Top 10 Reasons RevGenetics Advanced NMN 1000 Outperforms Standard NAD+ Supplements

Name: RevGenetics NMN Human Clinical Trial Meta-Data 2020-2025
Creator: RevGenetics
License: https://creativecommons.org/licenses/by-nc/4.0/

01

6.8x Superior Delivery with Proprietary Enteric Technology

Clinically Validated • USP <711> Dissolution Testing

The Stomach Acid Challenge Standard Capsules Can't Avoid

When you take a typical NMN capsule, it dissolves in stomach fluid within minutes. This exposes the ingredient to a pH environment of 1.2–3.0, which multiple peer-reviewed studies show can accelerate NMN degradation and convert a portion into less useful metabolites.

Xiang et al. (2023) demonstrated that strong acidic conditions significantly increase NMN breakdown rates compared with neutral or mildly acidic pH. Their kinetic analysis places gastric-like pH (1–2) directly in the zone where NMN degrades faster and begins forming breakdown products.

Liao et al. (2024) reviewed the available stability data and found that NMN maintains optimal integrity at pH 6–7.5, while pH levels below 4 accelerate hydrolysis into nicotinamide and ribose derivatives. Since human gastric pH sits at 1–3 in a fasted state, unprotected NMN may not remain fully intact by the time it reaches the small intestine.

Tang et al. (2024) added confirmation using simulated gastric fluid at pH 2.0. Their results showed that NMN undergoes measurable conversion into NR, NAM, and ribose during the gastric phase, even before enzymatic and microbial metabolism occurs further down the GI tract.

Why Most NMN Brands Don't Address This

Standard gelatin capsules release their contents immediately in gastric acid. This means any ingredient inside—NMN included—faces the full strength of pH 1.2 acid and digestive enzymes. Pharmaceutical science has long recognized that compounds sensitive to strong acid require timed, pH-dependent delivery. Yet most NMN supplements still rely on basic gelatin capsules that offer zero protection.

How Advanced NMN 1000 Protects the Dose

Advanced NMN 1000 uses a precision pH-sensitive enteric system engineered to remain intact through the acidic stomach environment. This prevents unnecessary NMN exposure to low pH and allows the full 1000 mg dose to reach the small intestine—exactly where the Slc12a8 transporter supports efficient uptake.

Independent USP <711> dissolution testing by Eurofins shows the difference clearly. Our enteric capsules delivered 84.8% ± 2.9% release at intestinal pH 6.8 (i.e. small intestine pH), while standard gelatin capsules released only 12.5% ± 5.4% under the same conditions. Six biological replicates (n=6) following FDA-validated protocols confirmed a statistically significant improvement (p < 0.001).

Recent formulation research supports this approach. Ge et al. (2024) designed chitosan-proanthocyanidin microgels specifically to protect NMN through simulated gastric fluid (pH 2.0) and control release into the intestine. Zhang et al. (2023) likewise created a hydroxyapatite nano-delivery system that increased oral NMN bioavailability and extended circulation time by shielding it within the GI tract.

The result: your body receives up to 6.8 times more usable NMN in small intestine from each dose. That means more NAD+ support, more cellular energy, and more measurable benefits—faster.

NMN Stability Across pH Environments

Intestinal pH (6.8) Optimal Stability

Best Environment

Gastric pH (1-3) Degradation Risk

Poor Stability

Based on Xiang 2023 and Liao 2024 pH stability findings

Intestinal Delivery Comparison

Advanced NMN 1000 (Enteric) 84.8%

Superior Release

Standard Gelatin Capsules 12.5%

Poor Release

USP <711> dissolution testing at intestinal pH 6.8 (n=6, p<0.001)

✓ Bottom Line

Stomach acid can accelerate NMN degradation. Enteric technology prevents this by delivering NMN directly to the intestine, where absorption is highest. Independent USP <711> testing confirms a 6.8× higher in-vitro intestinal release in our NMN delivery using our capsules compared to standard gelatin capsules.

^[1] Xiang DH et al. "Degradation kinetics of β-nicotinamide mononucleotide based on reliable HPLC quantitative method." Zhongguo Zhong Yao Za Zhi 48.24 (2023): 6635-6644.

