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What are the Anti-Aging Supplements that David Sinclair Takes?

What are the Anti-Aging Supplements that David Sinclair Takes?

anthony-loera anthony-loera
15 minute read

David Sinclair is a professor at Harvard University who has been researching the aging process for the duration of his career as a scholar.

David Sinclair, Ph.D. David Sinclair's principal research focus is his research on the epigenetics of the aging process and aging, with an extraordinary emphasis on epigenetic programming of the aging process (e.g., reversing aging by Yamanaka-related causes), NAD+ metabolism, and sirtuins NAD+ precursors, such as NMN. You might have seen his written New York Times best-selling book on the subject of aging, Lifespan: Why We Age – And Why We Don't Have To, in-depth research into these topics (you can read our most-loved longevity books here)

We highly recommend his published New York Times best-selling book on lifespan and aging called "Lifespan: Why We Age – And Why We Don't Have To." It goes deep into these subjects, as we have followed his work since 2006.

 

What supplements does the good Dr. Sinclair appear to take to live longer?

Dr. Sinclair has committed not to recommend or endorse any supplement products. We have compiled this list of supplements through past interviews and books where Dr. Sinclair mentions the supplements he consumes.

We aren't sure if he continues to use these supplements below or if he also takes other accessories that aren't on this list.

For instance, in his audiobook "Lifespan" (the author mentions in the chapter named "Conclusion" at minute 22:09 that his regimen includes NMN and resveratrol each morning, usually mixed into his yogurt.

So, based on a variety of recent interviews as well as his book... Sinclair's supplements and his longevity regimen could look like the following:

 

  1. Nicotinamide Mononucleotide (NMN): 1 gram daily, usually in the morning.
  2. Resveratrol 1 gram a day, usually in the morning.
  3. Metformin 800 mg late at night or evening.
  4. Vitamin D3 sometimes 4,000-5,000 IU daily
  5. Vitamin K2 sometimes 180-360 micrograms daily
  6. A Statin
  7. Low-dose aspirin: at about 83 mg daily
  8. Alpha lipoic acid (ALA): we are not sure if he takes this currently
  9. Coenzyme Q10 (coQ10): we are not sure if he takes this currently
  10. Spermidine 1 mg daily, usually in the morning.
  11. Quercetin 500mg and fisetin 500 mg, usually in the early morning
  12. TMG (trimethylglycine or betaine): we think (not sure) between 500 mg to 1,000 mg daily

 

1. Nicotinamide mononucleotide (NMN) 1 gram daily, taken in the early morning

NMN (Nicotinamide Mononucleotide) has been proven to reduce the effects of the process of aging in research on animals. [1][2]

NMN (Nicotinamide Mononucleotide) acts as a precursor of NAD+, a crucial metabolic protein that many proteins require to perform their purpose, including protecting and fixing the epigenome, DNA, and the epigenome.

This product only contains HPMC, the vegetarian capsule material, and Nicotinamide Mononucleotide. We do not add any magnesium stearates, rice flour, strange unpronounceable fillers, or use gelatin of any kind in this vegetarian product.

1,000 mg is an extremely high dose of NMR. 250-500 mg is sufficient to gain the health benefits of NMN and longevity-enhancing effects. Studies have shown that humans with NMN (Nicotinamide Mononucleotide) consume 250 mg daily. [3]

It's interesting to see that doctor Sinclair takes NMN (Nicotinamide Mononucleotide) and does not take NR (another highly praised "longevity" supplement). Despite the hype circulating on the web, NR does not extend its lifespan. So far, Professor Sinclair has led us to believe that NMN (Nicotinamide Mononucleotide) may be superior to NR. [4]

Click here to learn more about RevGenetics Advanced NMN.

 

2. Resveratrol 1 gram daily in the morning 

Resveratrol is one of the stilbenoids which is found in the grapes' skin in small amounts. Research has proven that resveratrol could lower the risk of cancer, heart disease, and neurodegeneration.

