Not Just DHB. A Smarter Berberine Delivery System.
Most DHB products stop at the ingredient. DiBerberine 300x goes further with a 500mg proprietary blend designed to protect dihydroberberine through the stomach, then support absorption with RGBooster1™ once it reaches the intestinal environment.*
Protect the DHB. Support the Absorption. Simplify the Routine.
Dihydroberberine is valuable because it is designed to be more absorbable than regular berberine. But if a capsule opens too early in stomach acid, DHB can convert back toward regular berberine, the lower-absorption form.
DiBerberine 300x was built around that problem. The enteric capsule helps protect the formula from stomach acid, while RGBooster1™ helps address the body’s natural P-glycoprotein efflux activity, the process that can push berberine compounds back out before they are used efficiently.
- Enteric capsule protection helps shield DHB from stomach acid before intestinal release
- RGBooster1™ absorption support helps address premature ejection through P-glycoprotein efflux activity
- 500mg proprietary blend combines DHB with RevGenetics’ delivery-support technology
- Third-party tested for identity, potency, and microbial quality
Proprietary Delivery Blend
Each capsule features RevGenetics’ DiBerberine 300x blend, designed around protection, delivery, and absorption support.
Do Not Compare Only Capsule Count
A basic DHB capsule may look similar on the surface, but capsule count does not tell the full story.
DiBerberine 300x is built as an advanced delivery system: enteric protection helps shield dihydroberberine from stomach acid, while RGBooster1™ helps support absorption by addressing the body’s natural tendency to eject berberine compounds too early.
Basic DHB vs. DiBerberine 300x
A basic DHB capsule gives you the ingredient. DiBerberine 300x gives you the ingredient plus a delivery system designed to help it survive, arrive, and absorb.
| Feature | DiBerberine 300x | Basic DHB Capsules |
|---|---|---|
| Formula Type | 500mg proprietary delivery blend | Usually single-ingredient DHB |
| Stomach Acid Protection | Enteric capsule protection | Usually standard capsule |
| Absorption Support | RGBooster1™ P-gp modulation support | Usually none |
| Delivery Strategy | Protect DHB first, then support absorption | Relies mostly on DHB alone |
| Daily Routine | 1 capsule daily | Varies by product |
| Testing | Third-party tested for identity, potency, and microbial quality | Varies by brand |
| Best For | Adults who want premium metabolic support with advanced delivery | People shopping mainly by price or capsule count |
If Berberine Has Let You Down Before, Delivery May Be the Reason
Many people try regular berberine, or even basic DHB, and feel underwhelmed. That does not always mean the ingredient is wrong. It may mean the formula was not built to handle the two biggest delivery problems.
Stomach Acid Can Work Against DHB
DHB is designed for better absorption, but standard capsules may release too early. Enteric delivery helps protect the formula before intestinal release.
Your Gut Can Push Berberine Back Out
P-glycoprotein efflux pumps can eject berberine compounds prematurely. RGBooster1™ is designed to support absorption by addressing this pathway.
High-Dose Routines Are Hard to Maintain
DiBerberine 300x keeps the routine simple with one enteric capsule daily, making consistency easier.
Greater plasma berberine exposure reported with DHB
Published pharmacokinetic research reported that dihydroberberine produced substantially greater plasma berberine exposure than standard berberine HCl.
DiBerberine 300x builds on DHB with enteric capsule protection and RGBooster1™ absorption support.
Advanced From Capsule to Absorption
DiBerberine 300x was not built like a commodity DHB supplement. It was built as a delivery-first formula.
Dihydroberberine
The advanced form of berberine used as the foundation for metabolic and cellular energy support.*
Enteric Capsule
Designed to help protect the formula from stomach acid and release it in the intestinal environment.
RGBooster1™
Patent-pending absorption-support technology designed to help reduce premature ejection through P-gp modulation.
For the Moment When Your Metabolism Starts Feeling Less Predictable
Many adults notice that energy, cravings, weight management, and post-meal balance become harder to manage with age. DiBerberine 300x is made for people who want a premium, better-delivered berberine option without making the routine complicated.
- Supports healthy blood sugar already within the normal range*
- Supports post-meal metabolic balance*
- Supports steady daily energy without stimulants*
- Designed for people who felt underwhelmed by regular berberine
Simple Daily Use
Take 1 Capsule Daily
Use daily with water. Many customers prefer taking it before their largest meal.
Swallow Whole
Do not crush, chew, break, or open the capsule. The enteric coating must stay intact.
Use Consistently
This is not a stimulant. Many people evaluate results over 6 to 12 weeks of daily use.
What People Notice First
Early access users received product in exchange for feedback. Results reflect individual experience and may not be typical.