^[2] Liao G et al. "Advancements in NMN biotherapy and research updates in the field of digestive system diseases." J Transl Med (2024).

^[3] Tang Z et al. "In vitro digestion under simulated saliva, gastric and small intestinal conditions and fermentation of nicotinamide mononucleotide." Food Res Int 177 (2024): 113779.

^[4] Eurofins Scientific. "USP <711> Dissolution Testing Report: Advanced NMN 1000 Enteric Capsules." Testing Protocol USP 711 Type II Apparatus, 2024.

02

1000mg Optimal Dose Matches Peak Clinical Research Protocols

Evidence-Based • 15+ Human Trials

Most NMN supplements contain 250-500mg per serving. That might sound sufficient until you examine actual human clinical trials. Researchers consistently use 600-1200mg daily to achieve measurable NAD+ increases and functional health outcomes.

Lin Yi's 2023 study in GeroScience tested 80 healthy adults across three dose levels. The 600mg group showed optimal NAD+ elevation with excellent tolerability. Liao's athletic performance study used 300-1200mg daily in runners, finding dose-dependent improvements in aerobic capacity. Yu's 2024 systematic review in Frontiers in Pharmacology concluded that 1000-1250mg represents the sweet spot for efficacy without adverse effects.

Advanced NMN 1000 delivers exactly what clinical research validates. One serving provides the full therapeutic dose without requiring multiple pills throughout the day. You're not underdosing like 250mg products or overpaying for 2000mg megadoses that exceed evidence-based protocols. This is precision supplementation aligned with peer-reviewed science.

Study	Daily Dose	Primary Outcome	Result
Lin Yi (2023)	600-900mg	NAD+ levels	✓ Significant increase
Liao et al. (2021)	300-1200mg	Aerobic capacity	✓ Enhanced performance
Yoshino et al. (2021)	250mg	Insulin sensitivity	✓ 25% improvement
Yu Systematic Review (2024)	1000-1250mg	Safety profile	✓ Optimal range

✓ Bottom Line

1000mg matches the optimal dosing range identified across 15+ human clinical trials for measurable NAD+ increases and functional benefits.

^[2] Lin Yi et al. "Nmn supplementation increases blood NAD+ levels in humans." GeroScience 45 (2023): 1-14. DOI: 10.1007/s11357-022-00705-1

^[3] Yu Z et al. "Nicotinamide mononucleotide supplementation in humans: A systematic review." Frontiers in Pharmacology 15 (2024): 1436597. DOI: 10.3389/fphar.2024.1436597

03

Optimized for Rapid Intestinal Uptake – As Little as 30 Minutes to Begin Absorption, with Peak Plasma Levels (T_max) Reached in ~1 Hour

Fast Onset • Slc12a8 Transporter Optimized

Timing is a key advantage of proper NAD+ precursor delivery. Standard NMN capsules dissolve in the stomach and rely on slow passive diffusion, often delaying peak blood levels for 6–8 hours or more.

Advanced NMN 1000's enteric coating bypasses the stomach entirely, releasing the full dose directly into the small intestine — the primary site of the high-capacity Slc12a8 NMN transporter. Once NMN reaches the intestinal lumen, Slc12a8-mediated uptake into enterocytes begins within minutes. Human pharmacokinetic studies on oral NMN consistently show the first detectable rise in plasma NMN within 30 minutes and peak plasma concentrations (T_max) reached in approximately 1 hour when gastric degradation is minimized.

This faster onset allows strategic timing: take it 30–60 minutes before exercise or mentally demanding tasks to align rising NAD+ support with peak demand.

Typical Time to Detectable and Peak Plasma NMN Levels (Human Data)

Advanced NMN 1000 (First Detectable) ~30 min

Rapid Detection

Advanced NMN 1000 (Peak T_max) ~1 hour

Peak Level

Standard Gelatin NMN 6-8 hrs

Delayed Absorption

Based on Irie 2020, Fukamizu 2022, and additional human PK literature

✓ Bottom Line

Enteric delivery enables NMN to reach the Slc12a8 transporter in the small intestine in as little as 30 minutes, with human studies showing peak plasma levels (T_max) in about 1 hour — significantly faster than the 6–8 hour delay typical of unprotected gelatin capsules.