From what we gather through interviews and studies,

The M98 Resveratrol Complete (M98-RC) is estimated to be absorbed virtually completely (98.4% metabolized) compared to regular resveratrol 1,2. While dry M98 super micronized resveratrol increases absorption when used with different emulsifiers (between 3x to 10x depending on the emulsifier used), the M98 micronized resveratrol is still mainly passively absorbed by a single cellular transport system and is limited.

David Sinclair believes that resveratrol interacts synergistically with NMN (Nicotinamide Mononucleotide). Resveratrol is required to stimulate the sirtuin gene (which protects our DNA and epigenome). NMN (Nicotinamide Mononucleotide) is essential to fuel the sirtuins.

But resveratrol is challenging to absorb through the digestive tract, and the small amount of resveratrol that ends in the body is rapidly broken down.MicroResveratrol™ 500mg - Pure Trans-Resveratrol *Meets The Same MicroResveratrol™ (Micronized Resveratrol) PCOS Study Standards We Helped Sponsor (Trans-Resveratrol) Pure resveratrol activates SIRT1, SIRT2, SIRT4, SIRT5, Fox01, P53, and many other longevity genes. This is Pure Resveratrol in Vegetarian Capsules For Best Absorption. We make it available for overall health with the same amount per capsule and purity provided to the scientists performing human studies. As a dietary supplement, we do not make any medical claims.Thus, Trans-resveratrol-3-O-glucoside (Piceid) is an alternative that is more soluble than resveratrol. Trans-resveratrol-3-O-glucoside is a molecule that appears similar to resveratrol. However, it is more efficiently absorbed and has a much higher stability within the human body without the increase of LDL that something like pterostilbene has unfortunately been shown to increase.

Numerous studies have shown that Trans-resveratrol-3-O-glucoside (Piceid) is more effective than resveratrol in solubility and absorption, providing a longer half-life and activating Sirtuins. [5][6][7]

On a separate topic, RevGenetics exclusively uses Trans-resveratrol-3-O-glucoside (Piceid) in its M98 Resveratrol Complete powder because of its high solubility compared with regular trans-resveratrol.

 

3. Metformin (prescription drug) 800 mg in the evening

Metformin has been proven to increase the longevity of many species, including mammals. [8][9]

In humans, we have observed that people who are diabetic taking metformin have longer life spans than healthy diabetics who do not take metformin. It was not so for those with diabetes taking other anti-diabetic medications. [10]

However, taking metformin may cause adverse negative effects. In the short run, metformin can cause diarrhea and stomach pain, which usually subsides within several weeks. In the long run, metformin can reduce the absorption of vitamin B12.

Metformin is probably a hormetic drug, meaning that it can cause a large amount of damage to cells, so cells are placed into a repair and protection mode. Metformin hinders mitochondrial function, meaning mitochondria can heal and protect themselves more effectively. 

So, since exercise "damages" the mitochondria somewhat (so that they eventually heal themselves, which is one of the benefits of exercise for health), Dr. Sinclair does not combine metformin and training, which could cause excessive stress on mitochondria. This is why Sinclair; Dr. Sinclair does not take metformin when he works out. [11]

Additionally, recent research suggests that older adults should not be taking metformin since metformin can cause excessive stress on already extremely old and overstressed mitochondria.

Our team wrote an article on natural alternatives to metformin here.

Additionally, David Sinclair takes metformin in the evening before going to sleep. This is because the body is fasting at night, and metformin may further accelerate the state.

But we recommend taking metformin every time you eat your most oversized food item (ideally 20 minutes before mealtime). This is because metformin may make the body more insulin-sensitive when it is most needed. During the following hours after eating, mitochondria are required to process the fats and sugars of the food. This is also why metformin is recommended according to the guidelines of a medical professional.

