Resveratrol: The Latest Science
What is Resveratrol?
Resveratrol was first isolated in 1940 from the roots of hellebore. In 1963, it was then isolated from the roots of Polygonum Cuspidatum, a traditional Chinese and Japanese medicinal plant. Resveratrol did not attract interest until 1992, when it was considered to explain some of the life long consumption cardio protective benefits of red wine. Since then, there have been many research reports that have shown Resveratrol can prevent or slow down a wide variety of illnesses from Cancer and Alzheimer’s to cardiovascular disease on animals.
M98 Micronized Resveratrol: Resveratrol particles smaller than red blood cells to provide the highest absorption.
While our resveratrol capsules are used in many studies, we still try to provide the best pricing we can to the general public. For example: As of 03/07/2013 our R250 and X500 Resveratrol products shown above, beat GNC online website regarding regular priced single bottle purchases of 50% and 99% pure resveratrol respectively.
Your Purchase For RevGenetics Brand Resveratrol Products Is Covered Through BuySafe, The BBB And Our 30 Day Money Back Guarantee. You Are Completely Covered And Safe To Buy Resveratrol Today!
We even provide special pricing to Doctors, Nurses and folks in the medical and educational fields, as well as AARP members and students. Call us if you need to setup special pricing. If you already know about the benefits, please click on the buttons above to purchase resveratrol. If you need more information please read below.
The following mentions research done in animals and in labs. Since there are no human studies we do not claim our products will act in a similar fashion in regular people. We only present the information for your consideration:
Resveratrol for cancer.
In 1997, Jang published a research paper reporting that resveratrol inhibits carcinogenesis at multiple stages. They found that topical application of resveratrol reduced the number of skin tumors in mice by up to 98%. This triggered resveratrol research around the world. Since then, systemic administration of resveratrol has been shown to inhibit, and limit the growth of tumors in a wide variety of rodent cancerous models. The research models suggest that resveratrol could inhibit cancerous tumor development using multiple mechanisms
Resveratrol (3,4’,5-trihydroxystilbene) belongs to a class of polyphenolic compounds called stilbenes. Some types of plants produce Resveratrol and other stilbenes in response to stress, injury, fungal infection, and ultraviolet (UV) radiation. It is found in the skins of certain red grapes, in peanuts, blueberries, some pines (Scots pine, eastern white pine) and the roots and stalks of Japanese knotweed (hu zhang in China) and giant knotweed.
Although a chemically produced version called Trans-Resveratrol was declared an Investigational New Drug by the National Institutes of Health in January of 2001, resveratrol did not gain large notoriety among the general public until a study released by Harvard Medical School in November 2006. In this study, researchers David Sinclair and Rafael de Cabo, Ph.D., determined that resveratrol increased the lifespan of obese mice and reversed nearly all of the changes in gene expression patterns found in mice on high calorie diets—some of which are associated with diabetes, heart disease, and other significant diseases related to obesity.
As of mid 2007, Dr. David Sinclair is part of a group testing a Resveratrol formulation on humans with doses of 2500mg and 5000mg a day, and has recently finished phase “Ia” safety tests, and is further testing Resveratrol for specific positive results on various diseases.
Dr. Sinclair is continuing his work. In 2008 he finishes his work with the 2006 study. In his observations he notes that resveratrol along with an EOD (Every other Day) diet did increase mouse lifespan. Resveratrol alone, appears to have maintained health and quality of life in mice longer than those without resveratrol.
What are the benefits of Resveratrol?
On non human mammals, it has been shown to prevent and shrink cancer, has been shown to have strong antiviral anti-fungal properties. RevGenetics has seen studies that have also shown neuro-protective, anti-aging, anti-inflammatory and life-prolonging effects on subjects*.
Resveratrol and Angiogenesis.
Angiogenesis is required for most cancer tumors to grow beyond a 2-3 mm diameter. When delivered systemically, at a dose of 2.5-100mg per kg of body weight, resveratrol has been found to inhibit the tumor activated neovascularization and wound healing. The suppression by resveratrol could have a role in its effect on stopping tumor growth.
In resveratrol obtained from dietary foods, such as red wine, their was some evidence of therapeutic effects. At higher doses that can be achieved through supplement concentrations and pharmacological sources, the protective effects and results were more dramatic. In one study, a dose of 40 mg per kg of body weight increased the survival of mice from 0% to 70% that had subcutaneous neuroblastomas.
Resveratrol and drug metabolism.
In studies using livers of resveratrol treated rats, it has been found that it may prevent carcinogens while at the same time increasing the body’s capacity to eliminate harmful molecules.
Resveratrol as Antioxidant.
Reactive oxygen species are shown to have a damaging role to DNA as well as other macromolecules. Resveratrol has a antioxidant capacity that can also be related to the chemo preventative effects it has shown. Resveratrol appears to prevent LDL oxidation in some studies. In stroke prone rats, resveratrol significantly reduced oxidative stress markers.
Resveratrol and cholesterol
In 1982 resveratrol was shown to inhibit the deposit of triglycerides and cholesterol in rat livers. Current studies are not conclusive.
Resveratrol and postmenopausal women
Resveratrol has been reported to act as a phytooestrogen in some systems. It has been suggested that it has helped the effects of it Cardioprotective effects. At this time the oestrogenic effects have been subjects of debate and research is working to see if there is a firm connection for the cardioprotective effects.
