Resveratrol: Science Reviewed And Which Is Best?
Update 10/31/2014: New Study Proves Resveratrol Increases Body Fat Burning Hormone In Human Subjects. (Resveratrol Body Fat Burning Hormone In Human Subjects Is Proved)
Resveratrol: which is the best?
RevGenetics Micronized Resveratrol powder has a particle size of 1.5 microns, and is absorbed up to 220% compared to regular Resveratrol supplements that average between 149 to 224microns. When the micronized natural material is combined with Tween we can see up to a 1000% absorption increase when compared to the regular material found in other supplements (Sirtris Resveratrol). The comparison of the regular material and the special micronized material increases are shown in the chart below. Then RevGenetics Nitro250 is the only product publicly available that combines micronized resveratrol and tween. The Sirtris Resveratrol formulation with tween is not available to the public.
Nitro250 Resveratrol: Micronized Resveratrol & Tween – Our version of the SRT501 formulation – Estimated to provide up to 10x the absorption
Micro500 Micronized Resveratrol: Resveratrol particles smaller than red blood cells to provide the highest absorption in a vegetarian capsule.
What is Micronized Resveratrol?
RevGenetics considered resveratrol that has been reduced to a particle size of 1.5 microns, called TrueMicronized(tm) resveratrol. This resveratrol has an increase in absorption between 2x to 10x or more depending on which particular RevGenetics product you are considering. You may see other companies offering resveratrol that states “Micronized” but upon close inspection, they offer a particle size much larger than 1.5 microns. We believe these other companies are simply using the term “Micronized” as a selling tool, since RevGenetics was the first supplement company to offer TrueMicronized(tm) resveratrol at a size that is smaller than a red blood cell. Products with a verified particle size of 1.5 microns and TrueMicronized(tm) certification can only be purchased at RevGenetics.
What is Sirtris Resveratrol?
This is the original formula designed by Sirtris Pharmaceuticals which was purchased by GlaxoSmithKline for $720 million dollars for its research on the natural molecule. Originally Sirtris Pharmaceuticals was created and gained popularity when Dr. David Sinclair announced his findings on the natural material. Later, the company was quickly bought out by GlaxoSmithKinle, the Pharmaceutical giant.
The original formulation used micronized material emulsified in tween which produced the very high absorption rates. The Nitro250 is the RevGenetics version of this high absorption Sirtris formulation shown in the chart above.
What is Resveratrol?
The material was first isolated in 1940 from the roots of hellebore. In 1963, it was then isolated from the roots of Polygonum Cuspidatum, a traditional Chinese and Japanese medicinal plant. This material did not attract interest until 1992, when it was considered to explain some of the life long consumption cardio protective benefits of red wine. Since then, there have been many research reports that have shown that it can prevent or slow down a wide variety of illnesses from Cancer and Alzheimer’s to cardiovascular disease on animals.
While our capsules are used in many university studies, we still try to provide the best pricing we can to the general public.
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A recommendation of 450mg was provided by the New York Academy of Sciences.
You can read about the recommendation of the New York Academy of Sciences here (link). RevGenetics can provide you with 250mg and 500mg capsules so you can decide if you would like to use the Harvard dosage used and take a maximum of 500mg for every 50lbs you have, or if you would like to take less on a daily basis to try the natural material as part of your nutritional regimen. We recommend healthy people to start with 250mg or more per day. If you want to take the best product RevGenetics has made based on the Sinclair formulation that others call the Sirtris Resveratrol, then you only need to purchase the Nitro250, as it is the only one that is close to the Sinclair SRT501 formulation because of its micronized natural material and tween.
The following mentions research done in animals and in labs. Since there are no human studies we do not claim our products will act in a similar fashion in regular people. We only present the information for your consideration:
Resveratrol for cancer.
In 1997, Jang published a research paper reporting that the natural material inhibits carcinogenesis at multiple stages. They found that topical application of resveratrol reduced the number of skin tumors in mice by up to 98%. This triggered research around the world. Since then, systemic administration of the material has been shown to inhibit, and limit the growth of tumors in a wide variety of rodent cancerous models. The research models suggest that it could inhibit cancerous tumor development using multiple mechanisms.
