Telomere Science By Anthony / July 30, 2013 Share 0 Tweet Share 0 Does Long Telomere Length Affect Muscular Dystrophy In A Positive Manner?UPDATE 01/07/2014:This product has been tested by RevGenetics on cells, however RevGenetics only provides it for its concentrated Astragalus benefits.Duchenne muscular dystrophy, or DMD, is a diseased caused by a defective dystrophin gene needed for proper muscle structure and function. DMD is the most common childhood inherited muscular dystrophy, which affects approximately one in every 3500 male boys in the world. Although early symptoms can be observed in the deterioration of calf muscles and other lower limb muscles, it is the muscles involved in respiration and muscles of the heart that normally claim the life of those afflicted. Scientist that study DMD use a DMD rodent model, were the dystrophin gene is also mutated and nonfunctional. However, it has been observed by those in this field of study that the rodents with the defective dystrophin gene do not die of cardiorespiratory failure like the human counterparts that suffer from DMD. In other words, something about DMD mice, even though they have the same defective gene, allows them to be more resistant to cardiac dysfunction than humans. This observation until recently remained a mystery, until they question if Telomere Length Affect Muscular Dystrophy in some manner.Study Shows Long Telomere Length Affect Muscular Dystrophy Cardio Issues:A group of scientists from Stanford University has now published their observations and determined what is causing the high cardiovascular mortality in humans suffering from DMD (Nature Cell Biology, July 2013). To understand the researcher’s observations and conclusions it is important to point out one less commonly known fact about whether Telomere Length Affect Muscular Dystrophy in rodents. Although rodents have a shorter lifespan than humans, they have much longer telomeres. The researchers speculated that because the rodent’s heart cells have longer telomeres they are better able to tolerate cellular stress than humans. To test this the scientist created mice that not only had the dystrophin gene mutation but also had shorter telomeres length comparable to humans. The researchers speculations proved to be correct when they observed that these mice now also suffered from severe cardiovascular malfunctions ranging from problems with ventricular dilation, contraction and conductance all combining to an accelerated mortality in the mice.Added Proof That Long Telomere Length Affect Muscular Dystrophy Heart Cells.As added proof of whether Telomere Length Affect Muscular Dystrophy, the researchers took heart cell samples from DMD patients and measured their telomere length and observed 45% shorter telomeres than their age match controls. As the researchers then stated, these findings support a strong link between dystrophin gene and telomere length but also very importantly these results also suggest preventative strategies in delaying the pathologies of this horrible disease may involve better care of telomeres.TA-65 affects telomere lengthIn a recent study done at UCLA with the help of RevGenetics, it was proved that TA-65 activated telomerase in human cells of different people. We regarding any positive news of telomere length a positive consideration as we believe that TA-65 affects telomere length through the transient activation of telomerase.