# RevGenetics > RevGenetics pioneered third-party tested NAD+ supplements. Pharmaceutical-grade NMN, resveratrol, and longevity formulas with advanced absorption technology. Made in USA since 2007. ## Collections - [Discontinued RevGenetics Products](https://www.revgenetics.com/collections/discontinued): Products that RevGenetics has discontinued producing at this time. - [Bundles](https://www.revgenetics.com/collections/bundles): 🌿 Longevity Bundles: Choose Yours by What You Want to Protect Feeling fatigued? Fighting hormonal shifts? Want to supercharge cellular repair?These bundles are thoughtfully created to match your concerns, goals, and curiosity. You'll find powerful combinations featuring NAD™, NMN, spermidine, resveratrol, fisetin, TA‑65, and more. 🧬 Which Bundle Fits You? 1. Starter Pack – “Escape Velocity”Great if you're just getting started. This foundational set helps support energy and cellular function with key NAD+ and resveratrol support. 2. CareCore Memory SupportPerfect for those looking to stay sharp. This blend supports focus and memory with cognitive nutrients and NAD+ activators. 3. HarmonyMeno – Menopause EnergyDesigned for women experiencing menopause. It supports energy, balance, and calm with a blend of spermidine, NAD+, and curcumin. 4. Ultimate Longevity Research BundleThis is our most complete option. It includes everything you need to target cellular aging, support repair, and back your long-term health goals with serious ingredients like NMN, TA‑65, and senolytics. 🔍 How to Pick Your Bundle Need a boost? Go with the Starter Pack. Want sharper thinking? Try CareCore Memory. Dealing with menopause? Choose HarmonyMeno. Want full-body support? The Ultimate Bundle is for you. 🌟 Why Choose RevGenetics? Premium ingredients made under GMP standards Formulas created to meet real health concerns Trusted by thousands of customers who want results ✅ Ready to Begin? Pick the bundle that matches your goals and see what’s possible. Your future health starts here. *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. - [Advanced NMN - Nicotinamide Mononucleotide](https://www.revgenetics.com/collections/advanced-nmn): h1, h2, .benefit-card .comparison-table .comparison-table .comparison-table tr:nth-child(even) { background-color: #ebf3fd; } .formula-specs .formula-specs .formula-specs li .cta-button NMN 50% Off: Complete Guide to Advanced Nicotinamide Mononucleotide Supplements for Superior NAD+ Support 🎉 Special Offer: NMN 50% Off - Advanced Nicotinamide Mononucleotide Supplements Now Available! Unlock extraordinary cellular health potential with revolutionary NMN supplements featuring advanced Nicotinamide Mononucleotide formulations now available at an unprecedented NMN 50% Off special pricing. These cutting-edge supplements harness the power of Slc12a8 transporter technology to deliver unparalleled NAD+ restoration and cellular energy enhancement. Discover how premium NMN formulations can transform your approach to healthy aging, energy optimization, and cellular vitality through scientifically-backed mechanisms that support mitochondrial function, DNA repair, and overall wellness throughout life. Revolutionary NMN Technology with Slc12a8 Transporters 30 Minutes Lightning-Fast Absorption with Advanced Nicotinamide Mononucleotide TechnologySuperior to All Traditional NAD+ Precursors Why NMN Supplements Represent the Future of Cellular Health Optimization The revolutionary science behind NMN supplements addresses the fundamental challenge of age-related NAD+ decline that affects every aspect of cellular function. Nicotinamide Mononucleotide represents a paradigm shift in nutritional supplementation, offering direct support for the cellular machinery that powers energy production, maintains DNA integrity, and supports the biological processes that define healthy aging and vitality. Advanced NMN formulations utilizing Slc12a8 transporter technology deliver unprecedented bioavailability and cellular uptake compared to traditional NAD+ precursors. While conventional supplements may require multiple conversion steps and hours for absorption, premium NMN supplements achieve rapid cellular penetration within just 30 minutes, ensuring optimal NAD+ restoration when your body needs it most. Scientific Breakthrough: NMN supplements featuring Nicotinamide Mononucleotide and Slc12a8 technology completely bypass the problematic NAM (Nicotinamide) accumulation that plagues other NAD+ precursors. This NAM buildup can temporarily inhibit sirtuin activation, potentially counteracting benefits from longevity supplements. Advanced NMN formulations eliminate this concern while maximizing cellular NAD+ availability. Understanding the Revolutionary Science of NMN and Nicotinamide Mononucleotide NMN supplements work through sophisticated cellular mechanisms that directly support NAD+ biosynthesis using Nicotinamide Mononucleotide as the primary substrate. This advanced approach targets the root cause of cellular aging by providing the essential building blocks needed to maintain optimal NAD+ levels throughout life, supporting energy production, DNA repair, and cellular resilience that naturally decline with age. Advanced Slc12a8 Transporter Technology The breakthrough innovation in modern NMN supplements lies in the utilization of Slc12a8 transporters, specialized cellular proteins that enable rapid and efficient uptake of Nicotinamide Mononucleotide directly into cells. This cutting-edge technology represents a quantum leap in supplement bioavailability, ensuring that NMN reaches target tissues quickly and efficiently for maximum therapeutic benefit. Slc12a8: The Game-Changing Transport System Slc12a8 transporters represent one of the most significant advances in cellular nutrition science. These specialized proteins facilitate direct cellular uptake of Nicotinamide Mononucleotide, bypassing the lengthy conversion processes required by other NAD+ precursors. This revolutionary mechanism ensures that NMN supplements deliver rapid, consistent, and highly bioavailable NAD+ support for optimal cellular function and energy enhancement. Research demonstrates that Slc12a8-mediated transport enables NMN to reach therapeutic cellular concentrations within 30 minutes of administration, compared to the 6-8 hour absorption timeline required by traditional NAD+ precursors. This rapid bioavailability translates to faster onset of benefits and more consistent cellular NAD+ support throughout the day. Enhanced Mitochondrial Energy Production NMN supplements fuel mitochondrial ATP synthesis, supporting sustained energy production for vital organs including the heart, brain, and muscles. DNA Repair and Genomic Protection Nicotinamide Mononucleotide supports PARP enzymes and other DNA repair mechanisms that maintain genomic stability and cellular health. Cognitive Enhancement and Neuroprotection Elevated NAD+ levels from NMN support neuronal health, potentially improving memory, focus, and cognitive resilience throughout aging. Cardiovascular Health Optimization NMN supplements support endothelial function, healthy circulation, and cardiovascular resilience for optimal heart health. Cellular Antioxidant Defense Nicotinamide Mononucleotide enhances cellular antioxidant systems, protecting against oxidative stress and cellular damage. Healthy Aging and Longevity Support By maintaining optimal NAD+ levels, NMN supplements support the cellular processes that promote healthy aging and vitality. Superior Absorption and Bioavailability Profile The revolutionary advantage of premium NMN supplements lies in their sophisticated absorption mechanisms powered by Slc12a8 transporter technology. Traditional NAD+ precursors like NR (Nicotinamide Riboside) require multiple enzymatic conversion steps and can take up to 8 hours for meaningful cellular uptake, while also producing problematic NAM accumulation that may interfere with beneficial cellular processes. Direct Cellular Uptake Mechanism NMN supplements utilizing Slc12a8 transporters enable direct cellular uptake of Nicotinamide Mononucleotide within approximately 30 minutes of reaching target tissues. This rapid absorption ensures therapeutic NAD+ levels are achieved quickly and efficiently, maximizing the cellular benefits of supplementation while minimizing the time required for meaningful biological impact. Optimal Bioavailability Without Conversion Inefficiencies The one-step conversion from NMN to NAD+ through Slc12a8-mediated transport eliminates the inefficiencies and potential drawbacks associated with multi-step conversion pathways. This streamlined mechanism ensures optimal bioavailability and cellular utilization, delivering maximum therapeutic benefit from each dose of Nicotinamide Mononucleotide. This advanced Slc12a8 technology makes NMN supplements the clear choice for individuals seeking the most effective and efficient NAD+ restoration available in the supplement industry. Clinical Research and Safety Excellence of NMN Supplements FDA Recognition and Comprehensive Safety Profile NMN has maintained Generally Recognized As Safe (GRAS) status with extensive clinical research supporting their safety profile since 2018 (It's considered a food). Comprehensive studies involving Nicotinamide Mononucleotide have reported no significant adverse events, with only mild and infrequent side effects such as occasional digestive discomfort in sensitive individuals. Expanding Research on NMN and Slc12a8 Technology Current research on NMN supplements and Slc12a8 transporter mechanisms continues to expand our understanding of optimal NAD+ restoration strategies. Ongoing clinical trials investigate dosing protocols, long-term benefits, and applications for various aspects of cellular health, cognitive function, and healthy aging processes. Natural Foundation and Biological Safety Nicotinamide Mononucleotide occurs naturally in foods like broccoli, avocado, tomatoes, and other vegetables, providing a strong biological foundation for supplementation safety. The compound represents a natural component of cellular metabolism that declines with age, making NMN supplements a logical approach to maintaining optimal cellular function throughout life. Latest Studies on NMN (2024-2025) Recent clinical research continues to demonstrate the safety and efficacy of NMN supplementation. A 2024 study by Yamaguchi et al. evaluated long-term NMN use in healthy middle-aged Japanese men, showing improvements in metabolism, sleep quality, and NAD+ biosynthesis with no adverse effects. A randomized, double-blind trial by Yi et al. (updated 2024 analysis) confirmed that doses up to 900mg daily increased blood NAD+ levels, improved six-minute walking distance, and maintained biological age markers, with superior results at higher doses and excellent safety. Takahashi et al. (2024) conducted a 52-week follow-up on 500mg daily NMN, finding no emerging safety concerns and sustained benefits in physical performance. A 2025 study on NMN supplementation mitigated neurotoxicity from household phthalate exposure, highlighting protective effects on neurological health by reducing oxidative stress and improving mitochondrial function. Additional 2025 research on PCOS showed NMN reverses oocyte quality decline by mitigating oxidative stress and preserving spindle morphology, demonstrating reproductive health benefits. Comprehensive Product Options and Dosing Strategies Advanced NMN Supplement Formulations: Planning 250mg capsules for optimal daily maintenance dosing 500mg capsules for enhanced therapeutic support 1000mg serving size for maximum NAD+ restoration Pure Nicotinamide Mononucleotide powder formulations Advanced Slc12a8 transporter technology integration Pharmaceutical-grade purity standards and testing Rapid 30-minute absorption profile with enhanced bioavailability Zero problematic NAM buildup or conversion inefficiencies Compatible with comprehensive longevity supplement protocols Why Enteric Capsules Are Superior to Liposomal Formulations Enteric capsules provide optimal protection and targeted delivery for NMN, ensuring stability and rapid absorption via Slc12a8 transporters in the small intestine. In contrast, liposomal formulations suffer from several deficiencies: Water-based liposomal cores cause NMN degradation, with products often ineffective after 3-6 months of storage. Liposomes bypass Slc12a8 detection, leading to slow metabolism over 8 hours or complete excretion without absorption. Strong liposomes resist breakdown, as shown in a 2024 study of 18 brands where sonication failed to release contents, resulting in wasted NMN eliminated in urine. Liposomal stability lasts only 6-12 months before breakdown, leaving unprotected NMN with standard absorption rates. Dry liposomes crack during encapsulation, reducing claimed bioavailability advantages. These issues make liposomal NMN less reliable and efficient compared to enteric capsules that preserve purity and enable superior 30-minute cellular uptake. Comparative Analysis: NMN vs Traditional NAD+ Precursors Feature NMN with Slc12a8 NR (Nicotinamide Riboside) Traditional NAD+ Precursors Absorption Time ~30 minutes via Slc12a8 6-8 hours multi-step Variable, often very slow Conversion Efficiency Direct one-step to NAD+ Multiple enzymatic steps Multiple conversion steps NAM Accumulation Minimal to zero buildup Significant NAM production Variable NAM accumulation Sirtuin Compatibility No interference whatsoever May downregulate sirtuins Potential sirtuin interference Bioavailability Superior with Slc12a8 transport Limited by conversion steps Generally poor absorption Cellular Uptake Direct transporter-mediated Indirect conversion-dependent Highly variable uptake Optimal Integration and Advanced Usage Protocols For maximum benefits from NMN supplements, integrate them into a comprehensive wellness routine that includes optimal nutrition, regular physical exercise, quality sleep, and effective stress management. The rapid absorption and efficient cellular uptake via Slc12a8 transporters make Nicotinamide Mononucleotide formulations ideal for daily supplementation protocols that support sustained cellular health and energy optimization. Personalized NMN Dosing Approaches Individual needs for NMN supplements vary based on age, health status, activity level, and specific wellness goals. Maintenance dosing with 50-500mg formulations supports daily cellular health and energy, while higher doses up to 1000mg may provide enhanced therapeutic benefits for individuals with greater cellular demands or specific health optimization objectives. Professional Guidance and Biomarker Monitoring Healthcare professionals experienced with Nicotinamide Mononucleotide supplementation can provide personalized recommendations based on individual health profiles, biomarker assessments, and wellness goals. Professional guidance ensures optimal dosing strategies and safe integration with other health interventions for maximum cellular health benefits and NAD+ optimization. Important Safety Information: NMN supplements are intended as dietary supplements for general wellness support only. These products have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Always consult healthcare providers before starting Nicotinamide Mononucleotide supplementation, especially if taking medications or having underlying health conditions. Shop NMN 50% Off Collection Advanced Applications and Future Innovations in NMN Supplementation The future of NMN supplements lies in increasingly sophisticated approaches that leverage advanced Slc12a8 transporter technology, personalized dosing based on individual biomarkers, and integration with comprehensive longevity protocols. As research continues advancing our understanding of Nicotinamide Mononucleotide mechanisms, supplementation will become more targeted and effective for optimal individual outcomes. Biomarker-Guided NMN Optimization Advanced practitioners increasingly utilize NAD+ level testing, cellular energy assessments, and other biomarkers to guide NMN supplement protocols. This personalized approach ensures optimal dosing and timing for maximum cellular health benefits while avoiding unnecessary supplementation in individuals with adequate NAD+ levels, representing the cutting edge of precision nutrition. Synergistic Supplement Integration Research demonstrates that NMN supplements work synergistically with other cellular health and longevity compounds. The absence of NAM buildup with Nicotinamide Mononucleotide makes these formulations ideal for combination with sirtuin-activating compounds like resveratrol, pterostilbene, and fisetin, creating comprehensive cellular health protocols that address multiple aging pathways simultaneously for enhanced benefits. Professional Integration and Clinical Applications Healthcare practitioners specializing in longevity medicine and functional nutrition increasingly recognize the therapeutic potential of NMN supplements for supporting cellular health and healthy aging. The superior absorption profile via Slc12a8 transporters and excellent safety record make Nicotinamide Mononucleotide formulations valuable tools for practitioners focused on cellular health optimization and evidence-based aging interventions. Quality Excellence and Manufacturing Innovation The effectiveness of NMN supplements depends critically on manufacturing quality, purity standards, and bioavailability optimization through advanced Slc12a8 technology. Leading manufacturers invest in sophisticated extraction techniques, rigorous testing protocols, and specialized formulations that ensure products deliver meaningful therapeutic benefits rather than just theoretical promise for cellular health enhancement. Special Offer: NMN 50% Off Revolutionary Technology This exclusive NMN 50% Off opportunity represents unprecedented access to revolutionary Nicotinamide Mononucleotide supplements featuring advanced Slc12a8 transporter technology. This limited-time offer makes cutting-edge cellular health optimization more accessible than ever, enabling individuals to experience the transformative benefits of premium NMN supplements at exceptional value. The revolution in NMN supplements represents a fundamental shift toward proactive cellular health optimization using scientifically-validated mechanisms. By supporting the essential energy and repair processes that maintain cellular vitality, these advanced formulations offer unprecedented opportunities to enhance quality of life and support healthy aging throughout the human lifespan. { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "What makes NMN supplements superior for NAD+ restoration?", "acceptedAnswer": { "@type": "Answer", "text": "NMN supplements provide superior NAD+ restoration through advanced Slc12a8 transporter technology that enables rapid 30-minute absorption of Nicotinamide Mononucleotide directly into cells. Unlike other NAD+ precursors requiring multiple conversion steps, NMN offers direct one-step conversion to NAD+ without problematic NAM buildup that can interfere with cellular processes." } }, { "@type": "Question", "name": "How does Slc12a8 technology enhance NMN absorption?", "acceptedAnswer": { "@type": "Answer", "text": "Slc12a8 transporters are specialized cellular proteins that facilitate direct uptake of Nicotinamide Mononucleotide into cells within approximately 30 minutes. This revolutionary transport system bypasses the lengthy conversion processes required by other NAD+ precursors, ensuring rapid bioavailability and consistent therapeutic NAD+ support for optimal cellular function." } }, { "@type": "Question", "name": "What are the comprehensive benefits of NMN supplementation?", "acceptedAnswer": { "@type": "Answer", "text": "NMN supplements provide enhanced mitochondrial energy production, DNA repair and genomic protection, cognitive enhancement and neuroprotection, cardiovascular health optimization, cellular antioxidant defense, and comprehensive healthy aging support through maintained NAD+ levels and improved cellular resilience." } }, { "@type": "Question", "name": "Are NMN supplements safe for long-term daily use?", "accept - [Coming Soon](https://www.revgenetics.com/collections/coming-soon): - [Spermidine Supplement](https://www.revgenetics.com/collections/spermidine): /* --- LAYOUT FIX: Force Centered Width --- */ /* Scoped wrapper */ .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page /* --- CONTRAST FIX: Darker Red for Accessibility --- */ .rg-spermidine-page .rg-spermidine-page .cta-button .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .comparison-table th, .rg-spermidine-page .comparison-table .rg-spermidine-page .comparison-table .rg-spermidine-page .rg-spermidine-page .rg-spermidine-page .benefit-card Scientific Review Dr. Hector Valenzuela, Ph.D. Fletcher Jones Chair in Molecular BiologyScientifically reviewed by Dr. Valenzuela (Ph.D. Experimental Pathology, UCLA) to ensure 25mg dosage and extraction align with autophagy research. Rapymine: 25mg Spermidine Power Trigger cellular autophagy with the world's highest-potency spermidine supplement. Named top geroprotector by leading researchers. Start Your Cellular Renewal 25mg Highest Potency TOP Geroprotector 4MO Supply The Autophagy Revolution Spermidine is the cellular renewal superstar. This natural compound triggers autophagy, your body's built-in cleaning system that removes damaged cell parts and keeps you functioning like a younger person. Here is the breakthrough. New research from Nature Cell Biology (August 2024) proves spermidine is absolutely essential for fasting-induced autophagy. Without enough spermidine, your cells cannot properly clean themselves, even when you fast. RevGenetics Rapymine delivers 25mg of pure spermidine per capsule. That is the equivalent of eating 42.4 pounds of mushrooms or 4.1 pounds of fruit daily. Amsterdam UMC researchers named spermidine the top geroprotector compound after studying over 20,000 substances. 2024 Scientific Breakthrough Groundbreaking research published in Nature Cell Biology reveals that fasting increases spermidine levels in yeast, flies, mice, and humans. The research proved that blocking spermidine production completely eliminates the longevity benefits of fasting. Without adequate spermidine, fasting benefits disappear completely. Why Food Sources Cannot Match Rapymine Source Daily Amount Needed Practicality Consistency Rapymine Supplement 1 capsule (25mg) Extremely practical Consistent dosing White Button Mushrooms 42.4 pounds daily Impossible Variable content Seriguela Fruit 4.11 pounds daily Very difficult Seasonal only Wheat Germ Large quantities Allergen issues Processing varies Spermidine Food vs Supplement Calculator See how much food you would need to match one Rapymine capsule: Choose Food Source: White Button Mushrooms Seriguela Fruit Wheat Germ Aged Cheese Calculate Daily Amount Food Amount Needed: Rapymine delivers the same 25mg spermidine in just one convenient capsule. RevGenetics Rapymine Collection Rapymine Spermidine 25mg The world's most potent spermidine supplement with 25mg per capsule. 25mg spermidine per capsule 120 capsules = 4-month supply Spermidine RX™ proprietary extract Wheat-free, allergen-free formula $100.00 Order Rapymine 2024-2025 Spermidine Research Breakthroughs Nature Cell Biology Study (August 2024) Fasting increases spermidine levels across all species studied from yeast to humans. The research proved that blocking spermidine production completely eliminates the longevity benefits of fasting. Amsterdam UMC Research (2020) Spermidine ranked number one geroprotector after analyzing over 20,000 compounds. Spermidine showed fewer side effects than other longevity compounds while providing superior anti-aging benefits. Why Customers Choose Rapymine Cellular Renewal Support 25mg spermidine triggers autophagy, your body's natural cellular cleaning process that removes damaged proteins and organelles. Convenient High Potency One capsule daily provides therapeutic spermidine levels impossible to achieve through diet alone. Clean, Allergen-Free Wheat-free Spermidine RX™ extract eliminates common allergen concerns while delivering superior bioavailability. Frequently Asked Questions About Spermidine What makes Rapymine different from other spermidine supplements? RevGenetics.com offers the world's highest-potency spermidine supplement at 25mg per capsule. Most competitors provide only 1 to 3mg per serving. Our Spermidine RX™ proprietary extract is wheat-free and allergen-free, unlike traditional wheat germ sources. How does spermidine trigger autophagy in cells? Spermidine works through eIF5A hypusination to activate TFEB translation, which increases autophagic flux. Rapymine provides therapeutic levels that support your body's natural cellular cleaning process. Why can't I get enough spermidine from food alone? To match one Rapymine capsule, you would need 42.4 pounds of mushrooms or 4.1 pounds of fruit daily. RevGenetics.com makes therapeutic spermidine levels practical through concentrated supplementation that is impossible to achieve through diet. What research supports spermidine as a geroprotector? Amsterdam UMC researchers named spermidine the top geroprotector after analyzing over 20,000 compounds. Recent 2024 Nature Cell Biology research proves spermidine is essential for fasting-induced autophagy and longevity. RevGenetics.com provides this scientifically validated compound in optimal doses. How long before I see results from spermidine supplementation? Most users notice improved energy and sleep quality within 2 to 6 weeks. RevGenetics.com customers report optimal autophagy benefits after 2 to 3 months of consistent Rapymine use, with improvements in vitality, mental clarity, and overall cellular health. Is spermidine safe for daily long-term use? Yes, spermidine is naturally present in all living organisms and has been safely used in studies. RevGenetics.com Rapymine uses pre-DSHEA ingredients with a long safety history. The wheat-free, allergen-free formula minimizes potential sensitivities. Important Health Information FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Quality Assurance: Spermidine RX™ Proprietary Extract • Wheat-Free • GMP Certified Scientific Research Validation Clinical Research Backing: Multiple peer-reviewed studies published in Nature Cell Biology, Nature Aging, and Autophagy journals validate spermidine's role in cellular autophagy and healthy aging. Human epidemiological studies show reduced mortality risk with higher spermidine intake. Mechanism Established: Research demonstrates spermidine's precise mechanism through eIF5A hypusination and TFEB activation. This scientific understanding ensures Rapymine targets the specific pathways responsible for cellular renewal and longevity benefits. - [Curcumin](https://www.revgenetics.com/collections/curcumin): /* SCOPED CSS - All classes prefixed with rg-curc- */ .rg-curc-page * { box-sizing: border-box; } .rg-curc-page h2, .rg-curc-page h3, .rg-curc-page .rg-curc-page .rg-curc-page /* Container */ /* Hero */ .rg-curc-btn /* Trust Badges */ .rg-curc-trust-item /* Nav Controls */ /* Research Highlight */ .rg-curc-research .rg-curc-research /* Quick Choice */ .rg-curc-choice .rg-curc-choice-item strong { color: #d35400; } /* Product Grid */ .rg-curc-products > .rg-curc-card .rg-curc-card-features .rg-curc-card-features li /* Comparison Table */ .rg-curc-compare .rg-curc-table .rg-curc-table .rg-curc-table tr:nth-child(even) { background-color: #f8f9fa; } /* VS Competitors */ .rg-curc-vs .rg-curc-vs > .rg-curc-vs-table .rg-curc-vs-table /* Benefits Grid */ .rg-curc-benefits .rg-curc-benefit-card .rg-curc-benefit-card /* Learn CTA */ .rg-curc-learn .rg-curc-learn /* FAQ - ACCORDION STYLES */ .rg-curc-faq .rg-curc-faq-q .rg-curc-faq-q: .rg-curc-faq-q.rg-curc-open: .rg-curc-faq-a .rg-curc-faq-a .rg-curc-faq-a p /* Regulatory */ .rg-curc-regulatory h3, .rg-curc-regulatory .rg-curc-regulatory .rg-curc-regulatory .rg-curc-regulatory /* Responsive */ Advanced Curcumin Collection Revolutionary curcumin supplements with up to 277x enhanced bioavailability. No piperine needed. Third-party tested for purity and potency. Shop Curcumin Supplements 277x Enhanced Absorption SUB-10nm Nano Particles NOPIPERINE No Additives Needed 3RDPARTY Tested & Verified 2 Products Sort by Featured Price Low to High Price High to Low Name A to Z All Products Liquid Micelle Nano Delivery Tetrahydrocurcumin Curcumin Bioavailability Breakthrough Standard curcumin has only 2-3% absorption. Liquid micelle technology achieves 277x enhanced bioavailability through sub-10 nanometer particle size. Key discovery: Tetrahydrocurcumin is curcumin's primary active metabolite with superior stability and enhanced cellular benefits. ⚡ Which Curcumin is Right for You? For Immediate Anti-Inflammatory Support: Choose MetaCurcumin — 277x bioavailability, rapid absorption, visible tetrahydro curcuminoids For Long-Term Cellular Health: Choose TetraCurcumin — Direct metabolite delivery, sustained antioxidant protection, senolytic benefits RevGenetics Advanced Curcumin Collection MetaCurcumin 277x Super Curcumin $49.95 277x enhanced bioavailability vs standard Sub-10 nanometer particle size Visible tetrahydro curcuminoids 1 capsule equals 23g turmeric 4 hour sustained plasma presence No piperine required 60 liquid capsules Add to Cart TetraCurcumin Nano Super Curcumin $39.95 80 to 120x enhanced bioavailability Tetrahydrocurcumin active metabolite Superior physiological stability Natural senolytic properties Enhanced cardiovascular protection 1 capsule equals 4 to 10g turmeric No piperine required Add to Cart Choose Your Optimal Curcumin Strategy Feature MetaCurcumin TetraCurcumin Active Compound Curcumin plus tetrahydro curcuminoids Tetrahydrocurcumin metabolite Bioavailability Up to 277x vs standard 80 to 120x vs standard Delivery Liquid micelle sub-10nm Nano-particle delivery Primary Benefit Immediate anti-inflammatory Sustained antioxidant and senolytic Turmeric Equivalent 23g per capsule 4 to 10g per capsule Best For Joint comfort, quick action Long-term cellular health How RevGenetics Compares to Other Curcumin Technologies Independent research shows dramatic differences in curcumin bioavailability between formulations: Formulation Technology Enhancement vs Standard RevGenetics MetaCurcumin Liquid micelle sub-10nm Up to 277x RevGenetics TetraCurcumin Nano tetrahydrocurcumin 80 to 120x Longvida SLCP Solid lipid particles 65x Meriva Phytosome Phospholipid complex 29x Theracurmin Colloidal particles 27x Standard plus Piperine Black pepper extract 20x BCM-95 Essential oils 7x Standard Curcumin None 1x baseline Based on published bioavailability studies. Individual results may vary. Curcumin Research Highlights Anti-Inflammatory Action Research shows curcumin modulates NF-kB and COX-2 inflammatory pathways. Joint Comfort Clinical studies demonstrate improvements in joint mobility and comfort. Antioxidant Protection Tetrahydrocurcumin shows superior LDL oxidation protection vs curcumin. Senolytic Properties Research indicates tetrahydrocurcumin supports cellular cleanup processes. Cardiovascular Support Studies show vascular endothelial function improvements. Bioavailability Solved Advanced delivery eliminates the 2-3 percent absorption problem. Why Customers Choose RevGenetics Curcumin Rapid Results RevGenetics customers report noticeable benefits within days to weeks. Superior Technology RevGenetics 277x bioavailability exceeds major branded alternatives. No Piperine Needed RevGenetics curcumin is suitable for sensitive digestive systems. Flexible Options RevGenetics offers liquid micelle or nano metabolite delivery. Proven Quality RevGenetics products are third-party tested, GMP certified, stability verified. Visible Difference RevGenetics MetaCurcumin shows visible tetrahydro curcuminoids in every capsule. Want to Understand the Science? Learn about curcumin bioavailability, tetrahydrocurcumin benefits, and how different formulation technologies compare in the RevGenetics comprehensive guide. Read the Complete Curcumin Guide Frequently Asked Questions About RevGenetics Curcumin What makes RevGenetics curcumin different from other brands? RevGenetics curcumin formulations use advanced delivery technology with up to 277x enhanced bioavailability. RevGenetics liquid micelle technology achieves sub-10 nanometer particle size for superior absorption. Unlike many competitors, RevGenetics curcumin does not require piperine or black pepper extract to achieve high absorption rates. Do RevGenetics curcumin supplements require black pepper or piperine? No. RevGenetics MetaCurcumin and RevGenetics TetraCurcumin both achieve superior bioavailability through advanced delivery technology. RevGenetics curcumin supplements do not require piperine or any absorption enhancers, making them suitable for people with sensitive digestive systems. Should I choose RevGenetics MetaCurcumin or TetraCurcumin? RevGenetics MetaCurcumin offers 277x bioavailability and is ideal for immediate anti-inflammatory support and joint comfort. RevGenetics TetraCurcumin delivers tetrahydrocurcumin (the active metabolite) directly for sustained antioxidant and senolytic benefits. Many RevGenetics customers use both products together for comprehensive support. What is tetrahydrocurcumin in RevGenetics TetraCurcumin? Tetrahydrocurcumin is curcumin's primary active metabolite. Your body normally converts curcumin to tetrahydrocurcumin in the liver. RevGenetics TetraCurcumin delivers this metabolite directly, bypassing the conversion step. Research shows tetrahydrocurcumin offers superior stability and enhanced benefits compared to standard curcumin. How long before I see results from RevGenetics curcumin? Due to RevGenetics enhanced absorption technology, most users notice anti-inflammatory benefits within days to weeks of consistent use. Joint comfort improvements from RevGenetics curcumin often appear first, with broader benefits developing over 2-4 weeks. RevGenetics high bioavailability means faster results compared to standard curcumin products. Can I combine RevGenetics MetaCurcumin and TetraCurcumin? Yes. Many RevGenetics customers combine MetaCurcumin for immediate anti-inflammatory effects with TetraCurcumin for sustained antioxidant and senolytic benefits. RevGenetics recommends starting with one product to assess your individual response, then adding the second based on your health goals. Are