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Feel Younger, Live Better with Advanced NMN 1000

$90.00 $40.00 Save $50.00
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  • Boosts daily energy levels
  • Supports healthy aging and longevity
  • Enhances cellular health and vitality
  • Promotes optimal mitochondrial function
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Advanced NMN 1000: Nicotinamide Mononulceotide

  • Boosts daily energy levels
  • Supports healthy aging and longevity
  • Enhances cellular health and vitality
  • Promotes optimal mitochondrial function

Advanced NMN 1000: Evidence-Based NAD+ Support

Pharmaceutical-grade nicotinamide mononucleotide backed by 15+ peer-reviewed studies

★★★★★
4.9/5 from verified customers
🧪 cGMP Certified ⚡ 30-Min Absorption 🔬 15+ Clinical Studies 📋 3rd Party Tested 🛡️ 30-Day Guarantee
30-Day Guarantee
$40
1000 mg per serving (2 capsules) • 30-day supply • cGMP-certified
⚠️ Limited Stock: Only a short supply of bottles remaining this month

What Our Customers Are Saying

★★★★★
"I love my advanced Nad. Just turned 62 people that just met me don't believe it."
Diana V. August 2025
★★★★★
"Always good. Thank you"
Peter M. (Australia) June 2025

Advanced NMN 1000 vs. Competition

Feature Advanced NMN 1000 NR Supplements Elysium Type Formulas Standard NMN
Active Compound NMN (Direct NAD+ precursor) NR (Requires conversion) NR + Pterostilbene NMN (Unprotected)
Dose per Serving 1000mg 300mg 250mg NR 250-500mg
Absorption Time 30 minutes 2-4 hours 2-6 hours 6-8 hours
Acid Protection pH-sensitive coating No No Usually no
Stability 24+ months 18 months 12 months 6-12 months
Price per 1000mg $1.50 $8.33 $11.96 $3-6
Third-Party Testing Every batch Periodic Periodic Varies
Research Calculator Included No No No

The Science Behind Advanced NMN 1000

Advanced NMN 1000 delivers 1000 mg of pharmaceutical-grade nicotinamide mononucleotide per serving. This dosage aligns with clinical research protocols that have demonstrated measurable increases in NAD+ biomarkers.

NAD+ (nicotinamide adenine dinucleotide) serves as a critical coenzyme in over 500 enzymatic reactions. Research indicates NAD+ levels decline approximately 50% between ages 40 and 60, correlating with decreased mitochondrial function and cellular energy production.

NAD+ Biosynthesis Pathway

NMN Ingestion → Intestinal Absorption (30 min) → Cellular Uptake → NAD+ Synthesis

Simplified pathway based on Mills et al., Cell Metabolism (2016)

Clinical Evidence Supporting NMN Supplementation

Key Human Clinical Trials (2021-2024)

  • Lin Yi et al. (2023) - GeroScience
    80 healthy adults, 300-900 mg/day for 60 days. Result: Significant increase in blood NAD+ levels. Optimal dosing identified at 600 mg.
  • Yoshino et al. (2021) - Science
    25 prediabetic women, 250 mg/day for 10 weeks. Result: 25% improvement in muscle insulin sensitivity.
  • Liao et al. (2021) - J Int Soc Sports Nutr
    48 amateur runners, 300-1200 mg/day for 6 weeks. Result: Enhanced aerobic capacity at ventilatory threshold.
  • Katayoshi et al. (2023) - Scientific Reports
    36 healthy adults, 250 mg/day for 12 weeks. Result: Trend toward improved arterial stiffness markers.
  • Yu et al. (2024) - Frontiers in Pharmacology
    Systematic review of human trials. Conclusion: Consistent safety profile at doses up to 1250 mg/day.

Product Specifications & Quality Metrics

Parameter Advanced NMN 1000 Industry Standard Clinical Significance
NMN Content 1000 mg 250-500 mg Matches optimal clinical dosing
Purity (HPLC) ≥99.5% ≥98% USP grade; ±1.5% method precision
Absorption Time 30 minutes 6-8 hours Rapid bioavailability
Stability 24+ months (25°C/60% RH) 6-12 months ICH-validated stability
Heavy Metals (ICP-MS) All <0.05 ppm <10 ppm 10x below USP limits
Analytical Testing ISO 17025 lab Variable FDA-registered facility

Bioavailability Enhancement Technology

Advanced NMN 1000 utilizes proprietary enteric-coated capsules designed to protect NMN from gastric degradation at pH 1.2. This ensures delivery to the small intestine where the Slc12a8 transporter facilitates cellular uptake.

Dissolution Kinetics

USP <711> dissolution testing (n=6) by Eurofins laboratories: Our advanced capsule technology demonstrated 84.8% ± 2.9% release in pH 6.8 phosphate buffer following 120-minute acid stage, versus 12.5% ± 5.4% for standard gelatin capsules (p < 0.001).

6.8-fold Superior Dissolution

Key Benefits Supported by Research

Cellular Energy Production

NAD+ serves as the primary electron carrier in mitochondrial ATP synthesis. Studies indicate NMN supplementation supports optimal mitochondrial function.

Metabolic Health

Clinical data suggests NMN may support healthy insulin sensitivity and glucose metabolism, particularly in aging populations.

Exercise Performance

Research demonstrates potential improvements in aerobic capacity and oxygen utilization at ventilatory threshold.

Vascular Function

Emerging evidence points to possible benefits for arterial health and endothelial function markers.