Additionally, at night you're in a state of fasting (insulin-sensitive). It is possible to bring your body into an insulin-sensitive state throughout the day, particularly when you process carbohydrates and fats following eating.

Doctor. Sinclair takes 800 mg of metformin just once a day. We prefer smaller doses spread out throughout the day, such as 500 mg twice a day, before the lunch break (500 mg), and before dinner (500 mg) -- not before breakfast because it is when your body is already insulin-sensitive.

 

4. Vitamin D3

Vitamin D can prolong life at a minimum in simple living organisms. Vitamin D helps reduce the chance of developing a variety of age-related illnesses. Vitamin D in humans is associated with a higher likelihood of suffering from heart problems, type 2 diabetes, autoimmune disease, and Alzheimer's disease. [12]

Vitamin D stimulates a variety of genes that provide significant advantages to health.

The amount of vitamin D that most governments recommend is insufficient (e.g., 400-800 IU daily). Many vitamin D experts recommend consuming at least 4,000 and 5 000 IU daily. Also, ensure that your vitamin D levels are tested at least once a year. [13]

Vitamin D is one of the supplements that everyone should consume for the best health.

 

5. Vitamin K2

Vitamin K is crucial not only in bone health. However, it is also essential for mitochondrial and vascular health. Vitamin K is also beneficial to the appearance of the skin.

If you are taking vitamin D, you should include it in combination with Vitamin K2 (MK-7 is the most effective form). The two vitamins are synergistic.

The ideal doses of vitamin K2 range from 180-360 micrograms per day.

But, taking just some vitamins, such as Vitamin K or vitamin D, will not be enough to cover it. Most people lack vitamins, minerals, and micronutrients even when they consume a balanced diet.

Learn more about vitamins and other supplements we should consume here.

 

6. Statin (prescription drug) -- in his 20s due to a family history of heart disease

Statins may reduce the risk of suffering from heart disease. However, there's much debate over how significant the impact of statins is in decreasing the risk of cardiovascular disease.

Some researchers suggest you consider taking statins when you're at an increased risk of suffering an attack on your heart (known in the field of "primary prevention"); some say you must only take statins once you've already experienced a heart attack (as "secondary prevention").

Another study suggests that for a large portion of people, statins aren't working effectively for primary prevention.

It will depend on your genetic makeup; we have seen that certain people respond better to statins, whereas others do not experience any effects. [14]

In addition, it is essential to note that not all statins are alike. Certain statins appear capable of extending mice's lifespan (like simvastatin); however, other statins don't have this effect. Additionally, statins may cause adverse effects such as nerve pain or muscle aches (nerve pain), and some serve more than others

Statins, in the end, block cholesterol production, which is an integral part of cell membranes, particularly muscle and neuron cells.

 

7. Aspirin (Low Dose) - 83 mg per day

A low dose of aspirin can help lower inflammation, decrease the chance of heart attack, and possibly the risk of developing cancer.

A recent study involving more than 20000 participants over 4.7 years found that even a tiny number of aspirin was ineffective in reducing the risk of cardiovascular disease and did not increase the survival rate. [15]

Indeed, one study revealed that it might increase the risk of developing cancer, despite numerous other studies showing that aspirin might benefit longevity and health. [16]

More studies must be conducted to determine the cause.

 

8. Alpha-lipoic acid (ALA)

Notice: According to previous sources, Dr. Sinclair mentioned taking alpha-lipoic acid. However, in a recent interview (done between 2022 and 2023), David Sinclair didn't specifically mention taking this supplement.

Alpha-lipoic acid (ALA) is a powerful antioxidant. There's been some hype about ALA, mainly when it is used in conjunction with acetyl-L -carnitine (ALCAR), which can slow the process of aging. [17]

However, numerous studies have shown that ALA doesn't extend lifespan or slow aging.

