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Resveratrol vs Pterostilbene

Resveratrol vs Pterostilbene

anthony-loera anthony-loera
5 minute read

A Comparative Study of Bioavailability in addition to Resveratrol Health Benefits

Two years ago, scientists discovered that Resveratrol reduced the yeast rate of aging cells. In 2003 Harvard Medical School Professor found that Resveratrol triggered a longevity gene called SIRT1 and the resulting sirtuin protein class. [1]

The exact mechanism was examined and proved to be the case in mice. Research on Resveratrol has shifted towards its impact on human health. Resveratrol has been found to help sustain the cardiovascular system, protect against antioxidants in glucose metabolism, maintain a healthy balance from inflammation, and much more. After publishing the results of this research, people became more inclined to drink red wine rich in Resveratrol and to take supplements containing Resveratrol. [2]

However, the most significant obstacles to reaping the benefits of Resveratrol in humans seem to be its low bioavailability and rapid elimination from the body. Nevertheless, a drug that is gaining some attention could overcome these obstacles.

Scientists became interested in its molecular counterpart, Pterostilbene, about ten years after discovering that Resveratrol activated the longevity gene. While it is found at higher concentrations in blueberries than in red wine, Pterostilbene is nearly the same chemical structure as the chemical structure of Resveratrol. [3]

The initial human safety study of Pterostilbene was published in 2013, and research has been accelerated since then. Pterostilbene is promoted to be the most vital form of Resveratrol. It is said to deliver the previously known benefits of Resveratrol with higher bioavailability. Are these claims accurate? Check out this article for an in-depth analysis of these two compounds. [4]

 

Structural Differences

Resveratrol and Pterostilbene are two natural plant compounds. Resveratrol is found in grape skins and red wine and is separated from the root in Japanese knotweeds. Pterostilbene is mainly present in blueberries; however, it is also isolated from cocoa, grapes, and peanuts.

Resveratrol and Pterostilbene belong to a group of compounds called stilbenes. These phenolic compounds contain two aromatic rings containing the hydroxyl group (-OH). Resveratrol contains three hydroxyl groups, while Pterostilbene has only one. Two groups are replaced by the methoxy group (O-CH 3) in Pterostilbene. [5]

The variation in the number of hydroxyl groups is essential as it influences the speed at which the compound is metabolized and removed from the human body. Three hydroxyl groups in the resveratrol molecule accelerate the elimination process, making it more difficult to reach and maintain significant levels of Resveratrol in the bloodstream. [6]

With a single hydroxy group per molecule, Pterostilbene can stay in the bloodstream longer. The slight variation in the structure makes Pterostilbene more liquid. Pterostilbene has a more remarkable ability to move through cell membranes, making it easier to assist in cellular pathways.

Pterostilbene and Resveratrol are found naturally in two different forms, cis and trans. The trans type is more stable and abundant in nature. Studies have shown that these trans are better than Cis forms in biological activities for Pterostilbene and Resveratrol.

Although Pterostilbene looks like a good product, it was recently found to increase LDL Cholesterol by its main manufacturer. (https://www.clinicalnutritionjournal.com/article/S0261-5614(18)32477-4/fulltext).

This 2018 study shows everyone that some ingredients like Pterostilbene can ultimately cause issues for many people.

 

So what has RevGenetics done since Pterostilbene can't be used?

RevGenetics uses a resveratrol molecule that is 25 times more soluble than trans-resveratrol, is actively and passively absorbed, and lasts longer in the bloodstream than Pterostilbene because the molecule uses a glucoside. RevGenetics is providing an alternative that is even better than Pterostilbene and Super Micronized Resveratrol, all without the issues.

We Call it M98 Resveratrol Complete.

RevGenetics has pure M98 Resveratrol Complete powder and has a unique capsule formula with the long-lasting Resveratrol that activates Sirtuins and is in the bloodstream for nearly 240 minutes (Half-Life).

 

Studies for M98 Resveratrol Complete Trans-Resveratrol-3-O-glucoside

(aka piceid, polydatin)

Pharm Biol, 2013; 51(11): 1347–1354

J Agric Food Chem 57:4572

Nat Rev Drug Discov, 2006, Jun; 5(6):493-506

J Agric Food Chem 53:798–803.

Pharm Res 14:763-766

 

Conclusion

Pterostilbene offers more pharmacokinetic benefits than regular Resveratrol, but it is still less effective than RevGenetics M98 Resveratrol Complete, which is 98.4% more absorbable than ordinary Resveratrol. Although dry M98 super micronized has a higher absorption rate when combined with different emulsifiers, it is still passively absorbed by one cellular transport system.

RevGenetics decided to provide both active and passive absorption by using a trans-Resveratrol type with a higher solubility than the others and is actively absorbed through glucose transports. We use Complete Absorption Resveratrol (TM) to refer to it. It can be used to provide complete passive and active absorption.

In other words, M98 Resveratrol complete is absorbed via both passive and active cellular transport systems. It is 25x more soluble* and has a longer half-life (approx. Four hours longer than standard Resveratrol). M98 Resveratrol complete is more absorbable than ordinary Resveratrol and lasts much longer.

 

References:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8935221/
  2. https://www.sciencedirect.com/science/article/pii/S175646462100517X
  3. https://www.sciencedirect.com/science/article/pii/S0925521421002842
  4. https://www.sciencedirect.com/science/article/abs/pii/S2210803322000185
  5. https://journals.sagepub.com/doi/full/10.1177/1934578X221113707
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966610/

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