How anti-aging properties in skin are affected by Resveratrol
Resveratrol Anti-aging Properties: In an article released ahead of press in the Journal of Gerontology, a group of scientists reports that treating a human fibroblast cells line (a cell found on our skin tissue) demonstrated a delay in aging (Journal of Gerontology A Biol Sci Med Sci., 2010 Sep 24). The fibroblast cell line (called MRC5), was not only able to replicate more than the control cells (in other words delay cellular aging) but it also maintained a more youthful cellular appearance as measured by its DNA content and increases in its nuclear size.
The authors also reported that not only were the cells delaying aging but were also more resistant to DNA oxidative damage. With regards to the mechanism of action used by resveratrol, the authors discuss the activation of sirtuin proteins being involved. Given the fact that sirtuin targets: histones and p53 proteins were deacetylated at a higher frequency than the control cells.
Frequently Asked Questions About Resveratrol and Skin Aging
How does resveratrol affect skin aging?
In a Journal of Gerontology study, a human skin fibroblast cell line (MRC5) treated with resveratrol replicated more times than untreated cells — a marker of delayed cellular aging — and maintained a more youthful cellular appearance, as measured by DNA content and nuclear size.
Does resveratrol protect skin cells from damage?
Yes. The researchers reported that resveratrol-treated fibroblasts were more resistant to oxidative DNA damage, in addition to showing delayed cellular aging.
What mechanism does resveratrol use in skin cells?
The study points to activation of sirtuin proteins: sirtuin targets such as histones and p53 proteins were deacetylated at a higher frequency in treated cells than in control cells.
What are fibroblasts and why do they matter for skin?
Fibroblasts are cells found in skin tissue that support its structure. How quickly they age — and how well they resist damage — influences visible skin aging.
What purity of resveratrol does RevGenetics offer?
RevGenetics offers pharmaceutical-grade resveratrol at 98%+ purity.
References:
- Anti-Glycation and Anti-Aging Properties of Resveratrol Derivatives in the in-vitro 3D Models of Human Skin - Clinical, cosmetic and investigational dermatology (2022): https://doi.org/10.2147/CCID.S364538
- Resveratrol and Its Derivatives in Inflammatory Skin Disorders-Atopic Dermatitis and Psoriasis: A Review - Antioxidants (Basel, Switzerland) (2023): https://doi.org/10.3390/antiox12111954
- Novel Nanotechnological Strategies for Skin Anti-aging - Current pharmaceutical biotechnology (2023): https://doi.org/10.2174/1389201024666221223095315