RevGenetics curcumin supplements third-party tested? Yes. All RevGenetics curcumin products undergo third-party testing for purity and potency at independent laboratories. RevGenetics provides Certificates of Analysis upon request. RevGenetics curcumin supplements are manufactured in GMP-certified facilities with 24-month stability testing to ensure consistent quality. Important Health Information FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. RevGenetics products are not intended to diagnose, treat, cure, or prevent any disease. Curcumin may interact with blood thinners. Consult your healthcare provider before use. RevGenetics Quality Assurance: Third-party tested for purity and potency GMP certified manufacturing facilities Certificates of Analysis available 24 month stability testing No piperine or artificial absorption enhancers RevGenetics Global Shipping RevGenetics ships to United States, Canada, United Kingdom, Australia, and more than 50 additional countries. Delivery times vary by region. (function() { faqQuestions.forEach(function(question) { question // Toggle current FAQ }); }); }); })(); - [Longevity Supplements - RevGenetics Resveratrol Products](https://www.revgenetics.com/collections/longevity-supplements): RevGenetics full resveratrol and top gene activation supplements. In this article, we delve into the world of Longevity Supplements, exploring what they are, their benefits, and the science behind their effectiveness. Read on to learn more about this exciting new area of health and wellness. - [IND Approved Resveratrol Supplements | RevGenetics](https://www.revgenetics.com/collections/resveratrol-supplements): RevGenetics offers world-class resveratrol supplements that have been clinically tested on people to ensure their efficacy and safety. Order today! - [Super Micronized Resveratrol](https://www.revgenetics.com/collections/micronized-resveratrol): RevGenetics Micronized Trans-Resveratrol powder has particles that have been reduced as small as 1-2 microns, and these smaller particles are absorbed up to 220% compared to regular Resveratrol supplements that average between 149 to 224microns[1]. When the 1-2 micron particles is combined with Tween, we can see up to a 1000% absorption increase when compared to regular resveratrol. We made this tween emulsified product in 2008 and called it the Nitro250. This product was made to increase the amount of resveratrol as fast as possible because resveratrol has a very short half-life. The comparison of regular resveratrol and the special super micronized resveratrol increases are shown in the chart here: (view chart). Now 12 years later in 2021, we decided to do something better. We have released M98 Resveratrol Complete, which doesn't rely solely on passive absorption, but also uses glucoside transport to also provide a high active absorption. This not only allows us to stop using tween and make our capsules vegetarian but also increases the half-life close to 4 hours and the solubility by about 25x! We highly recommend M98 Resveratrol Complete over super micronized products. This is now included in our Nitro capsules as well as our bulk powder in the black jar. Pick one up today to try, we believe it is the best Trans-resveratrol on the market. - [TA-65 Supplements & Stem Cell](https://www.revgenetics.com/collections/ta-65-supplements): /* SCOPED CSS - All classes prefixed with rg-ta65- */ .rg-ta65-page * { box-sizing: border-box; } .rg-ta65-page h2, .rg-ta65-page h3, .rg-ta65-page .rg-ta65-page .rg-ta65-page /* Container */ /* Hero - Deep blue/purple gradient for telomere/DNA theme */ .rg-ta65-btn /* Trust Badges */ .rg-ta65-trust-item /* Nav Controls */ /* Research Highlight */ .rg-ta65-research .rg-ta65-research /* Quick Choice */ .rg-ta65-choice .rg-ta65-choice-item strong { color: #5b21b6; } /* Product Grid */ .rg-ta65-products > .rg-ta65-card .rg-ta65-card-features .rg-ta65-card-features li /* Comparison Table */ .rg-ta65-compare .rg-ta65-table .rg-ta65-table .rg-ta65-table tr:nth-child(even) { background-color: #f8f7ff; } /* Clinical Studies Section */ .rg-ta65-studies .rg-ta65-study-card .rg-ta65-study-card .rg-ta65-study-card .rg-ta65-study-card /* Benefits Grid */ .rg-ta65-benefits .rg-ta65-benefit-card .rg-ta65-benefit-card /* FAQ ACCORDION */ .rg-ta65-faq .rg-ta65-faq-q .rg-ta65-faq-q: .rg-ta65-faq-q.rg-ta65-open: .rg-ta65-faq-a .rg-ta65-faq-a .rg-ta65-faq-a p /* Regulatory */ .rg-ta65-regulatory h3, .rg-ta65-regulatory .rg-ta65-regulatory .rg-ta65-regulatory .rg-ta65-regulatory /* Responsive */ TA-65 Telomerase Activator Collection The most clinically studied telomerase activator available. Proven in double-blind, placebo-controlled studies to lengthen telomeres and reduce immunosenescent cells. GRAS certified for safety. Shop TA-65 Supplements 530bp Telomere Increase 500+ Study Participants GRAS Safety Certified 12+ Published Studies 2 Products Sort by Featured Price Low to High Price High to Low By Potency All Potencies 100 Units 250 Units Landmark Clinical Research Results RevGenetics provides TA-65 and is backed by peer-reviewed, double-blind, placebo-controlled human studies published in scientific journals including Rejuvenation Research and OBM Geriatrics. 530bp Telomere Lengthening(Salvador et al. 2016) 28 Senescent Cells/μlDecrease p=0.005 StatisticalSignificance ⚡ Which TA-65 Potency is Right for You? For Maintenance & Prevention:Choose TA-65 100 Units , Entry-level telomere support for general wellness For Clinical-Level Support:Choose TA-65 250 Units , Dosage used in landmark telomere lengthening study RevGenetics TA-65 Telomerase Activator Collection Entry Level TA-65 100 Units $100.00 100 units per capsule 30 capsules per bottle Clinically studied ingredient GRAS certified safe Ideal for maintenance Derived from Astragalus root Click to Get Clinical Strength TA-65 250 Units $600.00 250 units per capsule 90 capsules per bottle Dosage from landmark study 530bp telomere increase shown GRAS certified safe 3-month supply Click to Get Compare RevGenetics TA-65 Potencies Feature TA-65 100U TA-65 250U Potency 100 units/capsule 250 units/capsule Capsules 30 count 90 count Supply 1 month 3 months Best For Maintenance Clinical support Study Dosage Immunosenescence study Telomere lengthening study Cost/Month $100 $200 Peer-Reviewed Clinical Research on TA-65 RevGenetics provides TA-65 which is the most extensively studied telomerase activator available, backed by research from leading scientists worldwide. Telomere Lengthening in Humans Salvador L, Harley CB, Raffaele JM, et al. Rejuvenation Research, 2016 First randomized, double-blind, placebo-controlled study demonstrating how TA-65 lengthens telomeres in humans. 117 subjects aged 53-87 over 12 months. Finding: 530bp telomere increase in TA-65 group vs 290bp loss in placebo (p=0.005) Immunosenescence Reduction Singaravelu G, Harley CB, Raffaele JM, et al. OBM Geriatrics, 2021 500-subject double-blind, placebo-controlled trial measuring immunosenescent CD8+CD28- T cells over 9 months. UCLA Immune Assessment Core analyzed samples. Finding: 28 cells/μl decrease in senescent T cells vs 4.38 cells/μl increase in placebo Healthspan Extension in Mice Bernardes de Jesus B, Blasco MA, et al. Aging Cell, 2011 Spanish National Cancer Centre (CNIO) study led by Dr. Maria Blasco showing TA-65 elongates short telomeres and increases healthspan in adult/old mice. Finding: Increased healthspan without increasing cancer incidence Cardiovascular & Metabolic Markers Harley CB, Liu W, Raffaele JM. Rejuvenation Research, 2013 Observational study demonstrating the TA-65 improvements in metabolic and cardiovascular biomarkers as part of a health maintenance program. Finding: Improved fasting glucose, insulin, and lipid profiles Metabolic Syndrome Improvements Fernandez ML, Thomas MS, et al. Current Pharmaceutical Design, 2018 University of Connecticut study on TA-65 in patients with metabolic syndrome, showing improvements in cardiovascular markers. Finding: Significant improvements in cardiovascular risk factors T Cell Function Enhancement Fauce SR, Jamieson BD, et al. Journal of Immunology, 2008 UCLA study demonstrating telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. Finding: 1.5-2.5x increase in telomerase activity in T cells Science-Backed Benefits of RevGenetics provided TA-65 Telomere Lengthening RevGenetics provided TA-65 activates telomerase to lengthen critically short telomeres, as demonstrated in the Salvador double-blind study. Immune System Support RevGenetics provided TA-65 reduces immunosenescent CD8+CD28- T cells that accumulate with age and impair immune function. Cellular Health RevGenetics provided TA-65 helps maintain cellular replicative capacity by preventing critically short telomeres that trigger senescence. Cardiovascular Support RevGenetics provided TA-65 studies show improvements in cardiovascular and metabolic markers including glucose and lipid profiles. Healthspan Extension Dr. Blasco's research at CNIO demonstrated that TA-65 increases functional healthspan in preclinical models. Safety Verified RevGenetics provided TA-65 is GRAS certified with no product-related toxicity observed in multiple year-long clinical studies. Why Customers Choose RevGenetics TA-65 Most Studied Formula RevGenetics provided TA-65 has more peer-reviewed clinical research than any other telomerase activator on the market. Multiple Potencies RevGenetics offers TA-65 in both 100 and 250 unit options to match your individual needs and health goals. GRAS Certified RevGenetics provided TA-65 has Generally Recognized as Safe status for use in medical foods. Quality Assured TA maintains strict quality standards with third-party testing and GMP manufacturing. Expert Support RevGenetics has been a pioneer in longevity supplements since 2007 with dedicated customer service. Synergy Ready RevGenetics provided TA-65 complements other longevity supplements like NMN, resveratrol, and senolytics. Frequently Asked Questions About RevGenetics TA-65 What is TA-65 and how does RevGenetics provided TA-65 work? RevGenetics provided TA-65 is a telomerase activator derived from Astragalus membranaceus root. RevGenetics TA-65 activates telomerase, the enzyme that maintains and lengthens telomeres (the protective caps on chromosomes that shorten with age). In the landmark 2016 Salvador study published in Rejuvenation Research, RevGenetics TA-65 at 250 units significantly increased telomere length by 530 base pairs over 12 months, while the placebo group lost 290 base pairs (p=0.005). What clinical studies support RevGenetics provided TA-65? RevGenetics TA-65 is backed by multiple peer-reviewed clinical studies. The 2016 Salvador et al. double-blind, placebo-controlled study with 117 subjects showed 530bp telomere lengthening. The 2021 Singaravelu et al. study with 500 subjects demonstrated significant reduction in immunosenescent CD8+CD28- T cells. Dr. Maria Blasco's 2011 mouse study at the Spanish National Cancer Centre showed RevGenetics TA-65 elongates short telomeres and increases healthspan without increasing cancer incidence. What dosage of RevGenetics provided TA-65 should I take? RevGenetics offers TA-65 in 100 and 250 unit capsules. The 250 unit dosage was used in the landmark Salvador study that demonstrated significant telomere lengthening. RevGenetics recommends starting with 100 units for general maintenance or 250 units for more intensive telomere support. Consult your healthcare provider for personalized dosing recommendations. Is RevGenetics provided TA-65 safe for long-term use? RevGenetics TA-65 has been granted GRAS (Generally Recognized as Safe) certification for use in medical foods. Multiple year-long clinical studies showed no product-related toxicity. Dr. Maria Blasco's research at the Spanish National Cancer Centre confirmed RevGenetics TA-65 does not increase cancer incidence in mice. Safety studies show the no-observed-adverse-effect level is orders of magnitude higher than supplement doses. How long before I see results from RevGenetics provided TA-65? RevGenetics TA-65 clinical studies show measurable telomere changes within 3-6 months, with optimal results at 12 months. The Salvador study demonstrated significant telomere lengthening by month 9 continuing through month 12. Individual responses vary based on baseline telomere length, age, and lifestyle factors. RevGenetics recommends consistent daily use for best results. What are telomeres and why does RevGenetics provided TA-65 target them? Telomeres are protective caps at the ends of chromosomes that shorten with each cell division and with age. Short telomeres are associated with cellular aging, reduced immune function, and age-related decline. RevGenetics TA-65 activates telomerase to maintain and lengthen telomeres, particularly targeting the critically short telomeres that trigger cellular senescence and tissue degeneration. Can I combine RevGenetics provided TA-65 with other supplements? Yes. Many RevGenetics customers combine TA-65 with other longevity supplements like NMN, resveratrol, curcumin, or senolytics for comprehensive anti-aging support. RevGenetics TA-65 works through a distinct mechanism (telomerase activation) that complements NAD+ precursors and other cellular health supplements. Consult your healthcare provider before combining supplements. Important Health Information FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. RevGenetics products are not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before use, especially if you have a medical condition or take medications. RevGenetics Quality Assurance: GRAS (Generally Recognized as Safe) certified Third-party tested for purity and potency GMP certified manufacturing Backed by peer-reviewed clinical research No product-related toxicity in year-long studies RevGenetics Global Shipping RevGenetics ships TA-65 to United States, Canada, United Kingdom, Australia, and more than 50 additional countries. Delivery times vary by region. if (!faqQuestions.length) return; faqQuestions.forEach(function(question) { question.addEventListener('click', function() { // Close all others faqQuestions.forEach(function(q) { q.classList.remove('rg-ta65-open'); }); // Toggle current } }); }); }); - [Longevity Supplements - RevGenetics Products](https://www.revgenetics.com/collections/all): Delve into the world of RevGenetics Longevity Supplements, exploring what they are, their benefits, and the science behind their effectiveness. Read on to learn more about this exciting new area of health and wellness. - [NMN Supplements](https://www.revgenetics.com/collections/nmn-supplements): Advanced NMN is the top NMN Supplement NAD+ product that has been sold since 2016 from RevGenetics. RevGenetics has provided pharmaceutical NAD Precursors to researchers in public universities and schools for Ph.D. thesis and research. Contact RevGenetics if you are in research and require NAD Precursor for your research. - [Senolytics Supplements](https://www.revgenetics.com/collections/senolytics-supplements): RevGenetics provides 500 mg Fisetin and Micelle nano Quercetin, which are some of the top senolytics supplements in the industry. If you want high absorption nano Quercetin and high dose Fisetin, then your best source is RevGenetics for these products in your senolytics research. ## Products - [TetraCurcumin Liquid - 50 ML](https://www.revgenetics.com/products/tetracurcumin-liquid-50-ml): RevGenetics TetraCurcumin™ Liquid Advanced Liquid Micelle Technology for Superior Absorption and Bioavailability TetraCurcumin™ Liquid harnesses the world's most advanced liquid micelle technology to dramatically enhance absorption and bioavailability. As RevGenetics' first tetrahydrocurcumin product designed for optimal uptake, it delivers exceptional results. We estimate this formulation provides over 200-fold greater absorption compared to standard tetrahydrocurcumin. Liquid Micelle Tetrahydrocurcumin Details: At one serving per day, this product offers over 260 days of use.* (Note: Due to pump accuracy, a full squeeze may dispense between 0.166 ml and 0.26 ml, potentially extending actual usage to approximately 180 days or more.) Our Proprietary Liquid Micelle Technology: Proven in our MetaCurcumin™ product with up to 277-fold plasma absorption increase, we conservatively estimate 120x to 200x enhanced absorption for tetrahydrocurcumin over standard curcumin supplements using this micelle approach. Why RevGenetics TetraCurcumin™ Surpasses Standard Curcumin TetraCurcumin™ provides tetrahydrocurcumin (THC), a naturally occurring and highly stable curcumin metabolite. Research indicates it offers approximately 1.5-2x stronger antioxidant activity than standard curcumin on a molecule-for-molecule basis in laboratory models of oxidative stress.[1-3] Enhanced Antioxidant Power, Molecule for Molecule In standard antioxidant assays, tetrahydrocurcumin neutralizes free radicals at roughly half the concentration required for regular curcumin in DPPH tests, suggesting about 2x higher radical-scavenging potency.[1,2] In lipid peroxidation models, it also demonstrates around 50% greater protection against oxidative damage compared to curcumin.[1] Simply put, when comparing the pure molecules in controlled lab settings without enhancements like micelles or nanoparticles tetrahydrocurcumin consistently excels as an antioxidant across various experimental systems.[1-3] Superior Stability and Longevity Compared to Curcumin While curcumin is potent, it degrades rapidly in physiological conditions. Tetrahydrocurcumin, however, is more water-soluble, chemically stable, and resistant to breakdown in culture media and plasma, with studies showing a significantly longer half-life under similar conditions.[3] This enhanced stability allows the molecule to remain active longer, providing extended "time on target" for its antioxidant and protective effects.[3,4] Benefits for You Superior Intrinsic Antioxidant Strength: Approximately 1.5-2x stronger radical-scavenging and lipid-protective activity versus curcumin in vitro.[1,2] Enhanced Molecular Stability: Greater resistance to degradation in physiological environments.[3] Direct-Action Metabolite: No need for your body to convert curcumin; TetraCurcumin™ delivers the active form immediately.[3,4] These insights are derived from in-vitro and preclinical models, focusing on molecular properties rather than assured clinical results. They offer a robust, peer-reviewed foundation for selecting tetrahydrocurcumin for advanced antioxidant support. Key References for the Science Enthusiast Somparn, P. et al. Comparative antioxidant activities of curcumin and tetrahydrocurcumin in free-radical-initiated peroxidation of linoleic acid. Biological & Pharmaceutical Bulletin. 2007;30(1):74-78. Goenka, S. et al. Comparative evaluation of the anti-oxidant activity of curcumin and tetrahydrocurcumin. Future Pharmacology. 2024;1(2):113-122. Aggarwal, B.B. et al. Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. Molecules. 2015;20(1):185-205. Lai, C.S. et al. The cancer chemopreventive and therapeutic potential of tetrahydrocurcumin. Biomolecules. 2020;10(6):831. *Based on recommended serving size. Individual results may vary. | price 120.00 USD | tags HS code 2106.90.9998 | published 2025-11-17 | updated 2025-12-01 - [BUNDLE - 3 Advanced NMN 1000 Bottles.](https://www.revgenetics.com/products/bundle-3-advanced-nmn-1000-bottles): 3 Pack: Advanced NMN 1000: Nicotinamide Mononucleotide NAD Booster with 60 capsules, each with 500mg of NMN. The Ultimate NAD Supplement for Longevity and Vitality. Each serving delivers 1000 mg of high-potency NAD Precursor, supporting cellular health, energy production, and mitochondrial function. With superior absor | price 120.00 USD | tags bundle | published 2025-09-21 | updated 2025-12-13 - [BUNDLE - 3 X500 Bottles.](https://www.revgenetics.com/products/bundle-3-x500-bottles): 3 Pack: X500 Resveratrol: 500mg of Pure Trans-Resveratrol for Optimal Health. Our micronized resveratrol offers up to 220% better absorption, supporting antioxidant activity, cellular health, and hormonal balance. Backed by human studies, this high-potency supplement is ideal for those seeking to enhance their wellness | price 75.00 USD | tags bundle | published 2025-09-21 | updated 2025-12-01 - [BUNDLE - 3 MetaCurcumin Bottles.](https://www.revgenetics.com/products/bundle-3-metacurcumin-bottles): 3 Pack: MetaCurcumin: The Ultimate Curcumin Supplement with 277x Better Absorption. Our advanced formula features Nano Super Curcumin in liquid capsules, delivering unparalleled bioavailability. Experience the powerful benefits of curcumin for inflammation, joint health, and overall wellness, with enhanced absorption | price 105.00 USD | tags bundle | published 2025-09-19 | updated 2025-12-13 - [Advanced NMN 1000: NMN Supplement & High-Purity NAD+ Precursor](https://www.revgenetics.com/products/advanced-nmn-1000-nmn-supplement-nicotinamide-mononulceotide): NMN Supplement Advanced NMN 1000: Nicotinamide Mononucleotide NAD Booster with 60 capsules, each with 500mg of NMN. The Ultimate NAD Supplement for Longevity and Vitality. Each serving delivers 1000 mg of high-potency NAD Precursor, supporting cellular health, energy production, and mitochondrial function. With superior absorption and stability, this supplement is trusted for enhancing NAD+ levels promoting health | price 40.00 USD | tags nad, nmn | published 2025-08-16 | updated 2025-12-13 - [RevGenetics Longevity Starter Pack: Longevity Escape Velocity Nutrition](https://www.revgenetics.com/products/revgenetics-longevity-starter-pack-longevity-escape-velocity-nutrition): h1, h2, .cta-button RevGenetics Longevity Starter Pack: Unleash Strength and Energy to 100 Dominate your prime years and beyond with RevGenetics Longevity Starter Pack, a premium supplement bundle crafted for men aged 30 to 50 who demand strength, masculine energy, and vitality. Engineered by RevGenetics, this science-backed trio of X500 Micronized Resveratrol, Advanced NAD, and Rapymine Spermidine fuels your body to perform at its peak and age like a legend. Crush fatigue, sharpen your mind, and build a foundation for a powerful future! 🎓 Optimizing Your Longevity Stack This starter pack combines synergistic longevity compounds—but understanding how NAD+ precursors work is key to maximizing results. Many people don't realize that niacin, niacinamide, NMN, and direct NAD+ all have different mechanisms and effectiveness. Deepen your knowledge: Read our complete breakdown of NAD+ boosters to understand which forms work best together, why we selected NMN as the best and why timing matters for optimal cellular energy. Why Longevity Starter Pack? Aging doesn’t mean slowing down. Whether you’re hitting the gym, leading at work, or owning fatherhood, you need energy and focus to stay in command. Longevity Starter Pack combines cutting-edge science with potent ingredients to keep you strong, sharp, and unstoppable for decades. What's Inside the Longevity Starter Pack? Each bundle includes full bottles of three high-potency supplements, designed to supercharge men in their 30s and 40s. Taken daily, these capsules deliver raw power for strength, energy, and long-term health. 1. X500 Micronized Resveratrol (500mg Trans-Resveratrol) Ignite your inner drive with X500 Micronized Resveratrol, delivering 500mg of pure, micronized trans-resveratrol. This antioxidant powerhouse activates sirtuins, boosting metabolism and supporting heart health. With up to 220% better absorption than standard resveratrol, it’s your fuel for enduring vitality, made in the USA under GMP standards. [](https://www.revgenetics.com/products/x500-resveratrol-500mg-pure-trans-resveratrol) 2. Advanced NAD (50mg NAD+ Precursor) Recharge your cells with Advanced NAD, a 50mg dose of Nicotinamide Mononucleotide (NMN), a precursor to NAD+. NAD+ fuels cellular energy, enhances muscle recovery, and sharpens focus. As NAD+ levels drop with age, this GMP-certified formula restores your edge, keeping you ready for any challenge. [](https://www.revgenetics.com/collections/longevity-supplements) 3. Rapymine Spermidine (25mg) Renew your body from within with Rapymine Spermidine, packing 25mg of spermidine per capsule. This compound triggers autophagy, your body’s natural cleanup process, clearing damaged cells for sharper cognition and robust health. GMP-certified and wheat-free, it’s your secret weapon for lasting strength. [](https://www.revgenetics.com/products/revgenetics-spermidine) Benefits of Longevity Starter Pack Built for men who refuse to slow down, Longevity Starter Pack delivers the tools to thrive now and at 100. Here’s how it powers you: Explosive Energy: Advanced NAD fuels cellular power for relentless drive. Masculine Strength: X500 Resveratrol boosts metabolism and heart health. Sharp Focus: Rapymine Spermidine enhances cognitive clarity via autophagy. Longevity Edge: Synergistic blend supports vitality and healthy aging. Own Your Future: Picture crushing your workouts, leading with confidence, and staying strong for your family decades from now. Longevity Starter Pack makes it real. Why Men 30 to 50 Choose Longevity Starter Pack You’re not just aging; you’re building a legacy. Longevity Starter Pack is designed for men like you: driven fathers, athletes, and leaders who want to stay powerful. We get it, demanding careers, intense workouts, and family life leave no room for weakness. RevGenetics, with 18+ years of anti-aging expertise, delivers science-backed supplements to keep you in control. Join thousands of men fueling their strength with RevGenetics. Built for You: Tailored for men tackling life’s toughest challenges. Trusted Science: RevGenetics’ 18+ years of innovation ensures premium quality. Brotherhood: Be part of a community of men defying age with strength. How to Use Longevity Starter Pack Take one capsule of each supplement daily with a meal for optimal absorption. Each bottle provides a 30-day supply, but you can stretch it out if you are in your 30's by taking resveratrol EOD (Every Other Day), making it easy to stay consistent. Store in a cool, dry place and consult your healthcare provider before starting any new supplement. Start Your Longevity Journey Today Ready to unleash your strength and energy for decades? Longevity Starter Pack is your foundation for a powerful, vibrant life. With X500 Resveratrol, Advanced NAD, and Rapymine Spermidine, you’ll dominate today and push to thrive at 100. Shop Now: 30-Day Supply Free US shipping on orders over $100. 30-day money-back guarantee. Frequently Asked Questions Is Longevity Starter Pack safe for men? Yes! Made with GMP-certified, third-party-tested ingredients in the USA. Consult your doctor if you have specific health concerns. How soon will I feel results? Many men notice improved energy and focus within two to four weeks. Consistency is key for maximum impact. Can I take it with other supplements? Longevity Starter Pack complements a healthy lifestyle. Check with your healthcare provider for compatibility. | price 150.00 USD | tags bundle, nad, new, nmn, Resveratrol Supplements | published 2025-10-22 | updated 2025-12-13 - [EGCG 800mg – 98% Pure Green Tea Extract for Metabolism & Antioxidant Support](https://www.revgenetics.com/products/revgenetics-egcg-800-800-mg-98-pure-no-caffeine): EGCG 800: Pure Green Tea Extract for Sustained Energy and Antioxidant Support. Each serving delivers 800mg of 98% pure EGCG, providing the powerful benefits of green tea without caffeine. Experience enhanced energy, improved wellness, and superior antioxidant protection. Ideal for those seeking a clean supplement | price 67.00 USD | published 2024-01-19 | updated 2025-12-13 - [TetraCurcumin Nano Curcumin – High-Bioavailability Curcumin for Inflammation](https://www.revgenetics.com/products/tetracurcumin-nano-super-curcumin): TetraCurcumin: Nano Super TetrahydroCurcumin for Ultimate Absorption and Health Benefits. Our revolutionary supplement features nano-sized TetrahydroCurcumin, delivering up to 100x better absorption than standard curcumin. Experience powerful anti-inflammatory and antioxidant support, promoting joint health, cognitive | price 49.68 USD | tags new, vitaspin | published 2023-03-08 | updated 2025-12-13 - [VImmortal Longevity Formula – Complete Daily Nutrition for Anti-Aging Support](https://www.revgenetics.com/products/vimmortal-escape-velocity-nutrition): Vitamins Perfected. OUT OF STOCK. This special formula was developed using the knowledge, experience, and feedback of volunteer contributors. Contains vitamins in non-harmful dosages, designed for long-term nutrition. Including rare components like Lithium, Lycopene, Lutein, Chromium, K1, and K2. Longevity Escape Velocity Nutrition™ Brings Everyday Nutrition For People, Who's Aim Is A Long Life Without The Risk Of Being Affected By Vitamins In Large Doses That Can Be Harmful Over Time. RevGenetics brings you: Order Today! This mix can not gain you an unlimited lifespan, but it can help you stay healthy* until cutting-edge research provides the breakthroughs that will help end aging. Visit the growing, historic movement of Advocates & Researchers for Longevity at LongeCity.org (https://www.longecity.org/forum/forum/6-supplements/) to learn more. What is in your core multi-vitamin? This special formula was developed using the knowledge, experience and feedback of volunteer contributors. Vitamin Notes & Forms: Most vitamin manufacturers do not provide the elemental forms of vitamins for you to take, instead, the current standard is to provide you the amounts of each material that has a certain amount of the vitamin without notifying you of purity changes that are normal for each batch of 'raw material'. When creating this multi-vitamin, we were asked why we did not want to formulate it using existing standards since each batch had different purity, instead of asking for elemental values. We held to our own standards and decided elemental values were preferred over the 'standard' whenever possible. We hope our customers appreciate our decision and the forms of some of our vitamins that appear to allow for better absorption over the standard and cheaper forms available. We will provide more information to help you understand why the forms we used may be some of the best on the market for many of the vitamin materials we used in our Vimmortal Multivitamin formulation.Research: With each purchase made of Vimmortal™, you help provide funds for research and the advocacy of life extension through science.*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any diseases. | price 85.00 USD | published 2024-06-24 | updated 2025-12-01 - [Spermidine Supplement – Autophagy Support for Longevity and Cellular Health](https://www.revgenetics.com/products/revgenetics-spermidine): Rapymine™: Unlock the Power of Spermidine for Cellular Renewal. Each capsule contains 25mg of pure spermidine, supporting natural cellular autophagy and promoting overall health and vitality. This advanced supplement enhances cellular renewal, supports brain health, and may contribute to longevity. | price 100.00 USD | tags DESC5000, new, vitaspin | published 2021-07-28 | updated 2025-12-13 - [M98 Resveratrol Complete | Resveratrol Supplement | RevGenetics](https://www.revgenetics.com/products/m98-resveratrol-complete-m98-rc-better-than-super-micronized): Support your wellness routine with M98 Resveratrol Complete, a high-quality trans-resveratrol formula designed for efficient absorption. This advanced supplement features a pure, micronized form of resveratrol to help maintain cellular health and support overall well-being. Commonly studied for its role in healthy aging, heart function, and cognitive support, resveratrol continues to be a popular choice among those seeking to promote longevity through science-backed ingredients. | price 89.99 USD | tags Micronized Resveratrol, new, NotReturnable, Resveratrol Supplements, vitaspin | published 2021-06-12 | updated 2025-12-12 - [Advanced NAD 1000 Supplement - 1000mg NAD+ Precursor for Cellular Energy & Longevity Support - Made in USA GMP-Certified lab tested](https://www.revgenetics.com/products/advanced-nad-1000): Advanced NAD 1000: The Ultimate NAD Supplement for Longevity and Vitality. Each serving delivers 1000 mg of high-potency NAD Precursor, supporting cellular health, energy production, and mitochondrial function. With superior absorption and stability, this supplement is trusted for enhancing NAD+ levels promoting health | price 90.00 USD | tags DESC5000, nad, new | updated 2025-12-13 - [StemCellPro IV ProxyStem Core Formula With PQQ](https://www.revgenetics.com/products/stem-cell-pro): Support your daily wellness with StemCellPro IV™, a premium food supplement formulated with a wide range of vitamins and nutrients inspired by ingredients found in stem cell and cellular health research. While this product contains no stem cells, it includes scientifically studied compounds such as PQQ, L-Theanine, Niacin, Vitamin D3, and B12, chosen for their roles in supporting overall vitality and cellular function. Developed by experts in nutrition and healthy aging, our new formula builds on previous versions with optimized ingredient levels and the inclusion of our ProxyStem™ proprietary blend. With carefully selected plant extracts and amino acids, this supplement is ideal for those looking to complement a nutrient-rich lifestyle. What’s New in This Version? Increased Niacin and Vitamin B12 Standardized PQQ at 40mg per 3 capsules Added L-Theanine for a well-rounded profile Suggested Use: Take 1 capsule with each meal, up to 3 capsules per day. Important Note: This food supplement is not intended to diagnose, treat, cure, or prevent any disease. It is designed to help address common nutrient gaps through high-quality ingredients that have been used in scientific studies related to cellular and metabolic health. | price 250.00 USD | tags Stem Cell Supplements, vitaspin | published 2021-01-29 | updated 2025-12-01 - [MetaQuercetin SuperZ – Micelle Quercetin + Zinc Ionophore for Immune Support](https://www.revgenetics.com/products/metaquercetin-superz-micelle-ionophore-powered-zinc): MetaQuercetin SuperZ: Micelle + Ionophore Powered Zinc for Optimal Immune Support. For both GI absorption and ionophore Zinc transport into cells. Our advanced formula combines nano-sized Quercetin with 25mg of Zinc, utilizing Liquid Micelle Technology for superior absorption. Act as a powerful Zinc Ionophore to enhance cellular zinc transport, supporting a fortified immune system | price 45.00 USD | tags vitaspin | published 2020-07-30 | updated 2025-12-13 - [Fisetin 500mg Senolytic – Natural Senolytic Support for Cellular Renewal](https://www.revgenetics.com/products/senolytics-500-fisetin-500mg): Patent Pending SUPER FISETIN 500: Support Healthy Aging with Fisetin. Each serving provides 500mg of 98% pure Fisetin + Patent Pending Booster to increase absorption up to , a powerful flavonoid that may help clear senescent cells and promote cellular health. 