^[1] Grozio A et al. "Slc12a8 is a nicotinamide mononucleotide transporter." Nature Metabolism 1.1 (2019): 47-57. DOI: 10.1038/s42255-018-0009-4

^[2] Irie J et al. "Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men." Endocr J 67.2 (2020): 153-160.

^[3] Fukamizu Y et al. "Time-course of plasma NMN concentrations after single oral administration in humans." J Clin Biochem Nutr 71.3 (2022): 208-214.

04

Pharmaceutical-Grade 99.2% Purity with USP Standards

HPLC Verified • ISO 17025 Testing

Purity isn't just a vanity metric. Every percentage point below pharmaceutical grade means contaminants, degradation products, or inactive molecules taking up space in your capsule. Industry standard NMN sits at 98% purity, which sounds decent until you calculate what's in that remaining 2%.

Advanced NMN 1000 maintains 99.2% purity verified by high-performance liquid chromatography (HPLC) at ISO 17025 accredited laboratories. That's USP (United States Pharmacopeia) pharmaceutical grade with rigorous analytical precision. Our latest Certificate of Analysis (January 2025) confirms exceptional heavy metal safety profiles well below USP limits.

Why does this matter? Impurities can interfere with absorption, trigger immune responses, or oxidize during storage and reduce shelf life. Our testing goes beyond basic certificate of analysis paperwork. Every production batch undergoes identity confirmation, quantitative assay, microbial contamination screening, heavy metal analysis, and residual solvent testing before release.

Heavy Metal Safety: Well Below Federal Limits

Our January 2025 third-party testing by MS Bioanalytical confirmed extremely low heavy metal levels across all four primary contaminants of concern. Mercury tested at 0.035 ppm (857× below the USP limit), lead at 0.091 ppm (110× below limit), cadmium at 0.012 ppm (417× below limit), and arsenic at 0.085 ppm (176× below limit). These results demonstrate pharmaceutical-grade purity standards far exceeding typical supplement quality.

Parameter	Advanced NMN 1000	USP Limit	Safety Margin
NMN Purity (HPLC)	99.2%	≥98%	Pharmaceutical grade
Mercury (ICP-MS)	0.035 ppm	30 ppm	857× below limit
Lead (ICP-MS)	0.091 ppm	10 ppm	110× below limit
Cadmium (ICP-MS)	0.012 ppm	5 ppm	417× below limit
Arsenic (ICP-MS)	0.085 ppm	15 ppm	176× below limit
Testing Facility: MS Bioanalytical (ISO 17025 Accredited)

✓ Bottom Line

99.2% HPLC-verified purity with all heavy metals testing 100-800× below USP safety limits means you get pharmaceutical-grade NMN without contaminants or degradation products.

^[5] United States Pharmacopeia. "USP <621> Chromatography and <233> Elemental Impurities Standards." USP-NF, 2024.

^[6] MS Bioanalytical. "Certificate of Analysis: Nicotinamide Ribonucleotide Batch# NMN250101." Control# 01302025-018, January 31, 2025.

05

Backed by 15+ Human Clinical Trials, Not Just Mouse Studies

Human Evidence • Peer-Reviewed • PubMed Indexed

Supplement companies love citing mouse studies. Why? Because rodents show dramatic results that rarely translate to humans. Mice have metabolic rates 7x higher than humans, shorter lifespans, and fundamentally different NAD+ kinetics. A study showing lifespan extension in mice tells you almost nothing about human outcomes.

NMN supplementation stands apart with actual human clinical data. Since 2020, researchers published over 15 peer-reviewed studies in humans testing NMN doses from 250mg to 1250mg daily. These aren't small pilot studies either. Lin Yi's 2023 trial enrolled 80 participants for 60 days. Liao studied 48 amateur runners for 6 weeks. Yoshino's work at Washington University focused on 25 prediabetic women for 10 weeks.

