The Hallmarks of Aging & Interventions

RevGenetics supporting Interventions of Aging

RevGenetics has been working diligently on addressing different aspects of aging. While others developed their own “Unified theory of aging” based on accumulation of minerals such as Iron and Calcium, we took a different route.

The Hallmarks of Aging & Interventions

The Hallmarks of Aging & Interventions

Rather than trying to reinvent the wheel or focus on a single aspect of aging, we instead focused on building on the work of scientists like Aubrey De Grey at the SENS Research Foundation who has provided leadership in this space to many scientists. We’ve also studied the work of Maria Blasco who has been on the cutting edge of aging and cancer science.

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In 2013 Maria Blasco, Director and researcher on aging and cancer at the National Cancer Institute in Spain (with over 30 international scientific awards), published with her collaborators an encompassing review on the 9 tentative hallmarks of aging that are found to be common in different organisms, especially in mammals like us. (Study In Cell)

The review has quickly been accepted by much of the scientific community as a landmark paper, and is used as a reference for many students in academia who are pursuing advanced degrees in the field and has been cited over 400 times by other scientific papers.
While we will not be delving deeply into the 9 hallmarks, we will provide general information on them. Below, we provide the hallmarks of aging, the interventions, and finally how we have been using our resources to create products to support some of these interventions.

9 Hallmarks of Aging- RevGenetics Line Up

9 Hallmarks of Aging- RevGenetics Line Up

What are the 9 hallmarks of aging?

To be considered as a hallmark of aging experimentally three criteria must be met: fisrt, the hallmark must manifest itself during normal aging, second, worsening of the hallmark leads to accelerated aging, and third, alleviating the hallmark leads to delay in aging and a healthier lifespan. The following hallmarks of aging are described thoroughly in the published scientific paper. You can review the paper in the link we provided above. Here we will simply name them for your reference:

Stem Cell Exhaustion
Altered inter-cellular communication
Genomic Instability
Telomere attrition

Epigenetic alterations
Loss of proteostasis
Deregulated nutrient sensing
Mitochondrial dysfunction
Cellular senescence

Which of these are the primary causes of damage that lead to aging? Out of the 9 hallmarks, there are 4 that appear to be the primary causes of cellular damage that lead to aging.

 

4 Principle Hallmarks of Aging - RevGenetics

4 Principle Hallmarks of Aging – RevGenetics

The 4 principal causes of cellular damage are:

1- Genomic instability
2- Telomere attrition
3- Epigenetic alterations
4- Loss of Proteostasis

 

These 4 hallmarks cause your body to produce responses to damage, which initially when a person is young, can compensate for the damage.

Though, in the long run these compensations lead to more damage in the form of 3 hallmarks.

The 3 “compensation” hallmarks are:

1- Deregulated nutrient sensing
2- Mitochondrial dysfunction
3- Cellular senescence

A combination of causative and compensatory hallmarks leads to what is referred to as the “integrative” hallmarks of aging. Integrative hallmarks are viewed as the final culprits that cause a young organism to lose it’s functionality and change its appearance from young to old, essentially, what we call aging.

The 2 “integrative” hallmarks are:

1- Stem cell exhaustion
2- Altered intercellular communication

What are the interventions that may help?

In the published paper, Maria Blasco and her collaborators provided areas of intervention that can be sought by science to help slow the aging process, deal with the present damage found, and prevent ongoing damage. The following areas of interventions are:

RevGenetics can help

RevGenetics can help

1- Stem cell based therapies
2- Anti-inflammatory drugs, blood borne rejuvenation factors
3- Elimination of damaged cells
4- Telomerase reactivation
5- Epigenetic drugs
6- Activation of chaperones and proteotic systems
7- Dietary restricition, mTOR inhibition, along with AMPK and sirtuin activation
8- Mitohormetics, mitophagy
9- Clearance of senescent cells

What has RevGenetics been doing related to these interventions?

At RevGenetics we are researching and following these strategies to combat aging. Although we can only make supplements we believe we can address and support many of these interventions. Below we provide the interventions and the products we use to support these interventions:

RevGenetics supporting Interventions of Aging

ProxyStem - Stem Cell Support

ProxyStem – Stem Cell Support

1- Stem cell based therapies
ProxyStem: We provide ProxyStem to support stem cells and maintaning their functionality. Medical therapies are still pretty far off, but we believe they will be available at one point because of the SENS Foundation.

2- Anti-inflammatory drugs, blood borne rejuvenation factors
MetaCurcumin: We can’t address the blood borne rejuvenation factors as a supplement company. We believe the upcoming lab we call the “Vampire Lab” will address blood borne rejuvenation factors, but ProxyStem, MetaCurcumin and Resveratrol do address some inflammatory issues in this area.

3- Elimination of damaged cells
Resveratrol & PolyMAX: Elimination of damaged cells is normally done through the activation of p16 & p53 genes, which resveratrol and polymax helps with.

TA-65 Telomerase Activator

TA-65 Telomerase Activator

4- Telomerase reactivation
We believe our recommended telomerase activator TA-65 can address this item until an RNA solution is medically tested and found to be safe in humans. Our recommended telomerase activator has been found to be safe in humans, and even provided to some cancer patients by doctors we know.

5- Epigenetic drugs
Resveratrol can modulate Sirtuin protein family members, which in turn have been shown to modulate epigenetics target known to affect longevity.

6- Activation of chaperones and proteotic systems
We are looking into this, and may provide an update in the future.

MetaCurcumin 200 - Anti-inflammatory

MetaCurcumin 200 – Anti-inflammatory

7- Dietary restricition, mTOR inhibition, along with AMPK and Sirtuin activation. Resveratrol, MetaCurcumin and Polymax will help with this item, along with an intermittent 3-5 day fast.

8- Mitohormetics, mitophagy
Studies on Resveratrol function through Sirtuins activation have provided convincing evidence of improved mitochondria respiration via the PGC-1α pathway.

9- Clearance of senescent cells
This may be a difficult item, and might only be addressed by specialized drugs, which no supplement maker can provide.

While RevGenetics cannot address every possible intervention through a supplement, we are considering creating a new company to delve more deeply into those items we currently cannot support because of FDA regulations. If you would like to support us, please consider purchasing one of our products on a monthly basis, starting today, thank you.

About the author

    Anthony

    Anthony Loera is the President and Founder of RevGenetics. His posts provide information on Telomerase Activators, TA-65, Resveratrol and C60 Olive Oil.

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