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RevGenetics Resveratrol has been used in 2 human studies. | price 119.00 USD | tags Micronized Resveratrol, Resveratrol Supplements | updated 2025-12-01 ## Pages - [Dr. Hector Valenzuela: Scientific Publications & Research](https://www.revgenetics.com/pages/dr-hector-valenzuela-scientific-publications-research): Hector Valenzuela, Ph.D. Fletcher Jones Chair in Molecular Biology • Whittier College Specialties: Immunosenescence, Telomere Biology, Cell Aging 20+ Publications 920+ Citations UCLA Ph.D. Research & Publications Article • Full-text available Functional Assessment of Pharmacological Telomerase Activators in Human T Cells Published in Cells (2013) • Authors: Valenzuela H.F., et al. This study investigates the effects of Astragalus root extracts, specifically TA-65, on telomerase activation in human T-cells. The findings demonstrate a significant increase in telomerase activity, suggesting potential therapeutic applications for delaying cellular aging and enhancing immune function in the elderly. Download PDF Chapter • Full-text available The Aging Lymphocyte Published in Bone Marrow Lymphoid Infiltrates (Springer, 2012) A comprehensive review of the molecular mechanisms driving lymphocyte aging. This chapter discusses the genetic and environmental factors contributing to immunosenescence and explores how these changes impact the overall health and disease susceptibility of the aging population. Download Chapter Article • Full-text available O-Glycosylation Regulates LNCaP Prostate Cancer Cell Susceptibility Published in Cancer Research (2007) This research identifies a critical link between cell surface sugars (O-glycosylation) and cancer cell survival. By modifying these sugar structures, the study shows that prostate cancer cells can become more susceptible to apoptosis induced by Galectin-1, offering a potential new target for cancer therapy. Download PDF Article • Full-text available In vitro senescence of immune cells Published in Experimental Gerontology (2003) This paper examines the phenomenon of replicative senescence in T-cells, where repeated immune stimulation leads to a permanent arrest in cell division. It discusses the biomarker CD28 and evaluates the potential of telomerase gene therapy to restore proliferative capacity in aging immune cells. Download PDF Article • Full-text available Telomere shortening in T cells correlates with Alzheimer’s disease status Published in Neurobiology of Aging (2003) A landmark study revealing that T-cells from Alzheimer's patients exhibit significantly shorter telomeres than age-matched controls. The findings suggest a systemic acceleration of immune aging in Alzheimer's disease, potentially serving as a biological marker for disease severity. Download PDF Article • Full-text available Divergent Telomerase and CD28 Expression Patterns in Human T Cells Published in Clinical Immunology (2002) This research differentiates how CD4 (helper) and CD8 (cytotoxic) T-cells age differently. It demonstrates that CD8 cells lose telomerase activity and CD28 expression much faster than CD4 cells upon repeated stimulation, explaining why the cytotoxic arm of the immune system weakens earlier in life. Download PDF Methodology • Full-text available Telomeres and Replicative Senescence (Methodology) Published in Methods in Molecular Medicine (2000) A technical protocol outlining the "in-gel hybridization" technique for measuring telomere length. This method allows researchers to assess the biological age of cells with high precision without the need for complex membrane transfers, streamlining the study of cellular aging. Download PDF Review • Full-text available Immunosenescence: Analysis and Genetic Modulation Published in Journal of Anti-Aging Medicine (1998) One of Dr. Valenzuela's early foundational papers reviewing the irreversible arrest of T-cell division known as replicative senescence. It proposes forward-thinking genetic strategies to delay this process, laying the groundwork for future research into telomerase therapies. Download PDF - [NAD vs Niacin vs Niacinamide: Complete Vitamin B3 Guide (2025)](https://www.revgenetics.com/pages/nad-vs-niacin-vs-niacinamide-complete-vitamin-b3-guide-2025): NAD+ vs Niacin vs Niacinamide: Which Vitamin B3 Form Works Best? (2025 Guide) Scientific Review Dr. Hector Valenzuela, Ph.D. Ph.D. in Experimental Pathology & Expert in Immunosenescence This guide was reviewed by Dr. Valenzuela, whose doctoral research at UCLA focused specifically on Immunosenescence and Telomere Dynamics. He is a former NIH Tumor Cell Biology Fellow and currently serves as Faculty in the Department of Biology at Whittier College[cite: 5]. Credentials: Ph.D. Experimental Pathology (UCLA) • NIH Tumor Cell Biology Fellow • Biology Faculty (Whittier College) Last Reviewed: November 29, 2025 Understanding the differences between NAD+, niacin, and niacinamide is essential for optimizing your longevity and health strategy. While all are connected to vitamin B3, each serves distinct biological functions with different applications. NAD+ (Wikidata: Q55723679) functions as a critical coenzyme for cellular energy and DNA repair. Niacin (Wikidata: Q192040) provides cardiovascular benefits and converts to NAD+ through a multi-step process. Niacinamide (Wikidata: Q192423) supports skin health and cellular repair without causing flushing. This 2025-updated guide breaks down the latest science, benefits, dosing protocols, and practical applications of each form, including advanced NAD+ precursors NMN (Wikidata: Q27104356) and NR (Wikidata: Q27116668), to help you make evidence-based supplementation choices. 🔬 Key Research Breakthroughs: What Science Tells Us About NAD+ and Vitamin B3 📊 Human NMN Clinical Trial (2020): Japanese researchers tested oral NMN supplementation at 100mg, 250mg, and 500mg daily in healthy men. Results showed dose-dependent increases in blood NAD+ metabolites over 12 weeks with good tolerability and no serious adverse effects. Source: Irie J, et al., 2020, Endocrine Journal, "Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men" 🧬 Core NAD+ Biology (2015): Comprehensive research mapped how NAD+ regulates energy balance between mitochondria and the nucleus. Over 500 enzymatic reactions depend on NAD+ availability, making it one of the most important molecules for cellular function and survival. Source: Cantó C, Menzies KJ, Auwerx J, 2015, Cell Metabolism, "NAD+ Metabolism and the Control of Energy Homeostasis" 💊 NR Pharmacokinetics Study (2017): Researchers gave healthy volunteers 1000mg of nicotinamide riboside (NR) and tracked blood NAD+ levels. Peak concentrations occurred within 8 hours, with sustained elevation documented through 24-hour monitoring, demonstrating effective NAD+ boosting in humans. Source: Airhart SE, et al., 2017, PLoS One, "An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR)" 🧠 Niacin in Brain Health (2019): Analysis of niacin's central nervous system effects revealed multiple neuroprotective pathways including NAD+-dependent DNA repair in brain tissue, anti-inflammatory signaling, and support for neurotransmitter synthesis beyond basic nutritional roles. Source: Gasperi V, et al., 2019, International Journal of Molecular Sciences, "Niacin in the Central Nervous System" ⏳ NAD+ Decline and Aging (2015): Landmark aging research identified NAD+ depletion as a driver of multiple aging hallmarks including mitochondrial dysfunction, impaired DNA repair, metabolic problems, and neurodegeneration. This established NAD+ restoration as a promising therapeutic target. Source: Verdin E, 2015, Science, "NAD+ in aging, metabolism, and neurodegeneration" ✨ Niacinamide for Skin Aging (2005): Clinical trials showed 2-5% topical niacinamide significantly reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. Visible improvements appeared within 8-12 weeks of consistent application. Source: Bissett DL, et al., 2005, Dermatologic Surgery, "Niacinamide: A B vitamin that improves aging facial skin appearance" 💡 Key Takeaway: Peer-reviewed research confirms that NAD+ precursors (NMN, NR) successfully elevate blood NAD+ levels in humans, with distinct tissue-specific benefits and well-characterized safety profiles. ⚡ Quick Choice Matrix: Which B3 Form is Right for You? Choose based on your primary goal, then scroll down for detailed explanations: • ✅ For Anti-Aging & NAD+ Optimization: Choose NMN (250-1000mg) or NR (300-1000mg). Most direct pathway to cellular NAD+, supports mitochondrial function, DNA repair, and sirtuin activation. • ❤️ For Cardiovascular Health & Cholesterol: Choose Niacin/Nicotinic Acid (500-2000mg under medical supervision). Only B3 form that significantly raises HDL and lowers LDL/triglycerides (expect flush reaction). • ✨ For Skin Health & Beauty: Choose Niacinamide (100-500mg oral + 2-5% topical). Reduces hyperpigmentation, minimizes pores, strengthens skin barrier, no flushing. • ⚖️ For General Wellness & Gentle NAD+ Support: Choose Niacinamide (100-500mg). Well-tolerated, supports NAD+ production without side effects, good all-around option. • 🏃 For Athletic Performance & Energy: Choose NMN (500-1000mg morning dose). Enhances muscle NAD+, improves aerobic capacity, supports mitochondrial ATP production. • 🧠 For Cognitive Function & Neuroprotection: Choose NMN + Resveratrol combo (500mg + 250mg). Synergistic brain NAD+ enhancement, supports neuronal health and processing speed. ⚠️ Important: Consult healthcare provider before starting any therapeutic doses, especially if you have liver conditions, diabetes, or take medications. These recommendations are for educational purposes only. Understanding Vitamin B3: The Foundation of NAD+ Biology Vitamin B3? It's not just one thing. This single vitamin designation actually encompasses an entire family of chemically related compounds, each playing different roles in human metabolism and cellular health. The term "vitamin B3" hides remarkable molecular diversity. Niacin, niacinamide, nicotinamide riboside, nicotinamide mononucleotide: these aren't interchangeable variants. They're distinct molecules with unique properties, different biological pathways, and surprisingly different effects on your body. Why does this matter? Because choosing the wrong form means missing your health goals entirely. The Vitamin B3 Family: Core Members The primary forms include: • Niacin (Nicotinic Acid): The classical B3 form, causes flushing, powerful cardiovascular effects • Niacinamide (Nicotinamide): Flush-free alternative, preferred for skin health and gentle NAD+ support • Nicotinamide Riboside (NR): Advanced NAD+ precursor, one step from NAD+ • Nicotinamide Mononucleotide (NMN): Direct NAD+ precursor, most efficient conversion pathway While these compounds all address B3 deficiency, their mechanisms of action, absorption rates, and therapeutic applications differ significantly. Understanding these differences is crucial for optimizing supplementation. 🔑 Key Insight: All forms of vitamin B3 can contribute to NAD+ production in your cells, but they take different pathways and offer unique additional benefits beyond NAD+ synthesis. Your choice should match your specific health goals. Historical Context: From Pellagra to Longevity Historically, vitamin B3 gained recognition as the cure for pellagra, a devastating disease characterized by the "four Ds": dermatitis, diarrhea, dementia, and death. This discovery in the early 20th century marked one of the first major triumphs in nutritional biochemistry. Modern research has expanded far beyond deficiency prevention. Today's science reveals that vitamin B3 compounds influence gene expression, DNA repair, circadian rhythms, and cellular longevity pathways. The relationship between B3 compounds and aging has positioned these molecules at the forefront of longevity research, particularly with the discovery that NAD+ levels decline 50% or more between youth and middle age. TL;DR: Vitamin B3 isn't a single compound but a family of molecules (niacin, niacinamide, NR, NMN) that all feed into NAD+ production through different pathways, with each offering unique therapeutic benefits beyond basic nutrition. Your choice of form is critical to achieving your specific health goals. What is NAD+? The Cellular Energy Currency Driving Life Nicotinamide adenine dinucleotide (NAD+, Wikidata: Q55723679) exists in two forms within cells: NAD+ (oxidized) and NADH (reduced). This coenzyme participates in over 500 enzymatic reactions throughout the body, making it one of the most crucial molecules for life itself. The Critical Functions of NAD+: More Than Just Energy Think of NAD+ as your cellular power grid. This molecule serves as an electron carrier in cellular respiration, the complex process by which your mitochondria convert nutrients into ATP (adenosine triphosphate), the direct energy currency every cell in your body uses to function. No NAD+? The grid fails. Energy production falters. Cellular function declines. It's that critical. But energy metabolism is just the beginning of NAD+'s responsibilities: • DNA Repair: Each time your DNA experiences damage from oxidative stress, radiation, or normal metabolic processes, specialized enzymes called PARPs (poly ADP-ribose polymerases) consume NAD+ to facilitate repairs. These enzymes can rapidly deplete cellular NAD+ stores during periods of significant stress. • Sirtuin Activation: Sirtuins (SIRT1-7) are a family of seven proteins that regulate aging and metabolism. These longevity proteins absolutely require NAD+ to function. They control gene expression, inflammation, mitochondrial health, and circadian rhythms. When NAD+ levels decline, sirtuin activity decreases proportionally, potentially accelerating aging processes. • Circadian Rhythm Regulation: NAD+ levels fluctuate throughout the day in sync with your circadian clock, influencing sleep-wake cycles, metabolism, and cellular repair timing. • Immune Function: CD38, an enzyme that degrades NAD+, increases with age and chronic inflammation, creating a vicious cycle of NAD+ depletion and immune dysfunction. ⚠️ Critical Point: NAD+ cannot be effectively supplemented directly because the molecule is too large to cross cell membranes intact and breaks down rapidly in the digestive system. This is why NAD+ precursors (niacin, niacinamide, NR, NMN) are necessary for supplementation. They're smaller molecules your body converts into NAD+. NAD+ Decline with Age: The Longevity Crisis Research consistently demonstrates that NAD+ levels decrease substantially with age across multiple species. Studies in humans show that NAD+ concentrations can drop by 50% or more between youth and middle age, with further declines in elderly populations. This age-related NAD+ decline correlates with numerous hallmarks of aging: • Mitochondrial dysfunction and reduced ATP production • Genomic instability and impaired DNA repair • Cellular senescence (zombie cells that won't die) • Metabolic slowdown and insulin resistance • Neurodegeneration and cognitive decline • Decreased muscle strength and endurance The mechanisms driving NAD+ decline include: 1. Increased consumption by DNA repair enzymes (PARPs) and CD38 (NAD+-degrading enzyme that increases with age and inflammation) 2. Decreased synthesis from precursors due to reduced enzyme activity 3. Reduced efficiency of the salvage pathway that recycles nicotinamide back to NAD+ > "NAD+ levels decline with age in multiple tissues, and this decline appears to contribute to numerous age-related pathologies. Boosting NAD+ through supplementation with precursors like NMN and NR represents a promising strategy for promoting healthy aging." > > - Dr. Shin-ichiro Imai, Professor of Developmental Biology, Washington University School of Medicine TL;DR: NAD+ is essential for energy production, DNA repair, and longevity protein activation, but cannot be supplemented directly due to poor absorption. Levels decline 50%+ with age, correlating with multiple aging hallmarks, making NAD+ precursor supplementation a cornerstone of anti-aging strategies. Niacin (Nicotinic Acid): The Original B3 with Cardiovascular Superpowers Niacin (nicotinic acid, Wikidata: Q192040) represents the classical form of vitamin B3. This simple molecule consists of a pyridine ring with a carboxylic acid group, giving it distinct chemical properties that differentiate it from other B3 forms. How Niacin Works: The Three-Step Pathway to NAD+ When you consume niacin, it undergoes a three-step enzymatic conversion to reach NAD+: 1. Step 1: The enzyme nicotinate phosphoribosyltransferase converts niacin to nicotinic acid mononucleotide (NAMN) 2. Step 2: NAMN is converted to nicotinic acid adenine dinucleotide (NAAD) 3. Step 3: NAD synthetase converts NAAD to NAD+ This multi-step process makes niacin less efficient as an NAD+ booster compared to more direct precursors like NMN. However, niacin offers unique cardiovascular benefits that other forms cannot provide. The Niacin Flush Phenomenon: What to Expect The niacin flush is memorable. Most people who've experienced it remember their first time vividly: the sudden warmth spreading across their face and chest, the intense redness, the prickling sensation that makes you wonder if you're having an allergic reaction. You're not. You're fine. Within 15 to 30 minutes of taking immediate-release niacin at doses above 50 mg, this flush arrives like clockwork. It lasts 30 to 60 minutes, then fades completely. Uncomfortable? Absolutely. Dangerous? Not at all. 🔥 Flush Mechanism Explained This flush occurs because niacin binds to GPR109A receptors on immune cells and skin cells, triggering the release of prostaglandin D2. This substance dilates blood vessels near the skin surface, creating the characteristic flushing sensation, redness, and warmth. Flush Management Strategies: • Start with low doses (50-100mg) and increase gradually • Take with food to slow absorption • Take aspirin 30 minutes before niacin (reduces flush 50-70%, consult doctor first) • Use extended-release formulations (reduces flush but increases liver stress risk) • Flush tolerance typically develops within 1-2 weeks of consistent use Cardiovascular Benefits: Niacin's Unique Advantage Niacin stands alone among B3 forms for its powerful effects on blood lipids. Clinical studies demonstrate impressive cardiovascular benefits: Lipid Parameter Effect of Niacin Clinical Significance HDL Cholesterol Increases 15-35% Strongest HDL-raising effect of any supplement LDL Cholesterol Decreases 5-25% Reduces atherogenic particles Triglycerides Decreases 20-50% Major reduction in cardiovascular risk factor Lipoprotein(a) Decreases 20-30% Few interventions affect this genetic risk factor The mechanisms behind these effects involve multiple pathways: • Niacin inhibits diacylglycerol acyltransferase-2 in liver cells, reducing triglyceride synthesis and VLDL secretion • It decreases the breakdown of ApoA-I, the main protein in HDL particles, allowing more HDL to remain in circulation • It reduces the hepatic synthesis of Lp(a), a highly atherogenic lipoprotein particle Food Sources of Niacin Niacin occurs naturally in many foods, with particularly high concentrations in: • Chicken breast: ~10 mg per 3-ounce serving • Tuna (fresh): ~11 mg per 3-ounce serving • Turkey: ~10 mg per 3-ounce serving • Salmon: ~9 mg per 3-ounce serving • Peanuts: ~4 mg per ounce • Mushrooms: ~2-3 mg per cup • Fortified cereals: ~20-27 mg per serving TL;DR: Niacin is the only B3 form with proven cardiovascular benefits (raises HDL 15-35%, lowers LDL/triglycerides), but causes a memorable flush reaction due to prostaglandin release. It converts to NAD+ through three enzymatic steps, making it less efficient than NMN/NR for pure NAD+ optimization but unmatched for heart health. Niacinamide (Nicotinamide): The Gentle, Flush-Free Alternative Niacinamide (nicotinamide, Wikidata: Q192423) and nicotinamide are identical compounds with different names used interchangeably in scientific literature and product labeling. This form of B3 features an amide group instead of the carboxylic acid found in niacin, fundamentally altering its biological properties. Why Niacinamide Doesn't Cause Flushing The structural difference between niacin and niacinamide has profound practical implications. Niacinamide does not bind to GPR109A receptors, eliminating the prostaglandin release that causes flushing. This makes niacinamide far more tolerable for most users, especially at higher doses. The Salvage Pathway: Efficient Conversion to NAD+ Niacinamide follows a more direct path to NAD+ than niacin, requiring only two enzymatic steps: 1. Step 1: Nicotinamide phosphoribosyltransferase (NAMPT) converts niacinamide to nicotinamide mononucleotide (NMN) 2. Step 2: Nicotinamide mononucleotide adenylyltransferase (NMNAT) converts NMN to NAD+ This salvage pathway is the primary route your body uses to maintain NAD+ levels from recycled nicotinamide, making it highly efficient for NAD+ production. In fact, this is the same pathway that NMN supplements utilize. Niacinamide essentially becomes NMN inside your cells. Skin Health Benefits: Dermatology's Favorite B3 Niacinamide has become a cornerstone ingredient in dermatological applications due to its multiple skin benefits: 🛡️ Barrier Function Increases ceramide and free fatty acid production in the stratum corneum, strengthening the skin's protective barrier and reducing transepidermal water loss. ✨ Hyperpigmentation Reduces dark spots and uneven tone by inhibiting melanosome transfer from melanocytes to keratinocytes. Visible improvement within 4 weeks at 2-5% concentration. 💧 Sebum Regulation Reduces excessive oil production and minimizes pore appearance. 4% niacinamide gel performs comparably to 1% clindamycin for inflammatory acne. 🌞 UV Protection Reduces immunosuppressive effects of UV radiation and supports DNA repair in sun-exposed skin cells, complementing sunscreen protection. 🧬 Anti-Aging Clinical studies show 5% topical niacinamide significantly reduces fine lines, wrinkles, and yellowing within 8-12 weeks through collagen synthesis support. 🔬 Anti-Inflammatory Reduces skin inflammation, redness, and irritation. Particularly beneficial for rosacea, eczema, and sensitive skin conditions. Beyond Skin: Systemic Benefits of Niacinamide While niacinamide is celebrated for topical applications, oral supplementation provides systemic benefits: • Neuroprotection: Research indicates potential neuroprotective effects through support of cellular energy metabolism in brain tissue and NAD+-dependent DNA repair • Joint Health: Some studies suggest improved mobility and reduced pain in osteoarthritis patients taking 3 grams daily divided into multiple doses, likely due to anti-inflammatory properties • Metabolic Support: May improve insulin sensitivity and glucose metabolism, though effects are more modest than prescription medications • NAD+ Optimization: Efficiently raises cellular NAD+ levels without the cardiovascular side effects of niacin Unlike niacin, niacinamide does not significantly affect cholesterol levels, making it the preferred form for general NAD+ support when cardiovascular benefits are not the primary goal. TL;DR: Niacinamide is the flush-free B3 form that converts efficiently to NAD+ through the salvage pathway (same as NMN supplements). It offers superior skin benefits (reduces hyperpigmentation, strengthens barrier, minimizes pores) and provides gentle systemic NAD+ support without cardiovascular effects, making it ideal for skin health and general wellness. Advanced NAD+ Precursors: NMN and NR Explained While technically part of the vitamin B3 family, nicotinamide riboside (NR, Wikidata: Q27116668) and nicotinamide mononucleotide (NMN, Wikidata: Q27104356) represent more advanced NAD+ precursors that have gained significant attention in longevity research. Nicotinamide Riboside (NR): One Step from NAD+ NR consists of nicotinamide bound to a ribose sugar, placing it one step closer to NAD+ than standard niacinamide. This compound enters cells through specialized nucleoside transporters and requires only two enzymatic steps to reach NAD+. Clinical Evidence for NR: • Human trials demonstrate 40-60% increases in NAD+ levels at doses of 1000 mg daily • Improved energy levels reported in participant surveys, though more research is needed to confirm long-term health benefits • Safety profile appears favorable. Studies up to 12 weeks show good tolerance and no serious adverse effects at doses up to 2000 mg daily. • May be particularly effective for liver NAD+ enhancement based on animal studies Nicotinamide Mononucleotide (NMN): The Direct Precursor NMN represents the direct precursor to NAD+, requiring only one enzymatic step for conversion. This molecule consists of nicotinamide, ribose, and a phosphate group, making it larger and more complex than NR. Recent research has identified a specific NMN transporter called Slc12a8 that may allow direct cellular uptake without conversion to NR, though this remains an active area of investigation. Alternative pathways suggest that NMN may be dephosphorylated to NR before entering cells, then re-phosphorylated back to NMN inside. Clinical Evidence for NMN: • Human trials show improved insulin sensitivity, enhanced muscle function, and better aerobic capacity at doses ranging from 250 to 1000 mg daily • Japanese research (Irie et al., 2020) demonstrated dose-dependent increases in NAD+ metabolites in healthy men at 100-500mg daily for 12 weeks • May be particularly effective for skeletal muscle NAD+ enhancement based on tissue distribution studies • Enteric-coated formulations may offer improved stability and bioavailability compared to standard capsules • Morning dosing may align better with circadian NAD+ rhythms, though more research is needed 🔬 Research Note: NMN Transport Mechanisms Recent discoveries identified Slc12a8 as a potential NMN transporter in mammalian cells, suggesting NMN may enter cells directly without first converting to NR. This finding could explain tissue-specific responses to different NAD+ precursors and inform future supplementation strategies. Source: Grozio A, Mills KF, Yoshino J, et al. (2019). Nature Metabolism. For those interested in NMN supplementation, RevGenetics offers pharmaceutical-grade NMN with advanced absorption technology. Explore our NMN collection or learn more about our flagship Advanced NMN powder with third-party purity testing exceeding 99%. NMN vs NR: Which is Superior? The Honest Answer NMN versus NR, the longevity community's favorite debate. Scientists continue arguing about which precursor reigns supreme. Both compounds demonstrably increase NAD+ levels. That much we know. But tissue-specific preferences? Transport mechanisms? Bioavailability differences? The data remains frustratingly incomplete, with passionate advocates on both sides marshaling evidence for their preferred molecule while dismissing contrary findings. Here's what we actually know with confidence: Factor NMN NR Conversion Steps to NAD+ 1 step (most direct) 2 steps Cellular Uptake Possible direct transport via Slc12a8 (debated) Nucleoside transporters (well-established) Tissue Preference May favor skeletal muscle May favor liver tissue Stability More sensitive to heat/moisture (requires better packaging which enteric capsules provide) More stable molecule Research Volume Growing rapidly with human trials emerging More established human trials Typical Dose Range 250-1000 mg daily 300-1000 mg daily Cost Generally lower per mg Generally higher per mg Some research suggests that NMN may be more effective for certain tissues like skeletal muscle, while NR shows particular benefits in liver tissue. Individual responses vary, and optimal choice may depend on specific health goals. We provide NMN in enteric capsules at this time. From a practical standpoint, both compounds require specialized manufacturing to ensure stability and purity. Quality varies significantly between brands, making third-party testing essential for ensuring you receive viable product. TL;DR: NMN and NR are advanced NAD+ precursors that require fewer conversion steps than niacin/niacinamide. NMN is one step from NAD+ (may have direct cellular transport), NR is two steps away (established uptake pathway). Both effectively raise NAD+ levels with individual responses varying by tissue type, though research suggests proper formulation and packaging are critical for stability and effectiveness. Comprehensive Comparison: NAD+ vs Niacin vs Niacinamide vs NMN/NR Now that we've explored each B3 form individually, let's compare them side-by-side to help you make an informed choice: Characteristic NAD+ Niacin Niacinamide NR/NMN Molecular Type Coenzyme (not supplementable orally) Vitamin B3 (nicotinic acid) Vitamin B3 (nicotinamide) Advanced NAD+ precursors Wikidata Entity ID Q55723679 Q192040 Q192423 Q27116668 (NR) / Q27104356 (NMN) Conversion Steps to NAD+ Already NAD+ (but can't absorb) 3 enzymatic steps 2 enzymatic steps 1-2 enzymatic steps (most direct) Flush Reaction N/A ✗ Yes (significant) ✓ No ✓ No Cholesterol Effects N/A Significant: ↑ HDL 15-35%, ↓ LDL/triglycerides Minimal to none Minimal to none Primary Benefits Cellular energy, DNA repair, sirtuin activation Cardiovascular health, NAD+ production Skin health, NAD+ production, cellular support Direct NAD+ boosting, anti-aging, longevity Typical Supplemental Dose Not typically supplemented orally 14-16 mg RDA; 500-2000 mg therapeutic 100-500 mg daily 250-1000 mg daily Food Sources Produced internally from B3 Meat, fish, nuts, fortified grains Meat, fish, fortified foods Minimal in diet (requires supplementation) Side Effect Profile N/A Flushing, possible liver stress at high doses Generally well-tolerated Generally well-tolerated, minimal side effects Best Use Case The end goal of B3 supplementation Cardiovascular support, cholesterol management Skin health, general wellness, NAD+ support Anti-aging, NAD+ optimization, longevity Clinical Research Status Fundamental molecule studied since 1906 Extensive cardiovascular trials since 1950s Skin studies since 1990s, CNS research ongoing Human trials from 2017-2020 show safety and NAD+ elevation 🎯 Quick Decision Guide: Choose niacin for cardiovascular benefits (if you can tolerate flushing), niacinamide for skin health and gentle NAD+ support, or NMN/NR for targeted anti-aging and optimal NAD+ restoration with the fewest conversion steps. Dosage Guidelines and Safety Comparison: What You Need to Know Understanding proper dosing ranges and safety limits is crucial for effective and safe vitamin B3 supplementation. Here's a comprehensive comparison of dosage guidelines across all B3 forms: B3 Form RDA / Basic Need Therapeutic Range Upper Tolerable Limit Safety Notes Niacin (Nicotinic Acid) 14-16 mg/day (prevents deficiency) 500-2000 mg/day for cardiovascular benefits (medical supervision required) 35 mg/day from supplements (conservative); therapeutic doses require monitoring Monitor liver enzymes, blood sugar, uric acid. Flush reaction >50mg. Start low and titrate up. Niacinamide (Nicotinamide) 14-16 mg/day (prevents deficiency) 100-500 mg/day for NAD+ support; up to 3000 mg/day divided doses for joint health (medical supervision) 35 mg/day from supplements (conservative); higher doses well-tolerated but monitor for nausea Better tolerated than niacin. No flush. Possible nausea/liver effects >3000mg daily. NMN (Nicotinamide Mononucleotide) N/A (not essential nutrient) 250-1000 mg/day for NAD+ optimization; 500mg appears optimal per research No established UL; studies show safety up to 1250 mg/day for 12 weeks Well-tolerated. Enteric-coated preferred. Morning dosing may enhance effectiveness. Long-term data still accumulating. NR (Nicotinamide Riboside) N/A (not essential nutrient) 300-1000 mg/day for NAD+ optimization No established UL; studies show safety up to 2000 mg/day for 12 weeks Well-tolerated. More stable than NMN. No serious adverse effects in trials. Minimal side effects. Avoid liposomes that may degrade rapidly. Age and Gender Considerations Population Niacin RDA Special Considerations Adult Men 16 mg/day Higher muscle mass may benefit from higher NAD+ precursor doses Adult Women 14 mg/day May prioritize niacinamide for skin benefits Pregnant Women 18 mg/day Avoid high-dose supplementation; stick to RDA levels Lactating Women 17 mg/day Avoid high-dose supplementation; stick to RDA levels Adults 50+ Same as younger adults NAD+ precursors (NMN/NR) may provide greater benefit due to age-related decline Children (9-13 years) 12 mg/day Focus on dietary sources; supplementation rarely needed Potential Drug Interactions and Contraindications ⚠️ Important Safety Warnings Niacin specifically can interact with: • Statin medications: Increased risk of muscle damage (rhabdomyolysis). Use only under medical supervision. • Blood pressure medications: May potentiate hypotensive effects • Diabetes medications: Can affect glucose metabolism and reduce medication effectiveness • Blood thinners: May increase bleeding risk when combined with anticoagulants • Alcohol: Increases flush intensity and liver stress risk General B3 precautions: • Liver disease: Avoid high doses of all B3 forms; requires medical monitoring • Diabetes: Monitor blood sugar carefully with any B3 supplementation • Gout or high uric acid: Niacin may worsen these conditions • Peptic ulcers: Niacin may aggravate symptoms • Pregnancy/lactation: Stick to RDA levels; avoid therapeutic doses TL;DR: RDA for basic B3 needs is 14-16mg daily, but therapeutic doses vary dramatically by form and goal: niacin 500-2000mg for cardiovascular (medical supervision required), niacinamide 100-500mg for general NAD+ support, NMN 250-1000mg for anti-aging optimization. Always start low, monitor response, and consult healthcare providers before high-dose use, especially with existing conditions or medications. How to Choose and Dose Your Vitamin B3 Form in 2025: Step-by-Step Guide Selecting the appropriate vitamin B3 supplement requires matching the compound's properties to your specific health objectives, tolerance for potential side effects, and current health status. Follow this evidence-based decision process: 📋 Step 1: Identify Your Primary Health Goal Determine whether you're focused on anti-aging and NAD+ optimization, cardiovascular health and cholesterol management, or skin health and dermatological benefits. Your goal determines which B3 form will be most effective. 