Resveratrol (3,4’,5-trihydroxystilbene) belongs to a class of polyphenolic compounds called stilbenes. Some types of plants produce it and other stilbenes in response to stress, injury, fungal infection, and ultraviolet (UV) radiation. It is found in the skins of certain red grapes, in peanuts, blueberries, some pines (Scots pine, eastern white pine) and the roots and stalks of Japanese knotweed (hu zhang in China) and giant knotweed.
Although a chemically produced version called Trans-Resveratrol was declared an Investigational New Drug by the National Institutes of Health in January of 2001, the natural material did not gain large notoriety among the general public until a study released by Harvard Medical School in November 2006. In this study, researchers David Sinclair and Rafael de Cabo, Ph.D., determined that the natural material increased the lifespan of obese mice and reversed nearly all of the changes in gene expression patterns found in mice on high calorie diets—some of which are associated with diabetes, heart disease, and other significant diseases related to obesity.
As of mid 2007, Dr. David Sinclair is part of a group testing a Resveratrol formulation on humans with doses of 2500mg and 5000mg a day, and has recently finished phase “Ia” safety tests, and is further testing the material for specific positive results on various diseases.
In 2008 Dr. Sinclair finished his work with the 2006 study. In his observations he notes that the natural material along with an EOD (Every other Day) diet did increase mouse lifespan. Resveratrol alone, appears to have maintained health and quality of life in mice longer than those without it.
What are the benefits of Resveratrol?
On non human mammals, it has been shown to prevent and shrink cancer, has been shown to have strong antiviral anti-fungal properties. RevGenetics has seen studies that have also shown neuro-protective, anti-aging, anti-inflammatory and life-prolonging effects on subjects*.
Resveratrol as Antioxidant.
Reactive oxygen species are shown to have a damaging role to DNA as well as other macromolecules. The material has a antioxidant capacity that can also be related to the chemo preventative effects it has shown. It also appears to prevent LDL oxidation in some studies. In stroke prone rats, the material significantly reduced oxidative stress markers.
Angiogenesis is required for most cancer tumors to grow beyond a 2-3 mm diameter. When delivered systemically, at a dose of 2.5-100mg per kg of body weight, the material has been found to inhibit the tumor activated neovascularization and wound healing. The suppression by the material could have a role in its effect on stopping tumor growth.
In resveratrol obtained from dietary foods, such as red wine, their was some evidence of therapeutic effects. At higher doses that can be achieved through supplement concentrations and pharmacological sources, the protective effects and results were more dramatic. In one study, a dose of 40 mg per kg of body weight increased the survival of mice from 0% to 70% that had subcutaneous neuroblastomas.
In studies using livers of treated rats, it has been found that it may prevent carcinogens while at the same time increasing the body’s capacity to eliminate harmful molecules.
In 1982 it was shown to inhibit the deposit of triglycerides and cholesterol in rat livers. Current studies are not conclusive.
Resveratrol has been reported to act as a phytooestrogen in some systems. It has been suggested that it has helped the effects of it Cardioprotective effects. At this time the oestrogenic effects have been subjects of debate and research is working to see if there is a firm connection for the cardioprotective effects.
resveratrol has been shown to reduce and suppress many types of inflammation, which is a main interest in arthritis, psoriasis, and crohn’s disease. Inflammation can also play a part in cardiovascular disease and cancer. The natural material could represent a positive alternative to current treatments for chronic inflammation as aspirin taken for long period can damage the lining of the stomach, while resveratrol does not. In addition, the natural material enhances immune response in mice, as well as shown to protect them from infection by herpes simplex virus 1 and 2. This suggests resveratrol interaction with the immune system is more complex, and that the immune system could even be enhanced.
Resveratrol has been reported to protect against hearing loss, act as an analgesic, reduce injury to spinal cord, liver, kidneys, lungs, intestine, and colon. The results indicate that the natural material is not limited to help against brain and heart injuries.
Studies we would like to see:
Because no comprehensive studies have been done for children regarding its effects on natural development, we do not recommend anyone under 18 take this natural product at this time.
How does Resveratrol make one live longer?
David Sinclair of the Harvard Medical School found that it increases an enzyme called SIRT1 in a subject, it ‘resets’ proteins that limit the cells longevity. RevGenetics believes that by increasing these enzymes, we can theoretically increase the lifespan of the cells. In theory this could increase the human lifespan dramatically*. In one study it increased the lifespan of fish by 60%, however in a recent study using an EOD diet, it appears to increase lifespan of mice by 15%.
