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Why Can NMN Protect You and Does Not Increase Your Cancer Risk?

Why Can NMN Protect You and Does Not Increase Your Cancer Risk?

anthony-loera anthony-loera
4 minute read

There is confusion online about whether NMN (nicotinamide mononucleotide) can increase cancer risk. Importantly, no studies have shown that NMN (nicotinamide mononucleotide) can cause breast cancer. Based on the way NMN (nicotinamide mononucleotide) works, it may lower your risk of developing cancer. Let's look at how and why this topic has been so confusing. The best for normal cells is also the best for cancer cells.

 

NMN (nicotinamide mononucleotide) is not a cause of cancer. However, NMN (nicotinamide mononucleotide) could theoretically accelerate cancer growth if one has already been diagnosed with cancer; this is like the many substances necessary for cell function, such as B vitamins and zinc.

 

It is logical: substances suitable for average healthy cells can also benefit growth-hungry tumor cells.

  • Folate, a B-vitamin, is one example. Folate is an essential vitamin necessary for DNA formation. Cancer cells also need it.
  • Folate can increase the likelihood of developing cancer in those already diagnosed with it, but it is essential to remember that folate could lower the chance of getting cancer.
  • Folate deficiency can lead to cancerous DNA mutations. Folate deficiency can increase your risk of developing cancer in this instance.
  • Folate reduces the chance of developing cancer. However, if someone already has it, it can accelerate growth.

Like the above, other essential or healthy substances, which cells require to function correctly, could theoretically also accelerate cancer growth.

 

 

NMN and cancer

 

It could theoretically be true for NMN (nicotinamide mononucleotide). NMN (nicotinamide mononucleotide) is essential for healthy cells to function correctly and to protect their epigenome and DNA [1]. NMN (nicotinamide mononucleotide) could be used to prevent cancer. It is because mutations in DNA and epigenome can cause cancer.

However, taking additional NMN (nicotinamide mononucleotide) if one has advanced cancer could theoretically speed up the growth of that cancer, as NMN could be used to treat those cells. However, even this is not certain.

 

Is NMN able to accelerate the growth of cancer?

 

It is unknown if NMN (nicotinamide mononucleotide) accelerates human cancer growth.

Some studies have shown that NMN (nicotinamide mononucleotide) may increase the development of a cancerous cell. These studies often take place in unnatural environments. Scientists may use genetically modified mice to develop deadly and aggressive tumors rapidly.

 

Other studies have shown that NMN (nicotinamide mononucleotide) given as a treatment to mice suffering from cancer does not increase cancer growth. [2]

It is possible for NMN (nicotinamide mononucleotide) not only to reduce cancer risk but also not accelerate cancer growth if one has it.

 

 

NMN to improve the effectiveness of cancer treatment

 

NMN may also be beneficial in the improvement of immunotherapies for cancer.

A recent study [3], suggests that NMN (nicotinamide mononucleotide) could be used to make tumors more responsive to immunotherapy. Immunotherapy could be made more effective by NMN (nicotinamide mononucleotide). Immunotherapy stimulates your immune system to fight off cancer cells.

This study also shows that NMN-treated mice don't increase tumor size compared with mice not undergoing cancer treatment; this suggests that NMN (nicotinamide mononucleotide) doesn't accelerate tumor growth.

 

 

NMN to lower the risk of developing cancer

 

NMN is known for its ability to decrease DNA mutations. Numerous studies have shown that NMN supplementation reduces DNA damage in human fibroblasts [4], irradiated blood cells [5], and organs such as the kidneys [6].

NMN could lower the chance of developing cancer, as DNA mutations are a vital driver for cancer development.

Other studies also show that NMN (nicotinamide mononucleotide) can enhance the function of cancer-fighting immune cell functions. Researchers discovered that NMN (nicotinamide mononucleotide) administration orally to mice increased NK-cell activity [7]. Natural Killer (NK) cells are immune cells that specialize in finding and eliminating cancer cells.

 

 

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971268/

https://pubs.rsc.org/en/content/articlelanding/2021/qm/d0qm00897d

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30554-4

https://pubmed.ncbi.nlm.nih.gov/34380043

https://www.science.org/doi/10.1126/science.aad8242

https://jasn.asnjournals.org/content/28/8/2337

https://www.semanticscholar.org/paper/Nicotinamide-mononucleotide-augments-the-cytotoxic-Takeda-Okumura/2ca57c60af9bc774ace5cfab1769f9e6ca574715

 

 

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