Alpha-lipoic acids are a powerful antioxidant, and researchers have discovered that antioxidants may speed up aging. [18]

We shouldn't be shocked to learn that studies show that lives are reduced when older mice are treated with alpha-lipoic acid.

This is why alpha-lipoic acids are the anti-aging supplements you shouldn't take.

In other words, we should be cautious when consuming supraphysiological amounts (much higher than what you'd get from a healthy diet) that contain antioxidants.

 

9. Coenzyme Q10 (coQ10) 

Notice: According to previous sources, Dr. Sinclair mentioned taking coenzyme Q10. However, in his recent conversations (done by 2022), David Sinclair didn't specifically mention taking this supplement.

Coenzyme Q10 is an antioxidant that enhances mitochondrial function. There isn't enough evidence (at most in well-studied studies using the appropriate model mice for disease) that coenzymeQ10 could extend the lifespan of mice.

Numerous studies have shown that coenzymeQ10 does not prolong the life span. Certain studies have shown that coenzyme Q10 may reduce the duration of life. [19][20][21][22]

CoenzymeQ10 is also an antioxidant. Recently, scientists have realized that antioxidants could speed up the process of aging (for reasons explained in this article). We should be cautious when taking powerful antioxidants like coenzyme Q10 to prolong the life span of our patients.

It is also why we added coenzymeQ10 to our list of supplements to fight the age you should not use to prolong their lives.

 

10. Spermidine 1 mg per day in the early morning 

Spermidine is a molecule that was first found in sperm. This is the reason for its name. It is a supplement that is taken by removing wheat germ. It is also present in food items like cheese, soy, legumes, and mushrooms.

RevGenetics Rapymine™ Is made for healthy customers who want to make sure they are doing everything they can to support their natural cellular Autophagy, all while seeing their doctor regularly. This product contains Spermidine RX™, which is a proprietary dry wheat seed and wheat seed oil extract.Spermidine has the potential to affect critical processes of aging, including autophagy. 

Studies have demonstrated that spermidine improves various biomarkers of longevity and health and also that spermidine may prolong the lifespan of multiple organisms, including rodents. [23][24]

We've written more about the topic of Spermidine Supplements here.

 

11. Quercetin and fisetin,500 mg each, twice a day, in the early morning

Quercetin, along with fisetin, is two very similar molecules. They're often referred to as "senolytics" because they're believed to eliminate senescent cells.

Senescent cells agglomerate during aging and secrete chemicals that can harm healthy, normal cells (learn about them here).

We believe that molecules like fisetin can prolong lifespan because of different effects other than being a "senolytic," such as reducing inflammation.

We prefer taking fisetin in lower doses (100 mg daily) as well as in a consistent manner rather than in larger quantities (e.g., 1,500 mg or more significant) once a month to "clear" senescent cells.

We would rather have fisetin than quercetin. This is because more studies are conducted with fisetin that shows longevity benefits; for instance, studies with mice show that fisetin prolongs the lifespan. [25]

 

12. The TMG (trimethylglycine, also known as betaine)

Dr. Sinclair mentioned in podcasts that he took TMG (trimethylglycine) for a reason. He wants to ensure that he is in the right direction regarding the possible effects of NMN cutting down on methylation in the body.

Methyl groups are tiny molecules placed on proteins, DNA, and substances to function correctly.

For instance, DNA that is methylated (DNA coated with molecules of methyl) hinders the DNA from functioning (learn more about epigenomics in this article). Methyl molecules can also be associated with specific substances to enable them to break down.

Cells can use NMN to produce NAD+, an essential molecule for good health. But it is the moment NAD+ is utilized in the human body an amide gets created. The molecule must be eliminated. To accomplish this, the methyl group must be added to nicotinamide to ensure it can be released from the kidneys.

If people consume, lots of NMN and methyl groups can be utilized.

 

TMG contains methyl groups (TMG comprises three methyl groups in each TMG molecule). We agree with Dr. Sinclair that adding TMG might be beneficial. The ideal dosage is at least 500 mg - 1 gram of TMG daily.