“The one-capsule-a-day thing matters. I used to dread my berberine stack. One enteric DiBerberine 300x capsule, done.”
Early access participant“I had taken regular berberine before and felt underwhelmed. This was the first version that made the delivery system make sense to me.”
Early access participantOpen the Details Only If You Want Them
The top of the page keeps the buying decision simple. These sections preserve the scientific authority for customers who want to go deeper.
What makes dihydroberberine different?
Dihydroberberine, also called DHB, is a reduced form of berberine. It is used because of its absorption advantages compared to standard berberine HCl.
Why does enteric delivery matter?
Standard capsules may dissolve in stomach acid. DiBerberine 300x uses an enteric capsule designed to help protect DHB through the stomach and release it in the intestinal environment.
What does RGBooster1™ do?
RGBooster1™ is RevGenetics’ patent-pending absorption-support technology designed to help address P-glycoprotein efflux activity.
In simple terms, it helps reduce the body’s tendency to push berberine compounds back out too early, so the formula has a better opportunity to be absorbed efficiently.
What does 300x mean?
300x refers to RGBooster1™ P-glycoprotein modulation potency compared to piperine in RevGenetics’ proprietary formulation research. It is a specific P-gp mechanism claim, not a general 300x bioavailability claim.
Why is L-Leucine included?
L-Leucine is a branched-chain amino acid included to support cellular pathway signaling alongside DHB’s role in metabolic energy support.
What is AMPK?
AMPK, adenosine monophosphate-activated protein kinase, is often described as a cellular energy sensor. Berberine and DHB are studied for their relationship with AMPK activation and cellular energy metabolism.
Built Because the Formula Did Not Exist
“I built DiBerberine 300x because I could not find the formula I wanted to take. I wanted dihydroberberine protected from stomach acid, plus a way to address P-glycoprotein efflux. That combination became DiBerberine 300x.”
Anthony Loera, Founder, RevGenetics
USA-Made, Third-Party Tested, 30-Day Satisfaction Guarantee
Manufactured in FDA-registered, cGMP-certified facilities and third-party tested for identity, potency, and microbial quality.
Each bottle contains 30 enteric capsules featuring a 500mg proprietary DiBerberine 300x blend.
Choose Your Bottle AboveStraight Answers Before You Buy
Is DiBerberine 300x the same as regular berberine?
No. DiBerberine 300x uses dihydroberberine, enteric capsule protection, and RGBooster1™ absorption support. Regular berberine products typically use berberine HCl in a standard capsule.
How does DiBerberine 300x compare to basic DHB capsules?
Basic DHB capsules usually focus only on the ingredient. DiBerberine 300x focuses on the delivery system around the ingredient, including enteric capsule protection and RGBooster1™ absorption support.
Why not just take a cheaper DHB product?
A cheaper DHB product may only focus on price, capsule count, or the active ingredient. DiBerberine 300x is built as a premium delivery system designed to help protect DHB from stomach acid and support absorption with RGBooster1™.
What does RGBooster1™ do?
RGBooster1™ is RevGenetics’ absorption-support technology designed to help address P-glycoprotein efflux activity, which can push berberine compounds back out too early before they are used efficiently.
What does 300x mean?
300x refers to RGBooster1™ P-glycoprotein modulation potency compared to piperine in RevGenetics’ proprietary formulation research. It is a specific P-gp mechanism claim, not a general 300x bioavailability claim.
Will this cause the same stomach discomfort as regular berberine?
DiBerberine 300x is designed to reduce stomach exposure by using an enteric capsule. Individual responses vary, but the formula was created for people who want a simpler alternative to high-dose berberine routines.
How long does it take to notice results?
DiBerberine 300x is not a stimulant. Many people evaluate results over 6 to 12 weeks of consistent daily use. Individual results vary.
How should I take it?
Take 1 capsule daily with water. Many customers take it before their largest meal of the day. Do not crush, chew, break, or open the capsule.
Can I take DiBerberine 300x with medication?
Talk to your healthcare provider before use if you take prescription medication, especially medication related to blood sugar, blood thinning, cholesterol, or liver enzyme metabolism.
What is the return policy?
DiBerberine 300x comes with a 30-day satisfaction guarantee. Customer pays return shipping. One opened bottle is accepted. Returns must be initiated within the 30-day window.
- Moon, J. M., et al. Absorption kinetics of berberine and dihydroberberine and their metabolic impact: a randomized, controlled, crossover pilot trial. Nutrients.
- Cheng, Z., et al. 8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models. Bioorganic and Medicinal Chemistry.
- Maeng, H. J., et al. P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayers. Journal of Pharmaceutical Sciences.
- RevGenetics proprietary formulation research and patent-pending application data for RGBooster1™.
- Third-party certificate of analysis confirming identity, potency, and microbial quality testing.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
