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Can NMN Supplements Avoid Kidney Damage and Restores Kidney Function?

Can NMN Supplements Avoid Kidney Damage and Restores Kidney Function?

anthony-loera anthony-loera
4 minute read

Kidneys eliminate unnecessary substances from our bloodstream. As we age, kidney scarring and hardening may hinder the capacity of our kidneys to filter our blood, which allows proteins to get into the urine, causing the condition known as glomerulosclerosis. Treatments for high levels of this age-related disease include kidney transplants or dialysis, and both are physically demanding procedures. As a result, finding innovative methods to stop the progression of this disorder is vital.

 

A university in Japan finds that injecting 500 mg/kg/day of NMN (Nicotinamide Mononucleotide) helps reduce kidney damage in a model mouse with a rare disease known as focal segmental glomerulosclerosis, which has an aging-related pathology similar to glomerulosclerosis. NMN (Nicotinamide Mononucleotide) increases the number of cells essential for kidney waste elimination, also known as podocytes. Furthermore, by increasing the critical molecule vital to cell health, nicotinamide adenine dinucleotide (NAD+), the NMN supplement (Nicotinamide Mononucleotide) increases the activation of the pro-longevity enzyme Sirtuin-1 and reduces enzymes that cause damage to kidney tissue. These findings are the first evidence suggesting that an NMN supplement (Nicotinamide Mononucleotide) helps restore kidney cells that filter waste in disease.

What about RevGenetics Products? RevGenetics products are only made for overall health and optimization* we don't make any medical claims as human studies have not been done regarding the information in this article. We provide a high-purity Nicotinamide Mononucleotide for University research labs to do human studies, and as a dietary supplement. Click to learn more about Advanced NMN Supplements!

 

How NMN helps Kidney Dysfunction?

 

As higher levels of urinary proteins are linked to kidney damage and decreased filtering, researchers examined how an NMN supplement (Nicotinamide Mononucleotide) influences urine protein levels. The team of researchers developed a glomerulosclerosis model by injecting mice with chemotherapy drugs (Adriamycin) which can cause damage the kidneys. The mice in the kidney disease model significantly increased protein levels in the urine. However, treating them with NMN (Nicotinamide Mononucleotide) reduced the amount of urine protein, suggesting less kidney damage and improved protein filtering. [1]

 

Because NMN Supplement (Nicotinamide Mononucleotide) lowers the amount of urinary protein, The research team speculated that NMN (Nicotinamide Mononucleotide) could preserve the number of podocytes and kidney cells that filter waste. They observed decreased podocytes in kidney diseased mice, and, as is expected, NMN (Nicotinamide Mononucleotide) increased these numbers. These results suggest that NMN Supplement (Nicotinamide Mononucleotide) enhances kidney function by cleaning podocytes from waste and helps keep urinary protein levels in check.

 

Sirtuin-1 is a protein that, when activated, can lead to prolonged longevity. In addition, low levels of Sirtuin-1 are linked to age-related conditions such as glomerulosclerosis. Because Sirtuin-1 uses NAD+ as a fuel source and NMN (Nicotinamide Mononucleotide) enhances NAD+ levels, researchers looked at how NMN (Nicotinamide Mononucleotide) influences Sirtuin-1 levels in kidney-related mice. The researchers discovered that an NMN supplement (Nicotinamide Mononucleotide) had restored low levels of Sirtuin-1 found inside the kidneys of mice.

 

The higher levels of Sirtuin-1 in NMN (Nicotinamide Mononucleotide) were also associated with kidney tissue preservation during adriamycin therapy. While adriamycin-induced kidney diseases cause significantly more damage, while an NMN supplement (Nicotinamide Mononucleotide) restores damaged kidney tissue. Improved tissue structure integrity leads to better functional capacity.

 

 

How NMN Preserves the Kidney's Waste Filtration?

 

It is the first study on how an NMN supplement (Nicotinamide Mononucleotide) influences the mouse model of glomerulosclerosis. The results show that by raising NAD+ levels and activating Sirtuin-1, NMN (Nicotinamide Mononucleotide) reduces kidney damage and improves kidney function. [2]

 

Other studies in mice that have examined the beneficial effects of NMN (Nicotinamide Mononucleotide) on kidney function have focused on the renal scarring (fibrosis) model. This study showed that an NMN supplement (Nicotinamide Mononucleotide) could help restore filtering cells from kidney waste to improve kidney function and also NMN Supplements on weight loss. Because kidney transplants and dialysis are the only options for treating age-related glomerulosclerosis, the use of NMN (Nicotinamide Mononucleotide) or other metabolites of NAD+ may offer other less invasive methods for treating kidney disease. 

Click here to know more about NMN Supplements and their benefits.

 

References:

 https://www.sciencedirect.com/science/article/pii/B9780128141182000136

 https://www.sciencedirect.com/science/article/pii/S0085253815560973

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