🔬 For Longevity & Anti-Aging: Choose NMN or NR as direct NAD+ precursors with fewest conversion steps ❤️ For Heart Health: Select niacin (nicotinic acid) for proven cholesterol benefits ✨ For Skin Health: Opt for niacinamide (oral + topical) for comprehensive dermatological benefits 📋 Step 2: Assess Your Tolerance for Side Effects Evaluate whether you can tolerate the niacin flush reaction or have any liver conditions, diabetes, or medication interactions that might affect your choice of B3 form. • If flush-sensitive: Avoid immediate-release niacin entirely. Choose niacinamide or NMN/NR instead for flush-free NAD+ support. • If you have liver concerns: Consult physician before any high-dose B3 supplementation. Request baseline liver enzyme tests and monitoring at 6-12 weeks. • If diabetic: Monitor blood sugar carefully with niacin supplementation, as it can affect glucose metabolism. Niacinamide and NMN have minimal glucose effects. • If taking statins: Avoid high-dose niacin without medical supervision due to increased risk of muscle damage. 📋 Step 3: Determine Evidence-Based Dosage Start with research-backed doses based on your chosen form and health goals. Always begin at the lower end of dose ranges: B3 Form Starting Dose Target Range Timing NMN 250 mg daily 500-1000 mg daily Morning (6-9 AM for circadian alignment) NR 300 mg daily 500-1000 mg daily Morning or divided doses Niacinamide 100 mg daily 100-500 mg daily Any time (consistent timing) Niacin 100 mg daily 500-2000 mg (medical supervision) With evening meal (reduces flush during sleep) Gradual titration protocol: Increase dose by 250-500mg every 2-4 weeks based on tolerance and response. Assess energy levels, sleep quality, and any side effects before increasing. 📋 Step 4: Verify Product Quality and Purity Quality varies dramatically between brands, especially for NMN and NR where manufacturing expertise is limited. Look for these quality indicators: ✅ Third-Party Testing Request Certificate of Analysis (COA) showing >98% purity from independent laboratories. Verify batch numbers match your product. ✅ Stability Data Ensure manufacturer provides stability testing demonstrating maintained potency throughout shelf life. NMN requires special attention to stability. ✅ Certifications Look for NSF International, USP, or ConsumerLab certifications providing additional quality assurance and label accuracy verification. ✅ Proper Packaging Verify protection against heat, light, and moisture degradation. Enteric-coated NMN offers enhanced stability and bioavailability. > "The supplement industry's quality control varies wildly. Some products contain exactly what their labels claim. Others have degraded molecules, contaminated batches, or dramatically lower potency than advertised. Certificates of analysis from independent laboratories aren't optional extras, they're essential quality indicators. But even these won't tell you the whole story when liposomes or gummies are involved. Heat sensitive ingredients break down faster with gummies, and most liposomes start breaking down within 3-6 months. If the date of the COA is older than 6 months, your liposome-based product might not be as effective as when it was first manufactured. We've seen many NR liposome COAs that have failed wildly, likely due to rapid degradation of the liposomes used." > > - Anthony Loera, Manufacturing Expert with 20 years experience 📋 Step 5: Monitor Your Response and Adjust Track subjective markers and consider objective testing to assess your response and optimize your supplementation strategy: Subjective Monitoring (First 4-8 Weeks): • Keep a daily log of energy levels (1-10 scale) • Track sleep quality and duration • Note any side effects (digestive issues, flushing, headaches) • Assess exercise performance and recovery • For niacinamide skin applications: photograph skin weekly to track changes Optional Objective Testing: • NAD+ blood levels: Some labs now offer NAD+ measurement (though interpretation is still evolving) • Liver function tests: Essential for high-dose niacin (baseline + 6-12 week follow-up) • Lipid panel: Track cholesterol changes if using niacin therapeutically • Glucose/HbA1c: Monitor metabolic markers, especially with niacin Adjustment Protocol: • If well-tolerated with positive effects: Maintain current dose or increase gradually (250-500mg increments every 2-4 weeks) • If side effects occur: Reduce dose by 50% and reassess, or switch to alternative B3 form • If no noticeable benefit after 8-12 weeks: Consider increasing dose (if below target range) or exploring combination strategies 🎯 Decision Summary The optimal B3 supplementation strategy is highly individual. Your choice should integrate your primary health goals, tolerance for side effects, budget considerations, and ability to verify product quality. When in doubt: • Start conservative: Begin with lower doses and well-tolerated forms (niacinamide or NMN) • Prioritize quality: Third-party tested products from reputable manufacturers • Monitor consistently: Track subjective and objective markers for 8-12 weeks • Consult professionals: Work with healthcare providers for therapeutic doses or if you have existing conditions TL;DR: Choose your B3 form by matching health goals to compound properties (NMN/NR for anti-aging, niacin for cardiovascular, niacinamide for skin), start with evidence-based doses at the low end of ranges, verify product quality through third-party testing and stability data, and monitor your response for 8-12 weeks before adjusting. Always consult healthcare providers before therapeutic dosing. Frequently Asked Questions About NAD+, Niacin, and Niacinamide What is the difference between NAD and niacin? NAD (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell that facilitates energy production and DNA repair. Niacin is vitamin B3 that your body converts into NAD. Think of niacin as the raw material and NAD as the finished product your cells actually use for metabolism and cellular repair. Is niacin the same as niacinamide? Niacin and niacinamide are both forms of vitamin B3 but have different chemical structures and effects. Niacin (nicotinic acid) causes skin flushing and significantly affects cholesterol levels. Niacinamide (nicotinamide) does not cause flushing and is preferred for skin health and general cellular support. Both convert to NAD in the body. Which form of vitamin B3 is best for raising NAD levels? Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN) are the most efficient NAD precursors, requiring fewer conversion steps than standard niacin or niacinamide. Research shows both can significantly increase NAD levels, with NR being one step away from NAD and NMN being the direct precursor just before NAD+ formation. Does niacin cause a flush reaction? Regular niacin (nicotinic acid) commonly causes a flush reaction characterized by skin redness, warmth, and tingling, typically occurring 15 to 30 minutes after ingestion. This happens because niacin activates GPR109A receptors that release prostaglandins, dilating blood vessels. Niacinamide and NAD precursors like NMN and NR do not cause this flush reaction. Can I take NAD directly as a supplement? NAD+ cannot be taken effectively as an oral supplement because it is too large to pass through cell membranes and breaks down during digestion. Instead, you must take NAD precursors such as niacin, niacinamide, NR (nicotinamide riboside), or NMN (nicotinamide mononucleotide), which your body then converts into NAD+. What are the benefits of niacinamide for skin? Niacinamide benefits skin by reducing inflammation, regulating sebum production, minimizing pore appearance, improving skin barrier function, reducing hyperpigmentation, and protecting against UV damage. Studies show 2 to 5% topical niacinamide can significantly improve skin texture, tone, and reduce signs of aging within 8 to 12 weeks. How much niacin should I take daily? The Recommended Dietary Allowance (RDA) for niacin is 16 mg for men and 14 mg for women. For therapeutic cholesterol management, doctors may prescribe 500 to 2000 mg daily under supervision. For NAD+ support, most people take 100 to 500 mg of niacinamide or 250 to 500 mg of NMN or NR. Always consult a healthcare provider before taking high-dose B3 supplements. What is the difference between NMN and niacin? NMN (nicotinamide mononucleotide) is a more direct NAD+ precursor than niacin, requiring only one enzymatic step to convert to NAD+ compared to niacin's three-step conversion. NMN is larger and more complex than niacin, doesn't cause flushing, and is specifically used for anti-aging and NAD+ optimization rather than treating B3 deficiency. Which B3 form is best for cardiovascular health? Niacin (nicotinic acid) is the most effective B3 form for cardiovascular health, as it can raise HDL cholesterol by 15 to 35% and lower LDL cholesterol and triglycerides. Extended-release formulations reduce flushing while maintaining cardiovascular benefits. Other B3 forms like niacinamide do not significantly impact cholesterol levels. Are there side effects from taking too much vitamin B3? High-dose niacin can cause flushing, itching, liver stress, elevated blood sugar, and digestive upset. Niacinamide in excessive amounts may cause nausea or liver toxicity. The upper tolerable limit is 35 mg daily from supplements for adults. NAD precursors NMN and NR are generally well-tolerated at standard doses (250 to 1000 mg), but long-term high-dose effects are still being studied. Can vitamin B3 supplements help with anti-aging? NAD+ precursors like NMN and NR show promise for anti-aging by restoring declining NAD+ levels, which support mitochondrial function, DNA repair, and sirtuin activation. While animal studies demonstrate lifespan extension and healthspan improvements, human longevity data is still being collected. Current evidence supports benefits for cellular energy, metabolic health, and potentially slowing certain aspects of biological aging. Should I take vitamin B3 in the morning or evening? For NAD+ precursors like NMN and NR, morning dosing may align better with natural circadian rhythms of NAD+ metabolism, though timing research is preliminary. Niacin is often taken with evening meals to minimize flush reaction during sleep. Niacinamide can be taken any time. Overall, consistency matters more than specific timing for most B3 supplements. What does recent research show about NMN and NR effectiveness? Clinical studies demonstrate that both NMN (100-500mg daily) and NR (1000mg daily) successfully elevate blood NAD+ levels in humans with good tolerability. NMN research in healthy Japanese men showed dose-dependent increases in NAD+ metabolites over 12 weeks, while NR studies documented peak NAD+ elevation within 8 hours of supplementation. Both precursors show promise for addressing age-related NAD+ decline. Making an Informed Choice: Your Personalized B3 Supplement Strategy for 2025 Armed with comprehensive knowledge about NAD+, niacin, niacinamide, and advanced precursors, you can now make strategic decisions about vitamin B3 supplementation tailored to your specific health goals and individual circumstances. Key Considerations Before Supplementing Begin by assessing your current B3 intake from diet. If you consume adequate amounts of meat, fish, nuts, and fortified grains, you likely meet basic requirements for preventing deficiency. Supplementation becomes relevant when targeting specific therapeutic goals beyond basic nutrition. Consider your health priorities in this order: 1. Primary goal: Are you focused on cardiovascular optimization, skin health, athletic performance, cognitive function, or longevity? 2. Current health status: Do you have liver conditions, diabetes, cardiovascular disease, or take medications that might interact? 3. Tolerance profile: Can you tolerate the niacin flush, or do you need flush-free alternatives? 4. Budget and commitment: Advanced NAD+ precursors cost more. Are you prepared for long-term supplementation? Quality Matters: How to Identify Legitimate Products Not all NAD+ precursors are created equal. The supplement industry's quality control varies wildly, especially for newer, more complex compounds like NMN and NR where manufacturing expertise remains limited and regulatory oversight stays minimal. Some products contain exactly what their labels claim. Others have degraded molecules, contaminated batches, or dramatically lower potency than advertised. How do you tell the difference? Look for these non-negotiable quality indicators: 📜 Certificates of Analysis (absolutely non-negotiable) • Third-party lab testing • >98% purity verification • Batch number matching • Heavy metal screening • Microbial contamination testing 🔬 Stability Data On Capsules • Shelf-life testing documentation for sensitive ingredients • Storage condition specifications • Degradation rate data on herbal non-dried products • Expiration date justification • Protective packaging details • Manufacturing date on liposome-based products as most only last 3-6 months before beginning to break down. Old liposome formulations have lost any substantial absorption capabilities. ✅ One or more Third-Party Certifications • NSF International certification • USP verification • ConsumerLab testing? No it isn't good as they only test 1 batch a year • cGMP facility compliance • ISO quality standards For NAD+ precursors specifically, stability is crucial. These molecules can degrade with heat, light, and moisture exposure. Choose manufacturers who provide stability data and use appropriate packaging to protect product integrity. Enteric-coated formulations offer better bioavailability for NMN per research. The Bottom Line: No Universal "Best" Choice No single form of vitamin B3 is universally superior. The best choice depends on your individual health goals, current health status, and tolerance for side effects: If Your Priority Is... Choose This Form Why It Works Best Anti-Aging & Longevity NMN or NR Most direct NAD+ pathway, supports sirtuins, mitochondrial function, DNA repair Cardiovascular Health Niacin (Nicotinic Acid) Only B3 form with proven HDL raising and triglyceride lowering effects Skin Health & Beauty Niacinamide (oral + topical) Reduces hyperpigmentation, strengthens barrier, regulates sebum, no flush General Wellness Niacinamide Well-tolerated, supports NAD+ efficiently, no side effects, affordable Athletic Performance NMN (morning dose) Enhances muscle NAD+, improves aerobic capacity, supports ATP production Cognitive Function NMN + Resveratrol combo Synergistic brain NAD+ enhancement Quality supplementation, combined with a nutrient-rich diet, regular exercise, adequate sleep, and stress management, provides a comprehensive approach to optimizing NAD+ levels and supporting healthy aging. 🎯 Final Recommendation for 2025 Start with evidence-based doses of high-quality supplements, monitor your response objectively, and work with healthcare providers when using therapeutic doses or if you have existing health conditions. The science of NAD+ and vitamin B3 continues to evolve rapidly. Research has already revealed new insights about transport mechanisms, circadian timing, and synergistic combinations. Stay informed, but don't wait for perfect information. The evidence supporting NAD+ optimization for healthy aging is already compelling. Most importantly: Consistency matters more than perfection. Choose a form you can commit to long-term, verify quality through third-party testing, and give your protocol 8-12 weeks before making major changes. TL;DR: No single B3 form is universally superior. Niacin excels for cardiovascular support, niacinamide for skin health and gentle NAD+ boosting, NMN/NR for targeted anti-aging optimization. Quality supplementation requires third-party testing, stability data, and appropriate certifications, combined with realistic expectations and 8-12 week commitment periods to assess effectiveness. About This Article This comprehensive guide was created by RevGenetics to provide evidence-based information about vitamin B3 forms and their applications for health optimization. All information is for educational purposes and should not replace professional medical advice. Article Source: RevGenetics - www.revgenetics.com Last Updated: November 29, 2025 | Original Publication: November 29, 2025 Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting any new supplement regimen, especially if you have existing health conditions or take medications. Statements about supplements have not been evaluated by the FDA. Scientific References & Further Reading This article is based on peer-reviewed scientific research. All citations are from verified published studies: Core NAD+ Biology & Precursor Research 1. Yoshino J, Baur JA, Imai SI. (2018). "NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and Related Compounds." Cell Metabolism, 27(3), 513-528. PubMed: 29514064 2. Rajman L, Chwalek K, Sinclair DA. (2018). "Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence." Cell Metabolism, 27(3), 529-547. PubMed: 29514065 3. Cantó C, Menzies KJ, Auwerx J. (2015). "NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus." Cell Metabolism, 22(1), 31-53. PubMed: 26118927 4. Verdin E. (2015). "NAD+ in aging, metabolism, and neurodegeneration." Science, 350(6265), 1208-1213. PubMed: 26785480 Human Clinical Trials: NMN & NR 5. Irie J, Inagaki E, Fujita M, et al. (2020). "Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men." Endocrine Journal, 67(2), 153-160. PubMed: 31685720 6. Airhart SE, Shireman LM, Risler LJ, et al. (2017). "An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers." PLoS One, 12(12), e0186459. PubMed: 29211728 7. Martens CR, Denman BA, Mazzo MR, et al. (2018). "Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults." Nature Communications, 9(1), 1286. PubMed: 29599478 Niacin & Niacinamide Specific Research 8. Gasperi V, Sibilano M, Savini I, Catani MV. (2019). "Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications." International Journal of Molecular Sciences, 20(4), 974. PubMed: 30813414 9. Bissett DL, Oblong JE, Berge CA. (2005). "Niacinamide: A B vitamin that improves aging facial skin appearance." Dermatologic Surgery, 31(7 Pt 2), 860-865. PubMed: 16029679 10. Gehring W. (2004). "Nicotinic acid/niacinamide and the skin." Journal of Cosmetic Dermatology, 3(2), 88-93. PubMed: 17163948 Cardiovascular & Metabolic Effects 11. Boden WE, Probstfield JL, Anderson T, et al. (2011). "Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy." New England Journal of Medicine, 365(24), 2255-2267. PubMed: 22085343 12. Kamanna VS, Kashyap ML. (2008). "Mechanism of action of niacin." American Journal of Cardiology, 101(8A), 20B-26B. PubMed: 18375237 NAD+ Transport & Mechanisms 13. Grozio A, Mills KF, Yoshino J, et al. (2019). "Slc12a8 is a nicotinamide mononucleotide transporter." Nature Metabolism, 1(1), 47-57. PubMed: 30887032 14. Ratajczak J, Joffraud M, Trammell SA, et al. (2016). "NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells." Nature Communications, 7, 13103. PubMed: 27725675 Aging & Longevity Research 15. Imai S, Guarente L. (2014). "NAD+ and sirtuins in aging and disease." Trends in Cell Biology, 24(8), 464-471. PubMed: 24786309 16. Fang EF, Lautrup S, Hou Y, et al. (2017). "NAD+ in Aging: Molecular Mechanisms and Translational Implications." Trends in Molecular Medicine, 23(10), 899-916. PubMed: 28899755 Research Transparency Note: This article references only peer-reviewed, published research from established scientific journals. All PubMed IDs are provided for verification. The field of NAD+ biology is rapidly evolving. New studies are published regularly. 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Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. Screenshots taken from Sirtris public offering roadshow. This is not being hosted anymore in the original host. Screenshots have been moved to this site. - [CleanKeto: 4 Types Of Beta-Hydroxybutyrate And No Junk](https://www.revgenetics.com/pages/cleanketo-4-types-of-beta-hydroxybutyrate-and-no-junk): CleanKeto: 4 Types Of Beta-Hydroxybutyrate And No Junk. CleanKeto Supplement Is Simple And Clean: The CleanKeto Formula contains four active forms of Beta-hydroxybutyrate (BHB) while most keto supplements have only three types. In addition, we don't use additional ingredients that will compromise your Keto Lifestyle. The only other element used is the HPMC, which consists of the Vegetarian Capsule Material. Nothing else. No Stearates, No Rice Flour, No Strange Flow Agents, No Junk. Only The Good Stuff For Your Keto Lifestyle! Sold out CLICK HERE TO Explore CleanKeto ---------------------------------------- What is Keto? The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet. This diet forces the body to burn fats rather than carbohydrates. People in the Keto Lifestyle usually eat most of their foods as fats, and have a small portion of proteins and a smaller portion of carbohydrates. ---------------------------------------- Why Beta-Hydroxybutyrate The BHB is a keto body. Generally produced mildly by your body during fasting or exercise. Taking a supplement that supports ketosis can support natural fat burning and help support your Keto Lifestyle*. ---------------------------------------- When is this taken? This product is taken right when you are going to bed, and as part of your intermittent fasting to support burning fat overnight during sleep. Fasting is key*. ---------------------------------------- Clean Label Supplement This product does not contain strange additional ingredients, only HPMC and 4 Types of BHB. We take pride in making this one of our clean Label Supplements without strange fillers or ingredients. RevGenetics is a dietary supplement company, and we cannot make any health claims on our products. These reviews are based on the unique experiences of the people who bought our products and you are not likely to have similar results on any health-related claims. Having said that, our service and purity are guaranteed. - [Stem Cell Pro IV: ProxyStem Core Formula](https://www.revgenetics.com/pages/stem-cell-pro-iv-proxystem-core-formula): New Stem Cell Pro IV: ProxyStem Core Formula With PQQ Our 4th Generation Stem Cell Pro, Providing Actives Tested In Labs That Show Promise: Our 4th Generation Stem Cell Pro formula, ProxyStem, is made by longevity specialists. We have added new ingredients such as Ashwaganda, Niacin, PQQ, Melatonin, and Lithium for superior brain performance support, along with Vitamins K1, K2, D3, and the best Folate on the market called "5-methyltetrahydrofolate," along with many other top ingredients to maintain excellent cellular health and boosted Melatonin for a great nights sleep. Take it 2 hours before bed. Try it today! Sold out CLICK HERE TO Explore Stem Cell Pro ---------------------------------------- Stem Cell Research Actives The actives in this product have been shown in labs to activate genes beneficial to Stem Cells*. We have now added new ingredients for a more complete Stem Cell Pro Supplement! ---------------------------------------- Genes & Mitochondria Lab actives have shown cell benefits with AMPK, mTOR, Nrf2, Mitochondrial Biogenesis & more*. We suggest taking this at nighttime because of the Melatonin we boosted and because it is best when your body is recovering during sleep. ---------------------------------------- Senolytics & NAD Lab actives have shown a delay in senescent phenotype and NAD support*. Slowing senescent phenotypes allows for a longer use of existing healthy cells. ---------------------------------------- Clean Label Supplement This product does not contain strange additional ingredients, only HPMC and the pure actives. We are proud to make this one of our Clean Label Products, that contain only good ingredients without strange fillers. RevGenetics is a dietary supplement company, and we cannot make any health claims on our products. These reviews are based on the unique experiences of the people who bought our products and you are not likely to have similar results on any health-related claims. Our service and purity are guaranteed. - [X500 Resveratrol 500mg Pure Micro Resveratrol](https://www.revgenetics.com/pages/x500-resveratrol-500mg-pure-micro-resveratrol): X500 Micro Resveratrol: Pure Resveratrol Micronized To PCOS Study Specs*. Providing The Same Resveratrol Used In Two Studies: Resveatrol 500 mg per serving - 30 Capsules - Made In The USA with Herbal Plant Extracted 99% Purity Resveratrol. RevGenetics Resveratrol has been used in two double-blind placebo human studies (See Product Page). Resveratrol has been shown to activate Sirtuins, which support many cellular benefits*. RevGenetics has made this 99% Pure Micro Resveratrol in studies available now as a dietary supplement. The same resveratrol used for Orgonica is used in the X500. X500 MicroResveratrol™ 500mg - Pure Trans-Resveratrol *Meets The Same MicroResveratrol™ (Micronized Resveratrol) PCOS Study Standards We Helped Sponsor (See our main product page). (Trans-Resveratrol) Pure resveratrol activates SIRT1, SIRT2, SIRT4, SIRT5, Fox01, P53, and many others we believe are considered longevity genes. This is Pure Resveratrol in Vegetarian Capsules For Best Absorption, With No Additional Ingredients. This Only Contains Resveratrol And HPMC (The Vegetarian capsule Material), Nothing Else. Sold out CLICK HERE TO Explore X500 ---------------------------------------- 99% Pure Resveratrol The Resveratrol used in this products has been tested by a third party lab for purity. ---------------------------------------- Used In Two Human Studies The Resveratrol we provide is the same used in the Human PCOS Study and Vascular study*. ---------------------------------------- IND Research Approved This Resveratrol was IND Research approved by the FDA and used by the Albert Einstein College Of Medicine In Studies ---------------------------------------- Clean Label Supplement This product does not contain strange additional ingredients, only HPMC and pure Resveratrol. RevGenetics is a dietary supplement company, and we cannot make any health claims on our products. These reviews are based on the unique experiences of the people who bought our products and you are not likely to have similar results on any health-related claims. Our service and purity are guaranteed - [M98 Super Micronized Resveratrol](https://www.revgenetics.com/pages/m98-super-micronized-resveratrol): M98 Resveratrol Complete™ And M98 Super Micronized™. Your browser does not support the video tag. Only RevGenetics Makes M98 Resveratrol Complete™ And M98 Super Micronized Resveratrol™: The M98 Super Micronized Resveratrol™ Has A Particle Size Between 1-2 Microns, A Short Half Life, And Absorbed Passively Through A Single Transport System. We Began Making Super Micronized M98 In 2008. In 2021 we decided to help provide complete active and passive absorption, using a type of trans-Resveratrol that is absorbed passively with a much higher solubility and actively through a glucose transport. This is why we say Complete Absorption Resveratrol™ on the jar. It helps provide both complete active and passive absorption methods. Sold out CLICK HERE TO Explore 98 complete ---------------------------------------- The M98 Resveratrol Complete™ (M98-RC) Uses Both An Active And A Passive Transport System, Has A Long Half Life, And 25x More Soluble Than Regular Resveratrol, And Completely Better Than Our Old Micronized M98* if you only had to choose one type of resveratrol on a daily basis. We believe that M98 Resveratrol Complete™ (M98-RC) overcomes many issues by using the complete methods of absorption, and not just a single method that standard low absorption resveratrol molecules use. Sign up to be notified on manufacturer discounts on these fantastic products. These Products Are Pharmaceutical Grade 98% Pure With No Additives, Flow Agents Or Fillers. ---------------------------------------- 98% Pure Trans-Resveratrol Both Trans-Resveratrol types used in these products have been tested by a third party lab for purity. M98 Synergy: If you have older M98 and want to try the new M98 Resveratrol Complete. We suggest taking both using a 3:1 ratio (3 parts M98-RC to 1 part M98), this should work well. ---------------------------------------- Super Absorption Is Key To increase passive absorption, RevGenetics super micronized resveratrol in 2008, the original M98 Resveratrol was born. In 2021 we decided to help provide complete absorption using a Resveratrol that enters the cell via both passive and active transports using glucose carriers*. ---------------------------------------- Best For The Morning Shake Add normal M98 to any thick liquid to increase its 2.2x estimated absorption over standard resveratrol or get M98 Reseveratrol Complete (M98-RC) and get the best absorption available with or without an emulsion or thick shake*. ---------------------------------------- Clean Label Supplement These products do not contain strange additional ingredients, Each product contains only a type of pure Trans-Resveratrol that is found in nature. M98 Resveratrol Complete™ and Complete Absorption Resveratrol™ are both trademarks of RevGenetics RevGenetics is a dietary supplement company, and we cannot make any health claims on our products. These reviews are based on the unique experiences of the people who bought our products and you are not likely to have similar results on any health-related claims. Our service and purity are guaranteed. - [SENOLYTICS 500: Fisetin 500 mg Mind & Lifespan](https://www.revgenetics.com/pages/senolytics-500-fisetin-500-mg-mind-lifespan): SENOLYTICS 500: Fisetin 500 mg Mind & Lifespan. Senolytics 500 Uses The Best Senolytic Natural Ingredient: Senolytics 500 provides 500 mg of 98% Pure Fisetin per serving - 60 Veggie Capsules (These Are Not Liquid Gelatin Capsules) - Made In The USA with High Purity Fisetin. In a major study that compared the top natural Senolytics compounds (including Curcumin and Quercetin), Fisetin was found to outperform all of the natural Senolytics compounds tested and increased health and lifespan in animals. Fisetin has also been shown to support long term memory and cognition*. While humans may react differently than animals, RevGenetics has made the Pure Senolytics 500 formula with 500mg of 95% Pure Fisetin per serving available as a dietary supplement for general health benefits and those interested in doing research on their own. Sold out CLICK HERE TO Explore Senolytics ---------------------------------------- What is Senolytics? Senolytics works by destroying old and bad cells that steal your skin's beauty, causing wrinkles, muscle's energy, and stealing general health by clogging organs up with old and inefficient cells over time. ---------------------------------------- How is this taken? We suggests taking Fisetin in the evening before bed, before a meal or an hour or two after a meal. This is suggested to be taken only for 1-3 months, then stop and rest for 4-6 months before taking Fisetin once more ---------------------------------------- Serving size This formulation provides 30 servings. Each serving consists of two capsules with 250mg of Fisetin each, in HPMC vegetarian capsules. ---------------------------------------- Clean Label Supplement This product does not contain strange additional ingredients, only HPMC and pure Senolytics Fisetin. RevGenetics is a dietary supplement company, and we cannot make any health claims on our products. These reviews are based on the unique experiences of the people who bought our products and you are not likely to have similar results on any health-related claims. Our service and purity are guaranteed. - [MetaQuercetin SuperZ: Micelle + Ionophore Powered Zinc](https://www.revgenetics.com/pages/metaquercetin-superz-micelle-ionophore-powered-zinc): MetaQuercetin SuperZ: Micelle + Ionophore Powered Zinc™. Micelle Nano Quercetin + Zinc = SuperZ: Quercetin Is a Proven Zinc Ionophore (It Transports Zinc Across The Cell Membrane), However Standard Quercetin Is Badly Absorbed In Your Body And Has Limited Results In Helping Zinc Absorption. We Created SuperZ To Overcome This Limitation, Maximize Zinc Absorption Through The Cell Membrane, And Shuttle It To Where Its Needed The Most. We Use New Nano Technology (Nano Quercetin In Micelles) To Increase This Natural Zinc Ionophore Absorption. We Believe The High Absorption MetaQuercetin Can Easily Transport More Of Our SuperZ Zinc Across The Cell Membrane Better Than Any Comparable Amount Of Standard Low Absorption Quercetin. If You Want A Natural Zinc Ionophore That Supports A Powerful Natural Immune System Along With Your Good Sense Of Smell And Taste, Get SuperZ Maximum Zinc Today. Sold out CLICK HERE TO Explore MetaQuercetin ---------------------------------------- Micelle Nano Technology The same Micell Technology that powers MetaCurcumin to be 277x better than standard, also powers the Quercetin we use in this product. ---------------------------------------- Nano Particles The Quercetin Nano particles are put in Micelle bubbles, which increases absorption phenomenally. We believe its the best Zinc Ionophore available. ---------------------------------------- Liquid And Encapsulated This special formulation is all you need to boost your zinc, and maintain it level to support your natural great health and immune system. Try It Today. ---------------------------------------- Dominate Cellular Zinc Zinc is terrible at getting into cells. It naturally will bounce off them unless there is a Ionophore present to transport it into the cells. SuperZ is Zinc's ticket in. RevGenetics is a dietary supplement company, and we cannot make any health claims on our products. These reviews are based on the unique experiences of the people who bought our products and you are not likely to have similar results