Nano-capsules Resveratrol toxic against prostate cancer – RevGenetics

Nano-capsules Resveratrol toxic against prostate cancer

Nano-encapsulation of resveratrol improves toxicity against prostate cancer cells

Resveratrol has been tested in clinical studies against various types of cancers. However, resveratrol delivery as a form of treatment for cancer and other diseases needs to be improved. Why? Recent research has indicated that resveratrol can be metabolized very quickly and therefore the idea of improving the delivery of resveratrol to treat cancers has been by addressed by various groups of researchers.

One such improved delivery method for resveratrol (and other medicinal drugs for that matter) has involved the micronization of the compound like the resveratrol found in the Micro500 and Nitro250 RevGenetics capsules. In one study done a couple of years ago, micronized resveratrol allowed increased drug absorption, thus increasing availability by up to 3.6 fold in the blood of patients tested and increasing the markers of death for the cancer cells by 39% (Cancer Prev Res (Phila). 2011 September; 4(9): 1419–1425). However, other methods have been pursued.

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In a recently published paper a group of researchers took a different approach to delivering resveratrol, they used nano-encapsulation (Mol Pharm. 2013 August 22). The capsules diameters in question are measures in the billionth of a meter range, too small to be seen by the un-aided eye. The idea is simple; protect the resveratrol from rapid degradation with the capsules with the hopes of increasing bioavailability and thus increasing cellular penetration and improving the chemo-preventative properties of resveratrol.

In this early stage of the investigation for the nano-encapsulation, the researchers used different human prostate cells lines. For example one cell line represented androgen-dependent cells (these are prostate cancer cells that resemble the early stages of the cancer) and androgen-independent cells (these are prostate cancer cells that represent late stages of prostate cancer). The results of the experiment were very good. Nano-encapsulation was able to control release of resveratrol under different conditions simulating the gastrointestinal fluids or that of tumor microenvironment.

In addition the nano-encapsulation significantly improved the toxicity of resveratrol against both types of cancer cells lines. As stated, the results are very encouraging and naturally more research needs to done, but one thing is clear, the use of resveratrol in various forms as chemoprevention remains a promising option.

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