Some people may experience digestive issues due to TMG or experience difficulty sleeping following the use of it. As a result of TMG, you can take phosphatidylcholine. It can provide methyl groups. It can also boost cognition and brain health.

It is also possible to take green tea while taking the NMN. Green tea is a source of EGCG that inhibits the enzyme responsible for putting the methyl groups on the nicotinamide (the enzyme is known as "NNMT"). This way, fewer methyl groups are needed to create methylation of nicotinamide.

Here, we've written more on Resveratrol NMN, and other anti-aging supplements.

 

MORE DAVID SINCLAIR TIPS TO LIVE LONGER

Of course, Dr. Sinclair does not only take the supplements that help them live longer but also to be healthier.

He's aware that exercising, nutrition, proper sleep, and stress reduction are crucial ways to prolong life. What is his method of doing this?

 

1. Nutrition

David Sinclair often eats only two meals a day instead of eating three meals.

He drinks a lot of green tea and only a minimal amount of alcohol.

He consumes small amounts of (red) flesh and eats a lot of green vegetables.

Prof. Sinclair is a proponent of the practice of regular intermittent fasting.

Read more details about the most effective longevity diet here.

 

2. Exercise

Regarding fitness regarding exercise, Dr. Sinclair runs in a high-intensity or low-intensity method once or twice a week. Additionally, he lifts weights at least once or twice per week.

 

3. Health monitoring

Professor Sinclair uses the continuous glucose monitor (CGM) to determine how the food he consumes raises his glucose levels.

Some examples of continuous glucose-monitoring devices include FreeStyle Libre and Levels (not paid for).

He also conducts regularly scheduled blood tests to monitor his health. We have written about the top tests for endurance on this page.

 

CONCLUSION

We believe that the list of supplements offered by David Sinclair is not bad; however, it could be improved.

In this way, we distinguish between supplements to prolong life and health supplements.

Supplements for longevity, such as NMN, micro-dosed lithium, and calcium alpha-ketoglutarate, may help slow the aging process.

Vitamins and supplements help our body perform at its best. Deficits of them can accelerate aging.

Please find here the top supplements we make in a cGMP facility for longevity and an overview of supplements for health that everyone should consider taking.

References:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668137/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854911/
  3. https://pubmed.ncbi.nlm.nih.gov/33888596/
  4. https://onlinelibrary.wiley.com/doi/10.1111/acel.13328
  5. https://www.sciencedirect.com/science/article/abs/pii/S019745801100337X
  6. https://pubmed.ncbi.nlm.nih.gov/29220106/
  7. https://pubmed.ncbi.nlm.nih.gov/27496184/
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736576/
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339796/
  10. https://pubmed.ncbi.nlm.nih.gov/25041462/
  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736576/
  12. https://www.cell.com/cell-reports/fulltext/S2211-1247(16)31362-6
  13. https://www.cell.com/cell-reports/fulltext/S2211-1247(16)31362-6
  14. https://www.technologyreview.com/2018/10/23/1960/your-genome-on-demand/
  15. https://www.nejm.org/doi/full/10.1056/nejmoa1805819
  16. https://www.nejm.org/doi/full/10.1056/nejmoa1803955
  17. https://pubmed.ncbi.nlm.nih.gov/15059645/
  18. https://pubmed.ncbi.nlm.nih.gov/22785389/
  19. https://pubmed.ncbi.nlm.nih.gov/16443163/
  20. https://pubmed.ncbi.nlm.nih.gov/15059645/
  21. https://pubmed.ncbi.nlm.nih.gov/9584986/
  22. https://pubmed.ncbi.nlm.nih.gov/26999099/
  23. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128428/
  24. https://pubmed.ncbi.nlm.nih.gov/27841876/
  25. https://pubmed.ncbi.nlm.nih.gov/30279143/

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