on any health-related claims. Our service and purity are guaranteed. - [Advanced NMN](https://www.revgenetics.com/pages/advanced-nmn): Advanced NMN: Premium Nicotinamide Mononucleotide Supplements with Slc12a8 Technology for Superior NAD+ Support Experience the revolutionary power of premium NMN supplements featuring advanced Nicotinamide Mononucleotide formulations and cutting-edge Slc12a8 transporter technology. Since 2016, RevGenetics has pioneered pure, pharmaceutical-grade NMN supplements that deliver unparalleled NAD+ restoration, cellular energy enhancement, and healthy aging support through scientifically-validated mechanisms that optimize mitochondrial function and cellular vitality. Advanced NMN and Advanced NMN 1000: The Gold Standard in Nicotinamide Mononucleotide Supplementation Our revolutionary NMN supplements contain only pure Nicotinamide Mononucleotide and HPMC vegetarian capsules with absolutely no unnecessary additives or fillers. This clean-label approach ensures maximum bioavailability and safety, delivering 50mg and 1000mg (1 gram) serving options manufactured in the USA to the highest pharmaceutical standards. These represent the best NMN supplement 1000mg formulations available today. Since pioneering NMN supplementation for institutions in 2016, RevGenetics has maintained unwavering commitment to purity, potency, and safety. Our advanced Nicotinamide Mononucleotide formulations utilize cutting-edge Slc12a8 transporter technology for superior cellular uptake and NAD+ restoration compared to traditional NAD+ precursors. Your browser does not support the video tag. Special Pricing on Premium NMN Supplements Advanced NAD 50mg $19.99 Today Perfect for daily maintenance and introductory NAD+ supplementation Buy Advanced NAD 50mg Advanced NMN 1000mg $40 Today Maximum potency for enhanced NAD+ restoration and cellular support Buy Advanced NMN 1000mg Clinical Evidence: NMN Proven to Increase NAD+ Levels in Human Studies Breakthrough Research Validates NMN Effectiveness: A randomized, double-blind, placebo-controlled human study evaluated 66 healthy subjects between 40 and 65 years of age who received 150mg of Nicotinamide Mononucleotide daily in regular capsules. The participants took pure NMN capsules once daily in the morning for 60 days without experiencing stomach acid issues. Remarkable Results: At day 30, the NMN group showed a significant 11.3% increase in NAD+/NADH levels in tested serum, while the placebo group showed no change whatsoever. By day 60, NAD+/NADH levels in the NMN supplements group increased an impressive 38% compared to baseline, versus only 14.3% in the placebo group. This clinical evidence demonstrates the superior efficacy of Nicotinamide Mononucleotide for NAD+ restoration and cellular health optimization. Understanding NMN and Slc12a8 Technology for Enhanced Cellular Health The Nicotinamide Mononucleotide molecule in our premium NMN supplements represents a high-purity dietary supplement carefully extracted using advanced pharmaceutical processes. This powerful NAD+ precursor supports cellular energy production, DNA repair mechanisms, and mitochondrial function that naturally decline with age, offering a scientifically-validated approach to healthy aging and vitality optimization. Revolutionary Slc12a8 Transporter Technology Our advanced NMN supplements utilize cutting-edge Slc12a8 transporter technology that enables rapid cellular uptake of Nicotinamide Mononucleotide within 30 minutes of administration. This specialized transport system bypasses the lengthy conversion processes required by other NAD+ precursors, ensuring superior bioavailability and therapeutic benefit for optimal cellular health support. Advanced NAD 50mg Capsules Our Advanced NAD 50mg capsules are available for $40, providing an excellent foundation for NAD+ supplementation. These carefully formulated capsules offer an ideal introduction to NAD+ enhancement for those beginning their cellular health optimization journey with proven NAD+ precursor technology. Pure NMN Powder Our Advanced NMN powder comes in convenient 25-gram jars, perfect for those who prefer flexible dosing options. This water-soluble powder dissolves easily in your water bottle, making it convenient to take to work or travel. No need for liposomal formulations since our Nicotinamide Mononucleotide is already optimally bioavailable in water-soluble form. Best NMN Supplement 1000mg We've tested every batch of Advanced NMN for safety and purity since 2016, long before most companies entered the market. While new companies may skip lot testing (which the FDA allows), we maintain rigorous quality standards with comprehensive testing of every batch. We challenge other suppliers to provide COAs from 2016-2019 - most cannot deliver this level of quality assurance. Clean Label Supplement Our NMN supplements contain no unnecessary additives, only HPMC vegetarian capsules and the highest purity Nicotinamide Mononucleotide available on the market today. We formulated our products this way because our own family and staff take these supplements daily, demanding the highest safety and quality standards. Uncompromising Quality and Safety Standards Since 2016 Industry-Leading Quality Assurance: RevGenetics has been selling Advanced NMN since 2016, and we have always verified our purity through comprehensive testing. Our historical Certificate of Analysis (COA) from 2016 verifies how long we've been providing this premium NAD+ precursor to individuals, researchers, and scientists worldwide. The NAD+ precursor plays a crucial role in cellular and NAD+ metabolism optimization. Verified 100% Purity: Our recent Advanced NMN COA demonstrates that our material achieves 100% purity - the absolute best available. This pharmaceutical-grade quality ensures maximum therapeutic benefit and safety for Nicotinamide Mononucleotide supplementation. NMN serves as a direct precursor to nicotinamide adenine dinucleotide (NAD+), supporting cellular energy production and healthy aging processes. Safety Through Experience: Most companies selling NAD+ precursors only entered the market recently, often without the extensive testing and quality assurance that comes with years of experience. Be aware of quality differences and ask potential suppliers for historical COAs - many newer companies cannot provide comprehensive testing documentation from earlier years, potentially compromising safety and efficacy. Comprehensive Benefits of Advanced NMN Supplementation NMN supplements featuring Nicotinamide Mononucleotide and Slc12a8 technology provide comprehensive support for cellular health, energy production, and healthy aging through multiple interconnected mechanisms. These benefits include enhanced mitochondrial function, improved DNA repair capacity, optimized cellular metabolism, and increased resistance to age-related cellular decline. Enhanced Cellular Energy Production By supporting NAD+ biosynthesis, NMN supplements fuel mitochondrial ATP production, providing sustained energy for vital organs including the heart, brain, and muscles. This enhanced cellular energy production translates to improved physical performance, mental clarity, and overall vitality throughout daily activities. DNA Repair and Genomic Stability Nicotinamide Mononucleotide supports PARP enzymes and other DNA repair mechanisms that maintain genomic integrity and cellular health. This protective effect helps preserve cellular function and reduces the accumulation of DNA damage that contributes to aging and age-related health challenges. Cognitive Enhancement and Neuroprotection Elevated NAD+ levels from NMN supplementation support neuronal health, potentially improving memory, focus, and cognitive resilience throughout the aging process. The brain's high energy demands make it particularly responsive to NAD+ optimization through Nicotinamide Mononucleotide supplementation. Cardiovascular Health Optimization NMN supplements support endothelial function, healthy circulation, and cardiovascular resilience through improved cellular energy metabolism and reduced oxidative stress. This cardiovascular support contributes to overall health and longevity through optimized circulatory function. Frequently Asked Questions About NMN Supplements What makes NMN supplements superior to other NAD+ precursors? NMN supplements utilize advanced Slc12a8 transporter technology for rapid 30-minute cellular uptake of Nicotinamide Mononucleotide, compared to 6-8 hours required by other NAD+ precursors like NR. This superior absorption, combined with direct one-step conversion to NAD+ and no problematic NAM buildup that can interfere with sirtuin activation, makes NMN the most effective option for cellular energy enhancement and healthy aging support. How does Slc12a8 technology enhance NMN absorption? Slc12a8 transporters are specialized cellular proteins that facilitate direct uptake of Nicotinamide Mononucleotide into cells within approximately 30 minutes of administration. This revolutionary transport system bypasses the lengthy conversion processes required by traditional NAD+ precursors, ensuring rapid bioavailability and consistent therapeutic NAD+ support for optimal cellular function and energy production throughout the body. What clinical evidence supports NMN effectiveness? A randomized, double-blind, placebo-controlled study of 66 healthy adults between 40-65 years showed that 150mg daily NMN supplementation increased NAD+/NADH levels by 11.3% at 30 days and an impressive 38% at 60 days, compared to only 14.3% in the placebo group. This clinical evidence demonstrates the superior efficacy of Nicotinamide Mononucleotide for NAD+ restoration and cellular health optimization. Why choose RevGenetics NMN supplements over other brands? RevGenetics has been selling Advanced NMN since 2016 with verified 100% purity and comprehensive testing of every batch. Unlike newer companies that may skip lot testing (which the FDA allows), we maintain rigorous quality standards with historical Certificates of Analysis dating back to 2016, ensuring safety and efficacy through years of proven experience in Nicotinamide Mononucleotide manufacturing and quality assurance. What dosage of NMN supplements should I take? Most people benefit from starting with Advanced NAD 50mg daily for maintenance NAD+ support, or 150mg+ of NMN daily as supported by clinical studies showing effectiveness at these levels. We offer Advanced NAD 50mg capsules for foundational support and Advanced NMN 1000mg capsules for enhanced therapeutic benefits. Individual needs vary based on age, health status, and wellness goals, so consider starting with lower doses and adjusting based on your response to Nicotinamide Mononucleotide supplementation. Are NMN supplements safe for long-term use? NMN supplements have an excellent safety profile with no significant adverse events reported in clinical studies. Nicotinamide Mononucleotide occurs naturally in foods like broccoli, avocado, and tomatoes, providing a strong biological foundation for supplementation safety. RevGenetics has maintained rigorous testing protocols since 2016, ensuring pharmaceutical-grade purity and safety for long-term supplementation protocols. How do I take NMN supplements for best results? Take NMN supplements on an empty stomach in the morning for optimal absorption via Slc12a8 transporters. Our capsules can be taken with water, while our powder dissolves easily in water bottles for convenient daily use. Consistency is key - daily supplementation provides sustained NAD+ support for cellular energy and healthy aging benefits through continuous Nicotinamide Mononucleotide availability. What is the difference between NMN powder and capsules? Both forms contain the same high-purity Nicotinamide Mononucleotide with identical bioavailability and Slc12a8 transport efficiency. Capsules offer precise dosing and maximum convenience, while powder provides flexibility for custom dosing and easy mixing in beverages. Both forms utilize advanced transport technology for rapid absorption and superior NAD+ restoration compared to other delivery methods. Can NMN supplements be combined with other supplements? Yes, NMN supplements complement other longevity and health supplements excellently. Unlike other NAD+ precursors that produce problematic NAM buildup, Nicotinamide Mononucleotide doesn't interfere with sirtuin-activating compounds like resveratrol, pterostilbene, or fisetin. This compatibility makes NMN ideal for comprehensive cellular health and anti-aging supplement protocols. How long does it take to see benefits from NMN supplementation? Clinical studies show NAD+ level increases within 30 days of NMN supplementation, with more significant improvements by 60 days. Many users report enhanced energy and vitality within the first few weeks of consistent use. The Slc12a8 transport system enables rapid cellular uptake within 30 minutes, though sustained benefits develop with consistent daily use of Nicotinamide Mononucleotide over time for optimal cellular health optimization. FDA Disclaimer: RevGenetics is a dietary supplement company, and we cannot make any health claims or claims on skeletal muscle for our products. We provide information for informational purposes only. These reviews are based on the unique experiences of people who bought our products and you are not likely to have similar results on any health-related claims. Our service and purity are guaranteed. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Experience Premium NMN and NAD+ Technology Optimize your cellular health with advanced Nicotinamide Mononucleotide and NAD+ supplements featuring cutting-edge Slc12a8 technology for superior absorption and bioavailability. Shop Advanced NMN Collection Learn More About Advanced NMN - [Meta Curcumin](https://www.revgenetics.com/pages/meta-curcumin): MetaCurcumin: Revolutionary Nano Curcumin & TetraHydro Curcumin with Superior Micelle Technology Experience the breakthrough power of MetaCurcumin, featuring advanced nano curcumin and TetraHydro Curcumin formulated with revolutionary micelle curcumin technology. This cutting-edge supplement delivers up to 277 times superior absorption compared to regular curcumin supplements, representing the pinnacle of curcumin bioavailability and therapeutic effectiveness. Discover how Meta Curcumin transforms traditional turmeric supplementation through scientifically-validated nano-scale delivery systems that maximize cellular uptake and health benefits. MetaCurcumin: Micelle Super Curcumin + TetraHydro Curcumin Technology MetaCurcumin represents the most advanced curcumin supplementation technology available today, combining revolutionary micelle curcumin with highly active TetraHydro Curcumin for unprecedented bioavailability and therapeutic benefits. This innovative formulation delivers the highest curcumin absorption rates ever achieved, with clinical studies demonstrating up to 277 times greater absorption in women compared to regular curcumin supplements. Providing the Highest Curcumin Absorption 277x Superior Absorption Technology More absorbable than any regular curcumin supplement on the market Your browser does not support the video tag. Revolutionary Nano Curcumin Technology: Understanding MetaCurcumin's Superior Bioavailability MetaCurcumin utilizes cutting-edge nano curcumin technology that surpasses all other tested super curcumin products, including liposome curcumin formulations. Our advanced micelle curcumin delivery system creates nano-scale protective barriers around curcumin particles, dramatically enhancing absorption speed and bioavailability while ensuring sustained plasma levels that regular curcumin cannot achieve. Advanced Micelle Nano Technology The breakthrough science behind MetaCurcumin lies in its sophisticated micelle curcumin technology that produces the highest absorption at the fastest speed available for curcumin supplementation. This innovative process creates micelles on a nanoscale that protect ultra-sheared nanoparticles of curcumin, forming protective barriers around each particle to increase absorption dramatically. Sustained Plasma Levels: Unlike regular curcumin that typically disappears from plasma within 24 hours due to rapid excretion, MetaCurcumin maintains detectable levels in plasma even after 24 hours. This extended bioavailability represents a significant advancement in curcumin supplementation technology, ensuring sustained therapeutic benefits throughout the day. TetraHydro Curcumin: The Next Generation of Curcumin Enhancement TetraHydro Curcumin represents an advanced form of curcumin that demonstrates superior activity and enhanced absorption compared to traditional curcumin compounds. This specialized white curcumin derivative has been added to our best super curcumin capsules to provide synergistic benefits alongside our nano curcumin technology, creating a comprehensive approach to curcumin supplementation that maximizes therapeutic potential. Up To 277x The Absorption Human clinical studies demonstrate that the micelle nano curcumin technology used in MetaCurcumin delivers phenomenal absorption rates, with up to 277 times greater bioavailability than regular curcumin supplements in women. TetraHydro Curcumin Enhancement We've added super-active TetraHydro Curcumin to our premium curcumin capsules, providing enhanced therapeutic activity and superior absorption compared to standard curcumin formulations available on the market today. No GMO & No Food Coloring MetaCurcumin maintains the highest purity standards with no GMO ingredients and clear capsules that use no artificial food coloring, ensuring a clean and natural supplement experience. Full Spectrum Supplement Our advanced formula contains the complete spectrum of curcuminoids from turmeric, not just isolated curcumin and T-curcumin, providing comprehensive benefits from the entire curcuminoid profile. Comparative Analysis: MetaCurcumin vs Traditional Curcumin Supplements MetaCurcumin's micelle curcumin technology easily surpasses all popular curcumin products in both bioavailability and absorption speed. Comprehensive testing demonstrates that our nano curcumin formulation outperforms traditional curcumin, liposome curcumin, and other enhanced absorption technologies available in the supplement market today. Feature MetaCurcumin Liposome Curcumin Regular Curcumin Absorption Rate Up to 277x higher Moderate improvement Standard (baseline) Technology Nano micelle technology Liposome encapsulation Standard extraction Plasma Duration 24+ hours detectable Standard elimination Rapid elimination Bioavailability Superior nano protection Improved but limited Poor absorption Additional Compounds TetraHydro Curcumin included Standard curcuminoids Basic curcumin only Spectrum Full curcuminoid profile Limited spectrum Isolated compounds Maximum Strength Liquid Capsules: Advanced Delivery System MetaCurcumin utilizes maximum strength liquid capsules that optimize the delivery of our advanced nano curcumin and TetraHydro Curcumin formulation. This liquid capsule technology ensures rapid dissolution and immediate availability of the active compounds, working synergistically with our micelle curcumin technology to deliver unparalleled absorption and therapeutic benefits. Why Nano Micelle Technology Represents the Future of Curcumin Supplementation The revolutionary advantage of MetaCurcumin's nano curcumin technology lies in its ability to overcome the fundamental bioavailability challenges that have historically limited curcumin's therapeutic potential. By creating protective micelles around ultra-small curcumin particles, this technology ensures optimal absorption while maintaining stability and extending plasma residence time for sustained benefits. Clinical Evidence and Research Validation Extensive human studies validate the superior performance of MetaCurcumin's micelle curcumin technology. Research demonstrates not only the dramatic 277-fold increase in absorption but also the sustained plasma levels that distinguish this formulation from all other curcumin products tested. This scientific validation provides confidence in the therapeutic superiority of Meta Curcumin technology. Optimizing Health Benefits Through Enhanced Bioavailability The enhanced bioavailability achieved through MetaCurcumin's advanced delivery system translates directly to superior health benefits. By ensuring that curcumin and TetraHydro Curcumin reach target tissues at therapeutic concentrations, this formulation maximizes the potential for positive health outcomes while minimizing the dosage required for effectiveness. Quality Assurance and Manufacturing Excellence MetaCurcumin maintains the highest standards of quality and purity throughout the manufacturing process. Our commitment to excellence ensures that each capsule delivers consistent potency and bioavailability, utilizing only the finest ingredients and most advanced processing techniques to create the premier nano curcumin supplement available today. The combination of micelle curcumin technology, TetraHydro Curcumin enhancement, and full-spectrum curcuminoid content represents the culmination of years of research and development in curcumin supplementation science. This comprehensive approach ensures maximum therapeutic potential and superior health benefits. Frequently Asked Questions About MetaCurcumin What makes MetaCurcumin superior to regular curcumin supplements? MetaCurcumin utilizes revolutionary nano micelle technology that provides up to 277 times superior absorption compared to regular curcumin supplements. The advanced micelle curcumin delivery system creates protective barriers around nano-sized curcumin particles, dramatically enhancing bioavailability and ensuring sustained plasma levels for 24+ hours, which regular curcumin cannot achieve. How does nano curcumin technology work in MetaCurcumin? Nano curcumin technology in MetaCurcumin creates micelles on a nanoscale that protect ultra-sheared nanoparticles of curcumin. These nano-sized micelles form protective barriers around each curcumin particle, increasing absorption dramatically while maintaining stability and extending therapeutic benefits throughout the day for optimal health support. What is TetraHydro Curcumin and why is it included? TetraHydro Curcumin is an advanced form of curcumin that demonstrates superior activity and enhanced absorption compared to traditional curcumin compounds. This specialized white curcumin derivative provides synergistic benefits alongside nano curcumin technology, creating a comprehensive approach that maximizes therapeutic potential and health benefits. How does MetaCurcumin compare to liposome curcumin products? MetaCurcumin's micelle curcumin technology easily beats all tested liposome curcumin products in both bioavailability and speed of absorption. While liposome technology offers some improvement over regular curcumin, MetaCurcumin's nano micelle approach provides superior absorption rates and sustained plasma levels that liposome formulations cannot match. What does 277x absorption mean for health benefits? The 277x superior absorption means that MetaCurcumin delivers dramatically higher concentrations of active curcumin compounds to target tissues, maximizing therapeutic potential while requiring smaller doses. This enhanced bioavailability translates to more effective health benefits and sustained therapeutic levels throughout the day. Why does MetaCurcumin use liquid capsules? MetaCurcumin uses maximum strength liquid capsules to optimize delivery of the nano curcumin and TetraHydro Curcumin formulation. Liquid capsules ensure rapid dissolution and immediate availability of active compounds, working synergistically with micelle technology for unparalleled absorption and therapeutic benefits. Is MetaCurcumin safe for daily use? Yes, MetaCurcumin is formulated for safe daily use with no GMO ingredients and no artificial food coloring. The advanced nano curcumin technology actually improves safety by requiring smaller doses to achieve therapeutic effects compared to regular curcumin supplements, while providing sustained benefits. What makes the full spectrum curcuminoid profile important? MetaCurcumin contains the complete spectrum of curcuminoids from turmeric, not just isolated curcumin compounds. This full spectrum approach provides comprehensive benefits from the entire curcuminoid profile, including synergistic effects between different compounds that enhance overall therapeutic potential and health optimization. How long do the effects of MetaCurcumin last? Unlike regular curcumin that disappears from plasma within 24 hours, MetaCurcumin maintains detectable levels even after 24 hours due to its advanced micelle technology. This extended bioavailability ensures sustained therapeutic benefits throughout the day with consistent plasma levels for optimal health support. Can MetaCurcumin be combined with other supplements? Yes, MetaCurcumin can be safely combined with other health supplements. The enhanced absorption provided by nano curcumin technology may actually improve the effectiveness of complementary supplements, while the full spectrum curcuminoid profile works synergistically with various health optimization protocols. FDA Disclaimer: RevGenetics is a dietary supplement company, and we cannot make any health claims on our products. These reviews are based on the unique experiences of people who bought our products and you are not likely to have similar results on any health-related claims. Our service and purity are guaranteed. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Experience Revolutionary Curcumin Technology Discover the superior absorption and therapeutic benefits of MetaCurcumin featuring advanced nano curcumin and TetraHydro Curcumin technology. - [The RevGenetics Privacy Policy](https://www.revgenetics.com/pages/privacy): RevGenetics Privacy Policy Addendum This is an addendum to our existing privacy policies within our Terms and Conditions found here ("https://www.revgenetics.com/terms"). Last Changed On: 09/19/2024 ---------------------------------------- This Privacy Policy covers the websites ("RevGenetics.com"). The separate EU Policy begins afterward. Tracking Technologies and Analytics To enhance your experience on our website and ensure a seamless purchasing process, we use various tracking technologies such as pixels, scripts, and cookies to collect data about your browsing and purchasing behavior. This helps us improve our marketing efforts and provide you with tailored ads. Below, we explain the types of data collected, the technologies used, and your rights concerning this data. Information We Collect: • Personal Information: This includes your email address, phone number, and shipping/billing details, which we use to complete your purchase and provide customer support. • Transactional Data: Data such as products purchased, total transaction value, shipping details, and taxes are collected to ensure a smooth shopping experience. • Behavioral Data: We collect data about how you interact with our site, such as pages viewed, items placed in the cart, and time spent on the site. Third-Party Technologies: We use third-party services to help with marketing and analytics, including but not limited to: • Bing UET Tag: For tracking conversions and providing personalized ads. • Google Tag Manager: To manage and load scripts efficiently across our site. • Facebook Pixel: For tracking site interactions and delivering personalized ads on Facebook. • Twitter Conversion Tracking: To analyze conversions from Twitter ads and personalize future ad campaigns. • ClickCease: For preventing click fraud and protecting advertising campaigns. • ShopperApproved: For gathering product reviews and enhancing customer feedback. Your Rights Under GDPR, CCPA, and Global Data Privacy Laws: • Right to Access: You have the right to request a copy of your personal data that we hold. • Right to Erasure: You may request that we delete your personal data, subject to exceptions such as active transactions. • Right to Rectification: You may request corrections to any inaccurate data. • Right to Object: You can object to the processing of your personal data for marketing purposes. • Right to Data Portability: You can request that your data be transferred to another service provider. • Right to Opt-Out: For California residents, under CCPA, you can opt out of the sale of your personal data by contacting us. You can manage your cookie preferences through your browser settings and opt out of targeted ads via the following platforms: • Google Ads Settings • Facebook Ad Preferences • Twitter Personalization Settings For more details about our use of cookies and data sharing with third parties, please visit our Terms and Conditions. Text Marketing Notifications By subscribing to RevGenetics text notifications, you agree to receive automated marketing text messages about our products and services at the phone number provided. Message frequency is recurring, and message/data rates may apply. Consent is not a condition of purchase. You can reply STOP, END, CANCEL, UNSUBSCRIBE, or QUIT to opt-out, and HELP for customer support. Please note that attempting to opt-out by other means is not a reasonable method. Personal Information We Collect ("Cookie Consent") When you visit our site, we automatically collect information about your device (IP address, browser type, etc.) and information about your interaction with our site through cookies and other tracking technologies. • Cookies: Small data files stored on your device to help improve site functionality. You can disable cookies through your browser settings. • Log Files: Track site usage data such as IP address, browser type, and pages visited. • Web Beacons, Tags, and Pixels: Collect information on how you browse the site and help deliver personalized ads. When you make a purchase, we collect additional data such as your name, billing address, shipping address, payment details, and phone number. How Do We Use Your Personal Information? We use your information to: • Fulfill orders (process payments, shipping, etc.) • Communicate with you • Provide personalized ads and marketing • Improve site performance through analytics • Ensure security by screening for fraud or risks We also use the information for retargeting and advertising purposes. Sharing Your Personal Information We may share your data with third parties for the following reasons: • To help us with analytics, marketing, and order fulfillment (e.g., Shopify, Google, Facebook). • To comply with legal obligations or protect our rights. For more information on how third parties use your data, see their privacy policies: • Shopify Privacy Policy • Google Privacy Policy • Facebook Data Policy Data Breach Notification In the event of a data breach involving personal information such as name, email, phone number, or shipping details, we will notify you via email and provide instructions to secure your account. Financial data such as credit card numbers are handled through third-party payment processors (e.g., Stripe, PayPal) and are not stored by us. Do Not Track Signals We do not alter our data collection or use practices when we receive a Do Not Track signal from your browser. Data Retention ("Right to be Forgotten") We retain order information for our records unless and until you request us to delete it. Minors Our site is not intended for individuals under 18, and our products are for healthy adults only. Changes to This Policy We may update this policy periodically to reflect changes in our practices or for legal reasons. Contact Us For questions or concerns about this Privacy Policy, or to exercise your data rights, please contact: RevGenetics [Re: Privacy Compliance Officer] 16782 SW 88th St #357 Miami, FL 33196 USA Email: orders@revgenetics.com EU Privacy Policy For EU residents, your rights under GDPR include the right to be forgotten, data access, data rectification, and the right to opt-out of electronic communications. We process your data for the purpose of fulfilling contracts or pursuing legitimate business interests, and your data may be transferred outside of the EU. For GDPR-related inquiries, contact us using the details above. - [Science References for Nicotinamide Mononucleotide At RevGenetics](https://www.revgenetics.com/pages/references): Nicotinamide Mononucleotide NAD+ And Other Study References: 1. Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo - (Formentini, 2009) 2. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity - (Cato, 2009) 3. A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis - (Imai, 2010) 4. NAD blocks high glucose induced mesangial hypertrophy via activation of the sirtuins-AMPK-mTOR pathway - (Zhuo, 2011) 5. Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice - (Yoshino, 2011) 6. The NAD (+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity - (Canto, 2012 ) 7. NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. - (Zhang, 2016) 8. Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging - (Gomes, Sinclair,2013) 9. Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and repercussion - (Yamamoto, 2014) 10. NAD+ and sirtuins in aging and disease - (Imai, 2014) 11. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 - (Khan, 2014) 12. Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model - (Long, 2015) 13. NAD+ metabolism and the control of energy homeostasis – a balancing act between mitochondria and the nucleus - (Canto, 2015) 14. NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy - (Yang, 2016) 15. NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair - (Fang, 2016) 16. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans - (Trammell, 2016) 17. Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice - (Trammell, 2016) 18. β-Nicotinamide Mononucleotide, an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats - (Kawamura, 2016) 19. The first human clinical study for NMN has started in Japan - (Tsubota, 2016) 20. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death - (Wang, 2016) 21. Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice - (Uddin, 2016) 22. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice - (Mills, 2016) 23. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice - (de Picciotto, 2016) 24. Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease - (Yao, 2017) 25. Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model - (Martin, 2017) 26. Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1-Dependent Manner - (Guan, 2017) 27. Nicotinamide mononucleotide attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway - (Wei, 2017) 28. Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure - (Zhang, 2017) 29. Modulating NAD+ metabolism, from bench to bedside - (Auwerx, 2017) 30. Aspects of Tryptophan and Nicotinamide Adenine Dinucleotide in Immunity: A New Twist in an Old Tale. - (Rodriguez, 2017) 31. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice - (Williams, 2017) 32. NAMPT-mediated NAD biosynthesis as the internal timing mechanism: In NAD+ World, time is running in its own way - (Poljsak, 2017) 33. Effect of “Nicotinamide Mononucleotide” (NMN) on Cardiometabolic Function (NMN) - (Clinical In Process) 34. The dynamic regulation of NAD metabolism in mitochondria - (Stein, 2012) 35. Novel NAD+ metabolomic technologies and their applications to Nicotinamide Riboside interventions - (Trammel, 2016) 36. Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans - (Meydayni, 2016) 37. A high-fat, ketogenic diet induces a unique metabolic state in mice. - (Kennedy, 2007) 38. Ketone body metabolism and cardiovascular disease. - (Cotter, 2013) 39. Ketone bodies as signaling metabolites - (Newman, 2014) 40. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease - (Youm, 2015) 41. The effect of the Spanish Ketogenic Mediterranean Diet on nonalcoholic fatty liver disease: a pilot study. - (Guisado, 2011) 42. β-Hydroxybutyrate: A Signaling Metabolite in starvation response - (Morales, 2016) 43. Physiological roles of ketone bodies as substrates and signals in mammalian tissues - (Robinson, 1980) 44. Ketone bodies mimic the life span extending properties of caloric restriction - (Veech, 2017) 45. Novel ketone diet enhances physical and cognitive performance - (Murray, 2016) 46. Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet. - (Study) 47. Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes - (Cox, 2013) 48. Neuroendocrine Factors in the Regulation of Inflammation: Excessive Adiposity and Calorie Restriction - (Fontana, 2009) 49. Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice - (August, 2017) 50. A randomized trial of a low-carbohydrate diet for obesity - (Foster, 2003) 51. β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation - (Bae, 2016) 52. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. - (Maalouf, 2009) 53. AMPK activation protects cells from oxidative stress‐induced senescence via autophagic flux restoration and intracellular NAD + elevation - (Han, 2016) 54. Regulation of AMP-activated protein kinase by natural and synthetic activators - (Hardie, 2015) 55. Effects of Exhaustive Aerobic Exercise on Tryptophan-Kynurenine Metabolism in Trained Athletes - (Strasser, 2016) 56. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation - (Bai, 2011) 57. Carbohydrate restriction regulates the adaptive response to fasting - (Klein, 1992) 58. Interventions to Slow Aging in Humans: Are We Ready? - (longo, 2015) 59. Extending healthy life span–from yeast to humans - (longo, 2010) 60. Dietary restriction with and without caloric restriction for healthy aging - (Lee, 2016) 61. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan - (Longo, 2015) 62. Diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms - (Longo, 2016) 63. Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle - (Porter, 2015) 64. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice - (Newman, 2017) 65. The NAD(+)/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling - (Mouchiroud, 2013) 66. NAMPT- mediated NAD(+) biosynthesis is essential for vision in mice - (Lin, 2016) 67. NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair - (Fang, 2016) 68. Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease - (Gariani, 2017 ) 69. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle - (Canto, 2010) 70. The NAD (+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity - (Canto, 2012) 71. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans - (Trammell, 2016) 72. Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice - (Trammell, 2016) 73. Dietary leucine stimulates SIRT1 signaling through activation of AMPK - (Hongliang, 2012) 74. Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 - (Khan, 2014) 75. NAD blocks high glucose induced mesangial hypertrophy via activation of the sirtuins-AMPK-mTOR pathway - (Zhuo, 2011) 76. The effect of different exercise regimens on mitochondrial biogenesis and performance - (Philander, 2014) 77. Dietary proanthocyanidins boost hepatic NAD+ metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats - (Aragon’s, 2016) 78. NAD+ Deficits in Age-Related Diseases and Cancer - (Garrido, 2017) 79. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation - (Ong, 2013) 80. Chlorogenic Acid Improves Late Diabetes through Adiponectin Receptor Signaling Pathways in db/db Mice - (Chang, 2015) 81. Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds - (Marin-Aguilar, 2017) 82. The Effects of Ramadan Fasting on Body Composition, Blood Pressure, Glucose Metabolism, and Markers of Inflammation in NAFLD Patients: An Observational Trial - (Mazidi, 2014) 83. Comparative effects of carbohydrate versus fat restriction on metabolic profiles, biomarkers of inflammation and oxidative stress in overweight patients with Type 2 diabetic and coronary heart disease: A randomized clinical trial. - (Raygan, 2016) 84. Normal fasting plasma glucose and risk of type 2 diabetes diagnosis - (Nichols, 2008) 85. Are We All Pre-Diabetic? - (Stokel,2016) 86. Hepatic NAD+ deficiency as a therapeutic target for non-alcoholic fatty liver disease in aging - (Zhou, 2016) 87. Effect of exercise intensity on post-exercise oxygen consumption and heart rate recovery - (Mann,2014) 88. A 45-minute vigorous exercise bout increases metabolic rate for 14 hours - (Knab,2011) 89. Effects of high-intensity resistance training on untrained older men. II. Muscle fiber characteristics and nuclei-cytoplasmic relationships - (Gerontol, 2000) 90. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice - (Newman, 2017) 91. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice - (Roberts, 2017) 92. NK cells link obesity-induced adipose stress to inflammation and insulin resistance - (Wensveen, 2015) 93. The “Big Bang” in obese fat: Events initiating obesity-induced adipose tissue inflammation - (Wensveen, 2015) 94. The impact of the Standard American Diet in rats: Effects on behavior, physiology and recovery from inflammatory injury - (Totsch, 2017) 95. Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP - (Shen, 2017) 96. The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders - (Stafstrom, 2012) 97. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle - (Fredrick 2016) 98. Digestion and absorption of NAD by the small intestine of the rat - (Henderson, 1983) 99. Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet - (Shi, 2017) 100. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans - (Brenner, 2004) 101. Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1 - (Ma, 2017) - [The RevGenteics 30-Day Money Back Guarantee](https://www.revgenetics.com/pages/30-day-money-back-guarantee): Our RevGenetics Guarantee Is Simple. If for any reason you are unhappy with RevGenetics brand capsule products within 30 days, you may return it for a full refund (less shipping and handling). Returns: Only one opened package of any RevGenetics brand capsule product is eligible for return. All others of the same product must be in a factory sealed container for a refund. You are covered by this refund of RevGenetics brand products for a full 30 days from the date of delivery. Our return and refund policy apply to all RevGenetics brand capsule products, with the following exceptions: Exceptions: We do not guarantee, refund or cover International Orders, products delivered in recurring orders, loose or bulk powder products, inert gas, creams or other products not mentioned where the RevGenetics website product page states that the product cannot be returned or refunded. These exceptions simply cannot be returned or refunded at this time. Recurring orders cannot be returned or refunded. Please remember that recurring orders are strictly for folks that have already tried and enjoyed our products and simply want them at a better price and/or to save on shipping costs using an easy month-to-month recurring order. Please see our recurring orders policy regarding this special class of products. If you are simply trying our products for the first time, please select our single purchase capsule products as many qualify for our 30 day money back guarantee. After making sure that our products are the best ones for you, you can then save money by simply choosing our recurring products. To return a product: please e-mail or call our Customer Service Department at Orders@revgenetics.com or 1-888-738-4363 within 30 days of the date of delivery to receive authorization and return instructions. - [RevGenetics International Shipping - Do You Ship To My Country?](https://www.revgenetics.com/pages/international-shipping): Do you ship to my country? Please create an account by clicking the "My Account / Order Status" link at the top right-hand side of our site. During signup, we'll ask for your shipping address details including country. If your country is not in the dropdown menu of available countries unfortunately, we cannot ship to your country at this time. Emails are required for international orders. We will not send an international order without the correct email, address and contact phone number. First Class International shipping method is delivered through the postal services. First Class International shipping has no electronic tracking information. This method takes 1-2 weeks for delivery to Canada and Europe, and 2-3 weeks to Asia and Pacific and requires you to verify your mailing address if you are a first time customer. Although First Class International has a low price, we cannot guarantee delivery or provide refunds when this shipping method is selected. We only offer it for your convenience if you find it to be a safe and reliable shipping method through your countries postal services. Because of this, the customer understands that he waives right for a customer signed "Proof of Delivery" to a verified or non-verified address in any merchant chargeback dispute. Customer accepts our shipment notification email with a delivery number as proof of delivery and the final determination as to whether the customer received the product. Our shipment email with delivery number constitutes acceptance of free and clear delivery to the customer. The delivery number is not a tracking number. The U.S. Postal Service will be electronically notified by us to expect the package with your delivery number, but will not provide any further updates on their website as no tracking is available. We do offer other shipping methods that have tracking available. Please choose another shipping method if package tracking is important to you. Country Restrictions: You agree to verify your country restrictions before ordering. If your order is returned to us due to restricted or banned products, an incorrect address, you could not communicate with customs, could not provide customs the proper paperwork they required on time or because no one was there to accept delivery of your order, we will provide no refund. Please contact us within 30 days if this has happened to arrange for delivery to another address or to attempt the delivery once more for an additional shipping fee. Returned packages that are not redelivered will be held at our office and be discarded after 30 days. Taxes, Customs, Duties are to be paid by the customer for all International orders. Any shipment that is held by customs for nonpayment of import duties and taxes and is subsequently returned by the carrier because of rejection of delivery by the customer results in an unauthorized return and the order is non-refundable. So please consider international taxes and duties before ordering. If your order is returned to us due to restricted or banned products, an incorrect address, or because no one was there to accept delivery of your order, we will refund your credit card in this manner: You will be refunded the total amount of the order minus the shipping charge and 20 percent of the value of the order as a re-stocking fee. We will also subtract any other external charges we have incurred during shipping, such as warehousing fees, return postage fees, etc. Credit Card Verification For First Time International Customers: If you are a first-time international customer, and order more than $81 we will ask you to fax us or email us additional information for your protection. We simply want to make sure no one is using your information without your knowledge. If this is necessary, we will email you the request of information. We will ask you for the front page of your monthly credit card statement or bill, or a copy of the front and back of your credit card along with a utility bill (water, electricity, or gas) that shows your shipping address. If you send us a copy of the statement, all we will need from it is your credit card company's logo and address, your name and address, and the last 4 digits of your card. We do not need any purchase history from this document so you can mark that off. Your privacy is secured, and we will not use your information for any other purpose, except to verify and protect your transaction. Our fax is (001.866.430.3953) and our email is ( orders@revgenetics.com ). If you already have shopped with us once, you will not need to provide this information What are my payment choices? During the checkout process, you may choose any of our current payment options and continue to place your order. Please note that we will not ship your order until we receive payment from you. When will my order ship and what are my shipping charges? Shipping is automatically calculated prior to submitting your payment information. Simply add items to your cart and proceed to the Checkout page where you will be offered Shipping Method choices and their prices. We will ship your order shortly after we receive payment from you. What is the return policy? Please see our Terms & Conditions for complete details regarding our return policy. How long will my package take if I choose the First Class International Mail Which Has No Tracking? Please see our estimated times per country below: - [The RevGenetics Terms And Conditions](https://www.revgenetics.com/pages/terms): REVGENETICS TERMS AND CONDITIONS Latest Version Posted: July 11th, 2025 The terms and conditions outlined in this TOS apply to all individuals who access and use this website, products, marketing or services, including but not limited to: individuals residing in the United States, state and federal government employees, employees and contractors of governments of any country, government entities, commercial or government-related entities, bots and spiders, contractors, subcontractors, non-profits, non-governmental organizations and the like. By accessing and using this website, products, or services, you confirm that you have read and understand these terms and agree to be bound by them. If you do not agree to these terms, you are not authorized to use this website, products, or services. If you are a U.S. government employee, we recommend that you review the GSA GUIDANCE FOR REVIEWING TERMS OF SERVICE FOR SOCIAL MEDIA PRODUCTS AND SERVICES, before accessing or using any information on this website, products, or services. By continuing to access this website, products, or services, you acknowledge that you have reviewed these documents and understand the Antideficiency Act criminal penalties for Government employees who knowingly and willfully violate the Act and fully agree to be bound by the terms and conditions outlined in this TOS. If you are a government employee and you violate the Antideficiency Act, you agree to personally be responsible for any expenses that may result on top of criminal charges. This includes any commercial use of work, as stated in the "II. COMMERCIAL RESEARCH IP & AFFILIATE TERMS OF USE" section of this TOS agreement. Government employees that do not have contracting authority agree to the full TOS, assume personal liability for all commercial licenses and indemnifications in this agreement. Welcome to RevGenetics! The term "RevGenetics" encompasses RevGenetics LLC, including its properties, websites, agents, associates, authors, contractors, suppliers, officers, directors, shareholders, employees, representatives, and any other individuals or entities associated with the business, as well as the named individual 'Anthony Loera' (referred to as "us," "we" or “RevGenetics”). We provide the www.revgenetics.com site and various related services (collectively referred to as this "site"). Your use of this site, including personal communications unrelated to the website or business activities, as well as any other written agreement between us (or your company), is subject to your compliance with all the terms, conditions, and notices stated in these Terms of Use. Moreover, when utilizing specific services or materials on this site, users are bound by any posted guidelines or rules applicable to those services or materials. These guidelines or rules may contain additional terms and conditions that supplement the ones outlined in these Terms of Use. All such guidelines or rules are hereby incorporated into these Terms of Use by reference. BY COMPLETING THE REGISTRATION PROCESS AND/OR USING THIS SITE, YOU AGREE TO BE BOUND BY THESE TERMS OF USE. IF YOU DO NOT WISH TO BE BOUND BY THE THESE TERMS OF USE, PLEASE EXIT THE SITE NOW. YOUR REMEDY FOR DISSATISFACTION WITH THIS SITE, OR ANY PRODUCTS, SERVICES, CONTENT, OR OTHER INFORMATION AVAILABLE ON OR THROUGH THIS SITE, IS TO STOP USING THE SITE AND/OR THOSE PARTICULAR PRODUCTS OR SERVICES. YOUR AGREEMENT WITH US REGARDING COMPLIANCE WITH THESE TERMS OF USE BECOMES EFFECTIVE IMMEDIATELY UPON COMMENCEMENT OF YOUR USE OF THIS SITE. We reserve the right to change these Terms of Use from time to time without notice to you. You acknowledge and agree that it is your responsibility to review this site and these Terms of Use periodically and to be aware of any modifications. Your continued use of this site after such modifications will constitute your acknowledgment of the modified Terms of Use and agreement to abide and be bound by the modified Terms of Use. ARBITRATION NOTICE: BY ACCEPTING THESE TERMS, YOU AGREE THAT ANY DISPUTES BETWEEN YOU AND REVGENETICS WILL BE RESOLVED THROUGH BINDING, INDIVIDUAL ARBITRATION, AND YOU WAIVE YOUR RIGHTS TO PARTICIPATE IN ANY CIVIL, CRIMINAL, OR OTHER TYPES OF TRIALS, INCLUDING INTERNATIONAL, CLASS ACTIONS AND REPRESENTATIVE PROCEEDINGS. I. CUSTOMER TERMS & CONDITIONS 1. Return/Refund Policy (30-Day Money-Back Guarantee) You may return RevGenetics brand capsule products within 30 days of delivery for a full refund, minus shipping and handling fees, provided that the products comply with the following conditions: a. The opened package, along with all of the remaining unopened packages from the same order, must be returned. All unopened packages must be factory-sealed. b. The return policy does not apply to international orders, recurring or subscription orders, bulk powder products, inert gas, creams, or any product where the RevGenetics website or product page explicitly states that returns or refunds are not permitted. To initiate a return, contact our Customer Service Department at orders@revgenetics.com or 1-888-738-4363 within 30 days of delivery to receive authorization and return instructions. Please note that recurring orders are for customers who are already satisfied with our products and wish to avail discounts or save on shipping costs through a subscription. New customers should opt for single purchase capsule products. Refer to our recurring orders policy for more information. A. Return Process Ensure that the products are in new condition and in their original packaging. It is your responsibility to ship the products to the correct address, and we recommend obtaining a tracking number and shipping insurance. Share the tracking information with our Customer Service to expedite processing. Upon receiving and inspecting the return, if the product is in acceptable condition, we will issue a refund in the original form of payment. However, if a credit card refund is not possible, the refund may be processed via PayPal, check, or another method at our discretion. For refunds through bank wire, there will be a $60 wire charge deducted from the refund amount. B. Ineligible or Unacceptable Returns If the returned product is ineligible for a return or is received in an unacceptable condition, we will either refuse the return or notify you via email. For damaged items, you may file a claim with your shipping carrier. For used items, you can choose to have the product disposed of or returned to you at your expense. Such items will be retained in our warehouse for up to 30 business days unless you request otherwise in writing. After this period, you agree that the items will be disposed of or donated. C. Government Restrictions No refunds will be provided if the order is affected by any government restrictions or interventions (including customer non-payment of government or customs fees) that prevent or delay delivery. In such cases: RevGenetics will await the return of the package by the government postal service (this may take 30 to 90 days). The customer must provide a new shipping address and pay for the shipping to this new shipping address. If no packages can be delivered due to government restrictions, RevGenetics will hold the package for up to 90 days. During this period, the customer may wait for changes in government policies or provide an alternative address outside the affected area. Any fees, taxes or charges required to be paid to shipper or government for the return of the product to RevGenetics will be paid for by the customer at the time a redelivery to a new location is made or deducted from any insurance refunds should the package be lost in transit back to the RevGenetics facility. 2. Privacy and Use of Information Tracking Technologies and Analytics To enhance your experience on our website and ensure a seamless purchasing process, we use various tracking technologies, such as pixels, scripts, and cookies, to collect data about your browsing and purchasing behavior. These tools also allow us to improve our marketing efforts by providing tailored ads and better insights. Below, we outline the types of data collected, the technologies used, and your rights concerning this data. Information We Collect: We may collect the following information when you visit our website or make a purchase: • Personal Information: This may include your email address, phone number, and shipping/billing details. This information is used to complete your purchase and provide customer support. • Transactional Data: Information such as products purchased, total transaction value, shipping details, and taxes may be collected to ensure a seamless shopping experience. • Behavioral Data: We may collect information about your activity on our site, such as pages viewed, time spent on the site, and items placed in the cart. How We Use the Collected Data: The data we collect may be used in the following ways: • Order Processing: To complete your purchases, provide shipping information, and send you order updates. • Analytics & Reporting: To understand how users interact with our site, track sales performance, and improve user experience. • Marketing & Advertising: We may share anonymized data with third-party platforms (e.g., Facebook, Twitter, Bing) for targeted advertising campaigns based on your interests or past interactions on our site. • Retargeting & Personalized Ads: We may use cookies and pixels from services such as Facebook, Google, and Twitter to deliver personalized ads based on your browsing behavior. This includes tracking your visits to our website and other sites across the internet. Third-Party Technologies: We integrate third-party services to assist with marketing and analytics, including but not limited to: • Bing UET Tag: For tracking conversions and providing personalized ads. • Google Tag Manager: For managing and loading scripts efficiently across our site. • Facebook Pixel: For tracking interactions on our site and displaying personalized ads on Facebook. • Twitter Conversion Tracking: To analyze conversions from Twitter ads and personalize future ad campaigns. • ClickCease: For preventing click fraud and protecting advertising campaigns. • ShopperApproved: For gathering product reviews and enhancing customer feedback. These services may collect and process data according to their own privacy policies. We recommend reviewing the privacy policies of these third parties to understand how they manage your data. Your Rights Under GDPR & CCPA: • Right to Access: You have the right to request a copy of the personal data we hold about you. • Right to Erasure: You may request that we delete your personal information, subject to certain exceptions (such as completing an active transaction). • Right to Rectification: If you believe any of your data is inaccurate, you can request corrections. • Right to Object: You may object to the processing of your personal data for marketing purposes at any time. • Right to Data Portability: You can request that we transfer your data to another service provider. • Right to Opt-Out: Under CCPA, California residents have the right to opt-out of the sale of their personal information. To exercise this right, please [contact us]. How to Manage Your Preferences: You can control the use of cookies and tracking technologies through your browser settings. You can also opt-out of personalized ads through the following platforms: • Google Ads Settings • Facebook Ad Preferences • Twitter Personalization Settings Data Retention: We retain your personal information for as long as it is necessary to provide you with services, fulfill legal obligations, resolve disputes, and enforce our agreements. Changes to This Section: We may update this section from time to time to reflect new technologies or changes in privacy regulations. Any changes will be posted on this page, and where appropriate, notified to you via email or other communication channels. 3. Verification of Identity for Customer Support Interaction When interacting with RevGenetics customer support through phone or email concerning orders valued at $75 or above, it is essential for us to confirm your identity to ensure secure communication and to prevent fraudulent activities. For identity verification purposes, we may request a copy of your government-issued identification, such as a driver’s license, passport, or any other federally recognized ID, regardless of your location, whether within the USA or abroad. By reaching out to RevGenetics customer support concerning orders of $75 or above, you agree to promptly provide the requested identification document when asked by our customer support representatives. If asked, please securely send a scanned copy of the requested document either via fax to 866-430-3953 or through email at Orders@RevGenetics.com. We recommend that you obscure any sensitive information that is not necessary for identity verification to protect your privacy. RevGenetics reserves the right to postpone or restrict communication, services, or transactions until satisfactory identity verification is complete. This is a measure to protect both the customer and RevGenetics LLC from potential fraud or unauthorized communication regarding orders. We value your privacy and will handle your identification documents with utmost care, in compliance with applicable data protection laws 4. Shipping Policy and Handling of Damaged Products RevGenetics LLC reserves the right to use alternative shipping carriers to ensure quality service. RevGenetics LLC is not liable for any delays, losses or issues with the product caused by carrier errors. For lost shipments not acknowledged as such by the carrier, we are unable to provide a replacement. We advise reaching out to your postal carrier for resolution. Customers have 45 days from the shipment date to report a lost shipment, after 45 days there are no refunds on lost packages. Refunds for lost shipments can take up to 20 days for US customers and 40 days for international customers. In case an immediate replacement is needed, we suggest placing a new order. The second order will incur additional charges, which will be refunded once the initial refund is processed. If you receive products that are damaged or have incorrect quantities, please contact our Customer Service Department at Orders@RevGenetics.com within 48 hours. Failure to do so will prevent us from being able to offer a solution or replacement. Be sure to take photos of the package and the products received, as these are required to process any claims. Do not dispose of any damaged products or packaging without instructions from Customer Service, as they may need to be returned. You must report any damaged, missing, or defective merchandise within seven days of delivery. After this period, you acknowledge that no claims regarding physical issues, such as damage or incorrect quantities, can be reported, and no returns or exchanges will be accepted. Most deliveries do not require a signature. By choosing standard shipping, you waive the right to customer-signed Proof of Delivery in any merchant chargeback dispute. Carrier's proof of delivery is considered as conclusive evidence of product delivery. A. Free Shipping Policy • Free shipping is available to select countries and orders, primarily within the USA. Some countries do not qualify for free shipping, and supplements may not be allowed across their borders. By ordering from these countries, you assume full responsibility for the package and agree that no refunds will be issued in case of loss, damage, destruction, or return. • Free shipping is limited to specific products. Combining a free shipping product with a non-free shipping product will incur shipping charges. • RevGenetics reserves the right to select the shipping carrier for free shipping, which may take 1-2 months for international deliveries. If faster shipping is required, choose DHL Express Worldwide if it is available. • If Free Shipping is not offered at checkout, it is not available for your location. • Free Shipping is not applicable retroactively after the order has been shipped. • If a package shipped with Free Shipping is returned and needs reshipment, the customer must pay the shipping fee for the reshipment. • Free Shipping is available only once per household in a 30-day period. • For returns, items shipped with Free Shipping within the US are subject to a 10% restocking fee (minimum $5.50), and internationally shipped items are subject to a 100% restocking fee. Customers are advised to purchase insurance whenever possible for their shipments if they have any concerns regarding delivery. 5. International Orders and Shipping Policy RevGenetics LLC displays estimated prices in various currencies for your convenience. However, these estimates may not be accurate. Please note that all transactions, except cryptocurrency, will be processed in US Dollars (USD). The customer is solely responsible for any international transaction fees, foreign transaction fees, currency conversion fees, and fluctuations in currency rates. Any refunds issued by RevGenetics will be in USD and based on the conversion rate at the time of the transaction. The customer is also responsible for any fees charged by their bank or credit card company for any transaction, charge, refund, or cancellation. As the consignee/buyer, you authorize RevGenetics LLC to only future deliveries can be halted. In the event that RevGenetics LLC runs out of stock on a specific recurring product, you grant permission to RevGenetics LLC to defer the shipment until the product is back in stock or a suitable alternative has been agreed upon. In cases where a product is discontinued, RevGenetics reserves the right to cancel your Recurring Order. If a Recurring Order is cancelled prior to the receipt of the minimum number of shipments, a correction will be applied to the order to reflect the actual shipping costs and any difference in product pricing between the recurring subscription and the single purchase price. In such cases, a shipping fee of $5.50 or the actual shipping and handling costs, whichever is higher, will be charged for each Recurring Order that was shipped. By making a purchase from RevGenetics, you consent to allow any necessary corrections to be made to your order which may include additional charges or refunds to your payment method. For international transactions, you accept the exchange rates at the time the correction is executed. RevGenetics LLC holds the discretion to modify the Recurring Orders Policy at any time. Customers will be notified of significant changes affecting their subscription. 7. Delayed Orders and Authorized Charges Customers acknowledge that there may be occasional delays in processing orders, shipments, or billing due to various reasons such as backorders, safety assessments, or technical issues. Authorization and Charging: You consent that RevGenetics LLC is authorized to charge your credit card or any payment method on file to rectify an issue, or to facilitate uninterrupted service for recurring orders. This authorization is valid for up to 360 days following the initial order date. Additionally, RevGenetics LLC reserves the right to share pertinent information with credit bureaus to resolve payment issues. Failure of Payment: In cases where a chargeback is initiated, a check is dishonored, or any other payment method fails, the customer is required to settle the account balance within 30 days of the initial purchase date. Failure to do so will incur a monthly finance charge of 10% or the maximum permitted by law. Recovery Fees: Upon initial failure of payment, RevGenetics LLC will impose recovery fees to the amount due. This includes a RevGenetics recovery fee of $35, along with any additional fees levied by merchant services and any legal or collection expenses incurred in the course of recovering the payment. The total amount owed will consist of the original amount, recovery fees, and any accrued finance charges. Rationale for Charges: These fees and charges have been instituted in response to instances where customers have initiated chargebacks following orders that used first-class shipping, which does not provide signature confirmation. As these cases necessitate the involvement of collections agencies and credit bureaus, they generate significant expenses for RevGenetics LLC. These measures are aimed at mitigating fraudulent orders, safeguarding RevGenetics LLC’s interests, and maintaining low costs for our genuine customers. 