Resveratrol Scientific Evidence: Beneficial Effects And Side Effects That Resveratrol Supplements Have on Cardiovascular Health
The chemical molecule known as trans - resveratrol can be found naturally in a variety of plants and foods, including grape skins, grape juice, berries, and peanuts. These and others can be a natural source of resveratrol. The first study to look at the effects of trans - resveratrol on cardiovascular health was conducted in 2008. The study found that effects of resveratrol had a positive effect on the blood vessels, reducing their stiffness and improving their ability to relax. This is important because stiffer blood vessels can lead to high blood pressure, which is a major risk factor for heart and cardiovascular disease making the potential of resveratrol interesting to scientists.
Recent years have seen a rise in interest in it as a result of the biological effects and potential benefits it may provide for cognitive performance, diabetic patients, the health of the heart and stave off coronary artery disease. In the following paragraphs, we will go over the activity of resveratrol research that backs the use of resveratrol supplements for the treatment as well as prevention of heart or cardiovascular disease, including maybe using resveratrol on blood pressure.
What exactly is resveratrol?
A phytoalexin is a type of molecule that belongs to a class called phytoalexins. Plants produce phytoalexins as a form of self-defense against pathogens and other types of environmental stress. One type of phytoalexin is known as trans-resveratrol. In addition to the skin of red grapes, it can be found in the skin of a variety of other fruits and vegetables, including berries, peanuts, and Japanese knotweed, among others and considered dietary resveratrol. It was thought to be the reason for the French paradox, as red wine also contained it, while white wine contained less of the molecule.
What effects of resveratrol supplementation can happen within the body?
Researchers have identified a variety of potential mechanisms of action for the biological effects of resveratrol, including the following in clinical studies:
- It has been discovered that activity of resveratrol can eliminate free radicals, which are chemicals that have the possibility of causing harm to cells and play a role in the development of chronic diseases. It accomplishes this by functioning as an antioxidant in the body.
- It has been demonstrated that resveratrol can inhibit the production of pro-inflammatory molecules. These molecules are thought to play a role in the development of a wide variety of chronic diseases, including heart disease. Because of this quality, resveratrol is able to reduce inflammation in the body.
- Researchers have discovered that resveratrol can alter the expression of particular genes, which may have repercussions for the development of chronic diseases. It is hypothesized that these genes participate in the process of gene regulation in some way and provide supplementation on energy metabolism.
- It has been demonstrated that resveratrol can stimulate the activity of the SIRT1 gene, which plays a role in the regulation of metabolism and may play a part in the aging process. The fact that resveratrol is capable of turning on the SIRT1 gene served as a key enabler for the discovery of this phenomenon.
What the Research Says About the Relationship Between Resveratrol Supplements, Cardiovascular Disease and the Health of the Cardiovascular System
Although the potential health benefits of resveratrol have been investigated in great detail in the laboratory and in studies that have been conducted on animals, there is still a lack of evidence from human studies that have been conducted on people. So more is needed on the effects of resveratrol supplementation on coronary heart disease and non-Alcoholic Fatty Liver Disease. On the other hand, a number of studies have shown that oral resveratrol may provide potential health advantages for the heart. Among these potential effects of resveratrol are the following:
- Taking resveratrol was associated with a lower risk of developing coronary heart disease, according to the findings of a meta-analysis that examined the findings of 13 separate studies on the subject.
- One study found that individuals suffering from cardiovascular disease who took resveratrol had improved blood vessel function and another improved the metabolic profile of obese humans.
- According to the findings of one study, hypertensive individuals who took resveratrol had significantly lower blood pressure compared to individuals who did not take the supplement.
- After taking resveratrol, people who had previously suffered from high cholesterol were found to have lower cholesterol levels than they had before taking the supplements.
The Risks and Possibilities That Come Alongside Accompanying Illnesses
While the effect of improving the metabolic profile in people seems positive. The vast majority of people have the misconception that high-dose resveratrol supplementation is completely risk-free, despite the fact that it could lead to a variety of adverse effects such as the following observed in one or more a healthy volunteer in a clinical trial or in a lab:
- Blood clotting
It is essential to keep in mind that the Food and Drug Administration has not provided its approval for the use of a resveratrol treatment, the days of resveratrol supplementation, it's protective effects, resveratrol on glucose control, cardioprotective effects or prevention of any disease or it's calorie restriction-like effects. This is something that needs to be kept in mind at all times. Additionally, a clinical trial (or double-blind pilot study) is the gold standard and additional studies are required to determine whether or not the supplement form of resveratrol is both safe and effective for human consumption.
Resveratrol is a molecule that forms on its own in nature and can be discovered in a wide variety of plant species. Researchers have only recently started paying attention to the possibility that it can improve cardiovascular health with it's protective effects. This is one of the reasons why. According to the findings of several studies, resveratrol may have potential benefits for heart health, including reducing the risk of heart disease, coronary artery disease, improving blood vessel function, lowering blood pressure, and improving cholesterol levels. These implications for protection are just some of the reasons that there is high interest in the potential benefits that may be associated with supplementation with resveratrol. Although a clinical trial is needed as there is still a lack of evidence from studies involving humans, these studies have found that resveratrol may have the potential health benefits listed above. However, additional study is required to determine whether or not the consumption of High-dose resveratrol supplementation by humans is not only safe but also beneficial.