Resveratrol and immunity
resveratrol has been shown to reduce and suppress many types of inflammation, which is a main interest in arthritis, psoriasis, and crohn’s disease. Inflammation can also play a part in cardiovascular disease and cancer. Resveratrol could represent a positive alternative to current treatments for chronic inflammation as aspirin taken for long period can damage the lining of the stomach, while resveratrol does not. In addition, resveratrol enhances immune response in mice, as well as shown to protect them from infection by herpes simplex virus 1 and 2. This suggests resveratrol interaction with the immune system is more complex, and that the immune system could even be enhanced.
Other Resveratrol studies.
Resveratrol has been reported to protect against hearing loss, act as an analgesic, reduce injury to spinal cord, liver, kidneys, lungs, intestine, and colon. The results indicate that Resveratrol is not limited to help against brain and heart injuries.
Studies we would like to see:
Because no comprehensive studies have been done for children regarding its effects on natural development, we do not recommend anyone under 18 take resveratrol at this time.
How does Resveratrol make one live longer?
David Sinclair of the Harvard Medical School found that it increases an enzyme called SIRT1 in a subject, it ‘resets’ proteins that limit the cells longevity. RevGenetics believes that by increasing these enzymes, we can theoretically increase the lifespan of the cells. In theory this could increase the human lifespan dramatically*. In one study it increased the lifespan of fish by 60%, however in a recent study using an EOD diet, it appears to increase lifespan of mice by 15%.
How much Resveratrol should I take?
Several Clinical Trials are currently underway for oral resveratrol in humans at dosages from 2.5 grams to 7.5 grams of regular resveratrol a day, including National Cancer Institute sponsored studies at the University of Michigan, USA, and the University of Lericester, in the UK, and some private corporations looking to produce similar drugs.
David Sinclair of the Harvard Medical School used it on non-human subjects. The dosage he used on the non-human subjects of his study, is equivalent to about 500mg for each 50lbs of a person’s weight. Although this target was optimum in the Harvard study, many folks can take less on a daily basis as studies haven’t concluded what the correct dosage would be.
In January 2008, David Sinclair finished the first Human study of resveratrol specifically for diabetes. The formula used was a Resveratrol formulation and not the drug that is being creating for 2012, using the current Resveratrol discoveries.
In 2011 a new recommendation of 450mg was provided by the New York Academy of Sciences. You can read about it here (link). RevGenetics can provide you with 250mg and 500mg capsules so you can decide if you would like to use the Harvard dosage used and take a maximum of 500mg for every 50lbs you have, or if you would like to take less on a daily basis to try Resveratrol as part of your nutritional regimen. We recommend healthy people to start with 250mg or more per day.
Why should I buy Resveratrol from RevGenetics?
The following may help you compare us to other companies:
1- All of our capsule products (except for the R250), use 99% pure trans-resveratrol.
2- We are one of a three other companies that make such high purity products, but the only one that offers bulk powder.
3- We are the only company that makes independently verified micronized powder capsules that are smaller than a red blood cell. Only two companies offer micronized capsules in the world, and we are one of them.
4- We are the only company in the world that offers bulk regular and micronized trans-resveratrol powder to the general public.
5- We are also the only company that uses Licaps capsules in our micronized resveatrol liquid tween emulsion formula. These are the nitrogen protected capsules. If you heard of the capsules with the nitrogen bubble, you have heard of our capsules.
6- We do not make our capsules outside of the US like other companies do. We make our capsules here in the United States by US workers that have to abide by FDA rules and cGMP regulations. Ask others if they import the finished bottles, or encapsulate them inside the US. Many others import from china, or Africa where our laws cannot verify FDA cGMP manufacturing.
7- We test all our material in an independent lab that is certified internationally. We simply test every batch. The United States FDA allows companies to test batches as little as once a year for compliance, while as many as 10-12 batches in ordinary manufacturing plants do not get tested.
We simply cannot do this even if it is acceptable by the FDA. We simply have many family members of company employees take our own products, as well as the President of RevGenetics. We have tested bad batches in the past from unscrupulous vendors with extraordinary levels or Mercury that were not acceptable by any one’s standards, so skipping a test for purity and safety is simply not an option for us.
This is an example of a bad batch that was sent to us where the paperwork from China looked fine, but upon testing, provided us with an illegal amount of mercury content. Here we show page one and two of the actual lab results for the high mercury batch that was sent to us from china. Be advised that do due our current FDA regulations, others could have used this bad batch without testing it. Since we test every batch, we can assure our customers that we provide a pure and safe product:
RevGenetics simply offers one of the best products, at some of the best pricing, for your daily needs. No one else offers a 1000mg capsule of Resveratrol or micronized resveratrol powder. Beware of capsules that may say 500mg or less of grape extract but only provide a tiny percentage of Resveratrol.
RevGenetics simply recommends 250mg of pure Trans-Resveratrol or more in each capsule. If you decide not to purchase from RevGenetics, we ask that you please search for this minimum quantity for your next purchase.
As a natural herbal supplement *these statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Please refer to the scientific studies for detailed information of the possible benefits of RevGenetics Resveratrol. GNC (General Nutrition Centers) is a trademark of General Nutrition Investment Company Corporation, Arizona.