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In a murine model of allergic asthma, tetrahydrocurcumin supplementation improves dexamethasone's therapeutic effect

In a murine model of allergic asthma, tetrahydrocurcumin supplementation improves dexamethasone's therapeutic effect

anthony-loera anthony-loera
3 minute read

What is Dexamethasone?

Dexamethasone, a corticosteroid drug, is prescribed to treat several ailments. The adrenal gland naturally produces corticosteroids, which play several crucial roles in the body, including regulating metabolism, immune system performance, and stress response.

Numerous medical diseases, such as inflammation, allergic responses, and autoimmune disorders, are treated with dexamethasone. It functions by lowering bodily inflammation and repressing the immunological system.

There are several ways to get dexamethasone, including pills, oral solutions, and injectable versions. Although it is commonly consumed orally, it can also be injected directly into a muscle or vein.

 

Tetrahydrocurcumin Supplementation

Tetrahydrocurcumin may enhance the health of people with certain medical disorders, such as allergic asthma, according to some data. A kind of asthma called allergic asthma is brought on by exposure to allergens like dust, pollen, or pet dander. It is characterized by inflammation and airway restriction, making breathing difficult.

Tetrahydrocurcumin supplementation has been demonstrated to improve the therapeutic effects of dexamethasone; a corticosteroid drug frequently used to treat asthma, in a murine (mouse) model of allergic asthma. Dexamethasone decreases airway inflammation, which can aid in lowering asthma symptoms. However, prolonged use of corticosteroids may result in unwanted side effects, such as weight gain, increased risk of infection, and bone loss. [1][2]

 

There are several ways to get dexamethasone, including pills, oral solutions, and injectable versions. Although it is commonly consumed orally, it can also be injected directly into a muscle or vein.

Dexamethasone commonly causes the following adverse effects:

·         Upset stomach

·         Mood changes

·         Weakness

·         Higher appetite

 

Dexamethasone can cause significant adverse effects, such as an elevated risk of infections, bone loss, and weight gain, when used for an extended period. See a healthcare provider if you are currently taking dexamethasone or are thinking about doing so to grasp the potential hazards and advantages fully.[3][4][5]

 

Tetrahydrocurcumin supplementation efficiency

Tetrahydrocurcumin supplementation was found to be more efficient than dexamethasone alone at reducing airway inflammation and enhancing lung function in mice with allergic asthma, according to the study. Tetrahydrocurcumin may contribute to the improvement of dexamethasone's therapeutic benefits by lowering airway inflammation and oxidative stress.[6]

To assess the efficacy and safety of tetrahydrocurcumin in treating allergic asthma in humans, additional research is required. It is important to remember that this study was carried out in a mouse model of allergic asthma. It is crucial to speak with a healthcare provider before beginning any treatment if you have allergic asthma and are considering taking tetrahydrocurcumin or another supplement to address your disease. A healthcare practitioner can assist you in understanding the treatment's potential dangers and advantages and select the best course of action for your particular circumstances.

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References:

  1. http://jik.fk.unri.ac.id/index.php/jik/article/view/471
  2. https://www.sciencedirect.com/science/article/pii/S0944711322003622
  3. https://link.springer.com/article/10.1007/s43440-021-00341-0
  4. https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13966
  5. https://www.mdpi.com/2077-0383/11/6/1694
  6. https://www.mdpi.com/1498492

 

 

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