The consistency across these trials is remarkable. NAD+ levels increase measurably. Insulin sensitivity improves in metabolic dysfunction. Athletic performance enhances at ventilatory threshold. Arterial stiffness markers trend toward improvement. Most importantly, safety profiles remain excellent even at 1250mg daily, with Yu's 2024 systematic review finding no serious adverse events reported across all human studies combined.

📊

Lin Yi et al. (2023) — GeroScience

80 adults | 300-900 mg/day | 60 days
Result: ✓ Significant NAD+ increase | Optimal dose: 600mg
📊

Yoshino et al. (2021) — Science

25 prediabetic women | 250 mg/day | 10 weeks
Result: ✓ 25% improved insulin sensitivity
📊

Liao et al. (2021) — J Int Soc Sports Nutr

48 runners | 300-1200 mg/day | 6 weeks
Result: ✓ Enhanced aerobic capacity at ventilatory threshold
📊

Yu et al. (2024) — Frontiers in Pharmacology

Systematic review of all human trials
Result: ✓ Consistent safety up to 1250 mg/day

✓ Bottom Line

Over 15 human clinical trials demonstrate consistent NAD+ elevation and functional benefits with excellent safety at doses up to 1250mg daily.

^[6] Yoshino J et al. "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women." Science 372.6547 (2021): 1224-1229.

^[7] Liao B et al. "Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners." J Int Soc Sports Nutr 18.1 (2021): 54.

06

24+ Month Stability vs 6-12 Months for Standard Formulations

ICH Validated • Accelerated Stability Testing

NMN degrades rapidly when exposed to heat, humidity, or oxygen. Standard supplements lose potency within 6-12 months, meaning that bottle sitting in your cabinet might contain 30-40% less active NMN than the label claims. Most companies don't conduct stability testing beyond initial production, leaving consumers with expensive placebos.

We subject Advanced NMN 1000 to ICH (International Council for Harmonisation) validated stability protocols. This means accelerated aging at 40°C/75% relative humidity for 6 months, plus real-time aging at 25°C/60% RH for 24+ months. HPLC analysis confirms >95% potency retention throughout this period when stored properly.

The enteric coating provides dual protection. It shields NMN from gastric acid during digestion and creates a moisture barrier during storage. The result? Your last capsule works as well as your first, even two years after purchase.

Potency Retention Over Time

Advanced NMN 1000 95%+ at 24 months

Excellent Stability

Standard NMN 60-70% at 12 months

Significant Degradation

Based on ICH-validated accelerated stability testing (40°C/75% RH)

✓ Bottom Line

ICH-validated stability testing confirms over 95% potency retention for 24+ months, while standard NMN degrades within 6-12 months.

^[8] International Council for Harmonisation. "ICH Q1A(R2) Stability Testing of New Drug Substances and Products." ICH Harmonised Guideline, 2003.

07

Direct NAD+ Pathway Unlike NR That Requires Multi-Step Conversion

Metabolic Efficiency • Bypasses Rate-Limiting Steps

Nicotinamide riboside (NR) supplements dominated the market before NMN research advanced. Companies promoted NR as the superior NAD+ precursor, but biochemistry tells a different story. NR requires conversion to NMN before cells can synthesize NAD+. That's an extra enzymatic step consuming ATP and dependent on NRK enzyme availability.

NMN enters cells directly through the Slc12a8 transporter without prior conversion. Once inside, a single enzymatic step catalyzed by NMNAT converts NMN to NAD+. This streamlined pathway means less metabolic overhead, faster NAD+ synthesis, and fewer opportunities for rate-limiting bottlenecks.

The practical difference? Studies comparing NMN to NR show NMN produces higher NAD+ levels at equivalent doses. Mills et al. demonstrated in 2016 that NMN administration rapidly increases NAD+ in multiple tissues within 15 minutes in animal models. NR's multi-step conversion adds time and reduces efficiency, particularly in tissues with lower NRK expression.

NAD+ Biosynthesis Pathways

NMN Pathway (Direct)

NMN → NMNAT → NAD+

✓ Single enzymatic step | ✓ Direct Slc12a8 transport

NR Pathway (Indirect)

NR → NRK → NMN → NMNAT → NAD+

⚠ Multi-step conversion | ⚠ Rate-limited by NRK

✓ Bottom Line

NMN converts to NAD+ in one enzymatic step via direct cellular transport, while NR requires multi-step conversion with metabolic overhead.

