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Micronized Resveratrol and Tween 80 - 250mg


Micronized Resveratrol and Tween 80 - 250mg

Micronized Resveratrol & Tween

Nitro250 

Pharmaceutical Grade - Highest Absorption

Micronized Resveratrol & Tween
With Up To 10x The Absorption Over Standard Resveratrol

This high absorption product is exclusively produced by RevGenetics.

We Are Trusted by the BBB with an "A" rating and are a Doctor Trusted Store with a 99% on our on time shipping. Why are we better? We are the only company who has independently tests our products using third party laboratories. This product uses patented licaps nitrogen gas capsules. 250 mg per capsule, 30 capsules, 1.4 Microns, 99% Purity. Best cost effective product as you may need to purchase up to 10 times the amount of pure resveratrol to compare against this product.


Price: $50.00
On Sale Now: $45.00
Options:
Nitro250 30 Caps - (1 Bottle) $50/Bottle - Single Purchase
Nitro250 30 Caps - (4 Bottle) $45/Bottle - Single Purchase
Nitro250 30 Caps - (8 Bottle) $40/Bottle - Single Purchase
Nitro250 30 Caps - (1 Bottle) $45/Bottle - Monthly Autoship

Quantity:  


Liquid Micron Delivery System, in Nitrogen Gas Capsule.
1 Nitro250 Capsule is powerful enough to be compared with up to 2500 mg of pure resveratrol capsules when it comes to absorption. We have formulated this capsule strictly for this high absorption, as there is not doubt this is key for any resveratrol benefits and P53 activation.

The following mentions research done in animals and in labs. We do not claim our products will act in a similar fashion in regular people. As a dietary supplement company, we only present the information for your consideration.

Micronized Resveratrol Absorption Chart

*The chart compiled from study from USPTO Document #20060292099. The absorption study made public by Westphal, the CEO of Sirtris. We are only interested in the absorption studies, and are not infringing on any patent claims as we only sell an herbal trans-resveratrol extract and not a drug. 

Recommended Dosage:
Because of the estimated increased absorption, we recommend only 1 capsule a day.

Why 250mg Dose?
Because 100mg is fine for mice, but is simply much too low for humans:

About 70% of the resveratrol dose given orally as a pill is absorbed; nevertheless, oral bioavailability of resveratrol is low because it is rapidly metabolized in intestines and liver into conjugated forms: glucuronate and sulfonate. [1] Only trace amounts (below 5 ng/mL) of unchanged resveratrol could be detected in the blood after 25 mg oral dose.[1] Even when a very large dose of regular resveratrol (2.5 and 5g) was given as uncoated pill, the concentration of resveratrol in blood was only 2.4umol/L.[2]

We believe 250mg of Micronized resveratrol with tween 80 will allow greater absorption compared to regular resveratrol and to all of our other micronized resveratrol capsules without tween 80.

[1]."High absorption but very low bioavailability of oral resveratrol in humans". Walle T, Hsieh F, DeLegge MH, Oatis JE, Walle UK (2004).

[2]. "Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent".
David J. Boocock, et al (2007).

What about the stability of Resveratrol?
Resveratrol has been found to be stable. The trans-form can undergo isomerisationto the cis-form when exposed to ultraviolet irradiation.[3]Trans-resveratrol in the powder form was found to be stable under "accelerated stability" conditions of 75% humidity and 40 degrees C in the presence of air. [4] Resveratrol content also stayed stable in the skins of grapes and pomace taken after fermentation and stored for a long period.[5]

Having explained resveratrol's good stability, we add that each individual capsule of the Nitro 250 product, is opaque and filled with nitrogen and protected for long term storage even if you take out the capsules from our bottles and decide to transfer them to another container. If long term storage is important, and you want the product to last more than 2 years even after opening the bottle, this is the product to purchase.


[3]."Direct HPLC Analysis of cis- and trans-Resveratrol and Piceid Isomersin Spanish Red Vitis vinifera Wines". Lamuela-Raventos, RM (1995).

[4].
"Resveratrol and its glycon piceid are stable polyphenols". Prokop J, Abrman P, Seligson AL, Sovak M (2006).

[5]. "Stability of resveratrol over time and in the various stages of grape transformation".
Bertelli AA, Gozzini A, Stradi R, Stella S, Bertelli A (1998).


Does It Work ?
Resveratrol is one of 3 supplements we are working on for longevity. Resveratrol is aimed at the P53 gene along with many other benefits.
Telomerase supplements are aimed to produce a strong immune system and support DNA. A third supplement that we have not yet made available is aimed at the P16 gene. We believe maintaining these 3 genes in a healthy state will allow a person to naturally live healthier for a longer period of time. This article explains the importance of these 3 master genes, and a study in mice: News Article

We have looked through the literature, and there have only been small human studies regarding resveratrol. There are no clinical studies regarding longevity in humans, as it may take 20 years or more to produce a longevity study. The only thing we can do is discuss current animal studies, and see how they may or may not relate to humans. Because of all the positive information from hundreds of studies in animals and in lab cells, it is believed that this maybe one of the most complex and beneficial herbal supplements available.

What else is recommended to take with Nitro250?
Products recommended by RevGenetics are found here

Are there any cautions I should be aware of?
In studies, resveratrol is suggested to be a weak inhibitor of the P4503A4 liver metabolism system, which is of unknown significance for humans. Taking large amounts of resveratrol may increase blood levels of drugs that are usually metabolized by CYP3A4.

This simply means that calcium channel blockers, statins, some immunosuppressant drugs, and erectile dysfunction drugs, may have increased blood levels. Please be cautious when taking resveratrol with anti coagulants or anti platelet drugs. An increase in adenosine availability is involved in resveratrol cardioprotection in rats. It maybe possible that an increase in adenosine can increase uric acid temporarily. As a caution, it is not recommended long term for people with a genetic pre-disposition to Gout.


We also advise the following:

* Keep out of reach and do not give to children.
* Do not exceed suggested maximum dose unless your doctor recommends it.
* If you have a bad reaction to the supplement discontinue use immediately.
* When undergoing treatment for any medical condition, are pregnant (or lactating) please inform your physician when using any nutritional supplements.

Product Summary:

* 250mg Micronized Trans-Resveratrol
* The only micronized resveratrol between 1-2 microns available.
* Estimated 10x more effective over our regular resveratrol supplements.
* Non-Vegetarian capsules specifically chosen because of absorption requirements.
* Nitrogen gas protected capsules, to eliminate long term storage oxidation.
* Powder is independently tested in a United States laboratory for safety and purity.
* The product is herbal and does not contain prescription ingredients.
* Made in the USA.

*Based on absorption comparison tests using resveratrol and micronized resveratrol published in USPTO document 20060292099. Licaps and Licaps Design are trademarks used under license. 





If for any reason you are unhappy with RevGenetics capsule products, simply return the unused portion to us within 30 days of your purchase and we will send you a full refund for the item(s) purchase price. No Questions Asked. Our return and refund policy applies to all capsule products. Products such as loose powder, inert gas, cream or others not mentioned here cannot be returned or refunded at this time.

RevGenetics is a "Research and Materials" Provider to Universities and Government Institutions such as The National Institutes of Health and Aging.

RevGenetics has been verified by Dunn and Bradstreet - Provider of business credit to global financial institutions.

RevGenetics products are tested by AACL an Independent United States Laboratory in Illinois - Recognized As An International 17025 ISO Accredited Lab.

RevGenetics is FDA Registered - Our FDA approved product manufacturing facilities meet or exceed rigorous U.S. cGMP requirements.




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