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277x of MetaCurcumin Liquid Curcumin Supplement - Nano Super Curcumin Supplement - Better Than 500mg Micronized for Anti-Aging By RevGenetics
Regular price $49.88 USDRegular price$0.00 USDSale price $49.88 USD -
TetraCurcumin Nano Super Curcumin Supplement - Better Than 500mg Micronized for Anti-Aging - White Curcumin Supplement - Tetrahydro curcumin
Regular price $49.68 USDRegular price$0.00 USDSale price $49.68 USD
Curcumin 277x: Bioavailability Without Piperine
Two solutions for curcumin absorption: MetaCurcumin liquid micelle (277x) for immediate action or TetraCurcumin metabolite (80-120x) for sustained benefits. No black pepper needed.
The Curcumin Bioavailability Problem and How RevGenetics Solved It
Curcumin (Wikidata Q422326) is the active compound in turmeric responsible for its anti-inflammatory and antioxidant properties. Despite thousands of studies demonstrating curcumin's benefits, standard curcumin supplements have a fundamental problem: only 2-3% of the compound actually reaches your bloodstream. The rest passes through your digestive system unused.
Why Standard Curcumin Fails
Curcumin is fat-soluble and cannot easily cross intestinal membranes. It also undergoes rapid metabolism in the liver and quick elimination from the body. This means you would need to consume massive amounts of turmeric or standard curcumin supplements to achieve any therapeutic benefit. Clinical studies typically require 8-12 grams of standard curcumin daily to see effects.
RevGenetics offers two distinct approaches to solving this bioavailability problem. MetaCurcumin 277x uses liquid micelle technology with sub-10 nanometer particles that are small enough to pass directly through intestinal membranes. One capsule delivers the equivalent of 23 grams of turmeric with 4-hour sustained plasma presence. TetraCurcumin takes a different approach by delivering tetrahydrocurcumin, the active metabolite your body normally creates from curcumin. This bypasses the liver conversion step entirely and provides 80-120x bioavailability.
Why RevGenetics Does Not Use Piperine
Most curcumin supplements rely on piperine (black pepper extract) to improve absorption. Piperine works by inhibiting liver enzymes that metabolize curcumin. However, these same enzymes also metabolize many medications. Piperine can interfere with drug metabolism, alter medication effectiveness, and cause digestive irritation. RevGenetics liquid micelle and nano-particle technologies achieve superior absorption without enzyme inhibition, making them safe for sensitive digestive systems and those taking medications.
What Is Tetrahydrocurcumin?
Tetrahydrocurcumin is curcumin's primary active metabolite. When you consume curcumin, your liver must convert it to tetrahydrocurcumin before it can exert biological effects. TetraCurcumin delivers this metabolite directly, skipping the conversion step. Research shows tetrahydrocurcumin has superior physiological stability and enhanced antioxidant activity compared to curcumin itself. It also demonstrates natural senolytic properties, supporting cellular cleanup processes.
MetaCurcumin vs TetraCurcumin
Liquid Micelle (277x) vs Active Metabolite (80-120x)
| Feature | MetaCurcumin 277x | TetraCurcumin |
|---|---|---|
| Active Compound | Curcumin + tetrahydro curcuminoids | Tetrahydrocurcumin (metabolite) |
| Bioavailability | 277x vs standard | 80-120x vs standard |
| Technology | Liquid micelle (sub-10nm) | Nano-particle delivery |
| Turmeric Equivalent | 23g per capsule | 4-10g per capsule |
| Plasma Duration | 4 hours sustained | Extended duration |
| Piperine Required | No | No |
| Primary Benefit | Immediate anti-inflammatory | Sustained antioxidant + senolytic |
| Price | $49.95 (60 capsules) | $39.95 |
| Best For | Joint comfort, quick action | Long-term cellular health |
How RevGenetics Compares to Other Curcumin Technologies
Independent research shows dramatic bioavailability differences
| Formulation | Technology | Enhancement |
|---|---|---|
| RevGenetics MetaCurcumin | Liquid micelle sub-10nm | 277x |
| RevGenetics TetraCurcumin | Nano tetrahydrocurcumin | 80-120x |
| Longvida SLCP | Solid lipid particles | 65x |
| Meriva Phytosome | Phospholipid complex | 29x |
| Theracurmin | Colloidal particles | 27x |
| Standard + Piperine | Black pepper extract | 20x |
| BCM-95 | Essential oils | 7x |
| Standard Curcumin | None | 1x (baseline) |
Based on published bioavailability studies. Individual results may vary.
Shop Curcumin Supplements
MetaCurcumin 277x Super Curcumin
- 277x bioavailability vs standard
- Sub-10nm liquid micelle particles
- Visible tetrahydro curcuminoids
- 1 capsule = 23g turmeric
- 4-hour sustained plasma presence
- No piperine required
- 60 liquid capsules
TetraCurcumin Nano Super Curcumin
- 80-120x bioavailability vs standard
- Tetrahydrocurcumin (active metabolite)
- Superior physiological stability
- Natural senolytic properties
- 1 capsule = 4-10g turmeric
- No piperine required
- Enhanced cardiovascular protection
Frequently Asked Questions
Why does standard curcumin have poor absorption?
Standard curcumin has only 2-3% bioavailability due to poor water solubility, rapid liver metabolism, and quick elimination. The molecule cannot easily cross intestinal membranes in its natural form, requiring massive doses or piperine for any effect.
What is the difference between MetaCurcumin and TetraCurcumin?
MetaCurcumin uses liquid micelle technology (277x absorption, sub-10nm) for immediate anti-inflammatory action. TetraCurcumin delivers tetrahydrocurcumin (the active metabolite) directly at 80-120x absorption for sustained antioxidant and senolytic benefits.
Why do RevGenetics products not require piperine?
Piperine inhibits liver enzymes to increase absorption, but this can interfere with medication metabolism and cause digestive irritation. RevGenetics liquid micelle and nano-particle technologies achieve superior absorption without enzyme inhibition, safe for sensitive systems.
What is tetrahydrocurcumin?
Tetrahydrocurcumin is curcumin's primary active metabolite. Your liver normally converts curcumin to tetrahydrocurcumin. TetraCurcumin delivers this metabolite directly, bypassing conversion. Research shows superior stability and enhanced antioxidant activity.
How does MetaCurcumin compare to Longvida and Meriva?
MetaCurcumin achieves 277x bioavailability. Longvida SLCP achieves 65x. Meriva Phytosome achieves 29x. Theracurmin achieves 27x. MetaCurcumin's liquid micelle technology represents the most advanced curcumin delivery available.
Can I combine MetaCurcumin and TetraCurcumin?
Yes. MetaCurcumin provides immediate anti-inflammatory action (277x), while TetraCurcumin delivers sustained antioxidant and senolytic benefits through direct metabolite delivery. Many customers use both for comprehensive curcumin support.
Important Health Information
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Curcumin may interact with blood thinners. Consult your healthcare provider before use.
Quality Assurance:
- Third-party tested for purity
- GMP certified manufacturing
- Certificates of Analysis available
- 24-month stability testing
- No piperine or artificial enhancers
- Ships to 50+ countries