How much should I take?
Several Clinical Trials are currently underway for oral resveratrol in humans at dosages from 2.5 grams to 7.5 grams of the regular natural material a day, including National Cancer Institute sponsored studies at the University of Michigan, USA, and the University of Lericester, in the UK, and some private corporations looking to produce similar drugs.
David Sinclair of the Harvard Medical School used it on non-human subjects. The dosage he used on the non-human subjects of his study, is equivalent to about 500mg for each 50lbs of a person’s weight. Although this target was optimum in the Harvard study, many folks can take less on a daily basis as studies haven’t concluded what the correct dosage would be.
In January 2008, David Sinclair finished the first Human study of the natural material specifically for diabetes. The formula used was a Resveratrol and tween formulation and not the proprietary drug that was being creating for 2012.
Why should I buy Resveratrol from RevGenetics?
The following may help you compare us to other companies:
1- All of our capsule products use 99% pure natural material.
2- We are one of a three other companies that make such high purity products, but the only one that offers bulk powder.
3- We are the only company that makes independently verified micronized powder capsules that are smaller than a red blood cell that is also part of the Natural Products Association and have been around since 2007.
4- We are the only company in the world that offers bulk regular and micronized trans-resveratrol powder to the general public.
5- We are also the only company that uses Licaps capsules in our micronized liquid tween emulsion formula with tween. These are the nitrogen protected capsules. If you heard of the capsules with the nitrogen bubble, you have heard of our capsules.
6- We do not make our capsules outside of the US like other companies do. We make our capsules here in the United States by US workers that have to abide by FDA rules and cGMP regulations. Ask others if they import the finished bottles, or encapsulate them inside the US. Many others import from china, or Africa where our laws cannot verify FDA cGMP manufacturing.
7- We test all our material in an independent lab that is certified internationally. We simply test every batch. The United States FDA allows companies to test batches as little as once a year for compliance, while as many as 10-12 batches in ordinary manufacturing plants do not get tested.
We simply cannot do this even if it is acceptable by the FDA. We simply have many family members of company employees take our own products, as well as the President of RevGenetics. We have tested bad batches in the past from unscrupulous vendors with extraordinary levels or Mercury that were not acceptable by any one’s standards, so skipping a test for purity and safety is simply not an option for us.
This is an example of a bad batch that was sent to us where the paperwork from China looked fine, but upon testing, provided us with an illegal amount of mercury content. Here we show page one and two of the actual lab results for the high mercury batch that was sent to us from china. Be advised that do due our current FDA regulations, others could have used this bad batch without testing it. Since we test every batch, we can assure our customers that we provide a pure and safe product:
RevGenetics simply offers one of the best products, at some of the best pricing, for your daily needs. No one else offers a capsule of the natural material or micronized resveratrol powder with tween for the highest absorption possible. Beware of capsules that may say 500mg or less of grape extract but only provide a tiny percentage of the material. The fact is that they may not activate SIRT1 at all.
RevGenetics simply recommends 250mg of pure micronized natural material or more in each capsule. If you decide not to purchase from RevGenetics, we ask that you please search for this minimum quantity for your next purchase.
As a natural herbal supplement *these statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Please refer to the scientific studies for detailed information of the possible benefits of RevGenetics Resveratrol. GNC (General Nutrition Centers) is a trademark of General Nutrition Investment Company Corporation, Arizona. The estimate is based on a study from USPTO Document #20060292099. The absorption study made public by Westphal, the CEO of Sirtris, shows the following absorption chart comparing regular material against micronized material. Our estimate is based on non-micronized resveratrol found in supplements vs micronized resveratrol. We are only interested in the absorption studies, and are not infringing on any patent claims as we only sell an herbal trans-resveratrol extract. We are not associated with Westphal or Sirtris in anyway, but do appreciate the absorption studies made available publicly through this document.
Title: Resveratrol: Science Reviewed And Which Is Best?
Reviewed by Anthony Loera on Nov 3
Summary: Resveratrol summary on studies improving health by improving aging, fighting off infections and improving the efficacy of drugs.
Description: Resveratrol information is reviewed along with news and studies using micronized resveratrol created based in the Sirtris Pharmaceutcals formulation which showed high absorption.
Date and Time: 11/01/2014 00:00
Locality: United States