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Advanced NMN 1000: High-Purity NAD+ Precursor Supplement
Regular price $40.00 USDRegular price$90.00 USDSale price $40.00 USDSale
Advanced NMN: Slc12a8 Transporter Technology
NMN with Slc12a8 transporter delivers NAD+ in 30 minutes vs 6-8 hours for NR. No NAM buildup. Enteric capsules outperform liposomal. Choose 250mg, 500mg, or 1000mg.
30 Minutes
Cellular Absorption via Slc12a8
Understanding Advanced NMN and Slc12a8 Transporter Technology
NMN (Nicotinamide Mononucleotide, Wikidata Q27125809) is a direct precursor to NAD+ (Wikidata Q71535049), the essential coenzyme required for cellular energy production, DNA repair, and sirtuin activation. NAD+ levels decline approximately 50% between ages 40 and 60, contributing to reduced mitochondrial function, impaired DNA repair, and accelerated aging. Advanced NMN supplementation addresses this decline through a revolutionary delivery mechanism.
The Slc12a8 Transporter: A Game-Changing Discovery
Slc12a8 is a specialized transporter protein located primarily in the small intestine that enables direct cellular uptake of NMN molecules. This transporter was identified in 2019 research and explains why NMN achieves therapeutic cellular concentrations within approximately 30 minutes of oral administration. NR (Nicotinamide Riboside) cannot use this transporter and must undergo multiple enzymatic conversion steps requiring 6-8 hours. This fundamental difference in absorption makes NMN the superior choice for NAD+ restoration.
RevGenetics Advanced NMN formulations are designed to maximize Slc12a8-mediated uptake. By using enteric-coated capsules that protect NMN through stomach acid and release it directly in the small intestine where Slc12a8 transporters are concentrated, we ensure optimal absorption efficiency. This targeted delivery system achieves rapid cellular NAD+ restoration impossible with other delivery methods.
The NAM Accumulation Problem with NR
When NR (Nicotinamide Riboside) converts to NAD+, it produces NAM (Nicotinamide) as a byproduct. NAM accumulation temporarily inhibits sirtuin enzymes, the very longevity-promoting proteins that NAD+ supplements are supposed to support. This creates a counterproductive cycle where the supplement undermines its own benefits. NMN via Slc12a8 transport converts directly to NAD+ without producing NAM, eliminating this problem entirely and allowing sirtuins to function optimally.
Why Enteric Capsules Outperform Liposomal NMN
Liposomal NMN has multiple problems that compromise effectiveness: water-based liposomal cores cause NMN degradation within 3-6 months, liposomes bypass Slc12a8 detection leading to slow 8-hour metabolism or complete excretion, and strong liposomes resist breakdown (a 2024 study of 18 brands showed sonication failed to release contents). Enteric capsules protect NMN through stomach acid and release it precisely where Slc12a8 transporters can absorb it, achieving superior bioavailability without stability concerns.
NMN vs NR vs Traditional NAD+ Precursors
Why Slc12a8-delivered NMN is superior
| Feature | NMN (Slc12a8) | NR (Riboside) | Traditional Precursors |
|---|---|---|---|
| Absorption Time | ~30 minutes | 6-8 hours | Variable, often slow |
| Conversion to NAD+ | Direct one-step | Multiple enzymatic steps | Multiple steps |
| NAM Accumulation | None | Significant | Variable |
| Sirtuin Interference | None | May inhibit | Potential |
| Transport Mechanism | Slc12a8 direct | Conversion-dependent | Highly variable |
| Bioavailability | Superior | Limited by conversion | Generally poor |
| Clinical Evidence | GRAS since 2018 | Established | Limited |
Enteric Capsules vs Liposomal NMN
Why delivery method matters for NMN effectiveness
| Factor | Enteric Capsules | Liposomal |
|---|---|---|
| Slc12a8 Compatibility | ✓ Optimal | ✗ Bypasses transporter |
| Absorption Time | 30 minutes | 8 hours or excretion |
| Stability | 24+ months | 3-6 months (degradation) |
| Content Release | ✓ Complete | ✗ Often fails (2024 study) |
| Water Exposure | Protected | Water core degrades NMN |
Shop Advanced NMN
Advanced NMN 1000
- 1000mg NMN per serving
- Slc12a8 transporter technology
- 30-minute absorption
- Enteric capsule delivery
- Zero NAM buildup
- Maximum NAD+ restoration
Advanced NMN 50
- 50mg NMN per capsule
- Slc12a8 transporter compatible
- 30-minute absorption
- Enteric capsule protection
- Balanced daily dosing
- Third-party tested
NMN Powder
- Pure NMN powder
- Custom dosing flexibility
- Slc12a8 compatible
- Cost-effective option
- Third-party tested purity
- Pharmaceutical grade
Frequently Asked Questions
What is Slc12a8 transporter technology?
Slc12a8 is a specialized transporter protein in the small intestine enabling direct cellular uptake of NMN within 30 minutes. NR cannot use this transporter and requires 6-8 hours for multiple enzymatic conversion steps. This makes NMN the superior choice for rapid NAD+ restoration.
Why is NMN better than NR?
NMN is superior for three reasons: (1) 30-minute absorption via Slc12a8 vs 6-8 hours for NR, (2) direct one-step conversion to NAD+ vs multiple steps, and (3) no NAM accumulation. NR produces NAM that inhibits sirtuins, counteracting its own benefits.
Why are enteric capsules better than liposomal?
Enteric capsules protect NMN and release it where Slc12a8 transporters absorb it. Liposomal NMN degrades in 3-6 months from water-based cores, bypasses Slc12a8 detection, and often fails to release contents (2024 study of 18 brands showed sonication could not release contents).
What is the NAM accumulation problem?
When NR converts to NAD+, it produces NAM (Nicotinamide) byproduct. NAM temporarily inhibits sirtuin enzymes, the longevity proteins NAD+ supplements support. This counterproductive cycle undermines benefits. NMN via Slc12a8 bypasses NAM production entirely.
What NMN dosage should I take?
250-500mg daily for maintenance and general support. 500-1000mg daily for enhanced therapeutic benefits or significant age-related decline. Clinical studies show doses up to 900mg increase blood NAD+ with superior results at higher doses. Start lower and increase based on response.
Is NMN safe for long-term use?
Yes. NMN has GRAS status since 2018 and is considered a food ingredient. A 2024 study (Takahashi et al.) followed 500mg daily for 52 weeks with no safety concerns and sustained benefits. NMN occurs naturally in broccoli, avocado, and tomatoes.
Important Health Information
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Consult healthcare providers before starting NMN supplementation, especially if taking medications.
Quality Assurance:
- GRAS status since 2018
- Third-party tested for purity
- Enteric capsule delivery
- Pharmaceutical-grade NMN
- 24-month stability tested
- Ships to 50+ countries