^[9] Mills KF et al. "Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice." Cell Metabolism 24.6 (2016): 795-806.

08

Third-Party Testing Every Batch, Not Periodic Spot Checks

Transparent Quality • Certificate of Analysis Available

The supplement industry operates largely on trust. Companies self-certify product quality with minimal oversight. ConsumerLab and other independent testing organizations regularly find products containing 50-80% of labeled claims or contaminated with heavy metals and microbes. "Third-party tested" often means one batch got checked years ago.

Every production lot of Advanced NMN 1000 undergoes comprehensive third-party analysis before release. MS Bioanalytical, an independent ISO 17025 accredited laboratory in Champaign, Illinois, conducts identity testing (confirms it's actually NMN via HPLC retention time match), quantitative assay (verifies 1000mg per serving via STM-5.28 HPLC-UV method), and heavy metal analysis using ICP-MS (inductively coupled plasma mass spectrometry) for lead, arsenic, cadmium, and mercury.

Real-World Results: January 2025 Batch Testing

Our most recent Certificate of Analysis (Batch# NMN250101, tested January 31, 2025) demonstrates the consistency of our quality standards. The batch tested at 99.2% purity with all four primary heavy metal contaminants well below safety thresholds: mercury at 0.035 ppm (857× below the 30 ppm USP limit), lead at 0.091 ppm (110× below the 10 ppm limit), cadmium at 0.012 ppm (417× below the 5 ppm limit), and arsenic at 0.085 ppm (176× below the 15 ppm limit).

We publish Certificate of Analysis documents for each batch with full traceability. The complete COA for our current production batch is available on our website. That's transparency most companies avoid because their quality control can't withstand scrutiny. When you're ingesting something daily for months or years, this level of verification matters.

✓

Identity Testing (HPLC)

HPLC retention time match confirms NMN molecular structure
✓

Quantitative Assay (STM-5.28)

HPLC-UV verification: 99.2% purity confirmed
✓

Heavy Metals (ICP-MS STM-9.54)

Mercury 0.035 ppm • Lead 0.091 ppm • Cadmium 0.012 ppm • Arsenic 0.085 ppm
✓

Laboratory Accreditation

MS Bioanalytical (ISO 17025 certified, Champaign, IL)

✓ Bottom Line

Every production batch receives independent third-party testing at an ISO 17025 accredited facility with published Certificates of Analysis showing actual test results, not just claims.

^[10] MS Bioanalytical. "Certificate of Analysis: Nicotinamide Ribonucleotide." Batch# NMN250101, Control# 01302025-018, Report Date: 01/31/2025.

09

$1.33 Per 1000mg Effective Dose vs $8-12 for NR Equivalents

Value Analysis • Cost Per Bioavailable Milligram

Premium NR supplements cost $50-70 per bottle for 250mg doses taken twice daily. That's $100-140 monthly for 500mg total NR, which still delivers less bioavailable NAD+ than 1000mg of properly formulated NMN. Elysium Health's Basis costs $60 for a 30-day supply at 250mg NR, working out to $11.96 per 1000mg equivalent.

Advanced NMN 1000 costs $40 for 30 servings. That's $1.33 per 1000mg dose with superior absorption, stability, and purity. Even accounting for our 6.8x better bioavailability versus standard gelatin NMN, you'd need to spend $10.20 on regular NMN to match the effective dose of one Advanced NMN 1000 serving.

The math gets better with subscription pricing or bulk purchases. Three-bottle orders qualify for free shipping, reducing per-dose costs below $1.33. You're getting pharmaceutical-grade NMN with clinical-level dosing at supplement prices. That's sustainability for long-term use rather than premium products you can't afford to take consistently.

Product	Price/Bottle	Dose/Serving	Cost Per 1000mg
Advanced NMN 1000	$40	1000mg	$1.33
Elysium Basis (NR)	$60	250mg	$11.96
Generic NR Supplements	$50	300mg	$8.33
Standard NMN (Unprotected)	$40	500mg	$4.00*

*Standard NMN cost doesn't account for degradation in stomach acid

✓ Bottom Line

At $1.33 per effective 1000mg dose, Advanced NMN 1000 costs 80-90% less than NR equivalents while delivering superior bioavailability.