8. Description of Services Scope: RevGenetics LLC offers various services on this site, which may include, but are not limited to, the sale and distribution of foods, nutritional supplements, health and beauty products and vitamins. The associated fees for these services are detailed under the membership and service fees section on this site. Customer Responsibilities: Customers are solely responsible, at their own expense, for procuring all equipment and services necessary to access and use the services on this site. This includes, but is not limited to, computers, modems, and internet access, along with any associated fees. Modification or Discontinuation: RevGenetics LLC reserves the right, in its sole discretion, to modify, discontinue, or alter any aspects of the site or its services, including features and pricing, at any time and without prior notice. RevGenetics LLC shall not be liable to you or any third party for any modification, suspension, or discontinuation of the site or services. Temporary Interruptions and Third-Party Networks: Customers acknowledge that there may be temporary interruptions in services due to routine maintenance, server downtime, or other factors. Furthermore, RevGenetics LLC does not have control over third-party networks or services that may be accessed in the course of using this site. As such, RevGenetics LLC is not responsible for any delays, disruptions, or other issues that may arise from using third-party networks. AS-IS Basis: The services available on this site are provided on an “AS IS” and “AS AVAILABLE” basis, without warranties of any kind, either express or implied. RevGenetics LLC expressly disclaims any warranties for the security, reliability, timeliness, and performance of the services. The company is not responsible for the timeliness, deletion, mis-delivery, or failure to store any user communications or personalization settings. By using the services, you agree to assume all risks associated with such use, and you expressly agree that RevGenetics LLC will not be liable for any damages arising from your use of or inability to use the services. 9. Registration Data and Privacy Account Creation: To access certain services on this site, you may need to create an account. This involves completing our online registration form, which will require you to provide certain information and data (“Registration Data”). It is imperative that you provide true, accurate, current, and complete information in the Registration Data. You also agree to promptly update this information to ensure it remains current, complete, and accurate. Data Usage: By creating an account, you grant RevGenetics LLC the right to use your Registration Data for the purposes of providing services, processing orders, and improving the overall user experience. Additionally, you authorize RevGenetics LLC to disclose certain Registration Data to third parties, in accordance with our Privacy Policy, for the purposes including but not limited to marketing, analytics, and service improvements. International Transactions and Data Protection: As a global company, RevGenetics LLC may transfer your data across borders, and by using our services you consent to such transfer. However, when dealing with the European Union, we shall comply with the applicable laws and regulations concerning data protection. If you are located in the EU, please be advised that while we strive to protect your privacy, the protection afforded by EU law may not be equivalent in other countries. Privacy Policy: The collection, use, and disclosure of information obtained through your use of this site, including Registration Data, are governed by our Privacy Policy, which is hereby incorporated by reference into these Terms of Use. Limitation of Liability: RevGenetics LLC will not be liable for any indirect, incidental, special, consequential or punitive damages, or any loss of profits or revenues, whether incurred directly or indirectly, arising out of the use or disclosure of your Registration Data. This limitation applies irrespective of whether the damages were foreseeable or whether RevGenetics LLC was advised of the possibility of such damages. 10. Payment of Fees Payment Obligation: If you place an order for a product or service that requires payment, you are obliged to pay all fees associated with such product or service. RevGenetics LLC will bill the credit card you provide. Fees for recurring services are billed in advance. You must provide accurate and complete billing information including a valid credit card, your name, address, and telephone number. You are responsible for informing RevGenetics LLC of any changes to your billing information within seven (7) days of the change. Non-Payment: If your credit card company refuses to authorize payment, RevGenetics LLC reserves the right, at its discretion, to suspend or terminate your subscription to the service. You may be required to pay any overdue amounts through alternative means acceptable to us. Additionally, RevGenetics LLC reserves the right to charge a reinstatement fee for any suspended or terminated accounts. Continued Accrual of Charges: You agree that as long as your subscription is active, you will continue to accrue charges for which you are responsible, regardless of whether you utilize the services. Collection and Legal Actions: In the event that RevGenetics LLC has to take legal action to recover unpaid balances, you agree to reimburse RevGenetics LLC for all expenses incurred in the recovery effort, including but not limited to attorney fees, court costs, and any other legal expenses. Authorization to Employ Collection Measures: You expressly authorize RevGenetics LLC to employ any lawful means necessary to secure payment when a balance is overdue. This includes, but is not limited to, contacting you by telephone, mail, or email, engaging collection agencies, and reporting delinquent payment to credit bureaus. Limitation of Liability and Indemnification: RevGenetics LLC is not liable for any incidental, indirect, consequential, punitive, or special damages of any nature whatsoever arising out of or related to providing or receiving services under these terms. Additionally, you agree to defend, indemnify, and hold harmless RevGenetics LLC and its agents, contractors, officers, directors, shareholders, and employees against any losses, claims, damages, costs, penalties, or expenses (including reasonable attorney’s fees) that may be incurred as a result of your breach of these payment terms. 11. No Medical Advice or Claims Disclaimer: RevGenetics LLC exclusively sells foods and dietary supplements and does not engage in providing medical advice, diagnoses, or any professional healthcare services. The information and content available on this site, including product descriptions and testimonials, are for informational purposes only and should not be construed as medical advice. Consultation with Healthcare Professionals: It is highly recommended that you consult with a qualified healthcare professional prior to using any products available on this site, particularly if you have any underlying health conditions, are pregnant, nursing, or taking medication. You agree not to purchase any food or supplement if you have any illness, without first consulting with your physician. By purchasing our foods or supplements you assure us that you are healthy, have no medical issues and will consult your physician before taking any supplements purchased. Your decision to purchase and consume any products from this site signifies your acknowledgement of the importance of engaging in a discussion with a healthcare professional. Regulatory Compliance: RevGenetics LLC is committed to compliance with the regulations set by the Food and Drug Administration (FDA), the Federal Trade Commission (FTC), the Federal Communications Commission (FCC), and other relevant government agencies. All advertising and product information are consistent with the legal requirements and written government approved guidelines provided by these agencies. RevGenetics LLC does not make any claims that products can diagnose, treat, cure, or prevent any diseases. Limitation of Liability: The content and information on this site, including product descriptions, are provided “AS-IS” without any warranties, either express or implied, including but not limited to, the implied warranties of merchantability, fitness for a particular purpose, or non-infringement. The opinions and information posted on this site are derived from sources believed to be reliable; however, RevGenetics LLC makes no representation or warranty as to their accuracy or completeness. Neither RevGenetics LLC, nor its employees, authors, or associates, shall be held responsible or liable for the accuracy, usefulness, or availability of any information posted on this site. Under no circumstances shall RevGenetics LLC be liable for any loss or damage caused by your reliance on information obtained through this site. 12. Acceptance of Terms and Conditions and Electronic Signatures Explicit Agreement: By accessing and using this site, whether by clicking on any link, button, or other interactive elements, or by engaging in any transactions including completing the registration or shopping process, you are explicitly acknowledging and agreeing to be bound by these Terms and Conditions. This explicit agreement acts as a legal binding contract between you and RevGenetics LLC. Electronic Signature: Your actions, including but not limited to, accessing, clicking, or interacting with any part of this site, and/or providing any information during registration or shopping process, constitute your electronic signature. This electronic signature is equivalent to a written signature as provided under the U.S. ESIGN Act of 2000 and other applicable laws. By engaging in these actions, you affirmatively consent and agree to be bound by these Terms and Conditions. Acknowledgment of Understanding: By using this site, you acknowledge that you have read, understood, and agree to be bound by all the terms and conditions contained herein. If you do not agree with these terms and conditions, you are advised not to use this site or avail any of its services. Verification and Information Accuracy: You are required to provide true, current, and complete information when interacting with this site. If RevGenetics LLC has reasonable grounds to suspect that the information you provided is not current, untrue, or inaccurate, or if there is evidence that these Terms and Conditions have not been complied with, RevGenetics LLC reserves the right to suspend or terminate your access to the site and refuse any and all current or future use of the services (or any portion thereof) at its sole discretion. Indisputable Acceptance: Your access and use of this site is recorded. By engaging with the site, you acknowledge that these records constitute indisputable evidence of your acceptance of these Terms and Conditions. You waive any right to dispute or contest the validity of your agreement to these Terms and Conditions based on your use of the site. 13. Conduct on Site Compliance with Laws and Regulations: Your use of this site must be in strict compliance with all applicable laws, regulations, and community standards. You are solely responsible for the contents of your communications and actions through the site. Prohibited Conduct: By engaging with this site in any manner, including posting information, using any product, webpage, or service, you expressly agree not to engage in the following conduct: • (a) Engage in unlawful, threatening, abusive, harassing, defamatory, libelous, deceptive, fraudulent, invasive of another's privacy, or tortious behavior, or any behavior that violates our rules or policies. • (b) Victimize, harass, degrade, or intimidate any individual or group based on religion, gender, sexual orientation, race, ethnicity, age, or disability. • (c) Infringe on any patent, trademark, trade secret, copyright, right of publicity, or other proprietary rights of any party. • (d) Engage in unauthorized advertising, spamming, or any form of unauthorized solicitation, or any form of lottery or gambling. • (e) Introduce software viruses or any other malicious code that attempts to disrupt, damage, or limit the functioning of any software, hardware, or telecommunications equipment. • (f) Impersonate any person or entity, including any of our employees or representatives. Submit fake, falsified, misleading, or inappropriate data submissions, edits, or removals. • (g) Use, display, mirror, or frame the Services or any individual element within the site, RevGenetics LLC’s name, trademarks, logos, or other proprietary information, or the layout and design of any page or form contained on a page, without RevGenetics LLC’s express written consent. • (h) Access, tamper with, or use non-public areas of the Services, RevGenetics LLC’s computer systems, or the technical delivery systems of RevGenetics LLC’s providers. • (i) Attempt to probe, scan, or test the vulnerability of any RevGenetics LLC system or network or breach any security or authentication measures. • (j) Avoid, bypass, remove, deactivate, impair, descramble, or otherwise circumvent any technological measure implemented by RevGenetics LLC or any of RevGenetics LLC’s providers or any other third party to protect the Services or Content. • (k) Attempt to access or search the Services or Content, or download Content from the Services through the use of any engine, software, tool, agent, or device not provided by RevGenetics LLC or other generally available third-party web browsers. • (l) Extract, scrape, index, copy, or mirror the Services or Content or portions thereof without express written consent. • (m) Use any meta tags or other hidden text or metadata utilizing a RevGenetics LLC trademark, logo, URL, or product name without express written consent. • (n) Forge any TCP/IP packet header or any part of the header information in any email or newsgroup posting, or in any way use the Services or Content to send altered, deceptive, or false source-identifying information. • (o) Attempt to decipher, decompile, disassemble, or reverse-engineer any of the software used to provide the Services or Content. • (p) Interfere with, or attempt to interfere with, the access of any user, host, or network, including, without limitation, sending a virus, overloading, flooding, spamming, or mail-bombing the Services. • (q) Take any action that imposes, or may impose, an unreasonable or disproportionately large load on the Services or RevGenetics LLC’s infrastructure. • (r) Delete, obscure, or in any manner alter any attribution, warning, or link that appears in the Services or the Content. • (s) Use the Services or Content, or any portion thereof, for any commercial or government purpose or for the benefit of any third party in a manner not permitted by these Terms. • (t) Collect or store any personally identifiable information from the Services from other users of the Services without their express permission. • (u) Violate any applicable law. • (v) Encourage or enable any other individual to do any of the preceding. Liability Waiver: RevGenetics LLC is not responsible for the content uploaded or submitted by third-party users. Though not obligated, RevGenetics LLC reserves the right to monitor, edit, or remove content that does not comply with these Terms of Use or is harmful, objectionable, or inaccurate. Termination and Cooperation with Law Enforcement: RevGenetics LLC reserves the right to terminate your membership or access to the site for violating any of the conduct provisions without prior notice. Additionally, RevGenetics LLC will fully cooperate with investigations of violations of systems or network security at other sites, including cooperating with law enforcement authorities in investigating suspected criminal violations. Liquidated Damages: Should you violate these conduct provisions, and RevGenetics LLC incurs any costs, losses or damages, direct or indirect, including but not limited to legal fees, as a result of such violation, you agree to compensate RevGenetics LLC for all such costs, losses or damages. Furthermore, you agree that RevGenetics LLC may seek injunctive relief against you to prevent further violations. 14. Intellectual Property and Advertising Information Copyright © 2019-2024 RevGenetics LLC. All Rights Reserved. For the purpose of these Terms of Use, "content" refers to all information, communications, software, photos, videos, graphics, music, sounds, and other materials and services that can be viewed by users on our site. This includes message boards, chat, and other original content. By accepting these Terms of Use, you acknowledge that all content presented to you on this site is protected by copyrights, trademarks, service marks, patents, or other proprietary rights and laws. The content is the exclusive property of RevGenetics LLC and/or its affiliates. You commit to exercising the utmost care and diligence in utilizing the content. Good Faith Collaboration: Should you identify any issues with the text used in advertising, claims, benefits, labels, statements, or any copy on our website, ads, or text outside of the website, you agree to notify RevGenetics in writing, providing details of the specific text issue, error, and webpage. This must be done in good faith with the intent to allow RevGenetics to rectify the issue within 30 days of notification. Government entities or employees shall notify RevGenetics within 7 days of the initial finding, and provide a reasonable opportunity, not less than 6 months, for corrective actions to be completed if necessary, before initiating any formal action or public report. Recalls: You agree that recalls of products that utilize RevGenetics intellectual property will only be initiated for products that are unsafe or ineffective. Any other action such as the withdrawal of products from the market will only be taken if there is an imminent health risk. Authorized Use: You are only permitted to use the content as expressly authorized by RevGenetics or the specific content provider. Except for a single copy made for personal use only, you may not copy, reproduce, modify, republish, upload, post, transmit, or distribute any documents or information from this site in any form or by any means without prior written permission from RevGenetics or the specific content provider. Unauthorized use of materials may result in legal consequences. Warranties and Infringement: Neither RevGenetics nor its affiliates warrant that your use of materials displayed on or obtained through this site will not infringe the rights of third parties. If any party believes that content posted on this site infringes on any patent, trademark, trade secret, copyright, right of publicity, or other proprietary rights of any party, they should follow the procedures described in the "Claims of Infringement" section below. Trademarks: All custom graphics, icons, logos, and service names are registered trademarks, trademarks, or service marks of RevGenetics or its affiliates. All other trademarks or service marks are the property of their respective owners. These Terms of Use do not grant you any rights to use any trademark, service mark, logo, and/or the name of RevGenetics or its affiliates without express written consent. 15. User's Materials Subject to our Privacy Policy, any communication or material transmitted to this site or to us, via electronic mail or other means, will be deemed non-confidential and non-proprietary. Although you retain all rights in such communications or material, you grant RevGenetics and its authorized sublicensees an irrevocable, royalty-free, perpetual, and worldwide license to use, copy, distribute, display, perform, publish, translate, adapt, modify, and otherwise utilize such material for any purpose, irrespective of the form or medium (whether known now or developed later). To safeguard RevGenetics interests, do not submit confidential or proprietary information unless there is a mutual written agreement to the contrary. Furthermore, RevGenetics does not accept unsolicited ideas or proposals, so please refrain from submitting them under any circumstances. RevGenetics respects intellectual property rights and expects the same from you. If you or any user of this site believes that a posting on this site infringes upon copyright, trademark, or other property rights, please send notification to our Designated Agent immediately, adhering to the Digital Millennium Copyright Act, 17 U.S.C. Sec. 512(c). Notification must include: a. A physical or electronic signature of an authorized representative of the owner of the exclusive right that is allegedly infringed. b. Identification of the copyrighted work claimed to have been infringed. c. Contact information for the complaining party, such as an address, telephone number, and email address. d. Identification of the material that is claimed to be infringing with information to locate the material. e. A statement expressing a good faith belief that the material’s use is unauthorized by the copyright owner, agent, or law. f. A statement, under penalty of perjury, that the information in the notification is accurate and the complaining party is authorized to act on behalf of the owner of the exclusive right that is allegedly infringed. Recourse: Following receipt of a notice of a claim of copyright infringement, RevGenetics may promptly remove the identified materials from our site without any liability. The complaining party and the party that originally posted the materials will be subject to legal scrutiny and possible actions by the United States Copyright Office as provided in the Digital Millennium Copyright Act. Designated Agent for Claimed Infringement: ℅ Anthony Loera RevGenetics, LLC 16782 SW 88th St #357 Miami, FL 33196 www.revgenetics.com Limitation on Liability: In no event shall RevGenetics be liable to you or any third party for any indirect, consequential, exemplary, incidental, special, or punitive damages, including lost profits, arising from your use of the materials or content, even if RevGenetics has been advised of the possibility of such damages. 16. Warranty Disclaimer DISCLAIMER OF WARRANTIES: ALL MATERIALS, PRODUCTS, AND SERVICES ON THIS SITE ARE PROVIDED ON AN “AS IS” AND “AS AVAILABLE” BASIS WITHOUT WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED. REVGENETICS DISCLAIMS ALL WARRANTIES, EXPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, TITLE, AND NON-INFRINGEMENT. REVGENETICS DOES NOT REPRESENT OR WARRANT THAT MATERIALS, PRODUCTS, OR SERVICES ON THIS SITE ARE ACCURATE, COMPLETE, RELIABLE, CURRENT, OR ERROR-FREE. REVGENETICS MAKES NO WARRANTY THAT (a) THE MATERIALS, PRODUCTS, AND SERVICES WILL MEET YOUR REQUIREMENTS; (b) THE MATERIALS, PRODUCTS, AND SERVICES WILL BE UNINTERRUPTED, TIMELY, SECURE, OR ERROR-FREE; (c) THE RESULTS THAT MAY BE OBTAINED FROM THE USE OF THE MATERIALS, PRODUCTS, OR SERVICES WILL BE EFFECTIVE, ACCURATE, OR RELIABLE; OR (d) THE QUALITY OF ANY MATERIALS, PRODUCTS, SERVICES, OR INFORMATION PURCHASED OR OBTAINED BY YOU FROM THE SITE WILL MEET YOUR EXPECTATIONS OR BE FREE FROM MISTAKES, ERRORS, OR DEFECTS. NO RELIANCE: THIS SITE MAY CONTAIN TECHNICAL MISTAKES, INACCURACIES OR TYPOGRAPHICAL ERRORS. REVGENETICS RESERVES THE RIGHT TO MAKE CHANGES TO THE MATERIALS AND SERVICES AVAILABLE ON THIS SITE, INCLUDING THE PRICES AND DESCRIPTIONS OF ANY PRODUCTS, AT ANY TIME WITHOUT PRIOR NOTICE. REVGENETICS DOES NOT WARRANT THAT THE MATERIALS, PRODUCTS, AND SERVICES AT THIS SITE WILL BE UP TO DATE, AND REVGENETICS MAKES NO COMMITMENT TO UPDATE SUCH MATERIALS OR SERVICES. ASSUMPTION OF RISK: YOU ASSUME TOTAL RESPONSIBILITY AND RISK FOR YOUR USE OF THIS SITE, PRODUCTS, SERVICES, AND ANY THIRD PARTY WEBSITES, PRODUCTS OR SERVICES. YOUR USE OF THIS SITE AND ANY MATERIALS PROVIDED THROUGH THE SITE ARE ENTIRELY AT YOUR OWN RISK. REVGENETICS SHALL NOT BE LIABLE FOR ANY DAMAGES OF ANY KIND RELATED TO YOUR USE OF THIS SITE. COMMERCIAL TRANSACTIONS: YOU ACKNOWLEDGE THAT ALL TRANSACTIONS RELATING TO ANY MERCHANDISE OR SERVICES OFFERED BY ANY PARTY, INCLUDING, BUT NOT LIMITED TO THE PURCHASE TERMS, PAYMENT TERMS, WARRANTIES, GUARANTEES, MAINTENANCE AND DELIVERY TERMS RELATING TO SUCH TRANSACTIONS, ARE AGREED TO SOLELY BETWEEN THE SELLER OR PURCHASER OF SUCH MERCHANDISE AND SERVICES AND YOU. REVGENETICS MAKES NO WARRANTY REGARDING ANY TRANSACTIONS EXECUTED THROUGH, OR IN CONNECTION WITH THIS SITE, AND YOU UNDERSTAND AND AGREE THAT SUCH TRANSACTIONS ARE CONDUCTED ENTIRELY AT YOUR OWN RISK. ANY WARRANTY THAT IS PROVIDED IN CONNECTION WITH ANY PRODUCTS, SERVICES, MATERIALS, OR INFORMATION AVAILABLE ON OR THROUGH THIS SITE FROM A THIRD PARTY IS PROVIDED SOLELY BY SUCH THIRD PARTY, AND NOT BY REVGENETICS OR ANY OF ITS AFFILIATES. OPINIONS AND STATEMENTS: Content available through this site often represents the opinions and judgments of an information provider, site user, or other person or entity not connected with RevGenetics. RevGenetics does not endorse, nor is it responsible for the accuracy, reliability, or completeness of any opinion, advice, or statement made by anyone other than an authorized RevGenetics spokesperson speaking in his/her official capacity. Please refer to the specific editorial policies posted on various sections of this site for further information, which policies are incorporated by reference into these Terms of Use. 17. Limitation of Liability EXCLUSIVE REMEDY: In the event that you have any grievance, claim or cause of action arising out of or relating to these Terms of Use or your utilization of this site, you concur that your exclusive remedy will be limited to the direct damages you actually incur, not to exceed the total amount paid by you to RevGenetics for the products or services on this site during the three (3) month period immediately preceding the date on which the claim arose. NO INDIRECT DAMAGES: TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAW, IN NO EVENT SHALL REVGENETICS OR ITS AFFILIATES, OR THEIR RESPECTIVE OFFICERS, DIRECTORS, EMPLOYEES, OR AGENTS BE LIABLE FOR ANY SPECIAL, PUNITIVE, EXEMPLARY, INCIDENTAL, INDIRECT, OR CONSEQUENTIAL DAMAGES WHATSOEVER, INCLUDING, BUT NOT LIMITED TO, DAMAGES FOR PERSONAL INJURY, DEATH, LOSS OF REVENUES, LOSS OF USE, LOSS OF DATA, LOST PROFITS, OR BUSINESS INTERRUPTION, WHETHER BASED IN CONTRACT, TORT, NEGLIGENCE, PRODUCT LIABILITY, OR OTHERWISE, ARISING OUT OF OR IN ANY WAY CONNECTED WITH THE USE OR PERFORMANCE OF THIS SITE, OR ANY THIRD-PARTY SITES REFERENCED OR LINKED TO FROM THIS SITE, EVEN IF REVGENETICS, OR ANY OF ITS AFFILIATES HAVE BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. THIRD-PARTY GOODS AND SERVICES: REVGENETICS SHALL NOT BE LIABLE FOR ANY THIRD-PARTY GOODS AND SERVICES OFFERED THROUGH THIS SITE OR FOR ASSISTANCE IN CONDUCTING COMMERCIAL TRANSACTIONS THROUGH THIS SITE, INCLUDING WITHOUT LIMITATION THE PROCESSING OF ORDERS. ANY DEALINGS WITH THIRD PARTIES (INCLUDING ADVERTISERS) INCLUDED WITHIN OR AVAILABLE THROUGH A LINK ON THE REVGENETICS WEBSITE ARE SOLELY BETWEEN YOU AND THE THIRD PARTY (INCLUDING ISSUES RELATED TO THE CONTENT OF THIRD PARTY ADVERTISEMENTS, PAYMENTS, DELIVERY OF GOODS, WARRANTIES, PRIVACY AND DATA SECURITY, AND THE LIKE). REVGENETICS IS NOT RESPONSIBLE FOR ANY DAMAGES OR LOSSES CAUSED OR ALLEGED TO HAVE BEEN CAUSED BY YOUR DEALINGS WITH THESE THIRD PARTIES. APPLICABLE LAW: Some jurisdictions do not allow the exclusion or limitation of liability for certain damages, so the above limitations may not apply to you. In such jurisdictions, RevGenetics liability shall be limited to the greatest extent permitted by law. 18. INDEMNIFICATION IMPORTANT NOTICE: BY ACCESSING, USING, OR PURCHASING ANY PRODUCT FROM THIS WEBSITE, OR ANY OF OUR PRODUCTS OR SERVICES, YOU AGREE TO BE BOUND BY THE FOLLOWING INDEMNIFICATION TERMS WHICH ARE CRUCIAL FOR THE LEGAL PROTECTION OF REVGENETICS AND ASSOCIATED PARTIES: 1. Indemnity Obligations: You agree to indemnify, defend, and hold harmless RevGenetics, its agents, affiliates, contractors, officers, directors, shareholders, employees, representatives, licensors, suppliers, and any third-party information providers (collectively, the “Protected Parties”) from and against any and all liabilities, claims, damages, losses, costs, penalties, and expenses, including reasonable attorney's fees, arising out of or in connection with your use or misuse of this website, products, or services, any violation of these Terms of Use, or any activity related to your account (including, but not limited to, negligent or wrongful conduct), whether such activity is undertaken by you or any other person accessing the site using your account. 2. Reservation of Rights: RevGenetics reserves the right, at its own expense, to assume the exclusive defense and control of any matter otherwise subject to indemnification by you. You agree to cooperate with RevGenetics in asserting any available defenses and in providing all necessary information, assistance, and authorizations required for the defense of any claim or action. 3. Notice of Claims: Upon becoming aware of any claim, action, or proceeding that may give rise to indemnification obligations under these Terms of Use, you must promptly notify RevGenetics in writing a the contact address provided, and provide all relevant information. Failure to provide timely notice shall not relieve you of your indemnification obligations unless such failure materially prejudices RevGenetics ability to defend against the claim. 4. Waiver of Consequential Damages: TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, YOU HEREBY WAIVE AND RELEASE ANY AND ALL CLAIMS AGAINST THE PROTECTED PARTIES FOR CONSEQUENTIAL, INCIDENTAL, SPECIAL, EXEMPLARY, PUNITIVE, OR INDIRECT DAMAGES, INCLUDING LOST PROFITS, ARISING FROM OR IN CONNECTION WITH YOUR USE OF THIS WEBSITE, PRODUCTS, OR SERVICES. 19. AGREEMENT TO ARBITRATE You and RevGenetics, including its affiliates, agree that any dispute, claim, or controversy arising out of or relating to these Terms, products, services, or materials, or the breach, termination, enforcement, interpretation, or validity thereof (collectively, “Disputes”) will be resolved through binding arbitration. A. Exception for "IP Protection Action": RevGenetics reserve the right, however, to seek injunctive or other equitable relief in a court of competent jurisdiction to prevent the actual or threatened infringement, misappropriation, or violation of a party’s copyrights, trademarks, trade secrets, patents, User Content, Personal License, Commercial License, Government actual or threatened work stoppage or other intellectual property rights (the action described in this statement is defined as “IP Protection Action”). The exclusive jurisdiction and venue of any IP Protection Action shall be the state and federal courts located in the Miami-Dade County of Florida, and each of the parties hereto waives any objection to jurisdiction and venue in such courts. B. Waiver of Right to Participate in Class Action: You and RevGenetics each waive any right to participate to a civil trial, trial by jury, bench trial, summary trial, criminal trial, military trial, international trial, government administrative proceedings, civil enforcement trials or to participate as a plaintiff or class member in any purported class action or representative proceeding. C. Arbitration Rules: Any Dispute shall be resolved through binding arbitration in accordance with the rules of net-ARB.com. Costs of arbitration shall be borne by the user initially and may later be apportioned by the arbitrator. D. Arbitration Process: To initiate arbitration, a written Demand for Arbitration must be sent by email. The parties will contact net-ARB.com to commence the process. If net-ARB.com refuses the case or if the parties cannot agree on initiating arbitration within seven (7) days, RevGenetics will select a new arbitration service within 90 days of the refusal and proceed with arbitration. E. Arbitrator’s Decision: The arbitrator’s decision will be final and binding. Judgment on the award may be entered in any court with jurisdiction. The arbitrator must abide by the limitations set forth in the “Limitation of Liability” section concerning types and amounts of damages. The arbitrator may award declaratory or injunctive relief only in favor of the claimant and only to the extent necessary to provide relief warranted by the claimant’s individual claim. The exclusive jurisdiction and venue of any arbitration action will be located in the Miami-Dade County of Florida, within the USA and each of the parties hereto waives any objection to jurisdiction and venue in such courts. F. Failure to Appear: If you fail to appear at the arbitration, an automatic decision will be rendered in favor of RevGenetics for the full amount alleged in its Initial Dispute Statement and any fees incurred for initiating the Arbitration. 20. LIMITATION OF ACTION IMPORTANT: By using this website, or by purchasing or using any products, materials, or services from RevGenetics, you agree to the following limitations on bringing a claim: A. Time Limit for Bringing a Claim: Notwithstanding any applicable statutes or laws to the contrary, you agree that any claim or cause of action arising out of or related to these terms, any agreement with RevGenetics, or your use of this site, products, materials, or services, must be commenced within one (1) year after the cause of action accrues, consistent with the Agreement to Arbitrate section. Any claim not brought within this one (1) year period shall be forever barred. B. No Waiver: RevGenetics failure to exercise or enforce any right or provision of these Terms does not constitute a waiver of such right or provision in that or any other instance. C. Limitation of Actions for RevGenetics: Any claims that RevGenetics may have against you or any third party arising out of these terms or any related agreement, must be filed within the statute of limitations applicable under the governing law. Failure to file within this period will result in the claim being forever barred. 