This study investigates the effects of Astragalus root extracts, specifically TA-65, on telomerase activation in human T-cells. The findings demonstrate a significant increase in telomerase activity, suggesting potential therapeutic applications for delaying cellular aging and enhancing immune function in the elderly.

A comprehensive review of the molecular mechanisms driving lymphocyte aging. This chapter discusses the genetic and environmental factors contributing to immunosenescence and explores how these changes impact the overall health and disease susceptibility of the aging population.

This research identifies a critical link between cell surface sugars (O-glycosylation) and cancer cell survival. By modifying these sugar structures, the study shows that prostate cancer cells can become more susceptible to apoptosis induced by Galectin-1, offering a potential new target for cancer therapy.

This paper examines the phenomenon of replicative senescence in T-cells, where repeated immune stimulation leads to a permanent arrest in cell division. It discusses the biomarker CD28 and evaluates the potential of telomerase gene therapy to restore proliferative capacity in aging immune cells.

A landmark study revealing that T-cells from Alzheimer's patients exhibit significantly shorter telomeres than age-matched controls. The findings suggest a systemic acceleration of immune aging in Alzheimer's disease, potentially serving as a biological marker for disease severity.

This research differentiates how CD4 (helper) and CD8 (cytotoxic) T-cells age differently. It demonstrates that CD8 cells lose telomerase activity and CD28 expression much faster than CD4 cells upon repeated stimulation, explaining why the cytotoxic arm of the immune system weakens earlier in life.

A technical protocol outlining the "in-gel hybridization" technique for measuring telomere length. This method allows researchers to assess the biological age of cells with high precision without the need for complex membrane transfers, streamlining the study of cellular aging.

One of Dr. Valenzuela's early foundational papers reviewing the irreversible arrest of T-cell division known as replicative senescence. It proposes forward-thinking genetic strategies to delay this process, laying the groundwork for future research into telomerase therapies.