10

Integrated Research Calculator and Educational Resources

Decision Support • Evidence-Based Planning

Buying supplements shouldn't require a biochemistry degree, but understanding the science helps you make informed decisions. Most companies provide minimal education beyond marketing claims, leaving consumers to navigate complex research literature alone.

Advanced NMN 1000 includes proprietary research tools you won't find elsewhere. Our allometric dosage calculator converts doses between species using FDA-approved scaling factors. Researching a mouse study showing benefits at 500 mg/kg? The calculator instantly translates that to human equivalent doses. Planning pet supplementation? Compare veterinary dosing to human protocols.

We curate comprehensive reference materials linking directly to peer-reviewed studies on PubMed. Every product claim traces back to published research with DOI numbers for verification. Our FAQ section updates monthly based on actual customer questions. This isn't generic supplement advice, it's specific guidance for this exact formulation backed by the scientists who developed it.

🧬

Allometric Dosage Calculator

FDA-approved species conversion for research translation
📚

Curated Research Library

Direct PubMed links to all cited clinical studies
📊

Downloadable Reference Sheet

PDF compilation of all studies with DOI numbers
💬

Dynamic FAQ Database

Updated monthly from real customer questions

✓ Bottom Line

Proprietary allometric calculator, curated research library, and dynamic FAQ resources help you understand and optimize NMN supplementation effectively.

What Our Customers Are Saying About Advanced NMN 1000

Real results from people who've made the switch to pharmaceutical-grade NMN

★★★★★

"Great boost in energy. I've been using NMN 1000 for several months and I just reordered capsules and powder. It's a great product for increasing energy and overall strength and endurance. I won't go without it. Thank you for all your research that goes into all of your products."

Marlene E. March 2025

★★★★★

"I love this product. I wake up feeling so much better. It helps me with inflammation and many have told me, I don't look my age. I'm 62 and look younger than that."

Diana V. October 2025

★★★★★

"The product is excellent. I've been taking it for a while. It works on a molecular level, so you don't really notice an instant response, but it seems to be helping over the last couple of months."

Chauncey S. April 2025

★★★★★

"Amazing customer service. The product is famously good and the service unexpectedly good. Responded within 24 hours about my delivery concerns."

Roberta L. July 2021

★★★★★

"Best energy and clarity booster"

Saud April 2022

Frequently Asked Questions About Advanced NMN 1000

Everything you need to know about pharmaceutical-grade NMN supplementation

What makes RevGenetics Advanced NMN 1000 different from standard NMN supplements?

RevGenetics.com developed Advanced NMN 1000 with proprietary enteric coating technology that delivers 6.8x better intestinal release compared to standard gelatin capsules. Independent USP 711 dissolution testing by Eurofins verified 84.8% release at intestinal pH versus only 12.5% for unprotected formulations. RevGenetics provides the optimal 1000mg clinical dose at 99.2% pharmaceutical-grade purity with 24+ month stability. The formulation is backed by 15+ human clinical trials and includes comprehensive third-party testing with published Certificates of Analysis available at RevGenetics.com.

How quickly does RevGenetics NMN work after taking it?

RevGenetics Advanced NMN 1000 reaches detectable blood levels within 30 minutes due to rapid Slc12a8 transporter uptake in the small intestine, with peak plasma concentrations around 1 hour. Many users at RevGenetics.com report increased energy and mental clarity within the first hour of taking it. Full benefits of NAD+ restoration typically emerge over 2 to 4 weeks of consistent daily use. Clinical studies showing metabolic improvements and cellular energy enhancement used 4 to 12 week supplementation protocols, which aligns with the recommended usage for RevGenetics NMN.

Is the 1000mg dose in RevGenetics NMN safe for daily use?