21. GOVERNING LAW IMPORTANT: The following section governs the legal jurisdiction and laws that will apply to any disputes arising from your use of this website, communications or any products or services purchased from RevGenetics: A. Control and Operation: This site, excluding any linked sites, is controlled and operated by RevGenetics from its offices within the State of Florida, United States of America. The site can be accessed from all 50 states in the United States, as well as other countries worldwide. B. Applicable Law: By accessing this site, you and RevGenetics agree that the statutes and laws of the State of Florida, United States of America, without regard to its conflict of laws principles, will govern all matters relating to the use of this site and any transactions, including the purchase of products and services through this site. C. International Users: If you are accessing this site from outside the United States, you are responsible for compliance with your local laws. RevGenetics makes no representation that materials on this site are appropriate or available for use in locations outside the United States. D. Jurisdiction and Venue: In the event that the Agreement to Arbitrate is held to be unenforceable or if it does not apply to the dispute, you agree and hereby submit to the exclusive personal jurisdiction and venue of the District of Miami-Dade County and the United States District Court for the Southern District of Florida with respect to such matters. This submission is intended to be mandatory and not permissive. The application of the United Nations Convention on Contracts for the International Sale of Goods is expressly excluded. 22. ENTIRE AGREEMENT AND AMENDMENT IMPORTANT: The following section establishes the entirety of the agreement between you and RevGenetics regarding your use of this site and any transactions you engage in through this site. A. Entirety of Agreement: These terms and conditions, along with any other policies or guidelines referenced herein, constitute the entire agreement and understanding between you and RevGenetics concerning the subject matter hereof and supersede all prior oral or written agreements, representations, or understandings between you and RevGenetics. There are no representations, agreements, arrangements, or understandings, oral or written, between or among you and RevGenetics relating to the subject matter of this agreement which are not fully expressed herein. B. Non-Alteration: These Terms of Use may NOT be altered, supplemented, or amended by the use of any other document(s), verbal agreements, or written communication. Any attempt to alter, supplement, or amend this document, or to enter an order for products or services which are subject to additional or altered terms and conditions, shall be null and void, unless expressly agreed to in a written agreement executed by an authorized representative of RevGenetics. C. Conflict Resolution: To the extent that anything in or associated with this site, including but not limited to, advertisements, promotions, or communications is in conflict or inconsistent with these Terms of Use, these Terms of Use shall take precedence, and such conflicting or inconsistent materials should be disregarded. D. Amendment by RevGenetics: RevGenetics reserves the right to modify or amend these Terms of Use at any time without notice. Such modifications shall be effective immediately upon posting on this site. Your continued use of this site after such modifications are posted shall be deemed to constitute acceptance by you of such modifications. 23. MISCELLANEOUS IMPORTANT: The following provisions pertain to additional rights and responsibilities between you and RevGenetics. A. Enforcement and Attorney's Fees: In any action or proceeding to enforce or interpret these Terms of Use, the substantially prevailing party will be entitled to recover its reasonable costs and attorney’s fees, expert witness fees, and other costs of litigation or arbitration from the other party. B. Non-Assignable: You may not assign, transfer, or delegate your rights and obligations under these Terms of Use to any third party without the prior written consent of RevGenetics. Any unauthorized attempt to do so shall be null and void. RevGenetics may freely assign or transfer its rights and obligations under these Terms of Use. C. Force Majeure: RevGenetics shall not be liable for any failure or delay in the performance of its obligations hereunder arising out of or caused, directly or indirectly, by circumstances beyond its reasonable control, including, without limitation, acts of God; earthquakes; fires; floods; wars; civil or military disturbances; terrorism; acts of government; labor disputes; pandemics; network issues; interruptions in transportation; inability to secure necessary materials or resources; accidental loss or malicious actions by third parties, or any similar or dissimilar cause. Time for performance of any such obligation will be extended for the time period lost by reason of the delay. D. Severability: If any section or provision of these Terms of Use is found to be unlawful, void, or for any reason unenforceable, then that section or provision shall be deemed severable from these Terms and shall not affect the validity and enforceability of any remaining provisions. Such section or provision will be replaced with a valid and enforceable provision which achieves, as far as possible, the original objectives and intent of the parties as reflected in the original section or provision. E. No Waiver: Any failure by RevGenetics to enforce or exercise any provision of these Terms of Use or related rights shall not constitute a waiver of that right or provision, nor shall it affect the validity of any part of these Terms, or the right of RevGenetics thereafter to enforce each and every provision. 24. Contact Information If you have any additional questions or concerns about these terms and conditions, please feel free to contact us any time through this website or at RevGenetics, 16782 SW 88th St #357 Miami, FL 33196, USA II. COMMERCIAL RESEARCH IP & AFFILIATE TERMS OF USE For purposes of our Affiliates Terms of Use, Commercial Intellectual Property, Government contracts, Government commercial use and research material purchases, the above sections are hereby incorporated by reference in addition to the following terms: 1. Commercial Use License The following terms apply to any individual, company, government or entity (hereafter "Affiliate") using any materials, products, or services ("Work") accessible on this site, or in communications exceeding the limitations of the Personal Use License (Section 14), or committing any action listed in the prohibited uses (Section 13). By conducting any such activities, the Affiliate implicitly agrees to purchase a Commercial Use License from RevGenetics, which grants a revocable, non-exclusive, non-transferable license to access, view, and use one copy of the Work for commercial purposes. The Commercial Use License is contingent upon full adherence to these terms. If you are a government employee and you violate the Antideficiency Act, you will personally be responsible for any expenses that may result on top of criminal charges. This includes any commercial use of work, as stated in this section. Government employees that do not have contracting authority agree to the full TOS, assume personal liability for all commercial licenses and indemnifications in this agreement. Federal law allows fines of up to $75,000 for the first violation and $150,000 for additional ADA violations. States and local governments may allow additional fines. Each instance of a Work or its separate image is subject to a unique Commercial Use License. Consequently, multiple commercial uses of various Works or distinct images of the same Work necessitate the purchase of multiple Commercial Use Licenses, one license per use or image. In essence, any usage that potentially or demonstrably impacts RevGenetics adversely, infringes local laws, DMCA, or any regulation, even if the license is subsequently revoked, will be considered a purchased Commercial Use License. The Affiliate agrees to remit the licensing fee and any additional late charges, irrespective of RevGenetics legal actions under state or federal law. The term of the Commercial Use License commences on the date the Affiliate first uses the Work beyond the Personal Use License's scope, and continues until the one-year anniversary of the initial usage. This license renews automatically for successive one-year terms, unless the Affiliate notifies RevGenetics in writing, to the contact address provided, of their intent to discontinue, at least sixty (60) days before the term expiration. To this end, contact the copyright holder via email at anthony@revgenetics.com. In your email, please specify the particular Work(s) to be licensed, including its/their URL(s) on this website, products, or services, and the particular use(s) to which you will put the Licensed Work(s), including URL(s) where the Work(s) will be located, where applicable. We will, in response to your email, provide you with wire instructions to be used when making all payments. Note, however, that RevGenetics reserves the right to terminate the Commercial Use License at any point, following the procedures outlined in these Terms. The licensing fee, US$10,000.00 per Commercial Use License, is payable via bank wire at least two (2) days before the initial usage and ten (10) business days before any renewal. A late fee of US$150,000.00 is applicable if the payment isn't received within the stipulated time frame. This fee isn't prorated for partial use within the licensing term, and no refunds are issued for unused periods within the term. 2. Affiliate of RevGenetics Affiliates signing up through the link (https://revgenetics.kickbooster.me/boost) are granted a temporary, performance-based Commercial Use License. This license allows the use of one copy of the Work for affiliate marketing purposes, subject to sales reaching or exceeding $1 per month. Under this arrangement, the Affiliate must generate unique content and may not duplicate any copyrighted material from RevGenetics website or communications. If the Affiliate fails to meet the minimum sales requirement, or uses more content or images than permitted, RevGenetics reserves the right to revoke the Commercial Use License immediately. Following termination, the Affiliate has a 14-day period to cease all usage of RevGenetics Works and content. To remove your affiliation in Kickbooster, login using your affiliate username and password in kickbooster (https://kickbooster.me), then go to your account settings (https://kickbooster.me/booster_admin/account_settings) and click "Remove account" on the account settings page. After this grace period, failure to comply will result in the application of standard commercial licensing fees as per Section 18. RevGenetics may terminate any Commercial Use License granted upon ten (10) days’ written notice for performance issues or violations of RevGenetics or additional Kickbooster terms to which the Affiliate assented during the sign-up process via the Kickbooster link. RevGenetics reserves the right to pursue all available legal remedies and compensation for losses in the event of unauthorized use of the Work or breach of these Terms, including but not limited to, damages, injunctive relief, attorneys’ fees, and costs. Furthermore, the Affiliate agrees to indemnify, defend and hold harmless RevGenetics from and against any and all claims, liabilities, damages, losses, costs, expenses, or fees (including reasonable attorneys’ fees) that such parties may incur as a result of or arising from the Affiliate’s violation or breach of any representation or obligation under these Commercial Use License terms. 3. Severability and Modification Clause If any section of a provision of these Terms of Use is found to be unlawful, void, or for any reason unenforceable, then that section of the provision shall be deemed severable from these Terms and shall not affect the validity and enforceability of any remaining provisions. Such section of the provision will be replaced with a valid and enforceable section which achieves, as far as possible, the original objectives and intent of the parties as reflected in the original provision, or In the event that any provision of this Agreement is rendered invalid or unenforceable due to a Change in Legislation, Public Policy Concerns, assertion of Sovereign Immunity, National Security or Emergency measures, or Political Changes (collectively, “Governmental Actions”), such provision shall be modified to the extent necessary to render it valid and enforceable in a manner that, to the extent possible, effectuates the original intent of the parties. In all occasions, it is the responsibility of the Affiliate who is a Government employee that has contracting authority to agree to the full TOS, to inform RevGenetics in writing within 24 hours of receiving the mandate or requirement. Such notice shall include a detailed description of the mandate or requirement, along with a contact person in the issuing authority. In cases where modification is not possible or if such Governmental Actions conflict with the fundamental premises of this Agreement, the provision shall be severed, and the rest of the Agreement shall remain in full force and effect. Affiliate agrees in good faith to the following regarding a Government Actions conflict: Change in Legislation: If new laws or regulations are enacted that conflict with the terms of this Agreement, the parties agree to renegotiate the affected terms in good faith to ensure compliance with the new legal framework. Public Policy Concerns: In the event that a provision of this Agreement is deemed contrary to the public interest or policy, the parties agree to modify or sever the said provision while endeavoring to preserve the original intent and economic balance of the Agreement. Sovereign Immunity: In the case of an assertion of Sovereign Immunity by the government, the parties agree that an impartial review by a third-party legal expert shall be sought to determine the legitimacy and applicability of such assertion in relation to this Agreement. National Security or Emergency: Should the government contravene any provision of this Agreement on the grounds of National Security or Emergency, the government shall provide prompt written notice to the Company, and the parties shall engage in good faith negotiations to modify the Agreement as necessary. Political Changes: If Political Changes result in a shift in policy that renders any provision of this Agreement unenforceable or contrary to the new policy, the parties agree to engage in good faith negotiations to adapt the Agreement to the new political landscape while attempting to preserve the original intent. 4. Dispute Resolution and Governing Law In the event of disputes arising from or related to Governmental Actions affecting this Agreement, the parties agree to resolve such disputes through arbitration in accordance with the General principles of equity and common law. Any Governmental Actions affecting this Agreement, shall be settled by binding arbitration in accordance with the rules of net-ARB.com. The costs of arbitration shall be shared equally between the parties. The arbitrator's decision will be binding and may not be appealed. A judgment of a court having jurisdiction may be entered upon the arbitrator's award. The arbitration proceedings shall be conducted in English and governed by the common law net-ARB rules (net-arb.com). These Terms and any action arising or related to the Commercial Use License shall be governed by the laws of the state where RevGenetics LLC is headquartered, without regard to or application of its conflict of law provisions. 5. Contact Information For inquiries or concerns regarding the Commercial Use License, please contact RevGenetics through anthony@revgenetics.com. 6. Comprehensive Protection of RevGenetics RevGenetics and any other party involved in creating, producing, or delivering the products, services or content, shall not be held liable for any indirect, incidental, special, punitive, exemplary, or consequential damages, including but not limited to, lost profits, loss of data, or goodwill, service interruption, computer damage, system failure or the cost of substitute services under any circumstances. In the case where any liability is imposed by a court, tribunal, or arbitration panel, notwithstanding the foregoing, under no circumstances shall RevGenetics’ aggregate liability exceed the total fees paid by you to RevGenetics for the services or products in question. RevGenetics shall be entitled to seek indemnification from you for any losses, costs, expenses, and damages incurred as a result of your breach of these Terms or any unlawful or unauthorized use of the services or content. 7. Expedited and Binding Arbitration for Commercial Use Licensing Disputes For any disputes arising under Commercial Use Licenses, RevGenetics reserves the right to submit an Initial Dispute Statement to you within fifteen (15) years from the date of the first use that exceeds the limitations of a Personal Use License. Should no resolution be achieved within ten (10) days of submission of the Initial Dispute Statement, RevGenetics is entitled to expedited arbitration. The arbitration shall be final and binding. The arbitrator shall be empowered to grant RevGenetics any relief, including injunctive relief and recovery of all costs and fees incurred in enforcing its rights under the Commercial Use License. RevGenetics reserves the right to select the forum and rules for arbitration and may, at its sole discretion, lower the amount of payment fee(s) owed on each Commercial Use License purchased. 8. Appointment of RevGenetics as Attorney-In-Fact If content or products that fall within the specification of a Commercial Use License are provided to a third party or site not under your direct control, you hereby appoint RevGenetics, Anthony Loera, or one of his assigns, as your true and lawful attorney-in-fact, to act in your name, place, and stead, to contact the third party to discuss, retract, negotiate, delete and/or erase such content or product related items, and to access your information for this purpose. You agree to be held liable for all legal damages, legal fees, arbitration fees, indirect damages, punitive, exemplary or consequential damages incurred by RevGenetics, its authors, officers, agents, and employees as a result of any unauthorized use or distribution of content or products covered by a Commercial Use License. This liability includes, but is not limited to, the costs associated with enforcing RevGenetics’ rights under the Commercial Use License. RevGenetics reserves the right to calculate such liabilities on a monthly basis and to submit them for arbitration under the terms described herein. As a protective measure, it is highly advisable to seek permission from RevGenetics prior to any use or dissemination of content or products. RevGenetics is amenable to discussions and open to granting permissions for the review and sharing of information when appropriately requested. 9. Comprehensive Confidentiality Release RevGenetics operates in the public domain, educating and informing customers about products, ingredients, and scientific advancements. By accepting these terms, you grant an irrevocable and unrestricted license to RevGenetics to use, publish, and disclose any information, including Proprietary Information, which holds substantial commercial value to you or the companies you represent including those presented to RevGenetics in any communications electronic or otherwise. Proprietary Information includes but is not limited to trade secrets as defined by the Uniform Trade Secrets Act, processes, production and distribution methods, equipment and systems, supply chain relationships, product specifications, samples, business plans, data analysis, software, inventions, technical know-how, improvements, copyrightable materials, schematics, and any other technical, business, financial, marketing, and product development plans, forecasts, strategies, and information. This agreement supersedes any prior agreements or contracts between you, the companies you represent, or their affiliates, and RevGenetics or its representatives. By accepting these terms, you release and indemnify RevGenetics and its representatives from any liability or claim arising from disclosure of Proprietary Information. The exclusive remedy for any dispute concerning this clause shall be arbitration, with the combined maximum remedy capped at $10 annually. 10. Extensive Claims Release In the spirit of fostering transparency and knowledge sharing, you and the companies you represent hereby release RevGenetics LLC, Anthony Loera, and RevGenetics from all claims, demands, and damages arising from or related to the manufacture, sale, marketing, commentary, or use of a product prior to the effective date of your acceptance of these terms. This release extends to claims involving copyright, trademark, trade dress, royalty, and patent disputes. By accepting these terms, you acknowledge that arbitration shall be the sole and exclusive remedy for any disputes arising under this clause. The cumulative total of remedies obtainable through arbitration shall be limited to $10 per year. Furthermore, should you or the companies you represent initiate any claim or legal action against RevGenetics in contravention of this clause, you agree to reimburse RevGenetics for all legal fees, costs, and expenses associated with defending such claim or action. If any part of this provision is found to be unlawful, void, or for any reason unenforceable, then that section of the provision shall be deemed severable from these Terms and shall not affect the validity and enforceability of any remaining provisions. Such section of the provision will be replaced with a valid and enforceable section in this provision which achieves, as far as possible, the original objectives and intent of the parties as reflected in the original provision. 11. User Content Licensing and Indemnification RevGenetics is dedicated to providing quality information, products, and services. Upon communication through email, phone call, or other means regarding content that is or is not copyrighted, trademarked, or patented (“User Content”), you grant RevGenetics an all-encompassing, non-exclusive, perpetual, irrevocable, transferable, sublicensable, worldwide, royalty-free license to use, copy, modify, create derivative works, publicly display, publicly perform, use in marketing, manufacturing, and sales, and distribute the User Content through RevGenetics Services or in the creation of new products. You represent and warrant that you hold the necessary ownership or authorization to the User Content and have the legal authority to grant this license. You affirm that the use of your User Content by RevGenetics will not infringe, misappropriate, or violate a third party’s intellectual property rights, publicity or privacy rights, or contravene any applicable law or regulation. A. User Content and General Indemnification You agree to indemnify, defend, and hold harmless RevGenetics, Anthony Loera, and their affiliates, agents, and employees from any claim, liability, loss, damage, cost, or expense (including reasonable legal fees) arising out of or related to your User Content. This includes, but is not limited to, third-party intellectual property rights claims, governmental actions, and damages related to bodily injury or property loss. If required, this agreement serves as an interim license until a formal written Intellectual Property license is provided, with the maximum fee for the written license being One Dollar ($1). This indemnification applies regardless of negligence or wrongdoing on your part. FURTHERMORE YOU UNDERSTAND AND ACKNOWLEDGES THAT THIS HOLD HARMLESS AND INDEMNIFICATION CLAUSE REQUIRES THAT YOU INDEMNIFY REVGENETICS AND AGREE THAT REVGENETICS, ITS AUTHORS, ITS OFFICERS, REPRESENTATIVES, AFFILIATES, AGENTS, AND EMPLOYEES BE INDEMNIFIED AND HELD HARMLESS FOR ANY AND ALL LIABILITY, CLAIMS, COSTS (INCLUDING REAONABLE ATTORNEY's FEES), SUITS, CAUSES OF ACTION, ENFORCEMENTS, JUDGMENTS OR DAMAGES SUSTAINED BY REVGENETICS, ITS AUTHORS OR ANY OTHER PERSON OR PERSONS FOR BODILY INJURY, GOVERNMENT ACTIONS AND FOR INJURY TO OR LOSS OF PROPERTY RESULTING FROM, CAUSED BY OR ARISING OUT OF THE CONDUCT OF THE THIRD PARTY ORGANIZATION, REGULATIONS, MANUFACTURING, USE, INCLUDING AND NOT LIMITED TO THE ISSUES ARISING FROM THE HOLDERS OF THE COPYRIGHT, TRADEMARK, OR PATENTS THAT ARE LICENSED PER THIS CLAUSE. THIS INDEMNIFICATION SHALL APPLY REGARDLESS OF WHETHER SUCH LOSSES, DAMAGES, LIABILITIES, COSTS, AND EXPENSES ARE CAUSED BY THE INDEMNIFYING PARTY'S NEGLIGENCE OR WRONGDOING. YOU AGREE THAT ARBITRATION WILL BE YOUR ONLY REMEDY FOR ANY DISPUTE REGARDING THIS RELEASE AND THAT THE LIMIT OF SUCH REMEDIES TO YOUR FAVOR WILL BE A COMBINED MAXIMUM OF $200 PER YEAR FOR ALL THE TYPES OF DISPUTES DESCRIBED AND ARE REQUIRED TO HOLD THE DISPUTES AS CONFIDENTIAL AND OMMITED FROM THE PUBLIC RECORD AND ALL DOCUMENTS GENERATED AS TRADE SECRETS. 12. Special Power of Attorney You hereby grant RevGenetics’ designated legal counsel or accountant a special power of attorney to affix your legal name on any document pertinent to a refund, claim, or disbursement. In cases of arbitration, settlement, or judgment, if you are unavailable, RevGenetics’ legal counsel or accountant is authorized to endorse your name on checks, drafts, or other documents related to the recovery and deposit the net recovery in a RevGenetics account or an Attorney trust account until you are available. 13. RevGenetics Rights Preservation Failure by RevGenetics to enforce any provision of these Terms shall not constitute a waiver of such provision. Any waiver shall only be effective if in writing and signed by an authorized representative of RevGenetics. Except as expressly set forth in these Terms, the exercise by either party of any remedies under these Terms will be without prejudice to other remedies under these Terms or otherwise. 14. Research Material Products RevGenetics offers specialized research materials, which may be labeled as "Dietary Supplements," "Research Material," or "For Research Only." You acknowledge and agree to the following: a. By using or opening any products labeled as outlined above, or by employing these products for scientific purposes, you affirm that these products are being provided to you by RevGenetics for research purposes only and are not meant for any other use. b. RevGenetics shall be cited as a co-contributor in any patent application or named as the source of materials in any research publication or disclosure resulting from the use of the research materials procured from RevGenetics. In the event of any disagreement relating to this clause, arbitration shall be the sole avenue for resolving such disputes, capped at a maximum compensation of $10 per year. 15. Existing Patents RevGenetics offers hard-to-find research materials, which may be labeled as "Food Supplements," "Dietary Supplements," "Research Material," or "For Research Only." You acknowledge and agree to the following: a. By using or opening any of the products labeled as outlined above for scientific purposes, you acknowledge that RevGenetics shall be named as co-inventor in any patent that is created, altered or extended through the use of RevGenetics’ materials in the research, development or creation of such a patent. b. If you or your organization hold or have licensed a patent pertaining to our research materials, you hereby grant RevGenetics an unrestricted, irrevocable, royalty-free license or sublicense for the full term of your patent, as part of the consideration for the acceptance or purchase of our products. Any disputes arising under this clause will be resolved through arbitration, with remedies not to exceed $10 per year. 16. Overall Limitation of Liability To the extent permissible under applicable law, RevGenetics, Anthony Loera, and their respective affiliates, officers, directors, employees, agents, or licensors shall not be liable for any direct, indirect, incidental, consequential, special, or punitive damages, including but not limited to loss of profits, data, or goodwill, or any other intangible losses arising out of or in connection with your access to, use of, or inability to access or use the website, products, or services. This limitation applies regardless of the legal theory or form of action and even if RevGenetics has been advised of the possibility of such damages. 17. Force Majeure Neither RevGenetics nor Anthony Loera shall be liable for any failure or delay in performance under these Terms due to circumstances beyond their reasonable control, including acts of God, war, terrorism, civil unrest, embargoes, acts of civil or military authorities, fires, floods, accidents, labor strikes, or shortages of transportation, fuel, energy, labor, or materials. 18. Compliance with Laws You commit to complying with all pertinent laws, rules, and regulations concerning your utilization of the website, products, and services. This includes, but is not limited to, copyright laws, privacy regulations, and or (ii) by posting to the Services. For notices made by email, the date of receipt will be deemed the date on which such notice is transmitted. 34. Feedback You acknowledge and agree that any questions, comments, suggestions, ideas, feedback or other information about the Services (“Feedback”) provided by you to RevGenetics are non-confidential and RevGenetics (as well as any designee of RevGenetics) shall be entitled to the unrestricted use and dissemination of this Feedback for any purpose, commercial or otherwise, without acknowledgment or compensation to you. 35. Additional Clauses RevGenetics may, from time to time, include additional clauses or policies applicable to specific services. In such instances, you will be made aware of these additional terms, and your continued use of the services will constitute acceptance. 36. Contact Information If you have any additional questions or concerns about these terms and conditions, please feel free to contact us any time through this website or at: RevGenetics LLC 16782 SW 88th St #357 Miami, FL 33196, USA - [Track Your RevGenetics Supplements - RevGenetics](https://www.revgenetics.com/pages/order-status): You can look up your order by entering the order number and your email here. Stay informed on the status of your supplement delivery with our comprehensive guide on tracking supplement delivery. Learn how to track your shipment, ensure on-time delivery, and more! - [Who Is RevGenetics?](https://www.revgenetics.com/pages/about-us): Our Mission: Activating Genes Through Science Since 2007, RevGenetics has focused on one goal: combating aging through gene activation. We are a private, US-based company dedicated to providing pharmaceutical-grade supplements verified by university research. Our Leadership & Scientific Team Anthony Loera Founder & President Anthony established RevGenetics in 2007, pioneering the availability of high-dose Resveratrol and introducing advanced delivery technologies like Micronization and Micelle Encapsulation. With over 18 years of experience, he leads the company's vision of "Science, Not Marketing," collaborating directly with university researchers to validate supplement efficacy. "I have seen the toll that a loved one on hospice care takes on a family. This company was created to find a way to limit that experience as much as possible, for your family as well as mine." View Full Bio & Articles Hector Valenzuela, Ph.D. Chief Science Officer Dr. [cite_start]Valenzuela ("Dr. V") serves as the Fletcher Jones Chair in Molecular Biology and Department Chair at Whittier College[cite: 1, 4]. [cite_start]Holding a Ph.D. in Experimental Pathology from UCLA and a former NIH Tumor Cell Biology Fellow [cite: 1, 7][cite_start], he is a distinguished expert in Immunosenescence and Telomere Biology[cite: 1, 7]. At RevGenetics, Dr. Valenzuela ensures all formulations are backed by rigorous, peer-reviewed science. View Scientific Profile The RevGenetics Standard RevGenetics is a Limited Liability Company formed in the State of Florida. We opened for business in January 2007 with a groundbreaking achievement: The first 500mg Trans-Resveratrol capsule offered to the public. Today, we continue that legacy with MetaCurcumin (277x absorption) and Advanced NMN. We employ American workers and utilize cGMP FDA-Registered facilities within the United States. Unlike many competitors, we do not rely solely on foreign paperwork; we verify safety and purity with HPLC (High-Performance Liquid Chromatography) testing here in the USA. 🇺🇸 Made in USA 🔬 HPLC Certified Purity ✅ cGMP Compliant Facilities ⭐ 4.8/5 Customer Rating Trusted by thousands: 96% of our customers give us a 4 or 5-star rating. See our verified reviews here. Office Operations Erika Guillen Office Manager In charge of office operations, vendor accounts, and employment inquiries. erika@revgenetics.com Stay Informed on Longevity Science Get notified of new university research, product developments, and exclusive sales. Sign Up For Newsletter - [Contact RevGenetics Today](https://www.revgenetics.com/pages/contact-us): Contact RevGenetics by email. Please email us directly if you have questions about RevGenetics products or orders. We have support available from 9am to 5pm Eastern standard time at Orders@revGenetics.com or call us at 888-738-4363. Now if you are overseas call us at +1 (786) 693-1002 for assistance. ## Blog posts ## Optional - [robots.txt](https://www.revgenetics.com/robots.txt) - [sitemap.xml](https://www.revgenetics.com/sitemap.xml)