - Science
25 prediabetic women, 250 mg/day for 10 weeks. Result: 25% improvement in muscle insulin sensitivity. -
Liao et al. (2021) - J Int Soc Sports Nutr
48 amateur runners, 300-1200 mg/day for 6 weeks. Result: Enhanced aerobic capacity at ventilatory threshold. -
Katayoshi et al. (2023) - Scientific Reports
36 healthy adults, 250 mg/day for 12 weeks. Result: Trend toward improved arterial stiffness markers. -
Yu et al. (2024) - Frontiers in Pharmacology
Systematic review of human trials. Conclusion: Consistent safety profile at doses up to 1250 mg/day.
Product Specifications & Quality Metrics
| Parameter | Advanced NMN 1000 | Industry Standard | Clinical Significance |
|---|---|---|---|
| NMN Content | 1000 mg | 250-500 mg | Matches optimal clinical dosing |
| Purity (HPLC) | ≥99.5% | ≥98% | USP grade; ±1.5% method precision |
| Absorption Time | 30 minutes | 6-8 hours | Rapid bioavailability |
| Stability | 24+ months (25°C/60% RH) | 6-12 months | ICH-validated stability |
| Heavy Metals (ICP-MS) | All <0.05 ppm | <10 ppm | 10x below USP limits |
| Analytical Testing | ISO 17025 lab | Variable | FDA-registered facility |
Bioavailability Enhancement Technology
Advanced NMN 1000 utilizes proprietary enteric-coated capsules designed to protect NMN from gastric degradation at pH 1.2. This ensures delivery to the small intestine where the Slc12a8 transporter facilitates cellular uptake.
Dissolution Kinetics
USP <711> dissolution testing (n=6) by Eurofins laboratories: Our advanced capsule technology demonstrated 84.8% ± 2.9% release in pH 6.8 phosphate buffer following 120-minute acid stage, versus 12.5% ± 5.4% for standard gelatin capsules (p < 0.001).
6.8-fold Superior DissolutionKey Benefits Supported by Research
Cellular Energy Production
NAD+ serves as the primary electron carrier in mitochondrial ATP synthesis. Studies indicate NMN supplementation supports optimal mitochondrial function.
Metabolic Health
Clinical data suggests NMN may support healthy insulin sensitivity and glucose metabolism, particularly in aging populations.
Exercise Performance
Research demonstrates potential improvements in aerobic capacity and oxygen utilization at ventilatory threshold.
Vascular Function
Emerging evidence points to possible benefits for arterial health and endothelial function markers.
DNA Repair Support
NAD+ acts as a substrate for PARP enzymes and sirtuins involved in DNA repair and cellular maintenance pathways.
Cognitive Support
Preclinical studies suggest NAD+ precursors may support neuronal health and cognitive function through multiple mechanisms.
Frequently Asked Questions
Experience Evidence-Based NAD+ Support
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FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The clinical studies referenced evaluate NMN as a research compound and do not constitute health claims for this specific product.
Medical Notice: Consult your healthcare provider before use if you have medical conditions, take prescription medications, are pregnant or nursing. Keep out of reach of children. Individual results may vary.
Quality Assurance: Certificate of Analysis available upon request. All products manufactured in FDA-registered, cGMP-certified facilities with third-party testing for purity, potency, and safety.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
🧬 Research Dosage Converter
Allometric scaling using FDA Km factors to compare doses across species
Equivalent Dosages
| Species | Equivalent Dose (mg/kg) | Total Amount / Day (mg) | Method |
|---|