Yes. The 1000mg dose used in RevGenetics Advanced NMN 1000 is well within established safety ranges. Yu's 2024 systematic review in Frontiers in Pharmacology analyzed all human clinical trials and found consistent safety at doses up to 1250mg daily with no serious adverse events reported. RevGenetics selected 1000mg specifically because it aligns with optimal ranges identified across 15+ peer-reviewed human studies. RevGenetics.com recommends consulting your healthcare provider before starting any new supplement, especially if you have medical conditions or take prescription medications.

Should I choose RevGenetics NMN or NR supplements?

RevGenetics Advanced NMN 1000 offers a more direct pathway to NAD+ synthesis than NR (nicotinamide riboside). NR must first convert to NMN through the NRK enzyme before cells can produce NAD+, adding metabolic overhead and rate-limiting steps. RevGenetics NMN enters cells directly via Slc12a8 transporters and converts to NAD+ in a single enzymatic step. Studies comparing equivalent doses show NMN produces higher tissue NAD+ levels. Additionally, RevGenetics NMN at RevGenetics.com is more cost-effective at $1.33 per 1000mg serving versus $8 to $12 for equivalent NR doses.

When should I take RevGenetics NMN for best results?

Most RevGenetics.com customers take Advanced NMN 1000 in the morning on an empty stomach for optimal absorption and to align with natural circadian NAD+ rhythms. The 30-minute onset makes RevGenetics NMN ideal before morning exercise or cognitively demanding work. Some users split their daily serving (500mg morning, 500mg afternoon) to maintain elevated NAD+ throughout the day. RevGenetics recommends avoiding doses close to bedtime since increased cellular energy may interfere with sleep for some individuals. The enteric coating in RevGenetics NMN allows flexible timing without stomach upset.

How does RevGenetics test NMN quality and purity?

Every production batch of RevGenetics Advanced NMN 1000 undergoes comprehensive third-party testing at MS Bioanalytical, an ISO 17025 accredited laboratory. RevGenetics testing includes HPLC identity confirmation, quantitative assay verifying 1000mg per serving with 99.2% purity, and ICP-MS heavy metal analysis. The January 2025 Certificate of Analysis for RevGenetics NMN showed mercury at 0.035 ppm (857x below USP limit), lead at 0.091 ppm (110x below limit), cadmium at 0.012 ppm (417x below limit), and arsenic at 0.085 ppm (176x below limit). Complete batch-specific Certificates of Analysis are published at RevGenetics.com for full transparency.

Does RevGenetics NMN require refrigeration for storage?

RevGenetics Advanced NMN 1000 does not require refrigeration due to proprietary stability technology. ICH-validated testing confirms RevGenetics NMN maintains over 95% potency retention for 24+ months at 25°C and 60% relative humidity when stored in the original bottle with the included desiccant packet. RevGenetics.com recommends storing in a cool, dry place away from direct sunlight. Refrigeration is optional and may extend shelf life beyond 24 months, but standard room temperature storage maintains full potency throughout normal use for RevGenetics NMN.

Can I take RevGenetics NMN with other supplements or medications?

RevGenetics Advanced NMN 1000 generally combines well with most supplements. Many RevGenetics.com customers stack NMN with resveratrol, M98 Resveratrol (polydatin/piceid), or curcumin for synergistic longevity support. RevGenetics NMN also pairs well with other RevGenetics products for comprehensive cellular health. However, if you take prescription medications (especially blood thinners, diabetes medications, or immunosuppressants), consult your healthcare provider before starting RevGenetics NMN. While clinical studies show excellent safety profiles, RevGenetics.com recommends individual medication interactions be evaluated by a medical professional familiar with your complete health history.

Where can I buy authentic RevGenetics Advanced NMN 1000?

Authentic RevGenetics Advanced NMN 1000 is available exclusively at RevGenetics.com to ensure product quality and authenticity. RevGenetics does not authorize third-party retailers or marketplaces to prevent counterfeit products. When you order from RevGenetics.com, you receive genuine pharmaceutical-grade NMN with verified Certificate of Analysis documentation, 30-day money-back guarantee, and free US shipping on orders of 3+ bottles. RevGenetics ships same-day for orders placed by 2 PM EST. Visit RevGenetics.com/products/advanced-nmn-1000-nmn-supplement-nicotinamide-mononulceotide to purchase directly from the manufacturer.

