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Questions Answered About NMN Supplements - FAQ

Questions Answered About NMN Supplements - FAQ

Anthony Loera Anthony Loera
5 minute read

How do NMN Supplements work?


We believe that NMN supplements work according to our testing and research. Several studies have shown increased levels of NAD. There are many other benefits that NMN supplements can offer to athletes, including sleep, sugar, and much more [1].



Are NMN supplements dangerous?


No evidence suggests that NMN supplements can be hazardous for short-term use. No studies concern the long-term use of NMN or the long-term consequences of a high concentration of NAD. There is evidence that levels of NAD high enough to fight aging may also help strengthen cancer cells. This is an area that requires further research [2].



What is the best dosage for NMN?


Each will have a different dosage of NMN. Determining the exact absorption differences among alternative delivery methods for NMN is also challenging. Start with a 500mg or less dose and move up the ladder. For the first few weeks, starting with 500 mg and then increasing your amount to two tablets (250 mg each) may be a good idea. The latest human study as of July of 2022, shows that 150 mg for 60 days increases NAD. This will allow you to test the product's efficacy while saving money.



Does it have more value than NR?


NMN seems superior to NR based on current scientific evidence. Because NMN is further along the NAD+ production path, this makes sense. Molecularly, NMN is more similar to NAD+ than NR.


Studies also show that NMN has impressive results on many aging mechanisms.



What are NMN and NAD?


NMN is nicotinamide mononucleotide. It is a precursor of your system's nicotinamide dinucleotide (NAD) coenzyme. In layman's terms, NMN is a compound that makes the body produce NAD. It can increase the efficiency of the way your cell’s function.


NAD supplementation can provide anti-aging benefits such as superior cognition and youthful appearance. It allows your cells to work more effectively, resulting in better cognitive function. After a brief period, some studies have shown that NAD supplementation can enhance sports performance by increasing your VO2 max. Some people link this with improved insulin resistance. This may lead to a reduced risk of diabetes and a smaller waist.




Orally, NMN can also be absorbed.


NMN studies clearly showed that NMN could easily be absorbed when taken orally.


SLC12A8 is a protein that transports NMN across cell membranes in mice [3]. This transporter was also found in humans [4].


It shouldn't be a surprise that there is a specialized NMN transporter. Studies have shown that oral administration of NMN increases NAD+ levels in various tissues [5], [6].


Studies in mice show that NMN can be used to improve aging and other health biomarkers [7], [8]. This indicates that NMN can be absorbed by mammals and has effects.


An oral administration of NMN to human subjects showed that NMN is absorbed. A variety of metabolites were also found in the blood [9].


NMN is administered orally by a variety of companies that develop anti-aging treatments.


Let's talk briefly about cellular uptake. NMN was not able to be taken up directly by cells until recently. To be taken up by cells, NMN must first be converted to NR. Recent research has shown that NMN can be absorbed directly by cells. This is possible through a unique mechanism [10].



Are NMN Supplements safe?


Research has shown no adverse reactions to NMN supplements. This includes doses that are considerably higher than those commonly used. You can expect positive feelings only when you are on NMN.


There is limited research on the long-term impacts of using NMN or NAD on cancer. There was no evidence to suggest that NMN and high NAD levels could cause cancer. There is still evidence that the ability of NAD to increase cell efficiency can be applied to cancerous cells. Researchers could halt tumor growth by diminishing cell access to NAD. This means that a high level of NAD may contribute to cancer development or pre-exist [11].


We need more data to assess whether high levels of NAD are a risk factor for cancer. Both things could be true.

  • Anti-aging properties of NAD
  • NAD may aggravate cancers


We do not know enough about the metabolic lifespan of NAD or its effects on various systems in the body. As a result, it is difficult to determine which of the two things NAD does best: promote youth or prevent cancer. One day, we can find the ideal dosage of NMN and NR or a method to accurately and cheaply measure and maintain a Goldilocks NAD concentration in the body. It is essential to know that certain unknowns exist.





  1. 1.       https://link.springer.com/article/10.1186/s12970-021-00442-4
  2. 2.       https://www.sciencedirect.com/science/article/pii/S2090123221001491
  3. 3.       https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530925/
  4. 4.       https://www.omim.org/entry/611316?search=slc12a8&highlight=slc12a8
  5. 5.       https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668137/
  6. 6.       https://www.sciencedirect.com/science/article/pii/S1550413116304958
  7. 7.       https://www.sciencedirect.com/science/article/pii/S1550413116304958
  8. 8.       https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12461
  9. 9.       https://www.jstage.jst.go.jp/article/endocrj/67/2/67_EJ19-0313/_article
  10. 1  .  https://www.nature.com/articles/s42255-018-0009-4
  11. 11     https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036060/


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