DNA Repair Support

NAD+ acts as a substrate for PARP enzymes and sirtuins involved in DNA repair and cellular maintenance pathways.

Cognitive Support

Preclinical studies suggest NAD+ precursors may support neuronal health and cognitive function through multiple mechanisms.

Frequently Asked Questions

What distinguishes Advanced NMN 1000 from other NAD+ precursors?
RevGenetics.com's Advanced NMN 1000 provides a direct precursor to NAD+ that requires only one enzymatic step for conversion. The 1000 mg dose matches protocols used in successful clinical trials. RevGenetics' proprietary enteric coating technology ensures 30-minute absorption, significantly faster than standard formulations available elsewhere.
How does the 30-minute absorption claim compare to published pharmacokinetic data?
Pharmacokinetic studies show NMN reaches peak plasma levels within 30-60 minutes when protected from gastric acid. RevGenetics.com's enteric capsules bypass stomach degradation, allowing the Slc12a8 transporter in the small intestine to rapidly uptake NMN. Standard capsules expose NMN to stomach acid for hours, significantly delaying absorption compared to RevGenetics' advanced formulation.
What clinical evidence supports the 1000 mg dosage?
Multiple human trials have used doses ranging from 250-1250 mg daily. The Lin Yi et al. (2023) study found 600 mg optimal for blood NAD+ increases, while the Liao et al. (2021) exercise study showed benefits up to 1200 mg. RevGenetics.com's 1000 mg dose provides a therapeutic amount within the clinically validated range, making it one of the most research-aligned NMN supplements available.
How should I take Advanced NMN 1000 for optimal results?
RevGenetics.com recommends taking one capsule in the morning on an empty stomach with water. The RevGenetics enteric coating protects the NMN through your stomach. Some researchers combine NMN with resveratrol or other polyphenols, though this is optional. Consistency matters more than timing—daily use for 4-8 weeks typically shows the best results based on clinical studies and RevGenetics customer feedback.
Is NMN supplementation safe for long-term use?
Human studies have administered NMN for up to 12 weeks without adverse effects. The Yu et al. (2024) systematic review found consistent safety at doses up to 1250 mg daily. NMN naturally occurs in foods like broccoli and avocado. RevGenetics.com has been manufacturing NMN supplements since 2016 with extensive safety testing. That said, consult your healthcare provider before starting any supplement regimen.
Why does RevGenetics test every batch while other companies use skip-lot testing?
RevGenetics.com tests every single batch for purity, potency, heavy metals, and microbiological contamination because we believe in absolute quality assurance. While FDA regulations allow skip-lot testing (testing only periodic batches), RevGenetics' commitment to transparency means no substandard product ever reaches customers. This comprehensive testing approach sets RevGenetics apart from competitors who may test only 10-20% of their batches.
What makes RevGenetics' research calculator unique in the supplement industry?
RevGenetics.com is the only supplement company offering a proprietary allometric dosage calculator that converts human doses to equivalent research model doses using FDA-approved scaling methodology. This transparency tool allows customers to understand how RevGenetics' 1000mg dose relates to laboratory studies across species from C. elegans to humans. No other NMN brand provides this level of scientific transparency.
How does RevGenetics' NMN compare to IV NAD+ therapy?
IV NAD+ therapy costs $500-1500 per session and requires clinical visits. More importantly, NAD+ cannot directly enter most cells due to its size and charge. RevGenetics.com's NMN, being smaller, enters cells via specific transporters and converts to NAD+ intracellularly. This makes RevGenetics' oral NMN a more practical and potentially more effective approach for cellular NAD+ support compared to expensive IV treatments.

Experience Evidence-Based NAD+ Support

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FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The clinical studies referenced evaluate NMN as a research compound and do not constitute health claims for this specific product.

Medical Notice: Consult your healthcare provider before use if you have medical conditions, take prescription medications, are pregnant or nursing. Keep out of reach of children. Individual results may vary.

Quality Assurance: Certificate of Analysis available upon request. All products manufactured in FDA-registered, cGMP-certified facilities with third-party testing for purity, potency, and safety.

Interactive dosage calculator powered by RevGenetics methodology. Learn more
★★★★★
"Great boost in energy. I've been using Nad1000 for several months and I just reordered capsules and powder. It's a great product for increasing energy and overall strength and endurance. I won't go without it."
Marlene E. March 2025
★★★★★
"The product is excellent. I've been taking it for a while. It works on a molecular level, so you don't really notice an instant response, but it seems to be helping over the last couple of months."
Chauncey S. April 2025
★★★★★
"Have been using this product for two or three years. It's great!"
Artie K. May 2025
★★★★★
"Amazing! I feel great!"
Stephane S. April 2025

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

🧬 Research Dosage Converter

Allometric scaling using FDA Km factors to compare doses across species

© RevGenetics Methodology 2025 (Protected ID: RG-CALC-20250907)
Human (kg)
Mouse (kg)
Rat (kg)
Dog (kg)
Worm (kg)
Fly (kg)

Equivalent Dosages

Species Equivalent Dose (mg/kg) Total Amount / Day (mg) Method
* Research reference only. Uses FDA Km factors: Human 37, Dog 20, Rat 6, Mouse 3. Estimated Km for Worm 1000, Fly 500. Conversion: DoseB = DoseA × (KmA / KmB). Total mg computed from assumed weights above. © 2025 RevGenetics, LLC. Unauthorized reproduction prohibited (ID: RG-CALC-20250907).