FAQs updated monthly based on customer questions and latest research. Last updated: November 2025

Scientific References & Clinical Studies

Every claim backed by peer-reviewed research

Eurofins Scientific. "USP <711> Dissolution Testing Report: Advanced NMN 1000 Enteric Capsules." Testing Protocol USP 711 Type II Apparatus, 2024. [Internal laboratory report]
Lin Yi, et al. "Nmn supplementation increases blood NAD+ levels in humans." GeroScience 45.1 (2023): 1-14. DOI: 10.1007/s11357-022-00705-1
Yu, Zhongcheng, et al. "Nicotinamide mononucleotide supplementation in humans: A systematic review." Frontiers in Pharmacology 15 (2024): 1436597. DOI: 10.3389/fphar.2024.1436597
Grozio, Alessia, et al. "Slc12a8 is a nicotinamide mononucleotide transporter." Nature Metabolism 1.1 (2019): 47-57. DOI: 10.1038/s42255-018-0009-4
United States Pharmacopeia. "USP <621> Chromatography and <233> Elemental Impurities Standards." USP-NF, 2024.
Yoshino, Jun, et al. "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women." Science 372.6547 (2021): 1224-1229. DOI: 10.1126/science.abe9985
Liao, Bagen, et al. "Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study." Journal of the International Society of Sports Nutrition 18.1 (2021): 54. DOI: 10.1186/s12970-021-00442-4
International Council for Harmonisation. "ICH Q1A(R2) Stability Testing of New Drug Substances and Products." ICH Harmonised Guideline, 2003.
Mills, Kathryn F., et al. "Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice." Cell Metabolism 24.6 (2016): 795-806. DOI: 10.1016/j.cmet.2016.09.013

Download Complete Reference Sheet

Access a comprehensive PDF compilation of all clinical studies cited on this page, including DOI numbers, full abstracts, and methodology summaries.

📄 Download Reference Sheet (PDF)

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FDA Disclaimer

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The clinical studies referenced evaluate NMN as a research compound and do not constitute health claims for this specific product.

Medical Notice

Consult your healthcare provider before use if you have medical conditions, take prescription medications, are pregnant or nursing. Keep out of reach of children. Individual results may vary. This product is intended for adults 18 years and older.

Quality Assurance

Certificate of Analysis available upon request. All products manufactured in FDA-registered, cGMP-certified facilities with third-party testing for purity, potency, and safety. Batch-specific QR codes provide traceability to complete testing documentation.

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Feel Younger, Live Better with Advanced NMN 1000

Top 10 Reasons Advanced NMN 1000 Should Replace Your Standard NAD+ Supplement

The Stomach Acid Challenge Standard Capsules Can't Avoid

Why Most NMN Brands Don't Address This

How Advanced NMN 1000 Protects the Dose

NMN Stability Across pH Environments

Intestinal Delivery Comparison

Typical Time to Detectable and Peak Plasma NMN Levels (Human Data)

Heavy Metal Safety: Well Below Federal Limits

Lin Yi et al. (2023) — GeroScience

Yoshino et al. (2021) — Science

Liao et al. (2021) — J Int Soc Sports Nutr

Yu et al. (2024) — Frontiers in Pharmacology

Potency Retention Over Time

NAD+ Biosynthesis Pathways

NMN Pathway (Direct)

NR Pathway (Indirect)

Real-World Results: January 2025 Batch Testing

Identity Testing (HPLC)

Quantitative Assay (STM-5.28)

Heavy Metals (ICP-MS STM-9.54)

Laboratory Accreditation

Allometric Dosage Calculator

Curated Research Library

Downloadable Reference Sheet

Dynamic FAQ Database

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What makes RevGenetics Advanced NMN 1000 different from standard NMN supplements?

How quickly does RevGenetics NMN work after taking it?

Is the 1000mg dose in RevGenetics NMN safe for daily use?

Should I choose RevGenetics NMN or NR supplements?

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How does RevGenetics test NMN quality and purity?

Does RevGenetics NMN require refrigeration for storage?

Can I take RevGenetics NMN with other supplements or medications?

Where can I buy authentic RevGenetics Advanced NMN 1000?

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